Apocynin (BioDeep_00000017335)

 

Secondary id: BioDeep_00000002580, BioDeep_00000858358

human metabolite PANOMIX_OTCML-2023 Chemicals and Drugs natural product


代谢物信息卡片


InChI=1/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H

化学式: C9H10O3 (166.063)
中文名称: 夹竹桃麻素, 罗布麻宁, 乙酰酮, 4-羟基-3-甲氧基苯乙酮, 加拿大麻素, 香草乙酮
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 100%

分子结构信息

SMILES: CC(=O)C1=CC(=C(C=C1)O)OC
InChI: InChI=1S/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H3

描述信息

Apocynin is an aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3. It has a role as a non-narcotic analgesic, a non-steroidal anti-inflammatory drug, an antirheumatic drug, a peripheral nervous system drug, an EC 1.6.3.1. [NAD(P)H oxidase (H2O2-forming)] inhibitor and a plant metabolite. It is a member of acetophenones, a methyl ketone and an aromatic ketone.
Acetovanillone has been used in trials studying the treatment of Bronchial Asthma and Chronic Obstructive Pulmonary Disease.
Acetovanillone is a natural product found in Iris tectorum, Apocynum cannabinum, and other organisms with data available.
Acetovanillone is a metabolite found in or produced by Saccharomyces cerevisiae.
An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D020011 - Protective Agents > D000975 - Antioxidants
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
D004791 - Enzyme Inhibitors
Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[1][2]. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model[3]. Apocynin can also be used for cancer research[4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass[5].
Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[1][2]. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model[3]. Apocynin can also be used for cancer research[4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass[5].
Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[1][2]. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model[3]. Apocynin can also be used for cancer research[4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass[5].

同义名列表

45 个代谢物同义名

InChI=1/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H; ACETOPHENONE,4-HYDROXY,3-METHOXY ACETOVANILLON; 4-08-00-01814 (Beilstein Handbook Reference); 1-(4-hydroxy-3-methoxyphenyl)ethan-1-one; 1-(4-Hydroxy-3-methoxyphenyl)-1-ethanone; Ethanone, 1-(4-hydroxy-3-methoxyphenyl)-; 4-Hydroxy-3-methoxyphenyl methyl ketone; 3-Metoksy-4-hydroksyacetofenon [Polish]; 1-(4-hydroxy-3-methoxy-phenyl)-ethanone; 4-Hydroxy-3-methoxyphenyl methyl keton; 1-(4-hydroxy-3-methoxyphenyl)-ethanone; 1-(4-hydroxy-3-methoxy-phenyl)ethanone; 4-Hydroxy-3-methoxyacetophenone, 98\\%; 1-(4-Hydroxy-3-methoxyphenyl)ethanone; 3-Methyl Methcathinone Hydrochloride; Acetovanillone, analytical standard; Acetophenone, 4-hydroxy-3-methoxy-; 4-hydroxy -3-methoxyacetophenone; 3-Methoxy-4-hydroxyacetophenone; 4-hydroxy-3-methoxyacetophenone; 4-hydroxy3-methoxyacetophenone; 4hydroxy-3-methoxyacetophenone; 3-Metoksy-4-hydroksyacetofenon; Acetovanillone, >=98\\%, FG; Phenol, 4-acetyl-2-methoxy; apocynin (acetovanillone); 2-methoxy-4-acetylphenol; 4-Acetyl-2-methoxyphenol; 4-Acetylguaiacol; WLN: 1VR DQ CO1; UNII-B6J7B9UDTR; Acetovanillone; Acetoguaiacone; APOCYNIN [MI]; Acetovanillon; Acetovanyllon; Acetovanilone; Acetoguaiacon; B6J7B9UDTR; apocynine; AI3-15892; apocynin; I75; Acetovanillone; Apocynin



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

202 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AKT1, ALB, MAPK14, MAPK8, NCF1, NLRP3, NOS1, NOS3, NOX4, PTGS2, RAC1, XDH
Peripheral membrane protein 3 NCF1, NOS1, PTGS2
Endoplasmic reticulum membrane 5 CYBA, HMOX1, NOX4, PTGS2, RAC1
Nucleus 10 AKT1, ALB, HMOX1, MAPK14, MAPK8, NLRP3, NOS1, NOS3, NOX4, RAC1
cytosol 12 AKT1, ALB, HMOX1, MAPK14, MAPK8, NCF1, NCF2, NLRP3, NOS1, NOS3, RAC1, XDH
dendrite 2 NCF1, RAC1
trans-Golgi network 1 RAC1
centrosome 1 ALB
nucleoplasm 6 AKT1, HMOX1, MAPK14, MAPK8, NOS1, NOS3
Cell membrane 5 AKT1, CYBA, NOX1, NOX4, RAC1
Lipid-anchor 1 RAC1
Cytoplasmic side 3 HMOX1, NCF1, RAC1
lamellipodium 2 AKT1, RAC1
ruffle membrane 1 RAC1
Multi-pass membrane protein 3 DUOX1, NOX1, NOX4
Golgi apparatus membrane 1 NLRP3
Synapse 3 MAPK8, NOS1, RAC1
cell cortex 2 AKT1, RAC1
cell surface 1 DUOX1
glutamatergic synapse 3 AKT1, MAPK14, RAC1
Golgi apparatus 2 ALB, NOS3
Golgi membrane 2 NLRP3, NOS3
neuronal cell body 1 NCF1
postsynapse 2 AKT1, RAC1
sarcolemma 1 NOS1
Cytoplasm, cytosol 2 NCF1, NLRP3
acrosomal vesicle 1 NCF2
endosome 1 CYBA
plasma membrane 11 AKT1, CYBA, DUOX1, NCF1, NCF2, NOS1, NOS3, NOX1, NOX4, RAC1, REN
Membrane 11 AKT1, CYBA, DUOX1, HMOX1, NCF1, NCF2, NLRP3, NOX1, NOX4, RAC1, REN
apical plasma membrane 1 DUOX1
axon 1 MAPK8
caveola 2 NOS3, PTGS2
extracellular exosome 2 ALB, RAC1
endoplasmic reticulum 6 ALB, DUOX1, HMOX1, NLRP3, NOX4, PTGS2
extracellular space 5 ALB, CCL2, HMOX1, REN, XDH
perinuclear region of cytoplasm 4 HMOX1, NOS1, NOS3, NOX4
mitochondrion 4 MAPK14, NLRP3, NOS1, NOX4
protein-containing complex 4 AKT1, ALB, NOS1, PTGS2
Microsome membrane 1 PTGS2
postsynaptic density 1 NOS1
Secreted 5 ALB, CCL2, NLRP3, RAC1, REN
extracellular region 6 ALB, CCL2, MAPK14, NLRP3, RAC1, REN
cytoplasmic side of plasma membrane 1 NCF1
mitochondrial outer membrane 1 HMOX1
anchoring junction 2 ALB, NOX1
photoreceptor inner segment 1 NOS1
dendritic spine 2 NOS1, RAC1
cytoplasmic vesicle 1 RAC1
microtubule cytoskeleton 1 AKT1
nucleolus 1 NOX4
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
Early endosome 1 NOX1
apical part of cell 1 REN
cell-cell junction 1 AKT1
vesicle 1 AKT1
Apical cell membrane 1 DUOX1
Cell membrane, sarcolemma 1 NOS1
Cell projection, lamellipodium 1 RAC1
Cytoplasm, perinuclear region 2 NOS1, NOX4
Membrane raft 1 NOS1
Cell junction, focal adhesion 1 NOX4
focal adhesion 2 NOX4, RAC1
spindle 1 AKT1
Peroxisome 1 XDH
sarcoplasmic reticulum 2 NOS1, XDH
Cell projection, dendritic spine 1 NOS1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 CYBA
nuclear speck 1 MAPK14
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 2 AKT1, ALB
cell leading edge 1 DUOX1
cell projection 1 NOX1
phagocytic vesicle membrane 1 CYBA
cell periphery 1 NOS1
cytoskeleton 3 NOS1, NOS3, RAC1
centriole 1 ALB
cytoplasmic ribonucleoprotein granule 1 RAC1
[Isoform 5]: Cytoplasm 1 NOX4
Nucleus, nucleolus 1 NOX4
spindle pole 2 ALB, MAPK14
blood microparticle 1 ALB
Recycling endosome membrane 1 RAC1
Endomembrane system 1 NLRP3
microtubule organizing center 1 NLRP3
Cell projection, dendrite 1 RAC1
specific granule membrane 1 CYBA
tertiary granule membrane 1 CYBA
Melanosome 1 RAC1
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
[Isoform 3]: Cytoplasm 1 NOX4
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
secretory granule membrane 1 RAC1
endoplasmic reticulum lumen 2 ALB, PTGS2
platelet alpha granule lumen 1 ALB
endocytic vesicle membrane 1 NOS3
Single-pass type IV membrane protein 1 HMOX1
perinuclear endoplasmic reticulum 1 NOX4
ficolin-1-rich granule membrane 1 RAC1
basal dendrite 1 MAPK8
[Isoform 4]: Nucleus 1 NOX4
NADPH oxidase complex 7 CYBA, DUOX1, NCF1, NCF2, NOX1, NOX4, RAC1
Cell projection, invadopodium membrane 1 NOX1
[Isoform 6]: Cytoplasm 1 NOX4
phagolysosome 2 NCF1, NCF2
ciliary transition fiber 1 ALB


文献列表

  • Xuan Li, Wenyu Wu, Huan He, Lin Guan, Guancheng Chen, Zhijun Lin, Huan Li, Jialin Jiang, Xin Dong, Zhuoji Guan, Pinliang Chen, Zigang Pan, Weiwei Huang, Runjia Yu, Wenxin Song, Lu Lu, Zhongqi Yang, Zixin Chen, Lingjun Wang, Shaoxiang Xian, Jie Chen. Analysis and validation of hub genes in neutrophil extracellular traps for the long-term prognosis of myocardial infarction. Gene. 2024 Jul; 914(?):148369. doi: 10.1016/j.gene.2024.148369. [PMID: 38485036]
  • Cunxiang Bo, Fang Liu, Zewen Zhang, Zhongjun Du, Haidi Xiu, Zhenling Zhang, Ming Li, Caiqing Zhang, Qiang Jia. Simvastatin attenuates silica-induced pulmonary inflammation and fibrosis in rats via the AMPK-NOX pathway. BMC pulmonary medicine. 2024 May; 24(1):224. doi: 10.1186/s12890-024-03014-9. [PMID: 38720270]
  • Xinglong Zhang, Ran Pang, Kai Zhang, Qian Xu, Chunlei Xu, Wei Shi, Xinyu Liang, Dong Li, Wenhao Cui, Shucai Bai, Zhijun Li, Hui Li, Huafeng Zhang. Apocynin exerts cytoprotective effects on dexamethasone-induced osteoblasts by inhibiting oxidative stress through the Nrf2 signalling pathway. Journal of cellular and molecular medicine. 2023 Sep; ?(?):. doi: 10.1111/jcmm.17974. [PMID: 37749949]
  • Reham Mokhtar Aman, Randa Ahmed Zaghloul, Wael M Elsaed, Irhan Ibrahim Abu Hashim. In vitro-in vivo assessments of apocynin-hybrid nanoparticle-based gel as an effective nanophytomedicine for treatment of rheumatoid arthritis. Drug delivery and translational research. 2023 Jun; ?(?):. doi: 10.1007/s13346-023-01360-5. [PMID: 37284937]
  • Yongzhen Du, Tong Xu, Dongliu Luo, Yixuan Wang, Hang Yin, Chengguo Liu, Shu Li. Perfluorooctane sulfonate-induced apoptosis in kidney cells by triggering the NOX4/ROS/JNK axis and antagonism of cannabidiol. Environmental toxicology. 2023 Mar; ?(?):. doi: 10.1002/tox.23794. [PMID: 36988283]
  • Gara N Dexter, Laura E Navas, Jason C Grigg, Harbir Bajwa, David J Levy-Booth, Jie Liu, Nathan A Louie, Seyed A Nasseri, Soo-Kyeong Jang, Scott Renneckar, Lindsay D Eltis, William W Mohn. Bacterial catabolism of acetovanillone, a lignin-derived compound. Proceedings of the National Academy of Sciences of the United States of America. 2022 10; 119(43):e2213450119. doi: 10.1073/pnas.2213450119. [PMID: 36256818]
  • Joanna Depciuch, Paweł Jakubczyk, Wiesław Paja, Jaromir Sarzyński, Krzysztof Pancerz, Merve Açıkel Elmas, Elif Keskinöz, Özlem Bingöl Özakpınar, Serap Arbak, Gökçe Özgün, Sevde Altuntaş, Zozan Guleken. Apocynin reduces cytotoxic effects of monosodium glutamate in the brain: A spectroscopic, oxidative load, and machine learning study. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Oct; 279(?):121495. doi: 10.1016/j.saa.2022.121495. [PMID: 35700610]
  • Adriel Ekozin, Chiagoziem A Otuechere, Adewale Adewuyi. Apocynin loaded silver nanoparticles displays potent in vitro biological activities and mitigates pyrogallol-induced hepatotoxicity. Chemico-biological interactions. 2022 Sep; 365(?):110069. doi: 10.1016/j.cbi.2022.110069. [PMID: 35944648]
  • Bin Li, Yuchun Shi, Yanbin Fu. Apocynin inhibits compressive force-induced apoptosis and autophagy of periodontal ligament stem cells. Oral diseases. 2022 Jun; ?(?):. doi: 10.1111/odi.14296. [PMID: 35770313]
  • Abhishek Kumar, Subrata Kumar Ghosh, Rahul Katiyar, Amare Eshetu Gemeda, Rupali Rautela, Amarjeet Bisla, Neeraj Srivastava, Sanjeev Kumar Bhure, Huidrom Lakshmi Devi, Vikash Chandra. Supplementation of Mito TEMPO and acetovanillone in semen extender improves freezability of buffalo spermatozoa. Andrology. 2022 05; 10(4):775-788. doi: 10.1111/andr.13158. [PMID: 35060362]
  • Venkata Prasuja Nakka, Raghu Gogada, Praveen Kumar Simhadri, Mohammed Abdul Qadeer, Prakash Babu Phanithi. Post-treatment with apocynin at a lower dose regulates the UPR branch of eIF2α and XBP-1 pathways after stroke. Brain research bulletin. 2022 05; 182(?):1-11. doi: 10.1016/j.brainresbull.2022.02.003. [PMID: 35143926]
  • Rüya Kuru Yaşar, Dilruba Kuru, Ali Şen, Göksel Şener, Feriha Ercan, Ayşen Yarat. Effects of Myrtus communis L. Extract and Apocynin on Lens Oxidative Damage and Boron Levels in Rats with a High Fat-Diet. Turkish journal of ophthalmology. 2021 Dec; 51(6):344-350. doi: 10.4274/tjo.galenos.2021.27981. [PMID: 34963261]
  • Cuneyt Tayman, Ufuk Çakır, Hasan Akduman, Şefika Karabulut, Murat Çağlayan. The therapeutic effect of Apocynin against hyperoxy and Inflammation-Induced lung injury. International immunopharmacology. 2021 Dec; 101(Pt A):108190. doi: 10.1016/j.intimp.2021.108190. [PMID: 34607228]
  • Shreya R Savla, Ankit P Laddha, Yogesh A Kulkarni. Pharmacology of apocynin: a natural acetophenone. Drug metabolism reviews. 2021 11; 53(4):542-562. doi: 10.1080/03602532.2021.1895203. [PMID: 33689526]
  • Omnia A M Abd El-Ghafar, Emad H M Hassanein, Ahmed M Sayed, Eman K Rashwan, Abdel-Gawad S Shalkami, Ayman M Mahmoud. Acetovanillone prevents cyclophosphamide-induced acute lung injury by modulating PI3K/Akt/mTOR and Nrf2 signaling in rats. Phytotherapy research : PTR. 2021 Aug; 35(8):4499-4510. doi: 10.1002/ptr.7153. [PMID: 33969557]
  • Di Liu, Wan-Pin Sun, Jing-Wei Chen, Yan Jiang, Rong Xue, Lin-Hui Wang, Koji Murao, Guo-Xing Zhang. Autophagy contributes to angiotensin II induced dysfunction of HUVECs. Clinical and experimental hypertension (New York, N.Y. : 1993). 2021 Jul; 43(5):462-473. doi: 10.1080/10641963.2021.1901110. [PMID: 33775188]
  • Ajmal Ahmad, Mohd Imtiaz Nawaz, Mohammad Mairaj Siddiquei, Ahmed M Abu El-Asrar. Apocynin ameliorates NADPH oxidase 4 (NOX4) induced oxidative damage in the hypoxic human retinal Müller cells and diabetic rat retina. Molecular and cellular biochemistry. 2021 May; 476(5):2099-2109. doi: 10.1007/s11010-021-04071-y. [PMID: 33515385]
  • T Y Chia, V Murugaiyah, N Ak Khan, M A Sattar, M H Abdulla, E J Johns, A Ahmad, Z Hassan, G Kaur, H Y Mei, F U Ahmad, S Akhtar. Inhibition of L-NAME-induced hypertension by combined treatment with apocynin and catalase: the role of Nox 4 expression. Physiological research. 2021 03; 70(1):13-26. doi: 10.33549/physiolres.934497. [PMID: 33728924]
  • Shugo Suzuki, Samuel M Cohen, Lora L Arnold, Karen L Pennington, Min Gi, Hiroyuki Kato, Taku Naiki, Aya Naiki-Ito, Hideki Wanibuchi, Satoru Takahashi. Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin. Toxicology letters. 2021 Jan; 336(?):32-38. doi: 10.1016/j.toxlet.2020.11.005. [PMID: 33176187]
  • Sai Bharadwaja, Praveen Kumar Issac, Jocelyn Cleta, Rakesh Jeganathan, Sri Snehaa Chandrakumar, Sujatha Sundaresan. An in vitro mechanistic approach towards understanding the distinct pathways regulating insulin resistance and adipogenesis by apocynin. Journal of biosciences. 2021; 46(?):. doi: . [PMID: 33709960]
  • T Y Chia, V Murugaiyah, M A Sattar, N A K Khan, A Ahmad, M H Abdulla, E J Johns, H Y Mei, S Akhtar, F U Ahmad. The restorative effect of apocynin and catalase in l-arginine induced hypotension on normotensive subjects - the role of oxidative stress. Physiological research. 2020 12; 69(6):1051-1066. doi: 10.33549/physiolres.934426. [PMID: 33210935]
  • Fen Zheng, Chao Ye, Guo-Wei Wan, Bing Zhou, Ying Tong, Jian-Zhen Lei, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. Interleukin-1β in hypothalamic paraventricular nucleus mediates excitatory renal reflex. Pflugers Archiv : European journal of physiology. 2020 11; 472(11):1577-1586. doi: 10.1007/s00424-020-02461-7. [PMID: 32915316]
  • Han Sha, Yanchao Ma, Yuli Tong, Jie Zhao, Fengzhi Qin. Apocynin inhibits placental TLR4/NF-κB signaling pathway and ameliorates preeclampsia-like symptoms in rats. Pregnancy hypertension. 2020 Oct; 22(?):210-215. doi: 10.1016/j.preghy.2020.10.006. [PMID: 33099123]
  • Kübra Kavram Sarihan, Melda Yardimoğlu Yilmaz, Fatma Ceyla Eraldemir, Yusufhan Yazir, Esra Acar. Protective effects of apocynin on damaged testes of rats exposed to methotrexate. Turkish journal of medical sciences. 2020 08; 50(5):1409-1420. doi: 10.3906/sag-1909-52. [PMID: 32394677]
  • Fangfei Liu, Lampson M Fan, Nicholas Michael, Jian-Mei Li. In vivo and in silico characterization of apocynin in reducing organ oxidative stress: A pharmacokinetic and pharmacodynamic study. Pharmacology research & perspectives. 2020 08; 8(4):e00635. doi: 10.1002/prp2.635. [PMID: 32761799]
  • Alejandra Z Vielma, Mauricio P Boric, Daniel R Gonzalez. Apocynin Treatment Prevents Cardiac Connexin 43 Hemichannels Hyperactivity by Reducing Nitroso-Redox Stress in Mdx Mice. International journal of molecular sciences. 2020 Jul; 21(15):. doi: 10.3390/ijms21155415. [PMID: 32751416]
  • Iñaki Robles-Vera, Néstor De La Visitación, Marta Toral, Manuel Sánchez, Manuel Gómez-Guzmán, Francisco O'valle, Rosario Jiménez, Juan Duarte, Miguel Romero. Toll-like receptor 7-driven lupus autoimmunity induces hypertension and vascular alterations in mice. Journal of hypertension. 2020 07; 38(7):1322-1335. doi: 10.1097/hjh.0000000000002368. [PMID: 32004206]
  • Sizhe Wan, Fangyun Luo, Chenkai Huang, Cong Liu, Qingtian Luo, Xuan Zhu. Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways. Aging. 2020 06; 12(11):10614-10632. doi: 10.18632/aging.103282. [PMID: 32496208]
  • Xiaojia Yang, Kailiang Zhao, Wenhong Deng, Liang Zhao, Hongzhong Jin, Fangchao Mei, Yu Zhou, Man Li, Weixing Wang. Apocynin Attenuates Acute Kidney Injury and Inflammation in Rats with Acute Hypertriglyceridemic Pancreatitis. Digestive diseases and sciences. 2020 06; 65(6):1735-1747. doi: 10.1007/s10620-019-05892-0. [PMID: 31617131]
  • Xianwen Peng, Yongqiang Yang, Li Tang, Jingyuan Wan, Jie Dai, Longjiang Li, Jiayi Huang, Yi Shen, Ling Lin, Xianqiong Gong, Li Zhang. Therapeutic benefits of apocynin in mice with lipopolysaccharide/D-galactosamine-induced acute liver injury via suppression of the late stage pro-apoptotic AMPK/JNK pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 May; 125(?):110020. doi: 10.1016/j.biopha.2020.110020. [PMID: 32106375]
  • Yun Qiu, Fen Zheng, Chao Ye, Ai-Dong Chen, Jue-Jin Wang, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. Angiotensin Type 1 Receptors and Superoxide Anion Production in Hypothalamic Paraventricular Nucleus Contribute to Capsaicin-Induced Excitatory Renal Reflex and Sympathetic Activation. Neuroscience bulletin. 2020 May; 36(5):463-474. doi: 10.1007/s12264-019-00460-y. [PMID: 31989424]
  • Poonam Rana, Kakulavarapu V Rama Rao, Arunreddy Ravula, Richa Trivedi, Maria D'Souza, Ajay K Singh, Raj K Gupta, Namas Chandra. Oxidative stress contributes to cerebral metabolomic profile changes in animal model of blast-induced traumatic brain injury. Metabolomics : Official journal of the Metabolomic Society. 2020 03; 16(3):39. doi: 10.1007/s11306-020-1649-4. [PMID: 32166461]
  • Viktoria Rungelrath, Sophie Öhlmann, Gottfried Alber, Wieland Schrödl, Maren von Köckritz-Blickwede, Nicole de Buhr, Alexander Martens, Christoph Georg Baums, Nicole Schütze. Survival of Streptococcus suis in Porcine Blood Is Limited by the Antibody- and Complement-Dependent Oxidative Burst Response of Granulocytes. Infection and immunity. 2020 02; 88(3):. doi: 10.1128/iai.00598-19. [PMID: 31843967]
  • Teng Liu, Wei Zheng, Linlin Wang, Lin Wang, Yanke Zhang. TLR4/NF-κB Signaling Pathway Participates in the Protective Effects of Apocynin on Gestational Diabetes Mellitus Induced Placental Oxidative Stress and Inflammation. Reproductive sciences (Thousand Oaks, Calif.). 2020 02; 27(2):722-730. doi: 10.1007/s43032-019-00078-5. [PMID: 32046403]
  • Qin Yang, Hai-Yong Chen, Jia-Nan Wang, Huai-Qin Han, Ling Jiang, Wei-Feng Wu, Biao Wei, Li Gao, Qiu-Ying Ma, Xue-Qi Liu, Qi Chen, Jia-Gen Wen, Juan Jin, Yan Huang, Wei-Jian Ni, Tao-Tao Ma, Jun Li, Xiao-Ming Meng. Alcohol promotes renal fibrosis by activating Nox2/4-mediated DNA methylation of Smad7. Clinical science (London, England : 1979). 2020 01; 134(2):103-122. doi: 10.1042/cs20191047. [PMID: 31898747]
  • Sanjin Kovacevic, Milan Ivanov, Zoran Miloradovic, Predrag Brkic, Una Jovana Vajic, Maja Zivotic, Nevena Mihailovic-Stanojevic, Djurdjica Jovovic, Danijela Karanovic, Rada Jeremic, Jelena Nesovic-Ostojic. Hyperbaric oxygen preconditioning and the role of NADPH oxidase inhibition in postischemic acute kidney injury induced in spontaneously hypertensive rats. PloS one. 2020; 15(1):e0226974. doi: 10.1371/journal.pone.0226974. [PMID: 31914135]
  • Nianxin Yang, Agustin Gonzalez-Vicente, Jeffrey L Garvin. Angiotensin II-induced superoxide and decreased glutathione in proximal tubules: effect of dietary fructose. American journal of physiology. Renal physiology. 2020 01; 318(1):F183-F192. doi: 10.1152/ajprenal.00462.2019. [PMID: 31760771]
  • Yong Chia Tan, Munavvar Abdul Sattar, Ahmad F Ahmeda, Nurzalina Abdul Karim Khan, Vikneswaran Murugaiyah, Ashfaq Ahmad, Zurina Hassan, Gurjeet Kaur, Mohammed Hadi Abdulla, Edward James Johns. Apocynin and catalase prevent hypertension and kidney injury in Cyclosporine A-induced nephrotoxicity in rats. PloS one. 2020; 15(4):e0231472. doi: 10.1371/journal.pone.0231472. [PMID: 32298299]
  • Emad H M Hassanein, Omnia A M Abd El-Ghafar, Marwa A Ahmed, Ahmed M Sayed, Wail M Gad-Elrab, Jamaan S Ajarem, Ahmed A Allam, Ayman M Mahmoud. Edaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats. Drug design, development and therapy. 2020; 14(?):5275-5288. doi: 10.2147/dddt.s281854. [PMID: 33299300]
  • Joanna Wieczfinska, Przemyslaw Sitarek, Ewa Skała, Tomasz Kowalczyk, Rafal Pawliczak. Inhibition of NADPH Oxidase-Derived Reactive Oxygen Species Decreases Expression of Inflammatory Cytokines in A549 Cells. Inflammation. 2019 Dec; 42(6):2205-2214. doi: 10.1007/s10753-019-01084-0. [PMID: 31612365]
  • A Walkowska, I Vaneckova, J Sadowski, E Kompanowska-Jezierska. Rapid blood pressure increase after renal denervation in anaesthetized rats: interaction of oxidative stress and neuronal nitric oxide synthase. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2019 Aug; 70(4):. doi: 10.26402/jpp.2019.4.12. [PMID: 31741458]
  • Matthew Kuriakose, Daniel Younger, Arun Reddy Ravula, Eren Alay, Kakulavarapu V Rama Rao, Namas Chandra. Synergistic Role of Oxidative Stress and Blood-Brain Barrier Permeability as Injury Mechanisms in the Acute Pathophysiology of Blast-induced Neurotrauma. Scientific reports. 2019 05; 9(1):7717. doi: 10.1038/s41598-019-44147-w. [PMID: 31118451]
  • A Yücel, M S Aydogan, M Ucar, K B Sarıcı, M G Karaaslan. Effects of Apocynin on Liver Ischemia-Reperfusion Injury in Rats. Transplantation proceedings. 2019 May; 51(4):1180-1183. doi: 10.1016/j.transproceed.2019.01.108. [PMID: 31101195]
  • Liyan Hou, Ruixue Huang, Fuqiang Sun, Lin Zhang, Qingshan Wang. NADPH oxidase regulates paraquat and maneb-induced dopaminergic neurodegeneration through ferroptosis. Toxicology. 2019 04; 417(?):64-73. doi: 10.1016/j.tox.2019.02.011. [PMID: 30797899]
  • Murilo E Graton, Simone R Potje, Jéssica A Troiano, Gabriel T Vale, Ligia A Perassa, Ana Cláudia M S Nakamune, Carlos R Tirapelli, Lusiane M Bendhack, Cristina Antoniali. Apocynin alters redox signaling in conductance and resistance vessels of spontaneously hypertensive rats. Free radical biology & medicine. 2019 04; 134(?):53-63. doi: 10.1016/j.freeradbiomed.2018.12.026. [PMID: 30586635]
  • Quan Liu, Yunlong Liu, Xiaofeng Guan, Jihua Wu, Ziqi He, Juening Kang, Zhiwei Tao, Yaoliang Deng. Effect of M2 Macrophages on Injury and Apoptosis of Renal Tubular Epithelial Cells Induced by Calcium Oxalate Crystals. Kidney & blood pressure research. 2019; 44(4):777-791. doi: 10.1159/000501558. [PMID: 31408871]
  • Basma G Eid, Alaa T Abu-Sharib, Hany M El-Bassossy, Khadijah Balamash, Sergey V Smirnov. Enhanced calcium entry via activation of NOX/PKC underlies increased vasoconstriction induced by methylglyoxal. Biochemical and biophysical research communications. 2018 12; 506(4):1013-1018. doi: 10.1016/j.bbrc.2018.10.171. [PMID: 30404736]
  • Leucio D Vieira, Juliane S Farias, Diego B de Queiroz, Edjair V Cabral, Manoel M Lima-Filho, Bruna R M Sant'Helena, Regina S Aires, Valdilene S Ribeiro, Juliana Santos-Rocha, Fabiano E Xavier, Ana D Paixão. Oxidative stress induced by prenatal LPS leads to endothelial dysfunction and renal haemodynamic changes through angiotensin II/NADPH oxidase pathway: Prevention by early treatment with α-tocopherol. Biochimica et biophysica acta. Molecular basis of disease. 2018 12; 1864(12):3577-3587. doi: 10.1016/j.bbadis.2018.09.019. [PMID: 30254014]
  • Jorge Osvaldo Montes-Rivera, Feliciano Tamay-Cach, Julio César Quintana-Pérez, Juan Alberto Guevara-Salazar, José Guadalupe Trujillo-Ferrara, Leonardo Del Valle-Mondragón, Mónica Griselda Arellano-Mendoza. Apocynin combined with drugs as coadjuvant could be employed to prevent and/or treat the chronic kidney disease. Renal failure. 2018 Nov; 40(1):92-98. doi: 10.1080/0886022x.2017.1421557. [PMID: 29299955]
  • Reham Mokhtar Aman, Irhan Ibrahim Abu Hashim, Mahasen Mohamed Meshali. Novel chitosan-based solid-lipid nanoparticles to enhance the bio-residence of the miraculous phytochemical 'Apocynin'. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2018 Nov; 124(?):304-318. doi: 10.1016/j.ejps.2018.09.001. [PMID: 30193859]
  • Rui Xin, Xuhong Sun, Ziying Wang, Wendan Yuan, Weidong Jiang, Lin Wang, Yanxiao Xiang, Hongqin Zhang, Xiaoyan Li, Yun Hou, Wangnan Sun, Pengchao Du. Apocynin inhibited NLRP3/XIAP signalling to alleviate renal fibrotic injury in rat diabetic nephropathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Oct; 106(?):1325-1331. doi: 10.1016/j.biopha.2018.07.036. [PMID: 30119203]
  • Shogo Shimizu, Takahiro Shimizu, Kumiko Nakamura, Youichirou Higashi, Motoaki Saito. Angiotensin II, a stress-related neuropeptide in the CNS, facilitates micturition reflex in rats. British journal of pharmacology. 2018 09; 175(18):3727-3737. doi: 10.1111/bph.14439. [PMID: 29981238]
  • Libing Huang, Juan Zhu, Man Zheng, Rong Zou, Yudi Zhou, Minghui Zhu. Tanshinone IIA protects against subclinical lipopolysaccharide induced cardiac fibrosis in mice through inhibition of NADPH oxidase. International immunopharmacology. 2018 Jul; 60(?):59-63. doi: 10.1016/j.intimp.2018.04.036. [PMID: 29704740]
  • Eleonora Cremonini, Patricia I Oteiza. (-)-Epicatechin and its metabolites prevent palmitate-induced NADPH oxidase upregulation, oxidative stress and insulin resistance in HepG2 cells. Archives of biochemistry and biophysics. 2018 05; 646(?):55-63. doi: 10.1016/j.abb.2018.03.027. [PMID: 29608879]
  • Weijing Feng, Kun Zhang, Yu Liu, Jie Chen, Qingqing Cai, Wanbing He, Yinyin Zhang, Mong-Heng Wang, Jingfeng Wang, Hui Huang. Advanced oxidation protein products aggravate cardiac remodeling via cardiomyocyte apoptosis in chronic kidney disease. American journal of physiology. Heart and circulatory physiology. 2018 03; 314(3):H475-H483. doi: 10.1152/ajpheart.00628.2016. [PMID: 29101185]
  • R Gimenes, C Gimenes, C M Rosa, N P Xavier, D H S Campos, A A H Fernandes, M D M Cezar, G N Guirado, L U Pagan, I D Chaer, D C Fernandes, F R Laurindo, A C Cicogna, M P Okoshi, K Okoshi. Influence of apocynin on cardiac remodeling in rats with streptozotocin-induced diabetes mellitus. Cardiovascular diabetology. 2018 01; 17(1):15. doi: 10.1186/s12933-017-0657-9. [PMID: 29343259]
  • Hyo Hee Yang, Kyung-Eon Oh, Yang Hee Jo, Jong Hoon Ahn, Qing Liu, Ayman Turk, Jae Young Jang, Bang Yeon Hwang, Ki Yong Lee, Mi Kyeong Lee. Characterization of tyrosinase inhibitory constituents from the aerial parts of Humulus japonicus using LC-MS/MS coupled online assay. Bioorganic & medicinal chemistry. 2018 01; 26(2):509-515. doi: 10.1016/j.bmc.2017.12.011. [PMID: 29254897]
  • Jie Liu, Yuzhang Zhu, Shipiao Chen, Bin Shen, Fang Yu, Yi Zhang, Ruilin Shen. Apocynin Attenuates Cobalt Chloride-Induced Pheochromocytoma Cell Apoptosis by Inhibiting P38-MAPK/Caspase-3 Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 48(1):208-214. doi: 10.1159/000491720. [PMID: 30007963]
  • R S Abdelrahman. Protective effect of apocynin against gentamicin-induced nephrotoxicity in rats. Human & experimental toxicology. 2018 Jan; 37(1):27-37. doi: 10.1177/0960327116689716. [PMID: 28116922]
  • Mostafa R Fayed, Reem N El-Naga, El-Sayed Akool, Ebtehal El-Demerdash. The potential antifibrotic impact of apocynin and alpha-lipoic acid in concanavalin A-induced liver fibrosis in rats: Role of NADPH oxidases 1 and 4. Drug discoveries & therapeutics. 2018 ; 12(2):58-67. doi: 10.5582/ddt.2017.01065. [PMID: 29760339]
  • Satvika Sharma, Ankush Parmar, Rishi Bhardwaj, Rakesh Kumar Bijarnia, Tanzeer Kaur. Design and Characterization of Apocynin Loaded PLGA Nanoparticles and their In vivo Efficacy in Hyperoxaluric Rats. Current drug delivery. 2018; 15(7):1020-1027. doi: 10.2174/1567201815666180228163519. [PMID: 29493454]
  • Xia Li, Hao Guo, Lei Zhao, Bodong Wang, Haixiao Liu, Liang Yue, Hao Bai, Haiyang Jiang, Li Gao, Dayun Feng, Yan Qu. Adiponectin attenuates NADPH oxidase-mediated oxidative stress and neuronal damage induced by cerebral ischemia-reperfusion injury. Biochimica et biophysica acta. Molecular basis of disease. 2017 12; 1863(12):3265-3276. doi: 10.1016/j.bbadis.2017.08.010. [PMID: 28844957]
  • Shuxian Zhang, Xiaohua Tan, Yan Chen, Xiuying Zhang. Postconditioning protects renal fibrosis by attenuating oxidative stress-induced mitochondrial injury. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2017 Oct; 32(10):1628-1636. doi: 10.1093/ndt/gfw469. [PMID: 28339958]
  • Arissa Felipe Borges, Camila Imai Morato, Rodrigo Saar Gomes, Miriam Leandro Dorta, Milton Adriano Pelli de Oliveira, Fátima Ribeiro-Dias. Platelet-activating factor increases reactive oxygen species-mediated microbicidal activity of human macrophages infected with Leishmania (Viannia) braziliensis. Pathogens and disease. 2017 09; 75(7):. doi: 10.1093/femspd/ftx082. [PMID: 28830073]
  • Md Mizanur Rahman, Awale Yousuf Muse, D M Isha Olive Khan, Ismaile Hussein Ahmed, Nusrat Subhan, Hasan Mahmud Reza, Md Ashraful Alam, Lutfun Nahar, Satyajit Dey Sarker. Apocynin prevented inflammation and oxidative stress in carbon tetra chloride induced hepatic dysfunction in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Aug; 92(?):421-428. doi: 10.1016/j.biopha.2017.05.101. [PMID: 28558355]
  • Bo Hu, Yuhong Wu, Fei Tong, Jie Liu, Xiaohua Shen, Ruilin Shen, Guangtao Xu. Apocynin Alleviates Renal Ischemia/Reperfusion Injury Through Regulating the Level of Zinc and Metallothionen. Biological trace element research. 2017 Jul; 178(1):71-78. doi: 10.1007/s12011-016-0904-z. [PMID: 27909865]
  • Jiuchun Qiu, Jianping Zhao, Jian Li, Xue Liang, Yajuan Yang, Zhiwei Zhang, Xiaowei Zhang, Huaying Fu, Panagiotis Korantzopoulos, Gary Tse, Tong Liu, Guangping Li. Apocynin attenuates left ventricular remodeling in diabetic rabbits. Oncotarget. 2017 Jun; 8(24):38482-38490. doi: 10.18632/oncotarget.16599. [PMID: 28388570]
  • Mercedes Muñoz, Maria Elvira López-Oliva, Estéfano Pinilla, María Pilar Martínez, Ana Sánchez, Claudia Rodríguez, Albino García-Sacristán, Medardo Hernández, Luis Rivera, Dolores Prieto. CYP epoxygenase-derived H2O2 is involved in the endothelium-derived hyperpolarization (EDH) and relaxation of intrarenal arteries. Free radical biology & medicine. 2017 05; 106(?):168-183. doi: 10.1016/j.freeradbiomed.2017.02.031. [PMID: 28212823]
  • Ho Tsoi, Eagle S H Chu, Xiang Zhang, Jianqiu Sheng, Geicho Nakatsu, Siew C Ng, Anthony W H Chan, Francis K L Chan, Joseph J Y Sung, Jun Yu. Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice. Gastroenterology. 2017 05; 152(6):1419-1433.e5. doi: 10.1053/j.gastro.2017.01.009. [PMID: 28126350]
  • Zhu Hui Liu, Dao Peng Dai, Feng Hua Ding, Wen Qi Pan, Yue Hua Fang, Qi Zhang, Man Li, Ping Yang, Xiao Qun Wang, Ying Shen, Ling Jie Wang, Xiao Xiang Yan, Yu Hu He, Ke Yang, Rui Yan Zhang, Wei Feng Shen, Ying Chen, Lin Lu. Association of serum HMGB2 level with MACE at 1 mo of myocardial infarction: Aggravation of myocardial ischemic injury in rats by HMGB2 via ROS. American journal of physiology. Heart and circulatory physiology. 2017 Mar; 312(3):H422-H436. doi: 10.1152/ajpheart.00249.2016. [PMID: 28011583]
  • Seok Ho Choi, Gil Joon Suh, Woon Yong Kwon, Kyung Su Kim, Min Ji Park, Taegyun Kim, Jeong In Ko. Apocynin suppressed the nuclear factor-κB pathway and attenuated lung injury in a rat hemorrhagic shock model. The journal of trauma and acute care surgery. 2017 03; 82(3):566-574. doi: 10.1097/ta.0000000000001337. [PMID: 28030501]
  • Shuang Chu, Xiaodong Mao, Hengjiang Guo, Li Wang, Zezheng Li, Yang Zhang, Yunman Wang, Hao Wang, Xuemei Zhang, Wen Peng. Indoxyl sulfate potentiates endothelial dysfunction via reciprocal role for reactive oxygen species and RhoA/ROCK signaling in 5/6 nephrectomized rats. Free radical research. 2017 Mar; 51(3):237-252. doi: 10.1080/10715762.2017.1296575. [PMID: 28277985]
  • Yuan-Yuan Qin, Mei Li, Xing Feng, Jian Wang, Lijuan Cao, Xi-Kui Shen, Jieyu Chen, Meiling Sun, Rui Sheng, Feng Han, Zheng-Hong Qin. Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke. Free radical biology & medicine. 2017 03; 104(?):333-345. doi: 10.1016/j.freeradbiomed.2017.01.034. [PMID: 28132925]
  • Sultan Zahiruddin, Washim Khan, Rinki Nehra, Md Javed Alam, Md Nasar Mallick, Rabea Parveen, Sayeed Ahmad. Pharmacokinetics and comparative metabolic profiling of iridoid enriched fraction of Picrorhiza kurroa - An Ayurvedic Herb. Journal of ethnopharmacology. 2017 Feb; 197(?):157-164. doi: 10.1016/j.jep.2016.07.072. [PMID: 27469200]
  • Janaina A Simplicio, Gabriel T do Vale, Natália A Gonzaga, Letícia N Leite, Ulisses V Hipólito, Camila A Pereira, Rita C Tostes, Carlos R Tirapelli. Reactive oxygen species derived from NAD(P)H oxidase play a role on ethanol-induced hypertension and endothelial dysfunction in rat resistance arteries. Journal of physiology and biochemistry. 2017 Feb; 73(1):5-16. doi: 10.1007/s13105-016-0519-z. [PMID: 27722988]
  • Chun-Lei Zhang, Guo-Ru Shi, Yan-Fei Liu, Yan Wang, Ruo-Yun Chen, De-Quan Yu. Apocynin derivatives from Iris tectorum. Journal of Asian natural products research. 2017 Feb; 19(2):128-133. doi: 10.1080/10286020.2016.1268128. [PMID: 28081623]
  • Gökçe Şeker Karatoprak, Gamze Aydin, Berrak Altinsoy, Cevahir Altinkaynak, Müberra Koşar, Ismail Ocsoy. The Effect of Pelargonium endlicherianum Fenzl. root extracts on formation of nanoparticles and their antimicrobial activities. Enzyme and microbial technology. 2017 Feb; 97(?):21-26. doi: 10.1016/j.enzmictec.2016.10.019. [PMID: 28010769]
  • Leonardo Sandrini, Alessandro Ieraci, Patrizia Amadio, Maurizio Popoli, Elena Tremoli, Silvia S Barbieri. Apocynin Prevents Abnormal Megakaryopoiesis and Platelet Activation Induced by Chronic Stress. Oxidative medicine and cellular longevity. 2017; 2017(?):9258937. doi: 10.1155/2017/9258937. [PMID: 29317986]
  • Xingsheng Ren, Feng Zhang, Mingxia Zhao, Zhenzhen Zhao, Shuo Sun, Dustin R Fraidenburg, Haiyang Tang, Ying Han. Angiotensin-(1-7) in Paraventricular Nucleus Contributes to the Enhanced Cardiac Sympathetic Afferent Reflex and Sympathetic Activity in Chronic Heart Failure Rats. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017; 42(6):2523-2539. doi: 10.1159/000480214. [PMID: 28848201]
  • Wenhong Deng, Ablikim Abliz, Sheng Xu, Rongze Sun, Wenyi Guo, Qiao Shi, Jia Yu, Weixing Wang. Severity of pancreatitis‑associated intestinal mucosal barrier injury is reduced following treatment with the NADPH oxidase inhibitor apocynin. Molecular medicine reports. 2016 Oct; 14(4):3525-34. doi: 10.3892/mmr.2016.5678. [PMID: 27573037]
  • C M Rosa, R Gimenes, D H S Campos, G N Guirado, C Gimenes, A A H Fernandes, A C Cicogna, R M Queiroz, I Falcão-Pires, D Miranda-Silva, P Rodrigues, F R Laurindo, D C Fernandes, C R Correa, M P Okoshi, K Okoshi. Apocynin influence on oxidative stress and cardiac remodeling of spontaneously hypertensive rats with diabetes mellitus. Cardiovascular diabetology. 2016 09; 15(1):126. doi: 10.1186/s12933-016-0442-1. [PMID: 27585437]
  • Minu Sharma, Amit Sud, Tanzeer Kaur, Chanderdeep Tandon, S K Singla. N-acetylcysteine with apocynin prevents hyperoxaluria-induced mitochondrial protein perturbations in nephrolithiasis. Free radical research. 2016 Sep; 50(9):1032-44. doi: 10.1080/10715762.2016.1221507. [PMID: 27494339]
  • Katia Colombo Marchi, Carla Speroni Ceron, Jaqueline J Muniz, Bruno S De Martinis, José E Tanus-Santos, Carlos Renato Tirapelli. NADPH Oxidase Plays a Role on Ethanol-Induced Hypertension and Reactive Oxygen Species Generation in the Vasculature. Alcohol and alcoholism (Oxford, Oxfordshire). 2016 Sep; 51(5):522-34. doi: 10.1093/alcalc/agw043. [PMID: 27382085]
  • Qinbo Yang, Jingang Cui, Peiwei Wang, Xiaoye Du, Wenjian Wang, Teng Zhang, Yu Chen. Changes in interconnected pathways implicating microRNAs are associated with the activity of apocynin in attenuating myocardial fibrogenesis. European journal of pharmacology. 2016 Aug; 784(?):22-32. doi: 10.1016/j.ejphar.2016.05.007. [PMID: 27174579]
  • Xi Cheng, Xizi Zheng, Yi Song, Lei Qu, Jiawei Tang, Liqiang Meng, Yu Wang. Apocynin attenuates renal fibrosis via inhibition of NOXs-ROS-ERK-myofibroblast accumulation in UUO rats. Free radical research. 2016 Aug; 50(8):840-52. doi: 10.1080/10715762.2016.1181757. [PMID: 27109518]
  • Neha Sharma, Bimla Nehru. Apocyanin, a Microglial NADPH Oxidase Inhibitor Prevents Dopaminergic Neuronal Degeneration in Lipopolysaccharide-Induced Parkinson's Disease Model. Molecular neurobiology. 2016 07; 53(5):3326-3337. doi: 10.1007/s12035-015-9267-2. [PMID: 26081143]
  • Roberta Francesca Capogrosso, Anna Cozzoli, Paola Mantuano, Giulia Maria Camerino, Ada Maria Massari, Valeriana Teresa Sblendorio, Michela De Bellis, Roberto Tamma, Arcangela Giustino, Beatrice Nico, Monica Montagnani, Annamaria De Luca. Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of duchenne muscular dystrophy: A comparison with the gold standard, α-methyl prednisolone. Pharmacological research. 2016 Apr; 106(?):101-113. doi: 10.1016/j.phrs.2016.02.016. [PMID: 26930420]
  • Minu Sharma, Tanzeer Kaur, S K Singla. Role of mitochondria and NADPH oxidase derived reactive oxygen species in hyperoxaluria induced nephrolithiasis: therapeutic intervention with combinatorial therapy of N-acetyl cysteine and Apocynin. Mitochondrion. 2016 Mar; 27(?):15-24. doi: 10.1016/j.mito.2016.01.002. [PMID: 26779823]
  • Li-Na Chen, Gang Zhou, le Wu, Shao-Hua Hou. [Effect of NADPH oxidase inhibitor apocynin on the exercise induced proteinuria in rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 2016 Feb; 32(2):116-120. doi: 10.13459/j.cnki.cjap.2016.02.006. [PMID: 29931860]
  • Jinlong Yang, Yichao Cheng, Yuanyuan Zhu, Junjun Zhu, Tingting Chen, Yong Xu, Qiang Yong, Shiyuan Yu. [Effect of phenolic ketones on ethanol fermentation and cellular lipid composition of Pichia stipitis]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2016 Feb; 32(2):185-94. doi: . [PMID: 27382768]
  • Ya J Jing, Jing W Ni, Feng H Ding, Yue H Fang, Xiao Q Wang, Hai B Wang, Xiao N Chen, Nan Chen, Wei W Zhan, Lin Lu, Rui Y Zhang. p-Cresyl sulfate is associated with carotid arteriosclerosis in hemodialysis patients and promotes atherogenesis in apoE-/- mice. Kidney international. 2016 Feb; 89(2):439-49. doi: 10.1038/ki.2015.287. [PMID: 26466319]
  • Valéria Nunes-Souza, Cheila Juliana César-Gomes, Lucas José Sá Da Fonseca, Glaucevane Da Silva Guedes, Salete Smaniotto, Luíza Antas Rabelo. Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL/6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy. Oxidative medicine and cellular longevity. 2016; 2016(?):1987960. doi: 10.1155/2016/1987960. [PMID: 27057272]
  • Dong-dong Tang, Hong-xin Niu, Fen-fen Peng, Hai-bo Long, Zong-rui Liu, Hao Zhao, Yi-hua Chen. Hypochlorite-Modified Albumin Upregulates ICAM-1 Expression via a MAPK-NF-κB Signaling Cascade: Protective Effects of Apocynin. Oxidative medicine and cellular longevity. 2016; 2016(?):1852340. doi: 10.1155/2016/1852340. [PMID: 26881015]
  • Yasir Furkan Cagin, Mehmet Ali Erdogan, Nurhan Sahin, Hakan Parlakpinar, Yahya Atayan, Alaadin Polat, Nigar Vardi, Azibe Yildiz, Kevser Tanbek. Protective Effects of Apocynin on Cisplatin-induced Hepatotoxicity in Rats. Archives of medical research. 2015 Oct; 46(7):517-26. doi: 10.1016/j.arcmed.2015.08.005. [PMID: 26319609]
  • Kun Zhang, Yu Liu, Xiaoqiang Liu, Jie Chen, Qingqing Cai, Jingfeng Wang, Hui Huang. Apocynin improving cardiac remodeling in chronic renal failure disease is associated with up-regulation of epoxyeicosatrienoic acids. Oncotarget. 2015 Sep; 6(28):24699-708. doi: 10.18632/oncotarget.5084. [PMID: 26322503]
  • Johanna Abrigo, María Gabriela Morales, Felipe Simon, Daniel Cabrera, Gabriella Di Capua, Claudio Cabello-Verrugio. Apocynin inhibits the upregulation of TGF-β1 expression and ROS production induced by TGF-β in skeletal muscle cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2015 Sep; 22(10):885-93. doi: 10.1016/j.phymed.2015.06.011. [PMID: 26321737]
  • Yimin Wang, Xiao Luo, Hao Pan, Wei Huang, Xueping Wang, Huali Wen, Kezhen Shen, Baiye Jin. Pharmacological inhibition of NADPH oxidase protects against cisplatin induced nephrotoxicity in mice by two step mechanism. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2015 Sep; 83(?):251-60. doi: 10.1016/j.fct.2015.05.007. [PMID: 26032634]
  • Izabella Z A Pawluczyk, Maryam G Najafabadi, Jeremy R Brown, Alan Bevington, Peter S Topham. Sialic acid supplementation ameliorates puromycin aminonucleoside nephrosis in rats. Laboratory investigation; a journal of technical methods and pathology. 2015 Sep; 95(9):1019-28. doi: 10.1038/labinvest.2015.78. [PMID: 26121320]
  • Roberto Ciarcia, Sara Damiano, Alessia Florio, Manuela Spagnuolo, Enza Zacchia, Caterina Squillacioti, Nicola Mirabella, Salvatore Florio, Ugo Pagnini, Tiziana Garofano, Maria Sole Polito, Giovambattista Capasso, Antonio Giordano. The Protective Effect of Apocynin on Cyclosporine A-Induced Hypertension and Nephrotoxicity in Rats. Journal of cellular biochemistry. 2015 Sep; 116(9):1848-56. doi: 10.1002/jcb.25140. [PMID: 25704923]