Carpaine (BioDeep_00001869496)

Main id: BioDeep_00000007897

 

natural product


代谢物信息卡片


Carpaine

化学式: C28H50N2O4 (478.377)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C2CCC(N1)CCCCCCCC(=O)OC3CCC(CCCCCCCC(=O)O2)NC3C
InChI: InChI=1S/C28H50N2O4/c1-21-25-19-17-23(29-21)13-9-5-3-8-12-16-28(32)34-26-20-18-24(30-22(26)2)14-10-6-4-7-11-15-27(31)33-25/h21-26,29-30H,3-20H2,1-2H3/t21-,22-,23+,24+,25-,26-/m0/s1

描述信息

An alkaloid that forms a major component of the papaya leaves and has been shown to exhibit cardiovascular effects.

同义名列表

2 个代谢物同义名

Carpaine; Carpaine



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

21 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 CAT, CCND1, EGFR, GFAP, LRSAM1, NEFL, PRKN
Peripheral membrane protein 2 ACHE, GORASP1
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 EGFR, SFTPD
Nucleus 5 ACHE, CCND1, EGFR, PCNA, PRKN
cytosol 6 CAT, CCND1, GFAP, LRSAM1, NEFL, PRKN
nuclear body 1 PCNA
centrosome 2 CCND1, PCNA
nucleoplasm 2 CCND1, PCNA
Cell membrane 2 ACHE, EGFR
Cytoplasmic side 1 GORASP1
ruffle membrane 1 EGFR
Cell projection, axon 1 NEFL
Early endosome membrane 1 EGFR
Golgi apparatus membrane 1 GORASP1
Synapse 1 ACHE
cell junction 1 EGFR
cell surface 2 ACHE, EGFR
glutamatergic synapse 1 EGFR
Golgi apparatus 3 ACHE, GORASP1, PRKN
Golgi membrane 2 EGFR, GORASP1
growth cone 1 NEFL
neuromuscular junction 2 ACHE, NEFL
Cytoplasm, cytosol 1 PRKN
Lysosome 1 SFTPD
Presynapse 1 PRKN
endosome 1 EGFR
plasma membrane 2 ACHE, EGFR
Membrane 4 ACHE, CAT, EGFR, LRSAM1
apical plasma membrane 1 EGFR
axon 1 NEFL
basolateral plasma membrane 1 EGFR
extracellular exosome 2 CAT, PCNA
endoplasmic reticulum 1 PRKN
extracellular space 3 ACHE, EGFR, SFTPD
perinuclear region of cytoplasm 3 ACHE, EGFR, PRKN
Schaffer collateral - CA1 synapse 1 NEFL
bicellular tight junction 1 CCND1
mitochondrion 2 CAT, PRKN
protein-containing complex 2 CAT, EGFR
intracellular membrane-bounded organelle 1 CAT
postsynaptic density 1 PRKN
Single-pass type I membrane protein 1 EGFR
Secreted 1 ACHE
extracellular region 3 ACHE, CAT, SFTPD
Mitochondrion outer membrane 1 PRKN
mitochondrial outer membrane 1 PRKN
astrocyte end-foot 1 GFAP
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
Nucleus membrane 1 CCND1
nuclear membrane 2 CCND1, EGFR
multivesicular body 1 SFTPD
axon cytoplasm 1 NEFL
Membrane raft 1 EGFR
Cytoplasm, cytoskeleton 1 NEFL
focal adhesion 2 CAT, EGFR
cis-Golgi network 1 GORASP1
Peroxisome 1 CAT
basement membrane 1 ACHE
collagen trimer 1 SFTPD
intracellular vesicle 1 EGFR
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
intermediate filament 2 GFAP, NEFL
nuclear speck 1 PRKN
receptor complex 1 EGFR
Cell projection, neuron projection 1 PRKN
neuron projection 1 PRKN
chromatin 1 PCNA
cell projection 1 GFAP
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
Lipid-anchor, GPI-anchor 1 ACHE
cell body 1 GFAP
side of membrane 1 ACHE
replication fork 1 PCNA
intermediate filament cytoskeleton 1 GFAP
ubiquitin ligase complex 1 PRKN
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
transcription repressor complex 1 CCND1
male germ cell nucleus 1 PCNA
endocytic vesicle 1 SFTPD
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
aggresome 1 PRKN
clathrin-coated endocytic vesicle 1 SFTPD
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
neurofilament 1 NEFL
nuclear lamina 1 PCNA
clathrin-coated endocytic vesicle membrane 1 EGFR
synaptic cleft 1 ACHE
dopaminergic synapse 1 PRKN
Lewy body 1 PRKN
Parkin-FBXW7-Cul1 ubiquitin ligase complex 1 PRKN
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, PCNA
cytoplasmic side of lysosomal membrane 1 GFAP
cholinergic synapse 1 NEFL
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
catalase complex 1 CAT
postsynaptic intermediate filament cytoskeleton 1 NEFL
presynaptic intermediate filament cytoskeleton 1 NEFL
cyclin D1-CDK4 complex 1 CCND1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
[Isoform H]: Cell membrane 1 ACHE
cyclin D1-CDK6 complex 1 CCND1


文献列表

  • Kalichamy Alagarasu, Madhura Punekar, Poonam Patil, Bhagyashri Kasabe, Mahadeo Kakade, Kusuma Sai Davuluri, Sarah Cherian, Deepti Parashar. Effect of carpaine, a major alkaloid from Carica papaya leaves, on dengue virus-2 infection and replication-an in-vitro and in-silico study. Phytotherapy research : PTR. 2023 Jan; ?(?):. doi: 10.1002/ptr.7715. [PMID: 36587936]
  • Yasuhide Hiraga, Takeshi Ara, Nao Sato, Nayumi Akimoto, Kenjiro Sugiyama, Hideyuki Suzuki, Kota Kera. Metabolic analysis of unripe papaya (Carica papaya L.) to promote its utilization as a functional food. Bioscience, biotechnology, and biochemistry. 2021 Apr; 85(5):1194-1204. doi: 10.1093/bbb/zbab014. [PMID: 33704369]
  • Vishwanath Zunjar, Ranjeet Prasad Dash, Mehul Jivrajani, Bhavna Trivedi, Manish Nivsarkar. Antithrombocytopenic activity of carpaine and alkaloidal extract of Carica papaya Linn. leaves in busulfan induced thrombocytopenic Wistar rats. Journal of ethnopharmacology. 2016 Apr; 181(?):20-5. doi: 10.1016/j.jep.2016.01.035. [PMID: 26812680]
  • Tasqiah Julianti, Mouhssin Oufir, Matthias Hamburger. Quantification of the antiplasmodial alkaloid carpaine in papaya (Carica papaya) leaves. Planta medica. 2014 Aug; 80(13):1138-42. doi: 10.1055/s-0034-1382948. [PMID: 25153096]
  • Yasmeen Maniyar, Prabhu Bhixavatimath. Antihyperglycemic and hypolipidemic activities of aqueous extract of Carica papaya Linn. leaves in alloxan-induced diabetic rats. Journal of Ayurveda and integrative medicine. 2012 Apr; 3(2):70-4. doi: 10.4103/0975-9476.96519. [PMID: 22707862]
  • R Gadekar, P K Singour, P K Chaurasiya, R S Pawar, U K Patil. A potential of some medicinal plants as an antiulcer agents. Pharmacognosy reviews. 2010 Jul; 4(8):136-46. doi: 10.4103/0973-7847.70906. [PMID: 22228953]
  • Sarah T Pruett, Anatoliy Bushnev, Kerri Hagedorn, Madhura Adiga, Christopher A Haynes, M Cameron Sullards, Dennis C Liotta, Alfred H Merrill. Biodiversity of sphingoid bases ('sphingosines') and related amino alcohols. Journal of lipid research. 2008 Aug; 49(8):1621-39. doi: 10.1194/jlr.r800012-jlr200. [PMID: 18499644]
  • Richard N Bennett, Fred A Mellon, Eduardo A S Rosa, Lionel Perkins, Paul A Kroon. Profiling glucosinolates, flavonoids, alkaloids, and other secondary metabolites in tissues of Azima tetracantha L. (Salvadoraceae). Journal of agricultural and food chemistry. 2004 Sep; 52(19):5856-62. doi: 10.1021/jf040091+. [PMID: 15366832]