Cloxacillin (BioDeep_00001867639)
Main id: BioDeep_00000002184
代谢物信息卡片
Cloxacillin
化学式: C19H18ClN3O5S (435.0656)
中文名称: 氯唑西林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O
InChI: InChI=1S/C19H18ClN3O5S/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27)/t13-,14+,17-/m1/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CF - Beta-lactamase resistant penicillins
A semisynthetic penicillin antibiotic carrying a 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido group at position 6.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
2 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:49566
- KEGG: C06923
- KEGGdrug: D07733
- PubChem: 6098
- DrugBank: DB01147
- ChEMBL: CHEMBL891
- MeSH: Cloxacillin
- CAS: 61-72-3
- MetaboLights: MTBLC49566
- PubChem: 9140
- PDB-CCD: CXN
- NIKKAJI: J4.818F
- RefMet: Cloxacillin
- KNApSAcK: 49566
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kasturi Devi Kondampati, Simrat Pal Singh Saini, Pritam K Sidhu, Arun Anand, Deepesh Kumar, Srinu Beesam, Jasbir Singh Bedi, Rajdeep Kaur, Rajesh Bhardwaj. Pharmacokinetic-Pharmacodynamic Study of Ampicillin-Cloxacillin Combination in Indian Thoroughbred Horses (Equus caballus) and Safety Evaluation of the Computed Dosage Regimen.
Journal of equine veterinary science.
2022 08; 115(?):104020. doi:
10.1016/j.jevs.2022.104020. [PMID: 35605881] - Efraím A Serna-Galvis, John F Guateque-Londoño, Javier Silva-Agredo, Jazmín Porras, Yenny Ávila-Torres, Ricardo A Torres-Palma. Superior selectivity of high-frequency ultrasound toward chorine containing-pharmaceuticals elimination in urine: A comparative study with other oxidation processes through the elucidation of the degradation pathways.
Ultrasonics sonochemistry.
2021 Dec; 80(?):105814. doi:
10.1016/j.ultsonch.2021.105814. [PMID: 34763213] - Johan Courjon, Margaux Garzaro, Pierre-Marie Roger, Raymond Ruimy, Thibaud Lavrut, Mikaël Chelli, Jean-Luc Raynier, David Chirio, Elisa Demonchy, Laura Cabane, François Jehl, Christophe Trojani, Antoine Grillon, Sylvain Goutelle. A Population Pharmacokinetic Analysis of Continuous Infusion of Cloxacillin during Staphylococcus aureus Bone and Joint Infections.
Antimicrobial agents and chemotherapy.
2020 11; 64(12):. doi:
10.1128/aac.01562-20. [PMID: 32988822] - Murilo Henrique M Facure, Rodrigo Schneider, Danilo M Dos Santos, Daniel S Correa. Impedimetric electronic tongue based on molybdenum disulfide and graphene oxide for monitoring antibiotics in liquid media.
Talanta.
2020 Sep; 217(?):121039. doi:
10.1016/j.talanta.2020.121039. [PMID: 32498857] - Sébastien Lalanne, Marc Le Vée, Florian Lemaitre, Pascal Le Corre, Marie-Clémence Verdier, Olivier Fardel. Differential interactions of the β-lactam cloxacillin with human renal organic anion transporters (OATs).
Fundamental & clinical pharmacology.
2020 Aug; 34(4):476-483. doi:
10.1111/fcp.12541. [PMID: 32100322] - Simony T Guerra, Henrique Orsi, Sâmea F Joaquim, Felipe F Guimarães, Bruna C Lopes, Felipe M Dalanezi, Domingos S Leite, Helio Langoni, Jose C F Pantoja, Vera L M Rall, Rodrigo T Hernandes, Simone B Lucheis, Márcio G Ribeiro. Short communication: Investigation of extra-intestinal pathogenic Escherichia coli virulence genes, bacterial motility, and multidrug resistance pattern of strains isolated from dairy cows with different severity scores of clinical mastitis.
Journal of dairy science.
2020 Apr; 103(4):3606-3614. doi:
10.3168/jds.2019-17477. [PMID: 32037173] - Steven Y C Tong, David C Lye, Dafna Yahav, Archana Sud, J Owen Robinson, Jane Nelson, Sophia Archuleta, Matthew A Roberts, Alan Cass, David L Paterson, Hong Foo, Mical Paul, Stephen D Guy, Adrian R Tramontana, Genevieve B Walls, Stephen McBride, Narin Bak, Niladri Ghosh, Benjamin A Rogers, Anna P Ralph, Jane Davies, Patricia E Ferguson, Ravindra Dotel, Genevieve L McKew, Timothy J Gray, Natasha E Holmes, Simon Smith, Morgyn S Warner, Shirin Kalimuddin, Barnaby E Young, Naomi Runnegar, David N Andresen, Nicholas A Anagnostou, Sandra A Johnson, Mark D Chatfield, Allen C Cheng, Vance G Fowler, Benjamin P Howden, Niamh Meagher, David J Price, Sebastiaan J van Hal, Matthew V N O'Sullivan, Joshua S Davis. Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial.
JAMA.
2020 02; 323(6):527-537. doi:
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Polish journal of microbiology.
2019 Dec; 68(4):477-491. doi:
10.33073/pjm-2019-047. [PMID: 31880892] - J A A S Jayaweera, W P H Abeydeera, G R Ranasinghe. Intravenously administered cloxacillin-induced neutropenia with eosinophilia in a patient with infective endocarditis: a case report.
Journal of medical case reports.
2018 Dec; 12(1):384. doi:
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International journal of antimicrobial agents.
2018 Sep; 52(3):344-349. doi:
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2018 03; 12(?):207-213. doi:
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Analytical chemistry.
2017 11; 89(21):11484-11490. doi:
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Antimicrobial agents and chemotherapy.
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2014 Aug; 70(8):957-63. doi:
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2012 Dec; 40(12):2332-41. doi:
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Molecular pharmaceutics.
2012 Aug; 9(8):2358-63. doi:
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2012 Jun; 52(?):98-110. doi:
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Emerging infectious diseases.
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Drug metabolism and disposition: the biological fate of chemicals.
2012 Jan; 40(1):130-8. doi:
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BMC complementary and alternative medicine.
2011 Nov; 11(?):104. doi:
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2011 Sep; 41(9 Suppl):1-6. doi:
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Iranian journal of kidney diseases.
2011 Sep; 5(5):328-31. doi:
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Veterinary research.
2011 Mar; 42(?):49. doi:
10.1186/1297-9716-42-49. [PMID: 21414189] - Shahedur Rahman, Anowar Khasru Parvez, Rezuanul Islam, Mahboob Hossain Khan. Antibacterial activity of natural spices on multiple drug resistant Escherichia coli isolated from drinking water, Bangladesh.
Annals of clinical microbiology and antimicrobials.
2011 Mar; 10(?):10. doi:
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BMC infectious diseases.
2011 Jan; 11(?):33. doi:
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PloS one.
2011; 6(10):e25236. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2010 Dec; 18(1):40-5. doi:
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Bioorganic & medicinal chemistry.
2010 Nov; 18(21):7486-96. doi:
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Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.
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North American journal of medical sciences.
2010 Jun; 2(6):263-6. doi:
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The Pan African medical journal.
2010 May; 5(?):12. doi:
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Analytical and bioanalytical chemistry.
2010 Apr; 396(8):3027-40. doi:
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Journal of health, population, and nutrition.
2009 Dec; 27(6):739-45. doi:
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Japanese journal of infectious diseases.
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Clinical therapeutics.
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La Revue de medecine interne.
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Journal of separation science.
2009 May; 32(9):1302-11. doi:
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Pediatric rheumatology online journal.
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PloS one.
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2008 Dec; 11(4):753-60. doi:
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The Canadian journal of urology.
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Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.
2008 Jun; 23(1-2):105-9. doi:
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Poultry science.
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Critical care (London, England).
2008; 12(5):R126. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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