Pomiferin (BioDeep_00000017366)

Main id: BioDeep_00000270639

Secondary id: BioDeep_00000003784

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


4H,8H-BENZO(1,2-B:3,4-B)DIPYRAN-4-ONE, 3-(3,4-DIHYDROXYPHENYL)-5-HYDROXY-8,8-DIMETHYL-6-(3-METHYL-2-BUTEN-1-YL)-

化学式: C25H24O6 (420.1573)
中文名称: 橙桑黄酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C12OC(C)(C)C=CC=1C1OC=C(C3=CC=C(O)C(O)=C3)C(=O)C=1C(O)=C2C/C=C(/C)\C
InChI: InChI=1S/C25H24O6/c1-13(2)5-7-15-21(28)20-22(29)17(14-6-8-18(26)19(27)11-14)12-30-24(20)16-9-10-25(3,4)31-23(15)16/h5-6,8-12,26-28H,7H2,1-4H3

描述信息

Pomiferin is a member of isoflavanones.
Pomiferin is a natural product found in Derris montana, Maclura pomifera, and other organisms with data available.

同义名列表

28 个代谢物同义名

4H,8H-BENZO(1,2-B:3,4-B)DIPYRAN-4-ONE, 3-(3,4-DIHYDROXYPHENYL)-5-HYDROXY-8,8-DIMETHYL-6-(3-METHYL-2-BUTEN-1-YL)-; 4H,8H-Benzo(1,2-b:3,4-b)dipyran-4-one, 3-(3,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methyl-2-butenyl)-; 3-(3,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methylbut-2-enyl)-4H,8H- pyrano[2,3-h]chromen-4-one; 3-(3,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methyl-2-butenyl)-4H,8H-pyrano[2,3-f]chromen-4-one; 3-(3,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methylbut-2-enyl)-4H,8H-pyrano(2,3-h)chromen-4-one; 4H,2-b:3,4-b]dipyran-4-one, 3-(3,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methyl-2-buten-1-yl)-; 3-(3,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one; Spectrum5_000515; NCIStruc2_001049; Spectrum4_001808; NCIStruc1_001168; Spectrum3_000685; Spectrum2_000799; POMIFERIN [INCI]; 3-HYDROXYOSAJIN; UNII-74YIS40APM; DivK1c_000996; KBio2_000775; KBio1_000996; KBio2_003343; KBio2_005911; KBio3_001629; NCI60_004233; IDI1_000996; 74YIS40APM; Pomiferin; AI3-22130; Pomiferin



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

25 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ANXA5, CA1, CA2, CASP3, FOXO1, HTT, MSMP, MTOR, PFDN5, PRKAA2, PTGS2
Peripheral membrane protein 3 ANXA5, MTOR, PTGS2
Endosome membrane 2 ABCC5, HTT
Endoplasmic reticulum membrane 2 MTOR, PTGS2
Nucleus 8 CASP3, FOXO1, GABPA, HTT, JUND, MTOR, PFDN5, PRKAA2
autophagosome 1 HTT
cytosol 9 ANXA5, CA1, CA2, CASP3, FOXO1, HTT, MTOR, PFDN5, PRKAA2
dendrite 3 HTT, MTOR, PRKAA2
phagocytic vesicle 1 MTOR
nucleoplasm 7 CASP3, FOXO1, GABPA, HTT, JUND, MTOR, PRKAA2
RNA polymerase II transcription regulator complex 1 JUND
Cell membrane 3 CA2, HTT, TNF
Cytoplasmic side 1 MTOR
Cytoplasmic granule 1 ABCC5
Multi-pass membrane protein 2 ABCC5, HTT
Golgi apparatus membrane 1 MTOR
Synapse 1 HTT
cell surface 1 TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 2 HTT, PRKAA2
Golgi membrane 2 INS, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 3 CASP3, PRKAA2, TNF
presynaptic membrane 1 HTT
sarcolemma 1 ANXA5
Lysosome 1 MTOR
plasma membrane 4 ABCC5, CA2, HTT, TNF
Membrane 4 ABCC5, ANXA5, MTOR, PRKAA2
apical plasma membrane 1 ABCC5
axon 3 CCK, HTT, PRKAA2
basolateral plasma membrane 1 ABCC5
caveola 1 PTGS2
extracellular exosome 3 ANXA5, CA1, CA2
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 HTT, PTGS2
extracellular space 4 CCK, INS, MSMP, TNF
perinuclear region of cytoplasm 1 HTT
mitochondrion 1 FOXO1
protein-containing complex 2 HTT, PTGS2
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 4 CCK, INS, MSMP, PRB1
extracellular region 7 ANXA5, CCK, DNAH9, ELN, INS, PRB1, TNF
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
transcription regulator complex 1 JUND
motile cilium 1 DNAH9
external side of plasma membrane 2 ANXA5, TNF
Secreted, extracellular space, extracellular matrix 1 ELN
Early endosome 1 HTT
apical part of cell 1 CA2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 HTT
Apical cell membrane 1 ABCC5
Membrane raft 2 HTT, TNF
Cell junction, focal adhesion 1 HTT
focal adhesion 2 ANXA5, HTT
microtubule 1 DNAH9
extracellular matrix 1 ELN
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 2 ANXA5, ELN
axoneme 1 DNAH9
nuclear speck 1 PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 HTT
Cell projection, neuron projection 1 HTT
Zymogen granule membrane 1 ANXA5
neuron projection 2 HTT, PTGS2
chromatin 3 FOXO1, GABPA, JUND
phagocytic cup 1 TNF
centriole 1 HTT
Cytoplasm, cytoskeleton, cilium axoneme 1 DNAH9
Basolateral cell membrane 1 ABCC5
nuclear envelope 1 MTOR
Endomembrane system 2 HTT, MTOR
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 HTT
cytoplasmic stress granule 1 PRKAA2
myelin sheath 1 CA2
intermediate filament cytoskeleton 1 PFDN5
secretory granule lumen 1 INS
Golgi apparatus lumen 1 ABCC5
Golgi lumen 2 ABCC5, INS
endoplasmic reticulum lumen 2 INS, PTGS2
transcription repressor complex 1 JUND
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
9+2 motile cilium 1 DNAH9
dynein complex 1 DNAH9
vesicle membrane 1 ANXA5
prefoldin complex 1 PFDN5
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
postsynaptic cytosol 1 HTT
Cytoplasmic vesicle, phagosome 1 MTOR
presynaptic cytosol 1 HTT
elastic fiber 1 ELN
transcription factor AP-1 complex 1 JUND
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
inclusion body 1 HTT
endothelial microparticle 1 ANXA5
serotonergic synapse 1 HTT
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT
outer dynein arm 1 DNAH9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
distal portion of axoneme 1 DNAH9


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Esra Dilek, Hüseyin Serkan Erol, Ahmet Cakir, Murat Koc, Mesut Bünyami Halici. Natural product inhibitors of carbonic anhydrase I and II isoenzymes: osajin and pomiferin. Archives of physiology and biochemistry. 2017 Oct; 123(4):219-224. doi: 10.1080/13813455.2017.1303742. [PMID: 28338341]
  • Giovanni Ribaudo, Mario Angelo Pagano, Valeria Pavan, Marco Redaelli, Maira Zorzan, Raffaele Pezzani, Carla Mucignat-Caretta, Tiziano Vendrame, Sergio Bova, Giuseppe Zagotto. Semi-synthetic derivatives of natural isoflavones from Maclura pomifera as a novel class of PDE-5A inhibitors. Fitoterapia. 2015 Sep; 105(?):132-8. doi: 10.1016/j.fitote.2015.06.020. [PMID: 26136059]
  • Hyung-In Moon. Effect of osajin and pomiferin on antidiabetic effects from normal and streptozotocin-induced diabetic rats. Natural product communications. 2014 Dec; 9(12):1723-4. doi: . [PMID: 25632468]
  • Tsung-Teng Huang, Fu-Guo Liu, Chia-Fong Wei, Chia-Chen Lu, Chang-Chieh Chen, Hung-Chi Lin, David M Ojcius, Hsin-Chih Lai. Activation of multiple apoptotic pathways in human nasopharyngeal carcinoma cells by the prenylated isoflavone, osajin. PloS one. 2011 Apr; 6(4):e18308. doi: 10.1371/journal.pone.0018308. [PMID: 21532751]
  • Lenka Bartošíková, Jiří Nečas, Tomáš Bartošík, Martin Pavlík, Petr Fráňa. Effect of pomiferin administration on kidney ischaemia-reperfusion injury in rats. Interdisciplinary toxicology. 2010 Jun; 3(2):76-81. doi: 10.2478/v10102-010-0015-1. [PMID: 21217877]
  • James V Gruber, Robert Holtz. Examining the genomic influence of skin antioxidants in vitro. Mediators of inflammation. 2010; 2010(?):. doi: 10.1155/2010/230450. [PMID: 20706672]
  • I Orhan, F S Senol, M Kartal, M Dvorská, M Zemlicka, K Smejkal, P Mokrý. Cholinesterase inhibitory effects of the extracts and compounds of Maclura pomifera (Rafin.) Schneider. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2009 Aug; 47(8):1747-51. doi: 10.1016/j.fct.2009.04.023. [PMID: 19394400]
  • Vaclav Diopan, Petr Babula, Violetta Shestivska, Vojtech Adam, Milan Zemlicka, Margita Dvorska, Jaromir Hubalek, Libuse Trnkova, Ladislav Havel, Rene Kizek. Electrochemical and spectrometric study of antioxidant activity of pomiferin, isopomiferin, osajin and catalposide. Journal of pharmaceutical and biomedical analysis. 2008 Sep; 48(1):127-33. doi: 10.1016/j.jpba.2008.05.025. [PMID: 18597965]
  • Il Hong Son, Ill-Min Chung, Sung Ik Lee, Hyun Duk Yang, Hyung-In Moon. Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera. Bioorganic & medicinal chemistry letters. 2007 Sep; 17(17):4753-5. doi: 10.1016/j.bmcl.2007.06.060. [PMID: 17662606]
  • L Bartosíková, J Necas, T Bartosík, M Pavlík, J Fránová, G Kuzmina, J Luza. [Examination of the antioxidative and antidiabetic effect of pomiferin in alloxan-induced diabetes mellitus in an experiment (a pilot study)]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti. 2007 Jun; 56(3):135-40. doi: . [PMID: 17867526]
  • J Necas, L Bartosíková, T Florian, J Klusáková, V Suchý, E M B Naggar, E Janostíková, T Bartosík, M Lisková. [Protective effects of the flavonoids osajin and pomiferin on heart ischemia-reperfusion]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti. 2006 Jul; 55(4):168-74. doi: . [PMID: 16921735]
  • Tomas Florian, Jiri Necas, Lenka Bartosikova, Jarmila Klusakova, Vaclav Suchy, Elmoataz B El Naggara, Eva Janostikova, Tomas Bartosik. Effects of prenylated isoflavones osajin and pomiferin in premedication on heart ischemia-reperfusion. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 2006 Jul; 150(1):93-100. doi: 10.5507/bp.2006.013. [PMID: 16936909]
  • Dagmar Veselá, Renáta Kubínová, Jan Muselík, Milan Zemlicka, Václav Suchý. Antioxidative and EROD activities of osajin and pomiferin. Fitoterapia. 2004 Mar; 75(2):209-11. doi: 10.1016/j.fitote.2003.12.005. [PMID: 15030927]
  • Rong Tsao, Raymond Yang, J Christopher Young. Antioxidant isoflavones in Osage orange, Maclura pomifera (Raf.) Schneid. Journal of agricultural and food chemistry. 2003 Oct; 51(22):6445-51. doi: 10.1021/jf0342369. [PMID: 14558760]