Carveol (BioDeep_00000017722)

Main id: BioDeep_00000004185

 

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


(1S-trans)-2-Methyl-5-(1-methylvinyl)cyclohex-2-en-1-ol

化学式: C10H16O (152.1201)
中文名称: 香芹醇, 卡维洛, L-香芹醇,顺反异构体混合物
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=C(C)C1CC=C(C)C(O)C1
InChI: InChI=1S/C10H16O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9-11H,1,5-6H2,2-3H3

描述信息

Carveol is a clear colorless liquid. Insoluble in water.
Carveol is a limonene monoterpenoid that is cyclohex-2-en-1-ol substituted by a methyl group at position 2 and a prop-1-en-2-yl group at position 5. It has a role as a volatile oil component and a plant metabolite.
Carveol is a natural product found in Echinophora tournefortii, Trachyspermum anethifolium, and other organisms with data available.
Present in oil of grapefruit (Citrus paradisi), mandarin (Citrus reticulata), blackcurrant berries, celery, black tea, dill, caraway seeds and lambs lettuce. Flavouring agent. Carveol is found in many foods, some of which are fruits, parsley, tea, and cumin.
Carveol is found in caraway. Carveol is present in oil of grapefruit (Citrus paradisi), mandarin (Citrus reticulata), blackcurrant berries, celery, black tea, dill, caraway seeds and lambs lettuce. Carveol is a flavouring agent
A limonene monoterpenoid that is cyclohex-2-en-1-ol substituted by a methyl group at position 2 and a prop-1-en-2-yl group at position 5.
Carveol is an endogenous metabolite.
Carveol is an endogenous metabolite.

同义名列表

36 个代谢物同义名

(1S-trans)-2-Methyl-5-(1-methylvinyl)cyclohex-2-en-1-ol; 2-Cyclohexen-1-ol, 2-methyl-5-(1-methylethenyl)-; 2-Cyclohexen-1-ol,2-methyl-5-(1-methylethenyl)-; 2-Methyl-5-[1-methylethenyl]-2-cyclohexen-1-ol; 2-Methyl-5-(1-methylethenyl)-2-cyclohexen-1-ol; 2-Methyl-5(1-methylethenyl)cyclohex-2-ene-1-ol; (5R)-5-Isopropenyl-2-methyl-2-cyclohexen-1-ol; 2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-ol; 2-06-00-00102 (Beilstein Handbook Reference); 2-methyl-5-prop-1-en-2-ylcyclohex-2-en-1-ol; 2-Methyl-5-(prop-1-en-2-yl)cyclohex-2-enol; 2-Methyl-5-(1-propen-2-yl)-2-cyclohexenol; 5-isopropenyl-2-methylcyclohex-2-en-1-ol; 1-Methyl-4-isopropenyl-6-cyclohexen-2-ol; 5-Isopropenyl-2-methyl-2-cyclohexen-1-ol; 2-Methyl-5-isopropenyl-2-cyclohexen-1-ol; 1H-Imidazol-1-amine, 2-methyl-4-nitro-; p-Mentha-6,8-dien-2-ol (VAN); BAVONGHXFVOKBV-UHFFFAOYSA-N; Allyl 4-aminobutylcarbamate; WLN: L6UTJ AQ B1 EY1 & U1; p-Mentha-1(6),8-dien-2-ol; L-p-mentha-6-8-dien-2-ol; p-Mentha-6,8-dien-2-ol; p-Mentha-1,8-dien-6-ol; 6,8-p-Menthadien-2-ol; p-Mentha-6, l-; Tox21_200175; CAS-99-48-9; (-)-Carveol; AI3-27596; a carveol; FEMA 2247; L-Carveol; Carveol; Carveol



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

258 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AKR1B1, CAT, ELAVL1, HPGDS, IL13, IL18, LPO, MAPK8, NQO1, PTGS2, SRARP, VEGFA
Peripheral membrane protein 2 CYP1B1, PTGS2
Endoplasmic reticulum membrane 3 CYP1B1, HMOX1, PTGS2
Nucleus 7 ELAVL1, GABPA, HMOX1, MAPK8, NQO1, SRARP, VEGFA
cytosol 8 AKR1B1, CAT, ELAVL1, HMOX1, HPGDS, IL18, MAPK8, NQO1
dendrite 1 NQO1
nucleoplasm 6 AKR1B1, ELAVL1, GABPA, HMOX1, HPGDS, MAPK8
Cell membrane 1 TNF
Cytoplasmic side 1 HMOX1
Synapse 2 MAPK8, NQO1
cell surface 2 TNF, VEGFA
glutamatergic synapse 1 ELAVL1
Golgi apparatus 2 ATRN, VEGFA
lysosomal membrane 1 GAA
neuronal cell body 2 NQO1, TNF
postsynapse 1 ELAVL1
Cytoplasm, cytosol 2 IL18, NQO1
Lysosome 1 GAA
plasma membrane 3 ATRN, GAA, TNF
Membrane 7 CAT, CYP1B1, ELAVL1, GAA, HMOX1, NQO1, VEGFA
axon 1 MAPK8
basolateral plasma membrane 1 LPO
caveola 1 PTGS2
extracellular exosome 5 AKR1B1, ATRN, CAT, GAA, LPO
Lysosome membrane 1 GAA
endoplasmic reticulum 4 ELAVL1, HMOX1, PTGS2, VEGFA
extracellular space 10 AKR1B1, ATRN, HMOX1, IL10, IL13, IL18, IL4, LPO, TNF, VEGFA
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 HMOX1
adherens junction 1 VEGFA
mitochondrion 3 AKR1B1, CAT, CYP1B1
protein-containing complex 2 CAT, PTGS2
intracellular membrane-bounded organelle 4 CAT, CYP1B1, GAA, HPGDS
Microsome membrane 2 CYP1B1, PTGS2
Single-pass type I membrane protein 1 ATRN
Secreted 7 GAA, IL10, IL13, IL18, IL4, LPO, VEGFA
extracellular region 9 CAT, GAA, IL10, IL13, IL18, IL4, LPO, TNF, VEGFA
mitochondrial outer membrane 1 HMOX1
[Isoform 2]: Secreted 1 ATRN
mitochondrial matrix 1 CAT
external side of plasma membrane 2 IL13, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
cytoplasmic vesicle 1 ELAVL1
sarcoplasm 1 ELAVL1
Cytoplasm, P-body 1 ELAVL1
P-body 1 ELAVL1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
focal adhesion 1 CAT
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 1 VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
chromatin 1 GABPA
phagocytic cup 1 TNF
[Isoform 3]: Secreted 1 ATRN
tertiary granule membrane 1 GAA
Cytoplasm, Stress granule 1 ELAVL1
cytoplasmic stress granule 1 ELAVL1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 PTGS2
platelet alpha granule lumen 1 VEGFA
azurophil granule membrane 1 GAA
Single-pass type IV membrane protein 1 HMOX1
ribonucleoprotein complex 1 ELAVL1
ficolin-1-rich granule membrane 1 GAA
basal dendrite 1 MAPK8
[Isoform 1]: Cell membrane 1 ATRN
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
autolysosome lumen 1 GAA
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Hyeonbin Kim, Mi Hee Kim, Ui-Lim Choi, Moonsoo Chung, Chul-Ho Yun, Youngkun Shim, Jaejun Oh, Sungbeom Lee, Gun Woong Lee. Molecular and Phenotypic Investigation on Antibacterial Activities of Limonene Isomers and Its Oxidation Derivative against Xanthomonas oryzae pv. Oryzae. Journal of microbiology and biotechnology. 2024 Jan; 34(3):1-10. doi: 10.4014/jmb.2311.11016. [PMID: 38247219]
  • Zhengyi Ling, Jingrui Li, Yanmei Dong, Wenying Zhang, Hongtong Bai, Shu Li, Su Wang, Hui Li, Lei Shi. Terpene produced by coexpression of the TPS and P450 genes from Lavandula angustifolia protects plants from herbivore attacks during budding stages. BMC plant biology. 2023 Oct; 23(1):477. doi: 10.1186/s12870-023-04490-7. [PMID: 37807036]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Asmaa Jan Muhammad, Liangliang Hao, Lina Tariq Al Kury, Najeeb Ur Rehman, Arooj Mohsin Alvi, Haroon Badshah, Ikram Ullah, Fawad Ali Shah, Shupeng Li. Carveol Promotes Nrf2 Contribution in Depressive Disorders through an Anti-inflammatory Mechanism. Oxidative medicine and cellular longevity. 2022; 2022(?):4509204. doi: 10.1155/2022/4509204. [PMID: 35295720]
  • Arooj Mohsin Alvi, Lina Tariq Al Kury, Abdullah Alattar, Ikram Ullah, Asmaa Jan Muhammad, Reem Alshaman, Fawad Ali Shah, Arif Ullah Khan, Jinxing Feng, Shupeng Li. Carveol Attenuates Seizure Severity and Neuroinflammation in Pentylenetetrazole-Kindled Epileptic Rats by Regulating the Nrf2 Signaling Pathway. Oxidative medicine and cellular longevity. 2021; 2021(?):9966663. doi: 10.1155/2021/9966663. [PMID: 34422216]
  • Renata Evaristo Rodrigues da Silva, Andressa de Alencar Silva, Luís Pereira-de-Morais, Nayane de Sousa Almeida, Marcello Iriti, Marta Regina Kerntopf, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Roseli Barbosa. Relaxant Effect of Monoterpene (-)-Carveol on Isolated Human Umbilical Cord Arteries and the Involvement of Ion Channels. Molecules (Basel, Switzerland). 2020 Jun; 25(11):. doi: 10.3390/molecules25112681. [PMID: 32527034]
  • Navneet Kaur, Khushminder Kaur Chahal, Amit Kumar, Ravinder Singh, Urvashi Bhardwaj. Antioxidant activity of Anethum graveolens L. essential oil constituents and their chemical analogues. Journal of food biochemistry. 2019 04; 43(4):e12782. doi: 10.1111/jfbc.12782. [PMID: 31353585]
  • Guo-Feng Mao, Xiao-Chang Mo, Hatem Fouad, Ghulam Abbas, Jian-Chu Mo. Attraction behaviour of Anagrus nilaparvatae to remote lemongrass (Cymbopogon distans) oil and its volatile compounds. Natural product research. 2018 Mar; 32(5):514-520. doi: 10.1080/14786419.2017.1326486. [PMID: 28503948]
  • Renilde Cordeiro de Souza, Mateus Matiuzzi da Costa, Bernardo Baldisserotto, Berta Maria Heinzmann, Denise Schmidt, Braulio Otomar Caron, Carlos Eduardo Copatti. Antimicrobial and synergistic activity of essential oils of Aloysia triphylla and Lippia alba against Aeromonas spp. Microbial pathogenesis. 2017 Dec; 113(?):29-33. doi: 10.1016/j.micpath.2017.10.013. [PMID: 29038058]
  • Lukas Schmidt, Thomas Göen. R-Limonene metabolism in humans and metabolite kinetics after oral administration. Archives of toxicology. 2017 Mar; 91(3):1175-1185. doi: 10.1007/s00204-016-1751-6. [PMID: 27325307]
  • Zheng Jiang, Hong Wang, Qi-nan Wu, Wei Yue, Da-wei Wu, Xiu-he Fan. [Qualitative and Quantitative Analysis of Major Constituents of Gland Products in Peltate Glandular Trichomes of Schizonepetae Spica]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2016 Jan; 39(1):31-6. doi: ". [PMID: 30079698]
  • Hana Moon, Min Jung Kim, Hee Jin Son, Hae-Jin Kweon, Jung Tae Kim, Yiseul Kim, Jaewon Shim, Byung-Chang Suh, Mee-Ra Rhyu. Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa. PloS one. 2015; 10(5):e0127060. doi: 10.1371/journal.pone.0127060. [PMID: 25978436]
  • M Govindarajan, R Sivakumar, M Rajeswari, K Yogalakshmi. Chemical composition and larvicidal activity of essential oil from Mentha spicata (Linn.) against three mosquito species. Parasitology research. 2012 May; 110(5):2023-32. doi: 10.1007/s00436-011-2731-7. [PMID: 22139403]
  • Tomoko Iizuka, Yasuhiro Nishikawa, Yoshihiro Mori, Natsuko Zenimura, Takuyuki Matsumoto, Katsutoshi Hiramatsu, Masahiro Komiya. Artist® tablets (carvedilol) for hypertensive patients in Japan: results of a long-term special survey. Drugs in R&D. 2011; 11(2):191-205. doi: 10.2165/11592460-000000000-00000. [PMID: 21679008]
  • Devin R Polichuk, Yansheng Zhang, Darwin W Reed, Janice F Schmidt, Patrick S Covello. A glandular trichome-specific monoterpene alcohol dehydrogenase from Artemisia annua. Phytochemistry. 2010 Aug; 71(11-12):1264-9. doi: 10.1016/j.phytochem.2010.04.026. [PMID: 20621795]
  • Ora A Carter, Reuben J Peters, Rodney Croteau. Monoterpene biosynthesis pathway construction in Escherichia coli. Phytochemistry. 2003 Sep; 64(2):425-33. doi: 10.1016/s0031-9422(03)00204-8. [PMID: 12943759]
  • Sarah A Holstein, Raymond J Hohl. Monoterpene regulation of Ras and Ras-related protein expression. Journal of lipid research. 2003 Jun; 44(6):1209-15. doi: 10.1194/jlr.m300057-jlr200. [PMID: 12671036]
  • Hossein Hosseinzadeh, Gholam Reza Karimi, Maryam Ameri. Effects of Anethum graveolens L. seed extracts on experimental gastric irritation models in mice. BMC pharmacology. 2002 Dec; 2(?):21. doi: 10.1186/1471-2210-2-21. [PMID: 12493079]
  • M Wüst, D B Little, M Schalk, R Croteau. Hydroxylation of limonene enantiomers and analogs by recombinant (-)-limonene 3- and 6-hydroxylases from mint (Mentha) species: evidence for catalysis within sterically constrained active sites. Archives of biochemistry and biophysics. 2001 Mar; 387(1):125-36. doi: 10.1006/abbi.2000.2248. [PMID: 11368174]
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