Pyroglutamic acid (BioDeep_00000001870)

 

Secondary id: BioDeep_00000229606, BioDeep_00000399909, BioDeep_00000400414, BioDeep_00000402913, BioDeep_00000405233, BioDeep_00000415816, BioDeep_00000872257

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs BioNovoGene_Lab2019


代谢物信息卡片


(S)-(-)-gamma-Butyrolactam-gamma-carboxylic acid

化学式: C5H7NO3 (129.0426)
中文名称: L-焦谷氨酸, 焦谷氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 17.7%

Reviewed

Last reviewed on 2024-08-20.

Cite this Page

Pyroglutamic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/pyroglutamic_acid (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001870). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1CC(=O)NC1C(=O)O
InChI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1

描述信息

Pyroglutamic acid (5-oxoproline) is a cyclized derivative of L-glutamic acid. It is an uncommon amino acid derivative in which the free amino group of glutamic acid cyclizes to form a lactam. It is formed nonenzymatically from glutamate, glutamine, and gamma-glutamylated peptides, but it can also be produced by the action of gamma-glutamylcyclotransferase on an L-amino acid. Elevated blood levels may be associated with problems of glutamine or glutathione metabolism. This compound is found in substantial amounts in brain tissue and other tissues in bound form, especially skin. It is also present in plant tissues. It is sold, over the counter, as a "smart drug" for improving blood circulation in the brain. Pyroglutamate in the urine is a biomarker for the consumption of cheese. When present in sufficiently high levels, pyroglutamic acid can act as an acidogen and a metabotoxin. An acidogen is an acidic compound that induces acidosis, which has multiple adverse effects on many organ systems. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of pyroglutamic acid are associated with at least five inborn errors of metabolism including 5-oxoprolinuria, 5-oxoprolinase deficiency, glutathione synthetase deficiency, hawkinsinuria, and propionic acidemia. Pyroglutamic acid is an organic acid. Abnormally high levels of organic acids in the blood (organic acidemia), urine (organic aciduria), the brain, and other tissues lead to general metabolic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy). These can progress to heart, liver, and kidney abnormalities, seizures, coma, and possibly death. These are also the characteristic symptoms of the untreated IEMs mentioned above. Many affected children with organic acidemias experience intellectual disability or delayed development. In adults, acidosis or acidemia is characterized by headaches, confusion, feeling tired, tremors, sleepiness, and seizures. It has been shown that pyroglutamic acid releases GABA from the cerebral cortex and displays anti-anxiety effects in a simple approach-avoidance conflict situation in the rat. In clinical pharmacology experiments, pyroglutamic acid significantly shortens the plasma half-life of ethanol during acute intoxication.
Found in vegetables, fruits and molasses. A cyclized derivative of L-glutamic acid. It is an uncommon amino acid derivative in which the free amino group of glutamic acid cyclizes to form a lactam. Pyroglutamate in the urine is a biomarker for the consumption of cheese
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent

同义名列表

82 个代谢物同义名

(S)-(-)-gamma-Butyrolactam-gamma-carboxylic acid; (S)-(-)-gamma-Butyrolactam-gamma-carboxylate; (S)-(-)-g-Butyrolactam-g-carboxylic acid; (5S)-2-Oxopyrrolidine-5-carboxylic acid; (S)-(-)-2-Pyrrolidone-5-carboxylic acid; (2S)-5-oxopyrrolidine-2-carboxylic acid; (S)-5-oxo-2-Pyrrolidinecarboxylic acid; 2-Oxopyrrolidine-5(S)-carboxylic acid; L-5-oxo-2-Pyrrolidinecarboxylic acid; (S)-(-)-g-Butyrolactam-g-carboxylate; (S)-2-Pyrrolidone-5-carboxylic acid; (-)-2-Pyrrolidone-5-carboxylic acid; (5S)-2-Oxopyrrolidine-5-carboxylate; (S)-(-)-2-Pyrrolidone-5-carboxylate; (S)-5-oxo-2-Pyrrolidinecarboxylate; 5-Oxopyrrolidine-2-carboxylic acid; 2-L-Pyrrolidone-5-carboxylic acid; 2-Pyrrolidinone-5-carboxylic acid; L-2-Pyrrolidone-5-carboxylic acid; 5-Pyrrolidinone-2-carboxylic acid; 2-Oxopyrrolidine-5(S)-carboxylate; L-5-Pyrrolidone-2-carboxylic acid; L-5-oxo-2-Pyrrolidinecarboxylate; (-)-2-Pyrrolidone-5-carboxylate; 5-Pyrrolidone-2-carboxylic acid; 2-Pyrrolidone-5-carboxylic acid; (S)-2-Pyrrolidone-5-carboxylate; L-Pyrrolidinonecarboxylic acid; Pyrrolidone-5-carboxylic acid; Oxopyrrolidinecarboxylic acid; L-5-Pyrrolidone-2-carboxylate; L-2-Pyrrolidone-5-carboxylate; 5-Pyrrolidinone-2-carboxylate; 2-L-Pyrrolidone-5-carboxylate; 2-Pyrrolidinone-5-carboxylate; L-Pyrrolidonecarboxylic acid; Pyrrolidinonecarboxylic acid; 5-Pyrrolidone-2-carboxylate; L-5-Carboxy-2-pyrrolidinone; L-Pyrrolidinonecarboxylate; Pyrrolidonecarboxylic acid; 5-Carboxy-2-pyrrolidinone; Pyrrolidone-5-carboxylate; Oxopyrrolidinecarboxylate; Pyrrolidinonecarboxylate; L-Pyrrolidonecarboxylate; L-Glutamic acid g-lactam; (S)-Pyroglutamic acid; (-)-Pyroglutamic acid; L-Pyroglutamic acid; Pidolate, magnesium; L-Pyroglutamicacid; Magnesium pidolate; (S)-Pyroglutamate; (-)-Pyroglutamate; Pyroglutamic acid; L-Glutiminic acid; L-5-Oxoproline(2); L-Glutimic acid; L-Pyroglutamate; Glutiminic acid; 5-oxo-L-Proline; L-5-Oxoproline; 5-Oxoprolinate; 5-L-Oxoproline; L-Glutiminate; Glutimic acid; Pyroglutamate; 5-Ketoproline; Pidolic acid; Ajidew a 100; 5-Oxoproline; L-Glutimate; Glutiminate; Pidolidone; Oxoproline; Glutimate; Pidolate; PCA; Pyroglutamic acid; L-Pyroglutamic acid; 5-Oxoproline



数据库引用编号

52 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

276 个相关的代谢反应过程信息。

Reactome(15)

BioCyc(1)

  • γ-glutamyl cycle: a 5-L-glutamyl-L-amino acid + cysteinylglycine ⟶ a standard α amino acid + glutathione

WikiPathways(2)

Plant Reactome(237)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(21)

PharmGKB(0)

192 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ACE, CA1, PGPEP1, TRHDE
Endosome membrane 1 ITM2B
Nucleus 2 EHMT2, FLG
cytosol 5 CA1, FLG, GLS, GSS, PGPEP1
nucleoplasm 2 EHMT2, SLC3A2
Cell membrane 4 ACE, ITM2B, SLC3A2, TNF
Cytoplasmic granule 1 FLG
Golgi apparatus membrane 2 ITM2B, QPCTL
Synapse 2 GLS, SLC3A2
cell junction 1 SLC3A2
cell surface 2 SLC3A2, TNF
glutamatergic synapse 1 FLG
Golgi apparatus 2 ITM2B, QPCTL
Golgi membrane 3 INS, ITM2B, QPCTL
lysosomal membrane 1 SLC3A2
neuronal cell body 1 TNF
postsynapse 1 FLG
Cytoplasm, cytosol 1 GLS
Cytoplasmic vesicle, secretory vesicle 2 CHGA, NTS
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 7 ACE, FLG, ITM2B, KNG1, SLC3A2, TNF, TRHDE
Membrane 6 ACE, FLG, ITM2B, QPCTL, SLC3A2, TRHDE
apical plasma membrane 1 SLC3A2
basolateral plasma membrane 1 SLC3A2
extracellular exosome 8 ACE, CA1, GSS, ITM2B, KNG1, QPCT, SLC3A2, TRHDE
Lysosome membrane 1 SLC3A2
extracellular space 8 ACE, CCL2, CHGA, INS, ITM2B, KNG1, TNF, TRHDE
perinuclear region of cytoplasm 1 CHGA
mitochondrion 1 GLS
intracellular membrane-bounded organelle 2 ITM2B, NTS
Single-pass type I membrane protein 2 ACE, QPCTL
Secreted 7 ACE, CCL2, CHGA, INS, NTS, QPCT, TRH
extracellular region 11 ACE, CCL2, CHGA, FLG, INS, ITM2B, KNG1, NTS, QPCT, TNF, TRH
mitochondrial matrix 1 GLS
anchoring junction 1 SLC3A2
external side of plasma membrane 2 ACE, TNF
cytoplasmic vesicle 1 FLG
recycling endosome 1 TNF
Single-pass type II membrane protein 3 ITM2B, SLC3A2, TNF
Apical cell membrane 1 SLC3A2
Membrane raft 1 TNF
cis-Golgi network 1 GOLGA6A
collagen-containing extracellular matrix 2 FLG, KNG1
secretory granule 2 CHGA, TRH
nuclear speck 1 EHMT2
receptor complex 1 FLG
chromatin 1 EHMT2
phagocytic cup 1 TNF
Chromosome 1 EHMT2
cytoplasmic ribonucleoprotein granule 1 FLG
Secreted, extracellular space 1 KNG1
[Isoform 1]: Mitochondrion 1 GLS
brush border membrane 1 ACE
blood microparticle 1 KNG1
sperm midpiece 1 ACE
Basolateral cell membrane 1 SLC3A2
organelle membrane 1 ITM2B
endosome lumen 1 INS
Cornified envelope 1 FLG
Melanosome 1 SLC3A2
Golgi cisterna membrane 1 GOLGA6A
Golgi-associated vesicle membrane 1 ITM2B
basal plasma membrane 2 ACE, SLC3A2
ficolin-1-rich granule lumen 1 QPCT
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, KNG1
platelet alpha granule lumen 1 KNG1
axon terminus 1 NTS
specific granule lumen 1 QPCT
tertiary granule lumen 1 QPCT
transport vesicle 3 CHGA, INS, NTS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 CHGA
[Isoform 3]: Mitochondrion 1 GLS
[Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix 1 GLS
[Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix 1 GLS
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 CHGA
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
chromaffin granule 1 CHGA
amino acid transport complex 1 SLC3A2
apical pole of neuron 1 SLC3A2
keratohyalin granule 1 FLG
[Serpinin]: Secreted 1 CHGA
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
Golgi cis cisterna 1 GOLGA6A
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Integral membrane protein 2B]: Golgi apparatus membrane 1 ITM2B
[BRI2, membrane form]: Cell membrane 1 ITM2B
[Bri23 peptide]: Secreted 1 ITM2B
[BRI2C, soluble form]: Secreted 1 ITM2B


文献列表

  • Shixiong Jiang, Heather G Marco, Nina Scheich, Shulin He, Zongqing Wang, Gerd Gäde, Dino P McMahon. Comparative analysis of adipokinetic hormones and their receptors in Blattodea reveals novel patterns of gene evolution. Insect molecular biology. 2023 12; 32(6):615-633. doi: 10.1111/imb.12861. [PMID: 37382487]
  • Xiaoyan Yang, Dongqun Xu, Bo Wen, Jian Ji, Zeyu Zhang, Li Li, Shaoping Zhang, Hong Zhi, Jian Kong, Chong Wang, Jun Wang, Hongjie Ruan, Ming Zhang, Lan Wei, Bin Dong, Qin Wang. The mediating role of exhaled breath condensate metabolites in the effect of particulate matter on pulmonary function in schoolchildren: A crossover intervention study. The Science of the total environment. 2023 Jul; 898(?):165517. doi: 10.1016/j.scitotenv.2023.165517. [PMID: 37459994]
  • Pat J Unkefer, Thomas J Knight, Rodolfo A Martinez. The intermediate in a nitrate-responsive ω-amidase pathway in plants may signal ammonium assimilation status. Plant physiology. 2023 01; 191(1):715-728. doi: 10.1093/plphys/kiac501. [PMID: 36303326]
  • Marta Hetman, Karolina Mielko, Sylwia Placzkowska, Aleksandra Bodetko, Piotr Młynarz, Ewa Barg. Predisposition to atherosclerosis in children and adults with trisomy 21: biochemical and metabolomic studies. Pediatric endocrinology, diabetes, and metabolism. 2023; 29(3):143-155. doi: 10.5114/pedm.2023.131162. [PMID: 38031830]
  • Salwa Afifi, Azizia Wahedi, Jean-Paul Paluzzi. Functional insight and cell-specific expression of the adipokinetic hormone/corazonin-related peptide in the human disease vector mosquito, Aedes aegypti. General and comparative endocrinology. 2023 01; 330(?):114145. doi: 10.1016/j.ygcen.2022.114145. [PMID: 36244431]
  • Rui-Kun Zhang, Kun Yan, Hai-Feng Chen, Yang Zhang, Gui-Jin Li, Xiao-Gang Chen, Lin-Pu Ge, Feng Cheng, Zhi-Neng Chen, Xin-Miao Yao. Anti-osteoporotic drugs affect the pathogenesis of gut microbiota and its metabolites: a clinical study. Frontiers in cellular and infection microbiology. 2023; 13(?):1091083. doi: 10.3389/fcimb.2023.1091083. [PMID: 37475958]
  • Yu Zhang, Jie Liu, Yan Wang, Chengpeng Sun, Wenjia Li, Jianjian Qiu, Yanling Qiao, Fan Wu, Xiaokui Huo, Yue An, Baojing Zhang, Shuangcheng Ma, Jian Zheng, Xiaochi Ma. Nucleosides and amino acids, isolated from Cordyceps sinensis, protected against cyclophosphamide-induced myelosuppression in mice. Natural product research. 2022 Dec; 36(23):6056-6059. doi: 10.1080/14786419.2022.2043307. [PMID: 35188001]
  • Yue-Bei Luo, Yangtengyu Liu, Qiuxiang Li, Huiqian Duan, Zhaohui Luo, Huan Yang, Liqun Xu. Integrating 16S RRNA gene sequencing and metabolomics to evaluate the association between gut microbiota and serum metabolites in patients with myositis. Journal of applied microbiology. 2022 Oct; 133(4):2547-2559. doi: 10.1111/jam.15724. [PMID: 35858765]
  • Heather G Marco, Simone König, Gerd Gäde. Mass Spectrometric Proof of Predicted Peptides: Novel Adipokinetic Hormones in Insects. Molecules (Basel, Switzerland). 2022 Oct; 27(19):. doi: 10.3390/molecules27196469. [PMID: 36235010]
  • Zisheng Han, Zongde Jiang, Hui Zhang, Chunyin Qin, Xiaoqing Rong, Guoping Lai, Mingchun Wen, Liang Zhang, Xiaochun Wan, Chi-Tang Ho. Amadori Reaction Products of Theanine and Glucose: Formation, Structure, and Analysis in Tea. Journal of agricultural and food chemistry. 2022 Sep; 70(37):11727-11737. doi: 10.1021/acs.jafc.2c04560. [PMID: 36084346]
  • Anna-Lena Gippert, Silvia Madritsch, Patrick Woryna, Sandra Otte, Martina Mayrhofer, Herbert Eigner, Adriana Garibay-Hernández, John C D'Auria, Eva M Molin, Hans-Peter Mock. Unraveling metabolic patterns and molecular mechanisms underlying storability in sugar beet. BMC plant biology. 2022 Sep; 22(1):430. doi: 10.1186/s12870-022-03784-6. [PMID: 36076171]
  • Ai Sun, Xiaoyu Yan, Jing Sun, Zhaohui Tian, Wei Wang, Hongxia Hu. Presence of GnRH3 in sturgeon and the roles of GnRH1 and GnRH2 on the regulation of LH/FSH in mature female sterlet Acipenser ruthenus in vitro. General and comparative endocrinology. 2022 07; 323-324(?):114026. doi: 10.1016/j.ygcen.2022.114026. [PMID: 35395226]
  • Qi-Mei Tan, Wei-Wei Chen, Hong-Hong Li, Shu-Cheng Liao, Guo-Qiang Yi, Yong Mei, Jie Luo, Hui-Hua Tan, Xue-Sheng Li. Adipokinetic hormone signaling regulates cytochrome P450-mediated chlorantraniliprole sensitivity in Spodoptera frugiperda (Lepidoptera: Noctuidae). Pest management science. 2022 Jun; 78(6):2618-2628. doi: 10.1002/ps.6896. [PMID: 35355392]
  • Yongzhao Dai, Siqi Chen, Yaqi Li, Guanglong Zhang, Pingping Bi, Ke Nie. Liujunzi Decoction ameliorated cisplatin-induced anorexia by inhibiting the JAK-STAT signaling pathway and coordinating anorexigenic and orexigenic neuropeptides in rats. Journal of ethnopharmacology. 2022 Mar; 285(?):114840. doi: 10.1016/j.jep.2021.114840. [PMID: 34800646]
  • Olga Kubrak, Takashi Koyama, Nadja Ahrentløv, Line Jensen, Alina Malita, Muhammad T Naseem, Mette Lassen, Stanislav Nagy, Michael J Texada, Kenneth V Halberg, Kim Rewitz. The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress. Nature communications. 2022 02; 13(1):692. doi: 10.1038/s41467-022-28268-x. [PMID: 35121731]
  • Evren Caglar Eroglu, Umran Kucukgoz Gulec, Mehmet Ali Vardar, Semra Paydas. GC-MS based metabolite fingerprinting of serous ovarian carcinoma and benign ovarian tumor. European journal of mass spectrometry (Chichester, England). 2022 Feb; 28(1-2):12-24. doi: 10.1177/14690667221098520. [PMID: 35503418]
  • Xiao-Yan Lan, Zheng-Wu Sun, Gui-Lian Xu, Cheng-Yan Chu, Hua-Min Qin, Shen Li, Xin Geng, Peng Gao, Johannes Boltze, Shen Li. Bone Marrow Mesenchymal Stem Cells Exert Protective Effects After Ischemic Stroke Through Upregulation of Glutathione. Stem cell reviews and reports. 2022 02; 18(2):585-594. doi: 10.1007/s12015-021-10178-y. [PMID: 34449012]
  • Sakura Tanaka, Nilli Zmora, Berta Levavi-Sivan, Yonathan Zohar. Vasoactive Intestinal Peptide Indirectly Elicits Pituitary LH Secretion Independent of GnRH in Female Zebrafish. Endocrinology. 2022 02; 163(2):. doi: 10.1210/endocr/bqab264. [PMID: 34978328]
  • Dalibor Kodrík, Václav Krištůfek, Zdeňka Svobodová. Bee year: Basic physiological strategies to cope with seasonality. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2022 02; 264(?):111115. doi: 10.1016/j.cbpa.2021.111115. [PMID: 34775045]
  • Weilong Zhang, Jihan Huang, Hongxia Liu, Xin Wen, Qingshan Zheng, Lujin Li. Whether Immunostimulants Are Effective in Susceptible Children Suffering From Recurrent Respiratory Tract Infections: A Modeling Analysis Based on Literature Aggregate Data. Journal of clinical pharmacology. 2022 02; 62(2):245-253. doi: 10.1002/jcph.1969. [PMID: 34535904]
  • Bryon N Hughson. PKG acts in the adult corpora cardiaca to regulate nutrient stress-responsivity through adipokinetic hormone. Journal of insect physiology. 2022 01; 136(?):104339. doi: 10.1016/j.jinsphys.2021.104339. [PMID: 34856210]
  • Alexandre Lasse, Marc Deveaux, Jean-Louis Beaudeux, Jean-Herlé Raphalen, Frédéric J Baud, Pascal Houzé. [Plasmatic and urinary pyroglutamic acid measurement by capillary zone electrophoresis in chronic poisoning with acetaminophen in children]. Annales de biologie clinique. 2021 Dec; 79(6):567-578. doi: 10.1684/abc.2021.1689. [PMID: 34961739]
  • Mingzhu Wang, Jiao Chen, Xiaoying Lin, Lin Huang, Haichang Li, Chengping Wen, Zhixing He. High humidity aggravates the severity of arthritis in collagen-induced arthritis mice by upregulating xylitol and L-pyroglutamic acid. Arthritis research & therapy. 2021 12; 23(1):292. doi: 10.1186/s13075-021-02681-x. [PMID: 34852827]
  • Jayoung Kim, Amanda De Hoedt, Emily Wiggins, Kelsey Haywood, Peng Jin, Bennett Greenwood, Niven R Narain, Vladimir Tolstikov, Valerie Bussberg, Kamil E Barbour, Michael A Kiebish, Stephen J Freedland, Jennifer T Anger. Diagnostic Utility of Serum and Urinary Metabolite Analysis in Patients with Interstitial Cystitis/Painful Bladder Syndrome. Urology. 2021 11; 157(?):85-92. doi: 10.1016/j.urology.2021.05.005. [PMID: 34010675]
  • Ashok Mahashur, Agam Vora, Pradyut Waghray, S Z Jafrey, Archana Karadkhele, Snehal Muchhala, Rahul Rathod, Viraj Suvarna. Expert Opinion on Usage of Pidotimod in Adult Patients with Chronic Obstructive Pulmonary Disease: An Indian Perspective. The Journal of the Association of Physicians of India. 2021 Sep; 69(9):11-12. doi: NULL. [PMID: 34585899]
  • Harald F Hofbauer, Christoph Heier, Anantha Krishnan Sen Saji, Ronald P Kühnlein. Lipidome remodeling in aging normal and genetically obese Drosophila males. Insect biochemistry and molecular biology. 2021 06; 133(?):103498. doi: 10.1016/j.ibmb.2020.103498. [PMID: 33221388]
  • Sifang Liao, Mirjam Amcoff, Dick R Nässel. Impact of high-fat diet on lifespan, metabolism, fecundity and behavioral senescence in Drosophila. Insect biochemistry and molecular biology. 2021 06; 133(?):103495. doi: 10.1016/j.ibmb.2020.103495. [PMID: 33171202]
  • Yang Yang, Ying Xiong, Hong-Fei Li, Huai-Jia Zhao, Guang-Hui Tang, Li-Wei Meng, Jin-Jun Wang, Hong-Bo Jiang. The adipokinetic hormone signaling system regulates the sensitivity of Bactrocera dorsalis to malathion. Pesticide biochemistry and physiology. 2021 May; 174(?):104808. doi: 10.1016/j.pestbp.2021.104808. [PMID: 33838709]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Qiong Zhang, Xin Li, Xiaofeng Yin, Haifang Wang, Chen Fu, Hongxia Wang, Kaifei Li, Yao Li, Xiaohe Zhang, Huijun Liang, Kui Li, Haixia Li, Yurong Qiu. Metabolomic profiling reveals serum L-pyroglutamic acid as a potential diagnostic biomarker for systemic lupus erythematosus. Rheumatology (Oxford, England). 2021 02; 60(2):598-606. doi: 10.1093/rheumatology/keaa126. [PMID: 32259244]
  • Anis Zand Irani, Grace Borchert, Brendan Craven, Holly Gibbons. Flucloxacillin and paracetamol induced pyroglutamic acidosis. BMJ case reports. 2021 Jan; 14(1):. doi: 10.1136/bcr-2020-237536. [PMID: 33419747]
  • Claudio Ucciferri, Katia Falasca, Marcella Reale, Manuela Tamburro, Antonio Auricchio, Francesca Vignale, Jacopo Vecchiet. Pidotimod and Immunological Activation in Individuals Infected with HIV. Current HIV research. 2021; 19(3):260-268. doi: 10.2174/1570162x18666210111102046. [PMID: 33430735]
  • Ling-Ling Wei, Tian-Tian Chen, Bi-Yun Luo, Gao-Feng Qiu. Evidences for Red Pigment Concentrating Hormone (RPCH) and Beta-Pigment Dispersing Hormone (β-PDH) Inducing Oocyte Meiotic Maturation in the Chinese Mitten Crab, Eriocheir sinensis. Frontiers in endocrinology. 2021; 12(?):802768. doi: 10.3389/fendo.2021.802768. [PMID: 34975771]
  • Hana Sehadova, Yoko Takasu, Anna Zaloudikova, Yu-Hsien Lin, Ivo Sauman, Hideki Sezutsu, Lenka Rouhova, Dalibor Kodrik, Michal Zurovec. Functional Analysis of Adipokinetic Hormone Signaling in Bombyx mori. Cells. 2020 12; 9(12):. doi: 10.3390/cells9122667. [PMID: 33322530]
  • Cristina Piras, Stella Conte, Monica Pibiri, Giacomo Rao, Sandro Muntoni, Vera Piera Leoni, Gabriele Finco, Luigi Atzori. Metabolomics and psychological features in fibromyalgia and electromagnetic sensitivity. Scientific reports. 2020 11; 10(1):20418. doi: 10.1038/s41598-020-76876-8. [PMID: 33235303]
  • Yefei Huang, Min Xiao, Jiayong Ou, Qing Lv, Qiujing Wei, Zena Chen, Jialing Wu, Liudan Tu, Yutong Jiang, Xi Zhang, Jun Qi, Minli Qiu, Shuangyan Cao, Jieruo Gu. Identification of the urine and serum metabolomics signature of gout. Rheumatology (Oxford, England). 2020 10; 59(10):2960-2969. doi: 10.1093/rheumatology/keaa018. [PMID: 32134107]
  • Qiankun He, Juan Du, Liya Wei, Zhangwu Zhao. AKH-FOXO pathway regulates starvation-induced sleep loss through remodeling of the small ventral lateral neuron dorsal projections. PLoS genetics. 2020 10; 16(10):e1009181. doi: 10.1371/journal.pgen.1009181. [PMID: 33104699]
  • Itai Gueta, Yarden Perach Ovadia, Noa Markovits, Yehoshua N Schacham, Avi Epsztein, Ronen Loebstein. Is Pyroglutamic Acid a Prognostic Factor Among Patients with Suspected Infection? A Prospective Cohort Study. Scientific reports. 2020 06; 10(1):10128. doi: 10.1038/s41598-020-66941-7. [PMID: 32576856]
  • Naoto Katakami, Kazuo Omori, Naohiro Taya, Shoya Arakawa, Mitsuyoshi Takahara, Taka-Aki Matsuoka, Hiroshi Tsugawa, Masahiro Furuno, Takeshi Bamba, Eiichiro Fukusaki, Iichiro Shimomura. Plasma metabolites associated with arterial stiffness in patients with type 2 diabetes. Cardiovascular diabetology. 2020 06; 19(1):75. doi: 10.1186/s12933-020-01057-w. [PMID: 32527273]
  • H Zheng, C Chen, C Liu, Q Song, S Zhou. Rhythmic change of adipokinetic hormones diurnally regulates locust vitellogenesis and egg development. Insect molecular biology. 2020 06; 29(3):283-292. doi: 10.1111/imb.12633. [PMID: 31904153]
  • Retno Widyowati, Melanny Ika Sulistyowaty, Nguyen Hoang Uyen, Sachiko Sugimoto, Yoshi Yamano, Hideaki Otsuka, Katsuyoshi Matsunami. New Methyl Threonolactones and Pyroglutamates of Spilanthes acmella (L.) L. and Their Bone Formation Activities. Molecules (Basel, Switzerland). 2020 May; 25(11):. doi: 10.3390/molecules25112500. [PMID: 32481486]
  • Immacolata Speciale, Flaviana Di Lorenzo, Valentina Gargiulo, Gitte Erbs, Mari-Anne Newman, Antonio Molinaro, Cristina De Castro. Biopolymer Skeleton Produced by Rhizobium radiobacter: Stoichiometric Alternation of Glycosidic and Amidic Bonds in the Lipopolysaccharide O-Antigen. Angewandte Chemie (International ed. in English). 2020 04; 59(16):6368-6374. doi: 10.1002/anie.201914053. [PMID: 32073204]
  • Keito Hoshitsuki, Alejandro R Molinelli, Hiroto Inaba, Jeffrey E Rubnitz, Patricia J Barker. Metabolic Acidosis in a Pediatric Patient with Leukemia and Fungal Infection. Clinical chemistry. 2020 04; 66(4):518-522. doi: 10.1093/clinchem/hvz035. [PMID: 32232459]
  • Amar Nath Chatterjee, Fahad Al Basir. A Model for SARS-CoV-2 Infection with Treatment. Computational and mathematical methods in medicine. 2020; 2020(?):1352982. doi: 10.1155/2020/1352982. [PMID: 32908574]
  • Michael E Mullins, Mary S Jones, Robert D Nerenz, Evan S Schwarz, Dennis J Dietzen. 5-Oxoproline concentrations in acute acetaminophen overdose. Clinical toxicology (Philadelphia, Pa.). 2020 01; 58(1):62-64. doi: 10.1080/15563650.2019.1609684. [PMID: 31050299]
  • Yan Shi, Tian-Yuan Liu, Yu-Xia Pei, Hong-Bo Jiang, Wei Dou, Guy Smagghe, Jin-Jun Wang. Crustacean cardioactive peptide (CCAP) of the oriental fruit fly, Bactrocera dorsalis (Diptera: Tephritidae): Molecular characterization, distribution and its potential roles in larva-pupa ecdysis. Peptides. 2019 12; 122(?):169929. doi: 10.1016/j.peptides.2018.02.007. [PMID: 29477306]
  • Phoebe B Chen, Ju Hyeon Kim, Lynnea Young, John M Clark, Yeonhwa Park. Epigallocatechin gallate (EGCG) alters body fat and lean mass through sex-dependent metabolic mechanisms in Drosophila melanogaster. International journal of food sciences and nutrition. 2019 Dec; 70(8):959-969. doi: 10.1080/09637486.2019.1602113. [PMID: 31010351]
  • Dongchao Xie, Weidong Dai, Meiling Lu, Junfeng Tan, Yue Zhang, Mei Chen, Zhi Lin. Nontargeted metabolomics predicts the storage duration of white teas with 8-C N-ethyl-2-pyrrolidinone-substituted flavan-3-ols as marker compounds. Food research international (Ottawa, Ont.). 2019 11; 125(?):108635. doi: 10.1016/j.foodres.2019.108635. [PMID: 31554114]
  • Wenqiang Wang, Jun Chen, Yan Fang, Bin Wang, Qiang Zou, Lei Wang, Wenwen Zhang, Xueying Huang, Haoyue Lv, Chenxiao Zhang, Kai Wang. Identification of gnrh2 and gnrh3 and their expression during brood pouch growth and short-term benzo(a)pyrene exposure in lined seahorse (Hippocampus erectus). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2019 Nov; 225(?):108579. doi: 10.1016/j.cbpc.2019.108579. [PMID: 31386905]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Francesca Santamaria, Silvia Montella, Matteo Stocchero, Paola Pirillo, Sara Bozzetto, Giuseppe Giordano, Marco Poeta, Eugenio Baraldi. Effects of pidotimod and bifidobacteria mixture on clinical symptoms and urinary metabolomic profile of children with recurrent respiratory infections: a randomized placebo-controlled trial. Pulmonary pharmacology & therapeutics. 2019 10; 58(?):101818. doi: 10.1016/j.pupt.2019.101818. [PMID: 31302340]
  • M Costello, M Brennan, C Newman, P O'Shea, M Bell. Pyroglutamic acidosis. QJM : monthly journal of the Association of Physicians. 2019 Aug; 112(8):613-614. doi: 10.1093/qjmed/hcz107. [PMID: 31086977]
  • Samuel P Klein, Bart Depreitere, Geert Meyfroidt. How I monitor cerebral autoregulation. Critical care (London, England). 2019 May; 23(1):160. doi: 10.1186/s13054-019-2454-1. [PMID: 31064383]
  • Yenifer Gamarra, Felipe C Santiago, Jorge Molina-López, José Castaño, Lourdes Herrera-Quintana, Álvaro Domínguez, Elena Planells. Pyroglutamic acidosis by glutathione regeneration blockage in critical patients with septic shock. Critical care (London, England). 2019 05; 23(1):162. doi: 10.1186/s13054-019-2450-5. [PMID: 31064391]
  • Yanjun Xu, Annika F Borcherding, Christoph Heier, Gu Tian, Thomas Roeder, Ronald P Kühnlein. Chronic dysfunction of Stromal interaction molecule by pulsed RNAi induction in fat tissue impairs organismal energy homeostasis in Drosophila. Scientific reports. 2019 05; 9(1):6989. doi: 10.1038/s41598-019-43327-y. [PMID: 31061470]
  • Samara Mejri, Ali Siah, Cristina-Maria Abuhaie, Patrice Halama, Maryline Magnin-Robert, Béatrice Randoux, Philippe Reignault, Benoît Rigo, Alina Ghinet. New salicylic acid and pyroglutamic acid conjugated derivatives confer protection to bread wheat against Zymoseptoria tritici. Journal of the science of food and agriculture. 2019 Mar; 99(4):1780-1786. doi: 10.1002/jsfa.9370. [PMID: 30226928]
  • Shir Raibman Spector, Haim Mayan, Ronen Loebstein, Noa Markovits, Eldar Priel, Eias Massalha, Yuval Shafir, Itai Gueta. Pyroglutamic acidosis as a cause for high anion gap metabolic acidosis: a prospective study. Scientific reports. 2019 03; 9(1):3554. doi: 10.1038/s41598-019-39257-4. [PMID: 30837497]
  • Kyumin Shim, Radhika Gulhar, Ishwarlal Jialal. Exploratory metabolomics of nascent metabolic syndrome. Journal of diabetes and its complications. 2019 03; 33(3):212-216. doi: 10.1016/j.jdiacomp.2018.12.002. [PMID: 30611573]
  • Hui Niu, Rui Wang, Yu-Ting Jia, Yun Cai. Pidotimod, an immunostimulant in pediatric recurrent respiratory tract infections: A meta-analysis of randomized controlled trials. International immunopharmacology. 2019 Feb; 67(?):35-45. doi: 10.1016/j.intimp.2018.11.043. [PMID: 30530167]
  • S Kostidis, J R Bank, D Soonawala, E Nevedomskaya, C van Kooten, O A Mayboroda, J W de Fijter. Urinary metabolites predict prolonged duration of delayed graft function in DCD kidney transplant recipients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2019 01; 19(1):110-122. doi: 10.1111/ajt.14941. [PMID: 29786954]
  • Jiwon Park, Yumi Shin, Tae Hyun Kim, Dong-Hyun Kim, Anbok Lee. Plasma metabolites as possible biomarkers for diagnosis of breast cancer. PloS one. 2019; 14(12):e0225129. doi: 10.1371/journal.pone.0225129. [PMID: 31794572]
  • Joevin Sourdon, Gizem Keceli, Merry L Lindsey, Nazareno Paolocci. Death of an antioxidant brings heart failure with preserved ejection fraction to life: 5-oxoproline and post-ischaemic cardio-renal dysfunction. Cardiovascular research. 2018 12; 114(14):1819-1821. doi: 10.1093/cvr/cvy239. [PMID: 30295759]
  • Atze van der Pol, Andres Gil, Jasper Tromp, Herman H W Silljé, Dirk J van Veldhuisen, Adriaan A Voors, Elke S Hoendermis, Niels Grote Beverborg, Elisabeth-Maria Schouten, Rudolf A de Boer, Rainer Bischoff, Peter van der Meer. OPLAH ablation leads to accumulation of 5-oxoproline, oxidative stress, fibrosis, and elevated fillings pressures: a murine model for heart failure with a preserved ejection fraction. Cardiovascular research. 2018 12; 114(14):1871-1882. doi: 10.1093/cvr/cvy187. [PMID: 30032247]
  • Michaela Mochanová, Aleš Tomčala, Zdeňka Svobodová, Dalibor Kodrík. Role of adipokinetic hormone during starvation in Drosophila. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 2018 Dec; 226(?):26-35. doi: 10.1016/j.cbpb.2018.08.004. [PMID: 30110658]
  • Katarzyna Bilska, Kinga Stuper-Szablewska, Tomasz Kulik, Maciej Buśko, Dariusz Załuski, Juliusz Perkowski. Resistance-Related l-Pyroglutamic Acid Affects the Biosynthesis of Trichothecenes and Phenylpropanoids by F. graminearum Sensu Stricto. Toxins. 2018 11; 10(12):. doi: 10.3390/toxins10120492. [PMID: 30477204]
  • Jing Chou, Rui Liu, Jiaying Yu, Xiaowei Liu, Xinshu Zhao, Ying Li, Liyan Liu, Changhao Sun. Fasting serum α‑hydroxybutyrate and pyroglutamic acid as important metabolites for detecting isolated post-challenge diabetes based on organic acid profiles. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Nov; 1100-1101(?):6-16. doi: 10.1016/j.jchromb.2018.09.004. [PMID: 30267980]
  • Andres Gil, Atze van der Pol, Peter van der Meer, Rainer Bischoff. LC-MS analysis of key components of the glutathione cycle in tissues and body fluids from mice with myocardial infarction. Journal of pharmaceutical and biomedical analysis. 2018 Oct; 160(?):289-296. doi: 10.1016/j.jpba.2018.08.001. [PMID: 30114606]
  • Daniela Giustarini, Federico Galvagni, Isabella Dalle Donne, Aldo Milzani, Filiberto Maria Severi, Annalisa Santucci, Ranieri Rossi. N-acetylcysteine ethyl ester as GSH enhancer in human primary endothelial cells: A comparative study with other drugs. Free radical biology & medicine. 2018 10; 126(?):202-209. doi: 10.1016/j.freeradbiomed.2018.08.013. [PMID: 30114478]
  • Laura Heireman, Boris Mahieu, Mark Helbert, Wim Uyttenbroeck, Jan Stroobants, Marian Piqueur. High anion gap metabolic acidosis induced by cumulation of ketones, L- and D-lactate, 5-oxoproline and acute renal failure. Acta clinica Belgica. 2018 Aug; 73(4):313-316. doi: 10.1080/17843286.2017.1358504. [PMID: 28749752]
  • Emad Ibrahim, Pavel Dobeš, Martin Kunc, Pavel Hyršl, Dalibor Kodrík. Adipokinetic hormone and adenosine interfere with nematobacterial infection and locomotion in Drosophila melanogaster. Journal of insect physiology. 2018 May; 107(?):167-174. doi: 10.1016/j.jinsphys.2018.04.002. [PMID: 29627353]
  • A B Segarra, I Prieto, M Martinez-Canamero, F Vargas, M De Gasparo, P Vanderheyden, S Zorad, M Ramirez-Sanchez. Cystinyl and pyroglutamyl-beta-naphthylamide hydrolyzing activities are modified coordinately between hypothalamus, liver and plasma depending on the thyroid status of adult male rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2018 04; 69(2):. doi: 10.26402/jpp.2018.2.04. [PMID: 29920473]
  • Hazem M Alhourani, Aneel Kumar, Lekha K George, Tahira Sarwar, Barry M Wall. Recurrent Pyroglutamic Acidosis Related to Therapeutic Acetaminophen. The American journal of the medical sciences. 2018 Apr; 355(4):387-389. doi: 10.1016/j.amjms.2017.08.001. [PMID: 29661353]
  • Keisuke Fukumura, Takahiro Konuma, Yusuke Tsukamoto, Shinji Nagata. Adipokinetic hormone signaling determines dietary fatty acid preference through maintenance of hemolymph fatty acid composition in the cricket Gryllus bimaculatus. Scientific reports. 2018 03; 8(1):4737. doi: 10.1038/s41598-018-22987-2. [PMID: 29549314]
  • Ruili Zhang, Mei Qiu, Li Zhao, Liangliang Cui, Chunyuan Wang, Jiajia Zhu, Zhihui Hao. Pharmacokinetics of pidotimod in broiler chickens by UHPLC-MS/MS after oral and intravenous administration. Biomedical chromatography : BMC. 2018 Mar; 32(3):. doi: 10.1002/bmc.4130. [PMID: 29105801]
  • Yi Jun Zhou, Keisuke Fukumura, Shinji Nagata. Effects of adipokinetic hormone and its related peptide on maintaining hemolymph carbohydrate and lipid levels in the two-spotted cricket, Gryllus bimaculatus. Bioscience, biotechnology, and biochemistry. 2018 Feb; 82(2):274-284. doi: 10.1080/09168451.2017.1422106. [PMID: 29325488]
  • Atze van der Pol, Andres Gil, Herman H W Silljé, Jasper Tromp, Ekaterina S Ovchinnikova, Inge Vreeswijk-Baudoin, Martijn Hoes, Ibrahim J Domian, Bart van de Sluis, Jan M van Deursen, Adriaan A Voors, Dirk J van Veldhuisen, Wiek H van Gilst, Eugene Berezikov, Pim van der Harst, Rudolf A de Boer, Rainer Bischoff, Peter van der Meer. Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH. Science translational medicine. 2017 Nov; 9(415):. doi: 10.1126/scitranslmed.aam8574. [PMID: 29118264]
  • Qiu-Li Hou, Er-Hu Chen, Hong-Bo Jiang, Dan-Dan Wei, Shun-Hua Gui, Jin-Jun Wang, Guy Smagghe. Adipokinetic hormone receptor gene identification and its role in triacylglycerol mobilization and sexual behavior in the oriental fruit fly (Bactrocera dorsalis). Insect biochemistry and molecular biology. 2017 11; 90(?):1-13. doi: 10.1016/j.ibmb.2017.09.006. [PMID: 28919559]
  • Tomáš Hložek, Tomáš Křížek, Petr Tůma, Miroslava Bursová, Pavel Coufal, Radomír Čabala. Quantification of paracetamol and 5-oxoproline in serum by capillary electrophoresis: Implication for clinical toxicology. Journal of pharmaceutical and biomedical analysis. 2017 Oct; 145(?):616-620. doi: 10.1016/j.jpba.2017.07.024. [PMID: 28797958]
  • Suwen Qi, Depeng Xu, Qiaoliang Li, Ni Xie, Jun Xia, Qin Huo, Pu Li, Qiwen Chen, Si Huang. Metabonomics screening of serum identifies pyroglutamate as a diagnostic biomarker for nonalcoholic steatohepatitis. Clinica chimica acta; international journal of clinical chemistry. 2017 Oct; 473(?):89-95. doi: 10.1016/j.cca.2017.08.022. [PMID: 28842175]
  • Lili Song, Pengwei Zhuang, Mengya Lin, Mingqin Kang, Hongyue Liu, Yuping Zhang, Zhen Yang, Yunlong Chen, Yanjun Zhang. Urine Metabonomics Reveals Early Biomarkers in Diabetic Cognitive Dysfunction. Journal of proteome research. 2017 09; 16(9):3180-3189. doi: 10.1021/acs.jproteome.7b00168. [PMID: 28722418]
  • Xiao Zhao, Jason Karpac. Muscle Directs Diurnal Energy Homeostasis through a Myokine-Dependent Hormone Module in Drosophila. Current biology : CB. 2017 Jul; 27(13):1941-1955.e6. doi: 10.1016/j.cub.2017.06.004. [PMID: 28669758]
  • Shaoqi Qu, Cunchun Dai, Mei Qiu, Ruili Zhang, Chunyuan Wang, Liangliang Cui, Zhihui Hao. Effects of pidotimod soluble powder and immune enhancement of Newcastle disease vaccine in chickens. Immunology letters. 2017 07; 187(?):14-18. doi: 10.1016/j.imlet.2017.05.001. [PMID: 28487096]
  • Francois-Pierre Martin, Ming-Ming Su, Guo-Xiang Xie, Seu Ping Guiraud, Martin Kussmann, Jean-Philippe Godin, Wei Jia, Andreas Nydegger. Urinary metabolic insights into host-gut microbial interactions in healthy and IBD children. World journal of gastroenterology. 2017 May; 23(20):3643-3654. doi: 10.3748/wjg.v23.i20.3643. [PMID: 28611517]
  • Mairi Cowan, José A Paullada-Salmerón, José Fernando López-Olmeda, Francisco Javier Sánchez-Vázquez, José A Muñoz-Cueto. Effects of pinealectomy on the neuroendocrine reproductive system and locomotor activity in male European sea bass, Dicentrarchus labrax. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2017 05; 207(?):1-12. doi: 10.1016/j.cbpa.2017.02.008. [PMID: 28188883]
  • Nan Nitra Than, Htoo Htoo Kyaw Soe, Senthil K Palaniappan, Adinegara Bl Abas, Lucia De Franceschi. Magnesium for treating sickle cell disease. The Cochrane database of systematic reviews. 2017 Apr; 4(?):CD011358. doi: 10.1002/14651858.cd011358.pub2. [PMID: 28409830]
  • Emad Ibrahim, Markéta Hejníková, Haq Abdul Shaik, David Doležel, Dalibor Kodrík. Adipokinetic hormone activities in insect body infected by entomopathogenic nematode. Journal of insect physiology. 2017 04; 98(?):347-355. doi: 10.1016/j.jinsphys.2017.02.009. [PMID: 28254268]
  • Paul R Territo, Jill A Meyer, Jonathan S Peters, Amanda A Riley, Brian P McCarthy, Mingzhang Gao, Min Wang, Mark A Green, Qi-Huang Zheng, Gary D Hutchins. Characterization of 11C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2017 03; 58(3):458-465. doi: 10.2967/jnumed.116.181354. [PMID: 27765863]
  • Carel J Pretorius, Michael C Reade, Chris Warnholtz, Brett McWhinney, Meng Mei Phua, Jeffrey Lipman, Jacobus P J Ungerer. Pyroglutamate (5-oxoproline) measured with hydrophilic interaction chromatography (HILIC) tandem mass spectrometry in acutely ill patients. Clinica chimica acta; international journal of clinical chemistry. 2017 Mar; 466(?):72-77. doi: 10.1016/j.cca.2017.01.012. [PMID: 28089749]
  • Gerd Gäde, Heather G Marco. The adipokinetic hormone of Mantodea in comparison to other Dictyoptera. Archives of insect biochemistry and physiology. 2017 Mar; 94(3):. doi: 10.1002/arch.21376. [PMID: 28225562]
  • Pamela V Martino Adami, Pablo Galeano, Marina L Wallinger, Celia Quijano, Alejandro Rabossi, Eleonora S Pagano, Natividad Olivar, Carlos Reyes Toso, Daniel Cardinali, Luis I Brusco, Sonia Do Carmo, Rafael Radi, Goar Gevorkian, Eduardo M Castaño, A Claudio Cuello, Laura Morelli. Worsening of memory deficit induced by energy-dense diet in a rat model of early-Alzheimer's disease is associated to neurotoxic Aβ species and independent of neuroinflammation. Biochimica et biophysica acta. Molecular basis of disease. 2017 03; 1863(3):731-743. doi: 10.1016/j.bbadis.2016.12.014. [PMID: 28039031]
  • Vincent W Wu, Craig M Dana, Anthony T Iavarone, Douglas S Clark, N Louise Glass. Identification of Glutaminyl Cyclase Genes Involved in Pyroglutamate Modification of Fungal Lignocellulolytic Enzymes. mBio. 2017 01; 8(1):. doi: 10.1128/mbio.02231-16. [PMID: 28096492]
  • L S Babinets, K Yu Kytsai, Yu Ya Kotsaba, I M Halabitska, N A Melnyk, I V Semenova, O S Zemlyak. Improvement of the complex medical treatment for the patients wіth chronic biliary pancreatitis. Wiadomosci lekarskie (Warsaw, Poland : 1960). 2017 ; 70(2):213-216. doi: ". [PMID: 28511162]
  • Saowaros Suwansa-Ard, Min Zhao, Tipsuda Thongbuakaew, Piyachat Chansela, Tomer Ventura, Scott F Cummins, Prasert Sobhon. Gonadotropin-releasing hormone and adipokinetic hormone/corazonin-related peptide in the female prawn. General and comparative endocrinology. 2016 09; 236(?):70-82. doi: 10.1016/j.ygcen.2016.07.008. [PMID: 27401259]
  • Noriko Masubuchi, Takayoshi Nishiya, Masako Imaoka, Kiyoko Mizumaki, Osamu Okazaki. Promising toxicological biomarkers for the diagnosis of liver injury types: Bile acid metabolic profiles and oxidative stress marker as screening tools in drug development. Chemico-biological interactions. 2016 Aug; 255(?):74-82. doi: 10.1016/j.cbi.2015.09.012. [PMID: 26365562]
  • Lorraine Jaimes-Hoy, Mariana Gutiérrez-Mariscal, Yamili Vargas, Adrián Pérez-Maldonado, Fidelia Romero, Edith Sánchez-Jaramillo, Jean-Louis Charli, Patricia Joseph-Bravo. Neonatal Maternal Separation Alters, in a Sex-Specific Manner, the Expression of TRH, of TRH-Degrading Ectoenzyme in the Rat Hypothalamus, and the Response of the Thyroid Axis to Starvation. Endocrinology. 2016 08; 157(8):3253-65. doi: 10.1210/en.2016-1239. [PMID: 27323240]
  • Martin Stenson, Anders Pedersen, Sverker Hasselblom, Herman Nilsson-Ehle, Bengt Göran Karlsson, Rui Pinto, Per-Ola Andersson. Serum nuclear magnetic resonance-based metabolomics and outcome in diffuse large B-cell lymphoma patients - a pilot study. Leukemia & lymphoma. 2016 08; 57(8):1814-22. doi: 10.3109/10428194.2016.1140164. [PMID: 26887805]
  • Guangji Wang, Qian Wang, Tai Rao, Boyu Shen, Dian Kang, Yuhao Shao, Jingcheng Xiao, Huimin Chen, Yan Liang. A robust LC-MS/MS method for the determination of pidotimod in different biological matrixes and its application to in vivo and in vitro pharmacokinetic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jun; 1023-1024(?):36-43. doi: 10.1016/j.jchromb.2016.04.047. [PMID: 27179190]
  • Maria Grazia Cusi, Daniela Fanigliulo. Virucidal activity of a novel non-alcoholic combination of disinfectants. Journal of chemotherapy (Florence, Italy). 2016 Apr; 28(2):140-2. doi: 10.1179/1973947815y.0000000072. [PMID: 26404483]
  • Lei Yin, Kevin Shengyang Yu, Kun Lu, Xiaozhong Yu. Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis. Toxicology in vitro : an international journal published in association with BIBRA. 2016 Apr; 32(?):297-309. doi: 10.1016/j.tiv.2016.01.010. [PMID: 26820058]