Amantadine (BioDeep_00000001837)

 

Secondary id: BioDeep_00000397824, BioDeep_00000400225

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


Pharmascience brand OF amantadine hydrochloride

化学式: C10H17N (151.1360922)
中文名称: 金刚烷胺, 1-金刚烷胺
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 16.06%

分子结构信息

SMILES: C1C2CC3CC1CC(C2)(C3)N
InChI: InChI=1/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2

描述信息

An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake. [PubChem]
N - Nervous system > N04 - Anti-parkinson drugs > N04B - Dopaminergic agents > N04BB - Adamantane derivatives
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
Acquisition and generation of the data is financially supported in part by CREST/JST.
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C38149 - Antiparkinsonian Agent
D002491 - Central Nervous System Agents > D000700 - Analgesics
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C254 - Anti-Infective Agent > C281 - Antiviral Agent
C93038 - Cation Channel Blocker
KEIO_ID A061
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

96 个代谢物同义名

Pharmascience brand OF amantadine hydrochloride; Infectopharm brand OF amantadine hydrochloride; Ciba geigy brand OF amantadine hydrochloride; Ciba-geigy brand OF amantadine hydrochloride; Ratiopharm brand OF amantadine hydrochloride; Azupharma brand OF amantadine hydrochloride; Llorente brand OF amantadine hydrochloride; Juventus brand OF amantadine hydrochloride; Alliance brand OF amantadine hydrochloride; Novartis brand OF amantadine hydrochloride; Thiemann brand OF amantadine hydrochloride; Genpharm brand OF amantadine hydrochloride; Desitin brand OF amantadine hydrochloride; Du pont brand OF amantadine hydrochloride; Solvay brand OF amantadine hydrochloride; Krewel brand OF amantadine hydrochloride; Neuro hexal brand OF amantadine sulfate; Neuraxpharm brand OF amantadine sulfate; Stada brand OF amantadine hydrochloride; Orion brand OF amantadine hydrochloride; endo Brand OF amantadine hydrochloride; Tricyclo[3.3.1.1(3,7)]decan-1-ylamine; Azupharma brand OF amantadine sulfate; AbZ brand OF amantadine hydrochloride; Tricyclo[3.3.1.1(3,7)]decane-1-amine; Hormosan brand OF amantadine sulfate; Tricyclo[3.3.1.1(3,7)]decan-1-amine; Stada brand OF amantadine sulfate; Hexal brand OF amantadine sulfate; Aliud brand OF amantadine sulfate; Merz brand OF amantadine sulfate; Hydrochloride, amantadine; Amantadine hydrochloride; Amantadin-neuraxpharm; Amantadin neuraxpharm; Amantadin ratiopharm; Juventus, amantadina; Llorente, amantadina; Amantadin-ratiopharm; Amantadinneuraxpharm; Amantadina llorente; Amantadinratiopharm; Sulfate, amantadine; Amantadina juventus; Amanta sulfate azu; Amantadine sulfate; Amanta-sulfate-azu; 1-Aminoadamantane; Adamantan-1-amine; 1 Aminoadamantane; 1-Adamantylamine; Amantasulfateazu; 1-Adamantanamine; Stada, amantadin; Amantadin stada; Aminoadamantane; Amantadine base; Amantadine HCL; Gen amantadine; PMS Amantadine; AZU, amantadin; Gen-amantadine; Amanta hci azu; Adamantanamine; Adamantylamine; PMS-Amantadine; Amanta-hci-azu; AL, amantadin; PMSAmantadine; GenAmantadine; Amantadin azu; AmantaHCIAZU; Amantadin al; Adamantamine; Endantadine; Infecto-flu; Amantadinum; Infecto flu; Amantadina; Amantidine; Cerebramed; amantadine; InfectoFlu; Symmetrel; Midantan; Symadine; Mantadix; Viregyt; Virosol; Wiregyt; Tregor; Adekin; Amanta; Infex; Amixx; Aman



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nusrat Jahan, Mohammad Sharif Raihan, M Moshiul Islam, Farzana Mustafa Era, Adel I Alalawy, Awatif M E Omran, Yasmene F Alanazi, Mohamed Sakran, Abdulrahman Alasmari, Fahad M Alzuaibr, Ayman El Sabagh, Danial Kahrizi, A K M Aminul Islam. Genome-wide association studies of salinity tolerance in local aman rice. Cellular and molecular biology (Noisy-le-Grand, France). 2024 Feb; 70(2):10-17. doi: 10.14715/cmb/2024.70.2.2. [PMID: 38430047]
  • Md Abdullah Al Mamun, Sheikh Arafat Islam Nihad, Mou Rani Sarker, Md Abdur Rouf Sarkar, Md Ismail Hossain, Md Shahjahan Kabir. Spatiotemporal mapping of rice acreage and productivity growth in Bangladesh. PloS one. 2024; 19(3):e0300648. doi: 10.1371/journal.pone.0300648. [PMID: 38489334]
  • Maria A Lapshina, Elena F Shevtsova, Vladimir V Grigoriev, Aleksey Yu Aksinenko, Aleksey A Ustyugov, Daniil A Steinberg, Grigoriy V Maleev, Elena S Dubrovskaya, Tatiana V Goreva, Tatiana A Epishina, Vladimir L Zamoyski, Galina F Makhaeva, Vladimir P Fisenko, Ivan M Veselov, Daria V Vinogradova, Sergey O Bachurin. New Adamantane-Containing Edaravone Conjugates as Potential Neuroprotective Agents for ALS Treatments. Molecules (Basel, Switzerland). 2023 Nov; 28(22):. doi: 10.3390/molecules28227567. [PMID: 38005288]
  • Yajuan Bi, Xue Wang, Lifeng Han, Yiqing Tian, Tongwei Bo, Caiyu Li, Bowen Shi, Chunshan Gui, Youcai Zhang. Selective Inhibition of Organic Cation Transporter 1 by Benzoylpaeoniflorin Attenuates Hepatic Lipid Accumulation through AMPK Activation. Journal of natural products. 2023 01; 86(1):191-198. doi: 10.1021/acs.jnatprod.2c00927. [PMID: 36563333]
  • Rakhi Rani Sarker, M H Rashid, Md Ariful Islam, M Jahiruddin, Khandakar Rafiq Islam, Mohammad Mofizur Rahman Jahangir. Conservation agriculture's impact on total and labile organic carbon pools in calcareous and non-calcareous floodplain soils under a sub-tropical rice-based system. PloS one. 2023; 18(11):e0293257. doi: 10.1371/journal.pone.0293257. [PMID: 37939097]
  • Wenda Zhu, Yiping Fan, Yanbing Li, Lizhi Peng, Yifang Li, Fengxia Yan, Jiaqiang Zhao, Lei Zhang, Hiroshi Kurihara, Rongrong He, Heru Chen. Hybridization of amantadine with gardenamide A enhances NMDA antagonism and in vivo anti-PD effects. Bioorganic chemistry. 2023 01; 130(?):106223. doi: 10.1016/j.bioorg.2022.106223. [PMID: 36356372]
  • Suhad Sami Humadi, Samir Mohamed Awad, Ahmed Abd Elkader El-Rashedy, Mohamed Fathy El-Shehry. Design, synthesis, ADME, biological evaluation and molecular dynamic studies of natural and synthetic remedy of Herpes simplex virus type-1. Pakistan journal of pharmaceutical sciences. 2022 Jul; 35(4(Special)):1181-1190. doi: . [PMID: 36218096]
  • John D Sund, Signe Bollerup, Jekob B Glamann, Caroline An Vinten, Louise R Jensen, Trine L Toft-Bethelsen, Bo H Bentzen, Thomas N Kledal, Nina Weis, Mette Rosenkilde. [The antiviral targeting potential of viroporins]. Ugeskrift for laeger. 2022 06; 184(24):. doi: . [PMID: 35703076]
  • Shu Yuan, Si-Cong Jiang, Zhong-Wei Zhang, Yu-Fan Fu, Feng Zhu, Zi-Lin Li, Jing Hu. Abuse of amantadine in poultry may be associated with higher fatality rate of H5N1 infections in humans. Journal of medical virology. 2022 06; 94(6):2588-2597. doi: 10.1002/jmv.27664. [PMID: 35170774]
  • Konrad Rejdak, Piotr Fiedor, Robert Bonek, Aleksander Goch, Agnieszka Gala-Błądzińska, Waldemar Chełstowski, Jacek Łukasiak, Sławomir Kiciak, Piotr Dąbrowski, Mateusz Dec, Zbigniew J Król, Ewa Papuć, Adriana Zasybska, Agnieszka Segiet, Paweł Grieb. The use of amantadine in the prevention of progression and treatment of COVID-19 symptoms in patients infected with the SARS-CoV-2 virus (COV-PREVENT): Study rationale and design. Contemporary clinical trials. 2022 05; 116(?):106755. doi: 10.1016/j.cct.2022.106755. [PMID: 35390511]
  • Maria Lazarova, Lyubka Tancheva, Radoslav Chayrov, Elina Tzvetanova, Albena Alexandrova, Andrey Popatanasov, Diamara Uzunova, Miroslava Stefanova, Ivanka Stankova, Reni Kalfin. Tyrosinyl-amantadine: A New Amantadine Derivative With an Ameliorative Effect in a 6-OHDA Experimental Model of Parkinson's Disease in Rats. Journal of molecular neuroscience : MN. 2022 Apr; 72(4):900-909. doi: 10.1007/s12031-021-01964-x. [PMID: 35091981]
  • Muthiah Chellappandian, Sengottayan Senthil-Nathan, Sengodan Karthi, Prabhakaran Vasantha-Srinivasan, Kandaswamy Kalaivani, Wayne Brian Hunter, Ajmal M Ali, Chockalingam Veerabahu, Mohamed Soliman Elshikh, Dunia A Al Farraj. Larvicidal and repellent activity of N-methyl-1-adamantylamine and oleic acid a major derivative of bael tree ethanol leaf extracts against dengue mosquito vector and their biosafety on natural predator. Environmental science and pollution research international. 2022 Mar; 29(11):15654-15663. doi: 10.1007/s11356-021-16219-w. [PMID: 34636011]
  • Liv Bode, Detlef E Dietrich, Carsten W Spannhuth, Hanns Ludwig. Prominent Efficacy of Amantadine against Human Borna Disease Virus Infection In Vitro and In Vivo. Comment on Fink et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses 2021, 13, 539. Viruses. 2022 02; 14(3):. doi: 10.3390/v14030494. [PMID: 35336901]
  • Satoru Mitsuboshi, Ryohei Kaseda, Ichiei Narita. Amantadine and Fatal Events in Patients With Chronic Kidney Disease: Analysis of the Japanese Adverse Event Report Database. The Annals of pharmacotherapy. 2022 02; 56(2):227-228. doi: 10.1177/10600280211022439. [PMID: 34085553]
  • Konrad Rejdak, Paweł Grieb. Fluvoxamine and Amantadine: Central Nervous System Acting Drugs Repositioned for COVID-19 as Early Intervention. Current neuropharmacology. 2022; 20(4):777-781. doi: 10.2174/1570159x19666210729123734. [PMID: 34325642]
  • Nazrul Islam, Shafiqur Rahman. Novel Pulmonary Delivery of Antiviral Drugs for Treating COVID-19 in Patients with Parkinson's Disease. Current drug delivery. 2022; 19(3):260-265. doi: 10.2174/1567201818666210331121803. [PMID: 33797367]
  • Song Zhu, Fei Luo, Bin Zhu, Fei Ling, Er-Long Wang, Tian-Qiang Liu, Gao-Xue Wang. A Nanobody-Mediated Virus-Targeting Drug Delivery Platform for the Central Nervous System Viral Disease Therapy. Microbiology spectrum. 2021 12; 9(3):e0148721. doi: 10.1128/spectrum.01487-21. [PMID: 34817277]
  • Włodzimierz Bodnar, Gonzalo Aranda-Abreu, Monika Słaboń-Willand, Sylwia Kotecka, Małgorzata Farnik, Jarosław Bodnar. The efficacy of amantadine hydrochloride in the treatment of COVID-19 - a single-center observation study. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. 2021 12; 49(294):389-393. doi: NULL. [PMID: 34919079]
  • Julia A Townsend, Henry M Sanders, Amber D Rolland, Chad K Park, Nancy C Horton, James S Prell, Jun Wang, Michael T Marty. Influenza AM2 Channel Oligomerization Is Sensitive to Its Chemical Environment. Analytical chemistry. 2021 12; 93(48):16273-16281. doi: 10.1021/acs.analchem.1c04660. [PMID: 34813702]
  • Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde. Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2. Communications biology. 2021 12; 4(1):1347. doi: 10.1038/s42003-021-02866-9. [PMID: 34853399]
  • Yuyong Zhou, Karen A Gammeltoft, Andrea Galli, Anna Offersgaard, Ulrik Fahnøe, Santseharay Ramirez, Jens Bukh, Judith M Gottwein. Efficacy of Ion-Channel Inhibitors Amantadine, Memantine and Rimantadine for the Treatment of SARS-CoV-2 In Vitro. Viruses. 2021 10; 13(10):. doi: 10.3390/v13102082. [PMID: 34696509]
  • Zahide Betül Gündüz, Filiz Aktas, Husamettin Vatansev, Merve Solmaz, Ender Erdoğan. Effects of amantadine and topiramate on neuronal damage in rats with experimental cerebral ischemia-reperfusion. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2021 Oct; 30(10):1013-1023. doi: 10.17219/acem/138327. [PMID: 34510842]
  • Alfonso Mata-Bermudez, Camilo Ríos, Masha Burelo, Cuauhtémoc Pérez-González, Betzabé Anahí García-Martínez, Gustavo Jardon-Guadarrama, Francisco Calderón-Estrella, Norman Manning-Balpuesta, Araceli Diaz-Ruiz. Amantadine prevented hypersensitivity and decreased oxidative stress by NMDA receptor antagonism after spinal cord injury in rats. European journal of pain (London, England). 2021 09; 25(8):1839-1851. doi: 10.1002/ejp.1795. [PMID: 33982314]
  • Ling-Yang Wang, Fan-Zhi Bu, Yue-Ming Yu, Yuan-Yuan Niu, Yan-Tuan Li, Cui-Wei Yan, Zhi-Yong Wu. A novel crystalline molecular salt of sulfamethoxazole and amantadine hybridizing antiviral-antibacterial dual drugs with optimal in vitro/vivo pharmaceutical properties. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2021 Aug; 163(?):105883. doi: 10.1016/j.ejps.2021.105883. [PMID: 34022409]
  • Albert Cortés-Borra, Gonzalo Emiliano Aranda-Abreu. Amantadine in the prevention of clinical symptoms caused by SARS-CoV-2. Pharmacological reports : PR. 2021 Jun; 73(3):962-965. doi: 10.1007/s43440-021-00231-5. [PMID: 33604795]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Klaus Fink, Andreas Nitsche, Markus Neumann, Marica Grossegesse, Karl-Heinz Eisele, Wojciech Danysz. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 03; 13(4):. doi: 10.3390/v13040539. [PMID: 33804989]
  • Paweł Grieb, Maciej Świątkiewicz, Katarzyna Prus, Konrad Rejdak. Amantadine for COVID-19. Journal of clinical pharmacology. 2021 03; 61(3):412-413. doi: 10.1002/jcph.1802. [PMID: 33350472]
  • Tadeusz Płusa. [Anti-inflammatory effects of amantadine and memantine in SARS-CoV-2 infection]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. 2021 02; 49(289):67-70. doi: . [PMID: 33713098]
  • E A Katunina. [Amantadine in the treatment of Parkinson's disease. New opportunities in the context of COVID-19]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2021; 121(4):101-106. doi: 10.17116/jnevro2021121041101. [PMID: 34037362]
  • Gonzalo Emiliano Aranda-Abreu, José Dolores Aranda-Martínez, Ramiro Araújo. Use of amantadine in a patient with SARS-CoV-2. Journal of medical virology. 2021 Jan; 93(1):110-111. doi: 10.1002/jmv.26179. [PMID: 32542661]
  • Gonzalo Emiliano Aranda-Abreu, José D Aranda-Martínez, Ramiro Araújo, María Elena Hernández-Aguilar, Deissy Herrera-Covarrubias, Fausto Rojas-Durán. Observational study of people infected with SARS-Cov-2, treated with amantadine. Pharmacological reports : PR. 2020 Dec; 72(6):1538-1541. doi: 10.1007/s43440-020-00168-1. [PMID: 33040252]
  • Venkata S Mandala, Matthew J McKay, Alexander A Shcherbakov, Aurelio J Dregni, Antonios Kolocouris, Mei Hong. Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers. Nature structural & molecular biology. 2020 12; 27(12):1202-1208. doi: 10.1038/s41594-020-00536-8. [PMID: 33177698]
  • Steven R Brenner. The potential of memantine and related adamantanes such as amantadine, to reduce the neurotoxic effects of COVID-19, including ARDS and to reduce viral replication through lysosomal effects. Journal of medical virology. 2020 11; 92(11):2341-2342. doi: 10.1002/jmv.26030. [PMID: 32436995]
  • Ileana Marinescu, Dragoş Marinescu, Laurenţiu Mogoantă, Ion Cristian Efrem, Puiu Olivian Stovicek. SARS-CoV-2 infection in patients with serious mental illness and possible benefits of prophylaxis with Memantine and Amantadine. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. 2020 Oct; 61(4):1007-1022. doi: 10.47162/rjme.61.4.03. [PMID: 34171050]
  • Viroj Wiwanitkit. Amantadine, COVID-19 and Parkinsonism. Archives of medical research. 2020 10; 51(7):714. doi: 10.1016/j.arcmed.2020.07.001. [PMID: 32660794]
  • Gonzalo Emiliano Aranda-Abreu. Response to: Amantadine, COVID-19 and Parkinsonism. Archives of medical research. 2020 10; 51(7):715. doi: 10.1016/j.arcmed.2020.07.002. [PMID: 32723524]
  • Ramiro Araújo, José Dolores Aranda-Martínez, Gonzalo Emiliano Aranda-Abreu. Amantadine Treatment for People with COVID-19. Archives of medical research. 2020 10; 51(7):739-740. doi: 10.1016/j.arcmed.2020.06.009. [PMID: 32571606]
  • R Depoortere, T H Johnston, S H Fox, J M Brotchie, A Newman-Tancredi. The selective 5-HT1A receptor agonist, NLX-112, exerts anti-dyskinetic effects in MPTP-treated macaques. Parkinsonism & related disorders. 2020 09; 78(?):151-157. doi: 10.1016/j.parkreldis.2020.08.009. [PMID: 32846366]
  • Kyra J Berg, David Sanchez-Migallon Guzman, Heather K Knych, Tracy L Drazenovich, Joanne R Paul-Murphy. Pharmacokinetics of amantadine after oral administration of single and multiple doses to orange-winged Amazon parrots (Amazona amazonica). American journal of veterinary research. 2020 Aug; 81(8):651-655. doi: 10.2460/ajvr.81.8.651. [PMID: 32700994]
  • Guangwei Wu, Guihong Yu, Yunjia Yu, Shuang Yang, Zhongwei Duan, Wei Wang, Yankai Liu, Rilei Yu, Jing Li, Tianjiao Zhu, Qianqun Gu, Dehai Li. Chemoreactive-Inspired Discovery of Influenza A Virus Dual Inhibitor to Block Hemagglutinin-Mediated Adsorption and Membrane Fusion. Journal of medicinal chemistry. 2020 07; 63(13):6924-6940. doi: 10.1021/acs.jmedchem.0c00312. [PMID: 32520560]
  • Konrad Rejdak, Paweł Grieb. Adamantanes might be protective from COVID-19 in patients with neurological diseases: multiple sclerosis, parkinsonism and cognitive impairment. Multiple sclerosis and related disorders. 2020 Jul; 42(?):102163. doi: 10.1016/j.msard.2020.102163. [PMID: 32388458]
  • Gonzalo Emiliano Aranda Abreu, María Elena Hernández Aguilar, Deissy Herrera Covarrubias, Fausto Rojas Durán. Amantadine as a drug to mitigate the effects of COVID-19. Medical hypotheses. 2020 Jul; 140(?):109755. doi: 10.1016/j.mehy.2020.109755. [PMID: 32361100]
  • Maggie C Duncan, Pascal Amoa Onguéné, Ibuki Kihara, Derrick N Nebangwa, Maya E Naidu, David E Williams, Aruna D Balgi, Kerstin Andrae-Marobela, Michel Roberge, Raymond J Andersen, Masahiro Niikura, Fidele Ntie-Kang, Ian Tietjen. Virtual Screening Identifies Chebulagic Acid as an Inhibitor of the M2(S31N) Viral Ion Channel and Influenza A Virus. Molecules (Basel, Switzerland). 2020 Jun; 25(12):. doi: 10.3390/molecules25122903. [PMID: 32599753]
  • Yanyan Li, Yi Jiang, Tao Lin, Qi Wan, Xiaoquan Yang, Guoxing Xu, Jing Huang, Zhenlan Li. Amantadine hydrochloride monitoring by dried plasma spot technique: High-performance liquid chromatography-tandem mass spectrometry based clinical assay. Journal of separation science. 2020 Jun; 43(12):2264-2269. doi: 10.1002/jssc.201901298. [PMID: 32160411]
  • Sandra P Smieszek, Bart P Przychodzen, Mihael H Polymeropoulos. Amantadine disrupts lysosomal gene expression: A hypothesis for COVID19 treatment. International journal of antimicrobial agents. 2020 Jun; 55(6):106004. doi: 10.1016/j.ijantimicag.2020.106004. [PMID: 32361028]
  • Athina Konstantinidi, Maria Chountoulesi, Nikolaos Naziris, Barbara Sartori, Heinz Amenitsch, Gregor Mali, Tomaž Čendak, Maria Plakantonaki, Iro Triantafyllakou, Theodore Tselios, Costas Demetzos, David D Busath, Thomas Mavromoustakos, Antonios Kolocouris. The boundary lipid around DMPC-spanning influenza A M2 transmembrane domain channels: Its structure and potential for drug accommodation. Biochimica et biophysica acta. Biomembranes. 2020 03; 1862(3):183156. doi: 10.1016/j.bbamem.2019.183156. [PMID: 31846647]
  • Alina A Okhina, Artem D Rogachev, Olga I Yarovaya, Mikhail V Khvostov, Tatyana G Tolstikova, Andrey G Pokrovsky, Veniamin A Khazanov, Nariman F Salakhutdinov. Development and validation of an LC-MS/MS method for the quantitative analysis of the anti-influenza agent camphecene in rat plasma and its application to study the blood-to-plasma distribution of the agent. Journal of pharmaceutical and biomedical analysis. 2020 Feb; 180(?):113039. doi: 10.1016/j.jpba.2019.113039. [PMID: 31865208]
  • Detlef E Dietrich, Liv Bode, Carsten W Spannhuth, Hartmut Hecker, Hanns Ludwig, Hinderk M Emrich. Antiviral treatment perspective against Borna disease virus 1 infection in major depression: a double-blind placebo-controlled randomized clinical trial. BMC pharmacology & toxicology. 2020 02; 21(1):12. doi: 10.1186/s40360-020-0391-x. [PMID: 32066504]
  • Philip W Tipton, Zbigniew K Wszolek. Response to 'Does amantadine have a protective effect against COVID-19?'. Neurologia i neurochirurgia polska. 2020; 54(3):286-287. doi: 10.5603/pjnns.a2020.0048. [PMID: 32583401]
  • Albert Cortés Borra. Does amantadine have a protective effect against COVID-19?. Neurologia i neurochirurgia polska. 2020; 54(3):284-285. doi: 10.5603/pjnns.a2020.0041. [PMID: 32495926]
  • Gökçe Cihan-Üstündağ, Muhammet Zopun, Evelien Vanderlinden, Elif Ozkirimli, Leentje Persoons, Gültaze Çapan, Lieve Naesens. Superior inhibition of influenza virus hemagglutinin-mediated fusion by indole-substituted spirothiazolidinones. Bioorganic & medicinal chemistry. 2020 01; 28(1):115130. doi: 10.1016/j.bmc.2019.115130. [PMID: 31753804]
  • Caio P Gomes, Danilo E Fernandes, Fernanda Casimiro, Gustavo F da Mata, Michelle T Passos, Patricia Varela, Gianna Mastroianni-Kirsztajn, João Bosco Pesquero. Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics. Frontiers in cellular and infection microbiology. 2020; 10(?):589505. doi: 10.3389/fcimb.2020.589505. [PMID: 33364201]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Thomas Müller, Jan-Dominique Möhr. Recent Clinical Advances in Pharmacotherapy for Levodopa-Induced Dyskinesia. Drugs. 2019 Sep; 79(13):1367-1374. doi: 10.1007/s40265-019-01170-5. [PMID: 31332769]
  • Tina deVries, Angela Dentiste, Clifford Di Lea, Vincent Pichette, David Jacobs. Effects of Renal Impairment on the Pharmacokinetics of Once-Daily Amantadine Extended-Release Tablets. CNS drugs. 2019 08; 33(8):783-789. doi: 10.1007/s40263-019-00651-1. [PMID: 31342404]
  • Rami Musharrafieh, Panagiotis I Lagarias, Chunlong Ma, Gene S Tan, Antonios Kolocouris, Jun Wang. The L46P mutant confers a novel allosteric mechanism of resistance toward the influenza A virus M2 S31N proton channel blockers. Molecular pharmacology. 2019 08; 96(2):148-157. doi: 10.1124/mol.119.116640. [PMID: 31175183]
  • Thomas Müller, Wilfried Kuhn, Jan-Dominique Möhr. Evaluating ADS5102 (amantadine) for the treatment of Parkinson's disease patients with dyskinesia. Expert opinion on pharmacotherapy. 2019 Jul; 20(10):1181-1187. doi: 10.1080/14656566.2019.1612365. [PMID: 31058557]
  • Tianyu Niu, Xiaoqiang Zhao, Jing Jiang, Haiyan Yan, Yinghong Li, Sheng Tang, Yuhuan Li, Danqing Song. Evolution and Biological Evaluation of Matrinic Derivatives with Amantadine Fragments As New Anti-Influenza Virus Agents. Molecules (Basel, Switzerland). 2019 Mar; 24(5):. doi: 10.3390/molecules24050921. [PMID: 30845734]
  • Robert A Hauser, Rajesh Pahwa, William A Wargin, Cindy J Souza-Prien, Natalie McClure, Reed Johnson, Jack T Nguyen, Rajiv Patni, Gregory T Went. Pharmacokinetics of ADS-5102 (Amantadine) Extended Release Capsules Administered Once Daily at Bedtime for the Treatment of Dyskinesia. Clinical pharmacokinetics. 2019 01; 58(1):77-88. doi: 10.1007/s40262-018-0663-4. [PMID: 29777529]
  • Yongshi Yu, Qi Tang, Zhichao Xu, Siliang Li, Mengyu Jin, Zixuan Zhao, Chune Dong, Shuwen Wu, Hai-Bing Zhou. Synthesis and structure-activity relationship study of arylsulfonamides as novel potent H5N1 inhibitors. European journal of medicinal chemistry. 2018 Nov; 159(?):206-216. doi: 10.1016/j.ejmech.2018.09.065. [PMID: 30292897]
  • Athina Konstantinidi, Nikolaos Naziris, Maria Chountoulesi, Sophia Kiriakidi, Barbara Sartori, Dimitris Kolokouris, Heinz Amentisch, Gregor Mali, Dimitrios Ntountaniotis, Costas Demetzos, Thomas Mavromoustakos, Antonios Kolocouris. Comparative Perturbation Effects Exerted by the Influenza A M2 WT Protein Inhibitors Amantadine and the Spiro[pyrrolidine-2,2'-adamantane] Variant AK13 to Membrane Bilayers Studied Using Biophysical Experiments and Molecular Dynamics Simulations. The journal of physical chemistry. B. 2018 11; 122(43):9877-9895. doi: 10.1021/acs.jpcb.8b07071. [PMID: 30285441]
  • Elizabeth F Brigham, Tom H Johnston, Carl Brown, Jonathon D S Holt, Susan H Fox, Michael P Hill, Patrick A Howson, Jonathan M Brotchie, Jack T Nguyen. Pharmacokinetic/Pharmacodynamic Correlation Analysis of Amantadine for Levodopa-Induced Dyskinesia. The Journal of pharmacology and experimental therapeutics. 2018 11; 367(2):373-381. doi: 10.1124/jpet.118.247650. [PMID: 30087157]
  • Suo Decheng, Wang Peilong, Li Yang, Wang Ruiguo, Wei Shulin, Xiao Zhiming, Zhang Su. Simultaneous determination of antibiotics and amantadines in animal-derived feedstuffs by ultraperformance liquid chromatographic-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Sep; 1095(?):183-190. doi: 10.1016/j.jchromb.2018.07.025. [PMID: 30077099]
  • Weiyu Li, Yekkuni L Balachandran, Yanling Hao, Xie Hao, Runzhi Li, Zhangjie Nan, Hongying Zhang, Yiming Shao, Ye Liu. Amantadine Surface-Modified Silver Nanorods Improves Immunotherapy of HIV Vaccine Against HIV-Infected Cells. ACS applied materials & interfaces. 2018 Aug; 10(34):28494-28501. doi: 10.1021/acsami.8b10948. [PMID: 30085647]
  • Julia Paik, Susan J Keam. Amantadine Extended-Release (GOCOVRI™): A Review in Levodopa-Induced Dyskinesia in Parkinson's Disease. CNS drugs. 2018 08; 32(8):797-806. doi: 10.1007/s40263-018-0552-2. [PMID: 30088203]
  • Lawrence W Elmer, Jorge L Juncos, Carlos Singer, Daniel D Truong, Susan R Criswell, Sotirios Parashos, Larissa Felt, Reed Johnson, Rajiv Patni. Pooled Analyses of Phase III Studies of ADS-5102 (Amantadine) Extended-Release Capsules for Dyskinesia in Parkinson's Disease. CNS drugs. 2018 04; 32(4):387-398. doi: 10.1007/s40263-018-0498-4. [PMID: 29532440]
  • Mazen T Elkurd, Laxman B Bahroo, Rajesh Pahwa. The role of extended-release amantadine for the treatment of dyskinesia in Parkinson's disease patients. Neurodegenerative disease management. 2018 04; 8(2):73-80. doi: 10.2217/nmt-2018-0001. [PMID: 29564954]
  • María Del Pozo, Ángela Fernández, Carmen Quintana. On-line competitive host-guest interactions in a turn-on fluorometric method to amantadine determination in human serum and pharmaceutical formulations. Talanta. 2018 Mar; 179(?):124-130. doi: 10.1016/j.talanta.2017.10.064. [PMID: 29310211]
  • Yinghua Li, Zhengfang Lin, Min Guo, Mingqi Zhao, Yu Xia, Changbing Wang, Tiantian Xu, Bing Zhu. Inhibition of H1N1 influenza virus-induced apoptosis by functionalized selenium nanoparticles with amantadine through ROS-mediated AKT signaling pathways. International journal of nanomedicine. 2018; 13(?):2005-2016. doi: 10.2147/ijn.s155994. [PMID: 29662313]
  • Nathan A Gordon, Kelly L McGuire, Spencer K Wallentine, Gregory A Mohl, Jonathan D Lynch, Roger G Harrison, David D Busath. Divalent copper complexes as influenza A M2 inhibitors. Antiviral research. 2017 Nov; 147(?):100-106. doi: 10.1016/j.antiviral.2017.10.009. [PMID: 29032206]
  • X You, S Yang, J Zhao, Y Zhang, L Zhao, Y Cheng, C Hou, Z Xu. Study on the abuse of amantadine in tissues of broiler chickens by HPLC-MS/MS. Journal of veterinary pharmacology and therapeutics. 2017 Oct; 40(5):539-544. doi: 10.1111/jvp.12388. [PMID: 28133761]
  • Huihui Wang, Dongsheng Sun, Han Liao, Yanfang Wang, Shan Zhao, Ying Zhang, Guojun Lv, Xiaojun Ma, Yang Liu, Guangwei Sun. Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular imaging. Talanta. 2017 Aug; 171(?):8-15. doi: 10.1016/j.talanta.2017.04.046. [PMID: 28551157]
  • Mozibur Rahman, Sheikh Ariful Hoque, Mohammad Ariful Islam, Sabita Rezwana Rahman. Molecular analysis of amantadine-resistant influenza A (H1N1 pdm09) virus isolated from slum dwellers of Dhaka, Bangladesh. Virus genes. 2017 Jun; 53(3):377-385. doi: 10.1007/s11262-017-1447-x. [PMID: 28401407]
  • Wei Zheng, Shibin Wang, Gabor S Ungvari, Chee H Ng, Xin-Hu Yang, Yu-Hong Gu, Ming Li, Ying-Qiang Xiang, Yu-Tao Xiang. Amantadine for Antipsychotic-Related Weight Gain: Meta-Analysis of Randomized Placebo-Controlled Trials. Journal of clinical psychopharmacology. 2017 Jun; 37(3):341-346. doi: 10.1097/jcp.0000000000000598. [PMID: 28383359]
  • Oleg I Artyushin, Elena V Sharova, Natalya M Vinogradova, Galina K Genkina, Aleksandra A Moiseeva, Zinaida S Klemenkova, Iana R Orshanskaya, Anna A Shtro, Renata A Kadyrova, Vladimir V Zarubaev, Olga I Yarovaya, Nariman F Salakhutdinov, Valery K Brel. Synthesis of camphecene derivatives using click chemistry methodology and study of their antiviral activity. Bioorganic & medicinal chemistry letters. 2017 05; 27(10):2181-2184. doi: 10.1016/j.bmcl.2017.03.051. [PMID: 28366530]
  • Marta Barniol-Xicota, Sabrina Gazzarrini, Eva Torres, Yanmei Hu, Jun Wang, Lieve Naesens, Anna Moroni, Santiago Vázquez. Slow but Steady Wins the Race: Dissimilarities among New Dual Inhibitors of the Wild-Type and the V27A Mutant M2 Channels of Influenza A Virus. Journal of medicinal chemistry. 2017 05; 60(9):3727-3738. doi: 10.1021/acs.jmedchem.6b01758. [PMID: 28418242]
  • Yanmei Hu, Rami Musharrafieh, Chunlong Ma, Jiantao Zhang, Donald F Smee, William F DeGrado, Jun Wang. An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses. Antiviral research. 2017 04; 140(?):45-54. doi: 10.1016/j.antiviral.2017.01.006. [PMID: 28087313]
  • Huizhen Wu, Jianmei Wang, Hua Yang, Guoqin Li, Yinhuan Zeng, Wei Xia, Zuguang Li, Mingrong Qian. Development and application of an in-cell cleanup pressurized liquid extraction with ultra-high-performance liquid chromatography-tandem mass spectrometry to detect prohibited antiviral agents sensitively in livestock and poultry feces. Journal of chromatography. A. 2017 Mar; 1488(?):10-16. doi: 10.1016/j.chroma.2017.01.070. [PMID: 28159370]
  • Runfeng Li, Chunguang Yang, Qiuling Du, Xin Zhao, Haiming Jiang, Wenhui Hu, Zifeng Yang. Pinanamine Is a Promising Lead Compound against Influenza A Virus: Evidence from in Vitro and in Vivo Efficacy Compared to Amantadine. Biological & pharmaceutical bulletin. 2017; 40(7):954-959. doi: 10.1248/bpb.b16-00774. [PMID: 28674259]
  • Jonathan M Meyer. Forgotten but not gone: new developments in the understanding and treatment of tardive dyskinesia. CNS spectrums. 2016 12; 21(S1):13-24. doi: 10.1017/s1092852916000730. [PMID: 28044943]
  • Loretta T Ford, Jonathan D Berg. 1-Adamantylamine a simple urine marker for screening for third generation adamantyl-type synthetic cannabinoids by ultra-performance liquid chromatography tandem mass spectrometry. Annals of clinical biochemistry. 2016 Nov; 53(6):640-646. doi: 10.1177/0004563216628892. [PMID: 26748105]
  • Chunlong Ma, Jiantao Zhang, Jun Wang. Pharmacological Characterization of the Spectrum of Antiviral Activity and Genetic Barrier to Drug Resistance of M2-S31N Channel Blockers. Molecular pharmacology. 2016 09; 90(3):188-98. doi: 10.1124/mol.116.105346. [PMID: 27385729]
  • Alexander N Geisman, Vladimir T Valuev-Elliston, Alexander A Ozerov, Anastasia L Khandazhinskaya, Alexander O Chizhov, Sergey N Kochetkov, Christophe Pannecouque, Lieve Naesens, Katherine L Seley-Radtke, Mikhail S Novikov. 1,6-Bis[(benzyloxy)methyl]uracil derivatives-Novel antivirals with activity against HIV-1 and influenza H1N1 virus. Bioorganic & medicinal chemistry. 2016 06; 24(11):2476-85. doi: 10.1016/j.bmc.2016.04.010. [PMID: 27112451]
  • Jianghong Dong, Shengwei Chen, Runfeng Li, Wei Cui, Haiming Jiang, Yixia Ling, Zifeng Yang, Wenhui Hu. Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus. European journal of medicinal chemistry. 2016 Jan; 108(?):605-615. doi: 10.1016/j.ejmech.2015.12.013. [PMID: 26722757]
  • Siwen Niu, Longlong Si, Dong Liu, Andrew Zhou, Ziwei Zhang, Zongze Shao, Shaomeng Wang, Lihe Zhang, Demin Zhou, Wenhan Lin. Spiromastilactones: A new class of influenza virus inhibitors from deep-sea fungus. European journal of medicinal chemistry. 2016 Jan; 108(?):229-244. doi: 10.1016/j.ejmech.2015.09.037. [PMID: 26686929]
  • Nadine Homeyer, Harris Ioannidis, Felix Kolarov, Günter Gauglitz, Christos Zikos, Antonios Kolocouris, Holger Gohlke. Interpreting Thermodynamic Profiles of Aminoadamantane Compounds Inhibiting the M2 Proton Channel of Influenza A by Free Energy Calculations. Journal of chemical information and modeling. 2016 Jan; 56(1):110-26. doi: 10.1021/acs.jcim.5b00467. [PMID: 26690735]
  • L Jansen, Neeltje A Kootstra, Karel A van Dort, R Bart Takkenberg, Hendrik W Reesink, Hans L Zaaijer. Hepatitis B Virus Pregenomic RNA Is Present in Virions in Plasma and Is Associated With a Response to Pegylated Interferon Alfa-2a and Nucleos(t)ide Analogues. The Journal of infectious diseases. 2016 Jan; 213(2):224-32. doi: 10.1093/infdis/jiv397. [PMID: 26216905]
  • Jiaqiang Zhao, Lizhi Peng, Wenhua Zheng, Rikang Wang, Lei Zhang, Jian Yang, Heru Chen. Chemically Bonding of Amantadine with Gardenamide A Enhances the Neuroprotective Effects against Corticosterone-Induced Insults in PC12 Cells. International journal of molecular sciences. 2015 Sep; 16(9):22795-810. doi: 10.3390/ijms160922795. [PMID: 26402670]
  • Herman Burger, Alexander T den Dekker, Sandra Segeletz, Antonius W M Boersma, Peter de Bruijn, Maria Debiec-Rychter, Takahiro Taguchi, Stefan Sleijfer, Alex Sparreboom, Ron H J Mathijssen, Erik A C Wiemer. Lysosomal Sequestration Determines Intracellular Imatinib Levels. Molecular pharmacology. 2015 Sep; 88(3):477-87. doi: 10.1124/mol.114.097451. [PMID: 26108972]
  • I Chattopadhyaya, Sumeet Gupta, Asad Mohammed, N Mushtaq, S Chauhan, Saikat Ghosh, Saikant Ghosh. Neuroprotective effect of Spirulina fusiform and amantadine in the 6-OHDA induced Parkinsonism in rats. BMC complementary and alternative medicine. 2015 Aug; 15(?):296. doi: 10.1186/s12906-015-0815-0. [PMID: 26306668]
  • Héctor Torres-Gómez, Kirstin Lehmkuhl, Bastian Frehland, Constantin Daniliuc, Dirk Schepmann, Christina Ehrhardt, Bernhard Wünsch. Stereoselective synthesis and pharmacological evaluation of [4.3.3]propellan-8-amines as analogs of adamantanamines. Bioorganic & medicinal chemistry. 2015 Aug; 23(15):4277-4285. doi: 10.1016/j.bmc.2015.06.030. [PMID: 26145819]
  • Rokshana Parvin, Awad A Shehata, Kristin Heenemann, Malgorzata Gac, Antje Rueckner, Mohammad Y Halami, Thomas W Vahlenkamp. Differential replication properties among H9N2 avian influenza viruses of Eurasian origin. Veterinary research. 2015 Jul; 46(?):75. doi: 10.1186/s13567-015-0198-8. [PMID: 26149130]
  • Mario Suwalsky, Malgorzata Jemiola-Rzeminska, Mariella Altamirano, Fernando Villena, Nathan Dukes, Kazimierz Strzalka. Interactions of the antiviral and antiparkinson agent amantadine with lipid membranes and human erythrocytes. Biophysical chemistry. 2015 Jul; 202(?):13-20. doi: 10.1016/j.bpc.2015.04.002. [PMID: 25899993]
  • C Norkus, D Rankin, M Warner, B KuKanich. Pharmacokinetics of oral amantadine in greyhound dogs. Journal of veterinary pharmacology and therapeutics. 2015 Jun; 38(3):305-8. doi: 10.1111/jvp.12190. [PMID: 25427541]
  • Paul P Lerner, Chanoch Miodownik, Vladimir Lerner. Tardive dyskinesia (syndrome): Current concept and modern approaches to its management. Psychiatry and clinical neurosciences. 2015 Jun; 69(6):321-34. doi: 10.1111/pcn.12270. [PMID: 25556809]
  • Martin Mücke, Henning Cuhls, Vera Peuckmann-Post, Ollie Minton, Patrick Stone, Lukas Radbruch. Pharmacological treatments for fatigue associated with palliative care. The Cochrane database of systematic reviews. 2015 May; ?(5):CD006788. doi: 10.1002/14651858.cd006788.pub3. [PMID: 26026155]
  • Nathania J Leong, Richard J Prankerd, David M Shackleford, Michelle P Mcintosh. The effect of intravenous sulfobutylether7 -β-cyclodextrin on the pharmacokinetics of a series of adamantane-containing compounds. Journal of pharmaceutical sciences. 2015 Apr; 104(4):1492-8. doi: 10.1002/jps.24331. [PMID: 25573540]
  • Xueqing Chen, Longlong Si, Dong Liu, Peter Proksch, Lihe Zhang, Demin Zhou, Wenhan Lin. Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin. European journal of medicinal chemistry. 2015 Mar; 93(?):182-95. doi: 10.1016/j.ejmech.2015.02.006. [PMID: 25681711]