D-Glucuronate (BioDeep_00000001733)

 

Secondary id: BioDeep_00000003270, BioDeep_00000055253, BioDeep_00000265136, BioDeep_00000400046, BioDeep_00000859614

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


(2S,3S,4S,5R,6S)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid

化学式: C6H10O7 (194.0427)
中文名称: D-葡萄糖醛酸
谱图信息: 最多检出来源 Homo sapiens(blood) 27.28%

Reviewed

Last reviewed on 2024-08-21.

Cite this Page

D-Glucuronate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/d-glucuronate (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001733). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1(C(C(OC(C1O)O)C(=O)O)O)O
InChI: InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6+/m0/s1

描述信息

Glucuronic acid (CAS: 6556-12-3) is a carboxylic acid that has the structure of a glucose molecule that has had its sixth carbon atom (of six total) oxidized. The salts of glucuronic acid are known as glucuronates. Glucuronic acid is highly soluble in water. In humans, glucuronic acid is often linked to toxic or poisonous substances to allow for subsequent elimination, and to hormones to allow for easier transport. These linkages involve O-glycosidic bonds. The process is known as glucuronidation, and the resulting substances are known as glucuronides (or glucuronosides). Glucuronidation uses UDP-glucuronic acid (glucuronic acid linked via a glycosidic bond to uridine diphosphate) as an intermediate. UDP-glucuronic acid is formed in the liver of all animals.

D-Glucuronic acid is an important intermediate isolated from many gums. D-Glucuronic acid and its derivative glucuronolactone are as a liver antidote in the prophylaxis of human health. D-Glucuronic acid has an anti-inflammatory effect for the skin[1].
D-Glucuronic acid is an important intermediate isolated from many gums. D-Glucuronic acid and its derivative glucuronolactone are as a liver antidote in the prophylaxis of human health. D-Glucuronic acid has an anti-inflammatory effect for the skin[1].

同义名列表

28 个代谢物同义名

(2S,3S,4S,5R,6S)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid; α-δ-glucopyranuronic acid; alpha-D-Glucopyranosyluronic acid; α-D-glucopyranuronic acid; α-δ-glucuronic acid; α-D-Glucopyranosyluronic acid; alpha-D-Glucopyranuronic acid; δ-(+)-glucuronic acid; α-D-glucuronic acid; α-D-Glucopyranuronic acid; alpha-D-Glucuronic acid; D-Glucopyranuronic acid; δ-(+)-glucuronate; beta-D-glucuronic acid; D-(+)-Glucuronic acid; δ-glucuronate; Glucosiduronic acid; D-Glucuronic acid; D-(+)-Glucuronate; Glucosiduronate; Glucuronic acid; D-Glucuronate; Glucuronate; GlcAalpha; GlcAa; GCU; Glucuronic acid; D-Glucuronate



数据库引用编号

39 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(7)

PlantCyc(0)

代谢反应

458 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(58)

WikiPathways(0)

Plant Reactome(0)

INOH(1)

PlantCyc(369)

COVID-19 Disease Map(0)

PathBank(30)

PharmGKB(0)

28 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 AKR1B1, ALB, DAG1, MIOX
Peripheral membrane protein 2 CYP1B1, HSD17B6
Endoplasmic reticulum membrane 1 CYP1B1
Nucleus 3 ALB, HPSE, UGDH
cytosol 10 AGPS, AKR1A1, AKR1B1, ALB, ARAF, CD44, DAG1, HEXA, MIOX, UGDH
centrosome 1 ALB
nucleoplasm 4 AKR1B1, DAG1, HPSE, UGDH
Cell membrane 2 CD44, TNF
lamellipodium 1 DAG1
Early endosome membrane 1 HSD17B6
Golgi apparatus membrane 1 GLCE
Synapse 1 AKR1A1
cell surface 2 CD44, TNF
glutamatergic synapse 1 DAG1
Golgi apparatus 3 ALB, CD44, GLCE
Golgi membrane 2 GLCE, INS
lysosomal membrane 1 HPSE
neuronal cell body 1 TNF
sarcolemma 1 DAG1
Cytoplasm, cytosol 1 AKR1A1
Lysosome 3 GALNS, HEXA, HPSE
plasma membrane 4 CD44, DAG1, F2, TNF
Membrane 6 AGPS, CD44, CYP1B1, DAG1, HEXA, HPSE
apical plasma membrane 2 AKR1A1, CD44
basolateral plasma membrane 2 CD44, DAG1
extracellular exosome 9 AKR1A1, AKR1B1, ALB, CD44, DAG1, F2, GALNS, HEXA, UGDH
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 ALB, HSD17B6
extracellular space 10 AKR1A1, AKR1B1, ALB, DAG1, DCN, F2, HPSE, IL6, INS, TNF
lysosomal lumen 4 DCN, GALNS, HEXA, HPSE
adherens junction 1 DAG1
mitochondrion 4 AGPS, AKR1B1, ARAF, CYP1B1
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 5 CYP1B1, DAG1, HEXA, HPSE, HSD17B6
Microsome membrane 2 CYP1B1, HSD17B6
filopodium 1 DAG1
Single-pass type I membrane protein 1 CD44
Secreted 7 ALB, CD44, DCN, F2, HPSE, IL6, INS
extracellular region 10 ALB, CD44, DAG1, DCN, F2, GALNS, HPSE, IL6, INS, TNF
Single-pass membrane protein 1 CD44
anchoring junction 1 ALB
external side of plasma membrane 2 DAG1, TNF
Secreted, extracellular space, extracellular matrix 1 DCN
recycling endosome 1 TNF
Single-pass type II membrane protein 2 GLCE, TNF
postsynaptic membrane 1 DAG1
Apical cell membrane 1 AKR1A1
Cell membrane, sarcolemma 1 DAG1
Membrane raft 2 HPSE, TNF
focal adhesion 2 CD44, DAG1
GABA-ergic synapse 1 DAG1
extracellular matrix 1 HPSE
Peroxisome 1 AGPS
basement membrane 1 DAG1
peroxisomal matrix 1 AGPS
peroxisomal membrane 1 AGPS
collagen-containing extracellular matrix 3 DAG1, DCN, F2
Postsynaptic cell membrane 1 DAG1
ciliary basal body 1 ALB
cell projection 1 CD44
phagocytic cup 1 TNF
cytoskeleton 1 DAG1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, F2
endosome lumen 1 INS
microvillus 1 CD44
Cell projection, microvillus 1 CD44
Nucleus, nucleoplasm 1 DAG1
Peroxisome membrane 1 AGPS
azurophil granule 1 HEXA
plasma membrane raft 1 DAG1
secretory granule lumen 1 INS
secretory granule membrane 1 CD44
Golgi lumen 4 DAG1, DCN, F2, INS
endoplasmic reticulum lumen 5 ALB, DAG1, F2, IL6, INS
platelet alpha granule lumen 1 ALB
specific granule lumen 1 HPSE
transport vesicle 1 INS
node of Ranvier 1 DAG1
azurophil granule lumen 1 GALNS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
costamere 1 DAG1
dystrophin-associated glycoprotein complex 1 DAG1
contractile ring 1 DAG1
postsynaptic cytosol 1 DAG1
nuclear periphery 1 DAG1
lamellipodium membrane 1 CD44
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
inclusion body 1 MIOX
macrophage migration inhibitory factor receptor complex 1 CD44
interleukin-6 receptor complex 1 IL6
beta-N-acetylhexosaminidase complex 1 HEXA
photoreceptor ribbon synapse 1 DAG1
ciliary transition fiber 1 ALB
[Beta-dystroglycan]: Cell membrane 1 DAG1
dystroglycan complex 1 DAG1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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