apocynin (BioDeep_00000858358)

Main id: BioDeep_00000017335

 

PANOMIX_OTCML-2023


代谢物信息卡片


InChI=1\C9H10O3\c1-6(10)7-3-4-8(11)9(5-7)12-2\h3-5,11H,1-2H

化学式: C9H10O3 (166.062991)
中文名称: 香草乙酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)C1=CC(=C(C=C1)O)OC
InChI: InChI=1S/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H3

描述信息

D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D020011 - Protective Agents > D000975 - Antioxidants
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
D004791 - Enzyme Inhibitors
Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[1][2]. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model[3]. Apocynin can also be used for cancer research[4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass[5].
Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[1][2]. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model[3]. Apocynin can also be used for cancer research[4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass[5].
Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[1][2]. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model[3]. Apocynin can also be used for cancer research[4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass[5].

同义名列表

39 个代谢物同义名

InChI=1\C9H10O3\c1-6(10)7-3-4-8(11)9(5-7)12-2\h3-5,11H,1-2H; ACETOPHENONE,4-HYDROXY,3-METHOXY ACETOVANILLON; 4-08-00-01814 (Beilstein Handbook Reference); 1-(4-hydroxy-3-methoxyphenyl)ethan-1-one; Ethanone, 1-(4-hydroxy-3-methoxyphenyl)-; 4-Hydroxy-3-methoxyphenyl methyl ketone; 3-Metoksy-4-hydroksyacetofenon [Polish]; 1-(4-hydroxy-3-methoxy-phenyl)ethanone; 1-(4-Hydroxy-3-methoxyphenyl)ethanone; Acetophenone, 4-hydroxy-3-methoxy-; 4′-Hydroxy-3′-methoxyacetophenone; 3-Methoxy-4-hydroxyacetophenone; 4-hydroxy-3-methoxyacetophenone; 4-Acetyl-2-methoxyphenol; EINECS 207-854-5; W508454_ALDRICH; WLN: 1VR DQ CO1; AA-504\20839006; A10809_ALDRICH; Acetovanillone; Acetoguaiacone; Acetovanillon; Acetovanyllon; Acetovanilone; Acetoguaiacon; ZINC00162515; BRN 0637373; 55539_FLUKA; CHEBI:2781; CCRIS 7285; NSC 209524; SBB008060; NSC209524; apocynine; AI3-15892; 498-02-2; apocynin; NSC2146; C11380



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

65 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xuan Li, Wenyu Wu, Huan He, Lin Guan, Guancheng Chen, Zhijun Lin, Huan Li, Jialin Jiang, Xin Dong, Zhuoji Guan, Pinliang Chen, Zigang Pan, Weiwei Huang, Runjia Yu, Wenxin Song, Lu Lu, Zhongqi Yang, Zixin Chen, Lingjun Wang, Shaoxiang Xian, Jie Chen. Analysis and validation of hub genes in neutrophil extracellular traps for the long-term prognosis of myocardial infarction. Gene. 2024 Jul; 914(?):148369. doi: 10.1016/j.gene.2024.148369. [PMID: 38485036]
  • Cunxiang Bo, Fang Liu, Zewen Zhang, Zhongjun Du, Haidi Xiu, Zhenling Zhang, Ming Li, Caiqing Zhang, Qiang Jia. Simvastatin attenuates silica-induced pulmonary inflammation and fibrosis in rats via the AMPK-NOX pathway. BMC pulmonary medicine. 2024 May; 24(1):224. doi: 10.1186/s12890-024-03014-9. [PMID: 38720270]
  • Xinglong Zhang, Ran Pang, Kai Zhang, Qian Xu, Chunlei Xu, Wei Shi, Xinyu Liang, Dong Li, Wenhao Cui, Shucai Bai, Zhijun Li, Hui Li, Huafeng Zhang. Apocynin exerts cytoprotective effects on dexamethasone-induced osteoblasts by inhibiting oxidative stress through the Nrf2 signalling pathway. Journal of cellular and molecular medicine. 2023 Sep; ?(?):. doi: 10.1111/jcmm.17974. [PMID: 37749949]
  • Reham Mokhtar Aman, Randa Ahmed Zaghloul, Wael M Elsaed, Irhan Ibrahim Abu Hashim. In vitro-in vivo assessments of apocynin-hybrid nanoparticle-based gel as an effective nanophytomedicine for treatment of rheumatoid arthritis. Drug delivery and translational research. 2023 Jun; ?(?):. doi: 10.1007/s13346-023-01360-5. [PMID: 37284937]
  • Yongzhen Du, Tong Xu, Dongliu Luo, Yixuan Wang, Hang Yin, Chengguo Liu, Shu Li. Perfluorooctane sulfonate-induced apoptosis in kidney cells by triggering the NOX4/ROS/JNK axis and antagonism of cannabidiol. Environmental toxicology. 2023 Mar; ?(?):. doi: 10.1002/tox.23794. [PMID: 36988283]
  • Gara N Dexter, Laura E Navas, Jason C Grigg, Harbir Bajwa, David J Levy-Booth, Jie Liu, Nathan A Louie, Seyed A Nasseri, Soo-Kyeong Jang, Scott Renneckar, Lindsay D Eltis, William W Mohn. Bacterial catabolism of acetovanillone, a lignin-derived compound. Proceedings of the National Academy of Sciences of the United States of America. 2022 10; 119(43):e2213450119. doi: 10.1073/pnas.2213450119. [PMID: 36256818]
  • Joanna Depciuch, Paweł Jakubczyk, Wiesław Paja, Jaromir Sarzyński, Krzysztof Pancerz, Merve Açıkel Elmas, Elif Keskinöz, Özlem Bingöl Özakpınar, Serap Arbak, Gökçe Özgün, Sevde Altuntaş, Zozan Guleken. Apocynin reduces cytotoxic effects of monosodium glutamate in the brain: A spectroscopic, oxidative load, and machine learning study. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Oct; 279(?):121495. doi: 10.1016/j.saa.2022.121495. [PMID: 35700610]
  • Adriel Ekozin, Chiagoziem A Otuechere, Adewale Adewuyi. Apocynin loaded silver nanoparticles displays potent in vitro biological activities and mitigates pyrogallol-induced hepatotoxicity. Chemico-biological interactions. 2022 Sep; 365(?):110069. doi: 10.1016/j.cbi.2022.110069. [PMID: 35944648]
  • Bin Li, Yuchun Shi, Yanbin Fu. Apocynin inhibits compressive force-induced apoptosis and autophagy of periodontal ligament stem cells. Oral diseases. 2022 Jun; ?(?):. doi: 10.1111/odi.14296. [PMID: 35770313]
  • Abhishek Kumar, Subrata Kumar Ghosh, Rahul Katiyar, Amare Eshetu Gemeda, Rupali Rautela, Amarjeet Bisla, Neeraj Srivastava, Sanjeev Kumar Bhure, Huidrom Lakshmi Devi, Vikash Chandra. Supplementation of Mito TEMPO and acetovanillone in semen extender improves freezability of buffalo spermatozoa. Andrology. 2022 05; 10(4):775-788. doi: 10.1111/andr.13158. [PMID: 35060362]
  • Venkata Prasuja Nakka, Raghu Gogada, Praveen Kumar Simhadri, Mohammed Abdul Qadeer, Prakash Babu Phanithi. Post-treatment with apocynin at a lower dose regulates the UPR branch of eIF2α and XBP-1 pathways after stroke. Brain research bulletin. 2022 05; 182(?):1-11. doi: 10.1016/j.brainresbull.2022.02.003. [PMID: 35143926]
  • Rüya Kuru Yaşar, Dilruba Kuru, Ali Şen, Göksel Şener, Feriha Ercan, Ayşen Yarat. Effects of Myrtus communis L. Extract and Apocynin on Lens Oxidative Damage and Boron Levels in Rats with a High Fat-Diet. Turkish journal of ophthalmology. 2021 Dec; 51(6):344-350. doi: 10.4274/tjo.galenos.2021.27981. [PMID: 34963261]
  • Cuneyt Tayman, Ufuk Çakır, Hasan Akduman, Şefika Karabulut, Murat Çağlayan. The therapeutic effect of Apocynin against hyperoxy and Inflammation-Induced lung injury. International immunopharmacology. 2021 Dec; 101(Pt A):108190. doi: 10.1016/j.intimp.2021.108190. [PMID: 34607228]
  • Shreya R Savla, Ankit P Laddha, Yogesh A Kulkarni. Pharmacology of apocynin: a natural acetophenone. Drug metabolism reviews. 2021 11; 53(4):542-562. doi: 10.1080/03602532.2021.1895203. [PMID: 33689526]
  • Omnia A M Abd El-Ghafar, Emad H M Hassanein, Ahmed M Sayed, Eman K Rashwan, Abdel-Gawad S Shalkami, Ayman M Mahmoud. Acetovanillone prevents cyclophosphamide-induced acute lung injury by modulating PI3K/Akt/mTOR and Nrf2 signaling in rats. Phytotherapy research : PTR. 2021 Aug; 35(8):4499-4510. doi: 10.1002/ptr.7153. [PMID: 33969557]
  • Di Liu, Wan-Pin Sun, Jing-Wei Chen, Yan Jiang, Rong Xue, Lin-Hui Wang, Koji Murao, Guo-Xing Zhang. Autophagy contributes to angiotensin II induced dysfunction of HUVECs. Clinical and experimental hypertension (New York, N.Y. : 1993). 2021 Jul; 43(5):462-473. doi: 10.1080/10641963.2021.1901110. [PMID: 33775188]
  • Ajmal Ahmad, Mohd Imtiaz Nawaz, Mohammad Mairaj Siddiquei, Ahmed M Abu El-Asrar. Apocynin ameliorates NADPH oxidase 4 (NOX4) induced oxidative damage in the hypoxic human retinal Müller cells and diabetic rat retina. Molecular and cellular biochemistry. 2021 May; 476(5):2099-2109. doi: 10.1007/s11010-021-04071-y. [PMID: 33515385]
  • T Y Chia, V Murugaiyah, N Ak Khan, M A Sattar, M H Abdulla, E J Johns, A Ahmad, Z Hassan, G Kaur, H Y Mei, F U Ahmad, S Akhtar. Inhibition of L-NAME-induced hypertension by combined treatment with apocynin and catalase: the role of Nox 4 expression. Physiological research. 2021 03; 70(1):13-26. doi: 10.33549/physiolres.934497. [PMID: 33728924]
  • Shugo Suzuki, Samuel M Cohen, Lora L Arnold, Karen L Pennington, Min Gi, Hiroyuki Kato, Taku Naiki, Aya Naiki-Ito, Hideki Wanibuchi, Satoru Takahashi. Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin. Toxicology letters. 2021 Jan; 336(?):32-38. doi: 10.1016/j.toxlet.2020.11.005. [PMID: 33176187]
  • Sai Bharadwaja, Praveen Kumar Issac, Jocelyn Cleta, Rakesh Jeganathan, Sri Snehaa Chandrakumar, Sujatha Sundaresan. An in vitro mechanistic approach towards understanding the distinct pathways regulating insulin resistance and adipogenesis by apocynin. Journal of biosciences. 2021; 46(?):. doi: . [PMID: 33709960]
  • T Y Chia, V Murugaiyah, M A Sattar, N A K Khan, A Ahmad, M H Abdulla, E J Johns, H Y Mei, S Akhtar, F U Ahmad. The restorative effect of apocynin and catalase in l-arginine induced hypotension on normotensive subjects - the role of oxidative stress. Physiological research. 2020 12; 69(6):1051-1066. doi: 10.33549/physiolres.934426. [PMID: 33210935]
  • Fen Zheng, Chao Ye, Guo-Wei Wan, Bing Zhou, Ying Tong, Jian-Zhen Lei, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. Interleukin-1β in hypothalamic paraventricular nucleus mediates excitatory renal reflex. Pflugers Archiv : European journal of physiology. 2020 11; 472(11):1577-1586. doi: 10.1007/s00424-020-02461-7. [PMID: 32915316]
  • Han Sha, Yanchao Ma, Yuli Tong, Jie Zhao, Fengzhi Qin. Apocynin inhibits placental TLR4/NF-κB signaling pathway and ameliorates preeclampsia-like symptoms in rats. Pregnancy hypertension. 2020 Oct; 22(?):210-215. doi: 10.1016/j.preghy.2020.10.006. [PMID: 33099123]
  • Kübra Kavram Sarihan, Melda Yardimoğlu Yilmaz, Fatma Ceyla Eraldemir, Yusufhan Yazir, Esra Acar. Protective effects of apocynin on damaged testes of rats exposed to methotrexate. Turkish journal of medical sciences. 2020 08; 50(5):1409-1420. doi: 10.3906/sag-1909-52. [PMID: 32394677]
  • Fangfei Liu, Lampson M Fan, Nicholas Michael, Jian-Mei Li. In vivo and in silico characterization of apocynin in reducing organ oxidative stress: A pharmacokinetic and pharmacodynamic study. Pharmacology research & perspectives. 2020 08; 8(4):e00635. doi: 10.1002/prp2.635. [PMID: 32761799]
  • Alejandra Z Vielma, Mauricio P Boric, Daniel R Gonzalez. Apocynin Treatment Prevents Cardiac Connexin 43 Hemichannels Hyperactivity by Reducing Nitroso-Redox Stress in Mdx Mice. International journal of molecular sciences. 2020 Jul; 21(15):. doi: 10.3390/ijms21155415. [PMID: 32751416]
  • Iñaki Robles-Vera, Néstor De La Visitación, Marta Toral, Manuel Sánchez, Manuel Gómez-Guzmán, Francisco O'valle, Rosario Jiménez, Juan Duarte, Miguel Romero. Toll-like receptor 7-driven lupus autoimmunity induces hypertension and vascular alterations in mice. Journal of hypertension. 2020 07; 38(7):1322-1335. doi: 10.1097/hjh.0000000000002368. [PMID: 32004206]
  • Sizhe Wan, Fangyun Luo, Chenkai Huang, Cong Liu, Qingtian Luo, Xuan Zhu. Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways. Aging. 2020 06; 12(11):10614-10632. doi: 10.18632/aging.103282. [PMID: 32496208]
  • Xiaojia Yang, Kailiang Zhao, Wenhong Deng, Liang Zhao, Hongzhong Jin, Fangchao Mei, Yu Zhou, Man Li, Weixing Wang. Apocynin Attenuates Acute Kidney Injury and Inflammation in Rats with Acute Hypertriglyceridemic Pancreatitis. Digestive diseases and sciences. 2020 06; 65(6):1735-1747. doi: 10.1007/s10620-019-05892-0. [PMID: 31617131]
  • Xianwen Peng, Yongqiang Yang, Li Tang, Jingyuan Wan, Jie Dai, Longjiang Li, Jiayi Huang, Yi Shen, Ling Lin, Xianqiong Gong, Li Zhang. Therapeutic benefits of apocynin in mice with lipopolysaccharide/D-galactosamine-induced acute liver injury via suppression of the late stage pro-apoptotic AMPK/JNK pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 May; 125(?):110020. doi: 10.1016/j.biopha.2020.110020. [PMID: 32106375]
  • Yun Qiu, Fen Zheng, Chao Ye, Ai-Dong Chen, Jue-Jin Wang, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. Angiotensin Type 1 Receptors and Superoxide Anion Production in Hypothalamic Paraventricular Nucleus Contribute to Capsaicin-Induced Excitatory Renal Reflex and Sympathetic Activation. Neuroscience bulletin. 2020 May; 36(5):463-474. doi: 10.1007/s12264-019-00460-y. [PMID: 31989424]
  • Poonam Rana, Kakulavarapu V Rama Rao, Arunreddy Ravula, Richa Trivedi, Maria D'Souza, Ajay K Singh, Raj K Gupta, Namas Chandra. Oxidative stress contributes to cerebral metabolomic profile changes in animal model of blast-induced traumatic brain injury. Metabolomics : Official journal of the Metabolomic Society. 2020 03; 16(3):39. doi: 10.1007/s11306-020-1649-4. [PMID: 32166461]
  • Viktoria Rungelrath, Sophie Öhlmann, Gottfried Alber, Wieland Schrödl, Maren von Köckritz-Blickwede, Nicole de Buhr, Alexander Martens, Christoph Georg Baums, Nicole Schütze. Survival of Streptococcus suis in Porcine Blood Is Limited by the Antibody- and Complement-Dependent Oxidative Burst Response of Granulocytes. Infection and immunity. 2020 02; 88(3):. doi: 10.1128/iai.00598-19. [PMID: 31843967]
  • Teng Liu, Wei Zheng, Linlin Wang, Lin Wang, Yanke Zhang. TLR4/NF-κB Signaling Pathway Participates in the Protective Effects of Apocynin on Gestational Diabetes Mellitus Induced Placental Oxidative Stress and Inflammation. Reproductive sciences (Thousand Oaks, Calif.). 2020 02; 27(2):722-730. doi: 10.1007/s43032-019-00078-5. [PMID: 32046403]
  • Qin Yang, Hai-Yong Chen, Jia-Nan Wang, Huai-Qin Han, Ling Jiang, Wei-Feng Wu, Biao Wei, Li Gao, Qiu-Ying Ma, Xue-Qi Liu, Qi Chen, Jia-Gen Wen, Juan Jin, Yan Huang, Wei-Jian Ni, Tao-Tao Ma, Jun Li, Xiao-Ming Meng. Alcohol promotes renal fibrosis by activating Nox2/4-mediated DNA methylation of Smad7. Clinical science (London, England : 1979). 2020 01; 134(2):103-122. doi: 10.1042/cs20191047. [PMID: 31898747]
  • Sanjin Kovacevic, Milan Ivanov, Zoran Miloradovic, Predrag Brkic, Una Jovana Vajic, Maja Zivotic, Nevena Mihailovic-Stanojevic, Djurdjica Jovovic, Danijela Karanovic, Rada Jeremic, Jelena Nesovic-Ostojic. Hyperbaric oxygen preconditioning and the role of NADPH oxidase inhibition in postischemic acute kidney injury induced in spontaneously hypertensive rats. PloS one. 2020; 15(1):e0226974. doi: 10.1371/journal.pone.0226974. [PMID: 31914135]
  • Nianxin Yang, Agustin Gonzalez-Vicente, Jeffrey L Garvin. Angiotensin II-induced superoxide and decreased glutathione in proximal tubules: effect of dietary fructose. American journal of physiology. Renal physiology. 2020 01; 318(1):F183-F192. doi: 10.1152/ajprenal.00462.2019. [PMID: 31760771]
  • Yong Chia Tan, Munavvar Abdul Sattar, Ahmad F Ahmeda, Nurzalina Abdul Karim Khan, Vikneswaran Murugaiyah, Ashfaq Ahmad, Zurina Hassan, Gurjeet Kaur, Mohammed Hadi Abdulla, Edward James Johns. Apocynin and catalase prevent hypertension and kidney injury in Cyclosporine A-induced nephrotoxicity in rats. PloS one. 2020; 15(4):e0231472. doi: 10.1371/journal.pone.0231472. [PMID: 32298299]
  • Emad H M Hassanein, Omnia A M Abd El-Ghafar, Marwa A Ahmed, Ahmed M Sayed, Wail M Gad-Elrab, Jamaan S Ajarem, Ahmed A Allam, Ayman M Mahmoud. Edaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats. Drug design, development and therapy. 2020; 14(?):5275-5288. doi: 10.2147/dddt.s281854. [PMID: 33299300]
  • Joanna Wieczfinska, Przemyslaw Sitarek, Ewa Skała, Tomasz Kowalczyk, Rafal Pawliczak. Inhibition of NADPH Oxidase-Derived Reactive Oxygen Species Decreases Expression of Inflammatory Cytokines in A549 Cells. Inflammation. 2019 Dec; 42(6):2205-2214. doi: 10.1007/s10753-019-01084-0. [PMID: 31612365]
  • A Walkowska, I Vaneckova, J Sadowski, E Kompanowska-Jezierska. Rapid blood pressure increase after renal denervation in anaesthetized rats: interaction of oxidative stress and neuronal nitric oxide synthase. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2019 Aug; 70(4):. doi: 10.26402/jpp.2019.4.12. [PMID: 31741458]
  • Matthew Kuriakose, Daniel Younger, Arun Reddy Ravula, Eren Alay, Kakulavarapu V Rama Rao, Namas Chandra. Synergistic Role of Oxidative Stress and Blood-Brain Barrier Permeability as Injury Mechanisms in the Acute Pathophysiology of Blast-induced Neurotrauma. Scientific reports. 2019 05; 9(1):7717. doi: 10.1038/s41598-019-44147-w. [PMID: 31118451]
  • A Yücel, M S Aydogan, M Ucar, K B Sarıcı, M G Karaaslan. Effects of Apocynin on Liver Ischemia-Reperfusion Injury in Rats. Transplantation proceedings. 2019 May; 51(4):1180-1183. doi: 10.1016/j.transproceed.2019.01.108. [PMID: 31101195]
  • Liyan Hou, Ruixue Huang, Fuqiang Sun, Lin Zhang, Qingshan Wang. NADPH oxidase regulates paraquat and maneb-induced dopaminergic neurodegeneration through ferroptosis. Toxicology. 2019 04; 417(?):64-73. doi: 10.1016/j.tox.2019.02.011. [PMID: 30797899]
  • Murilo E Graton, Simone R Potje, Jéssica A Troiano, Gabriel T Vale, Ligia A Perassa, Ana Cláudia M S Nakamune, Carlos R Tirapelli, Lusiane M Bendhack, Cristina Antoniali. Apocynin alters redox signaling in conductance and resistance vessels of spontaneously hypertensive rats. Free radical biology & medicine. 2019 04; 134(?):53-63. doi: 10.1016/j.freeradbiomed.2018.12.026. [PMID: 30586635]
  • Quan Liu, Yunlong Liu, Xiaofeng Guan, Jihua Wu, Ziqi He, Juening Kang, Zhiwei Tao, Yaoliang Deng. Effect of M2 Macrophages on Injury and Apoptosis of Renal Tubular Epithelial Cells Induced by Calcium Oxalate Crystals. Kidney & blood pressure research. 2019; 44(4):777-791. doi: 10.1159/000501558. [PMID: 31408871]
  • Basma G Eid, Alaa T Abu-Sharib, Hany M El-Bassossy, Khadijah Balamash, Sergey V Smirnov. Enhanced calcium entry via activation of NOX/PKC underlies increased vasoconstriction induced by methylglyoxal. Biochemical and biophysical research communications. 2018 12; 506(4):1013-1018. doi: 10.1016/j.bbrc.2018.10.171. [PMID: 30404736]
  • Leucio D Vieira, Juliane S Farias, Diego B de Queiroz, Edjair V Cabral, Manoel M Lima-Filho, Bruna R M Sant'Helena, Regina S Aires, Valdilene S Ribeiro, Juliana Santos-Rocha, Fabiano E Xavier, Ana D Paixão. Oxidative stress induced by prenatal LPS leads to endothelial dysfunction and renal haemodynamic changes through angiotensin II/NADPH oxidase pathway: Prevention by early treatment with α-tocopherol. Biochimica et biophysica acta. Molecular basis of disease. 2018 12; 1864(12):3577-3587. doi: 10.1016/j.bbadis.2018.09.019. [PMID: 30254014]
  • Jorge Osvaldo Montes-Rivera, Feliciano Tamay-Cach, Julio César Quintana-Pérez, Juan Alberto Guevara-Salazar, José Guadalupe Trujillo-Ferrara, Leonardo Del Valle-Mondragón, Mónica Griselda Arellano-Mendoza. Apocynin combined with drugs as coadjuvant could be employed to prevent and/or treat the chronic kidney disease. Renal failure. 2018 Nov; 40(1):92-98. doi: 10.1080/0886022x.2017.1421557. [PMID: 29299955]
  • Reham Mokhtar Aman, Irhan Ibrahim Abu Hashim, Mahasen Mohamed Meshali. Novel chitosan-based solid-lipid nanoparticles to enhance the bio-residence of the miraculous phytochemical 'Apocynin'. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2018 Nov; 124(?):304-318. doi: 10.1016/j.ejps.2018.09.001. [PMID: 30193859]
  • Rui Xin, Xuhong Sun, Ziying Wang, Wendan Yuan, Weidong Jiang, Lin Wang, Yanxiao Xiang, Hongqin Zhang, Xiaoyan Li, Yun Hou, Wangnan Sun, Pengchao Du. Apocynin inhibited NLRP3/XIAP signalling to alleviate renal fibrotic injury in rat diabetic nephropathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Oct; 106(?):1325-1331. doi: 10.1016/j.biopha.2018.07.036. [PMID: 30119203]
  • Shogo Shimizu, Takahiro Shimizu, Kumiko Nakamura, Youichirou Higashi, Motoaki Saito. Angiotensin II, a stress-related neuropeptide in the CNS, facilitates micturition reflex in rats. British journal of pharmacology. 2018 09; 175(18):3727-3737. doi: 10.1111/bph.14439. [PMID: 29981238]
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