Magnolol (BioDeep_00000017310)

Main id: BioDeep_00000398485

Secondary id: BioDeep_00000002599

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


5,5 inverted exclamation mark -Diallyl-2,2 inverted exclamation mark -biphenyldiol

化学式: C18H18O2 (266.1306728)
中文名称: 厚朴酚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O
InChI: InChI=1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2

描述信息

Magnolol is a member of biphenyls.
Magnolol is a natural product found in Magnolia garrettii, Illicium simonsii, and other organisms with data available.
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively.
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively.
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively.

同义名列表

28 个代谢物同义名

5,5 inverted exclamation mark -Diallyl-2,2 inverted exclamation mark -biphenyldiol; 2-[2-hydroxy-5-(prop-2-en-1-yl)phenyl]-4-(prop-2-en-1-yl)phenol; 2-(2-oxidanyl-5-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol; Magnolol, European Pharmacopoeia (EP) Reference Standard; 2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol; 5,5-bis(prop-2-en-1-yl)-[1,1-biphenyl]-2,2-diol; [1,1-Biphenyl]-2,2-diol, 5,5-di-2-propen-1-yl-; 5,5-DI-2-PROPEN-1-YL-(1,1-BIPHENYL)-2,2-DIOL; [1,1-Biphenyl]-2,2-diol, 5,5-di-2-propenyl-; (1,1-Biphenyl)-2,2-diol, 5,5-di-2-propenyl-; 4-allyl-2-(5-allyl-2-hydroxy-phenyl)phenol; 5,5-Di-2-propenyl-[1,1-biphenyl]-2,2-diol; 5,5-di(prop-2-en-1-yl)biphenyl-2,2-diol; Magnolol, >=95\\% (HPLC), from plant; 5,5-Diallyl-[1,1-biphenyl]-2,2-diol; 5,5-diallyl-2,2-dihydroxybiphenyl; 2,2-DIHYDROXY-5,5-DIALLYLBIPHENYL; 5,5-Diallyl-2,2-biphenyldiol; 5,5-Diallylbiphenyl-2,2-diol; Dehydrodichavicol; MAGNOLOL [INCI]; MAGNOLOL [HSDB]; 2,2-Bichavicol; MAGNOLOL [MI]; 2-Bichavicol; Magnolol,(S); SMP2_000086; Magnolol



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

44 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Huiyun Zhang, Yu Zhang, Yunfei Hu, Shunru Wei, Michael Adu-Frimpong, Congyong Sun, Gang Qi. Improving cellular uptake and synergetic anti-tumor effects of magnolol and Brucea javanica oil through self-microemulsion. Drug development and industrial pharmacy. 2024 May; 50(5):401-409. doi: 10.1080/03639045.2024.2329730. [PMID: 38466185]
  • Wei Li, Jie Lin, Jie Zhou, Siqi He, Anqi Wang, Yingfan Hu, Hanmei Li, Liang Zou, Ya Liu. Hyaluronic acid-functionalized DDAB/PLGA nanoparticles for improved oral delivery of magnolol in the treatment of ulcerative colitis. International journal of pharmaceutics. 2024 Mar; 653(?):123878. doi: 10.1016/j.ijpharm.2024.123878. [PMID: 38325622]
  • Katarzyna Szałabska-Rąpała, Maria Zych, Weronika Borymska, Piotr Londzin, Sławomir Dudek, Ilona Kaczmarczyk-Żebrowska. Beneficial effect of honokiol and magnolol on polyol pathway and oxidative stress parameters in the testes of diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Mar; 172(?):116265. doi: 10.1016/j.biopha.2024.116265. [PMID: 38364735]
  • Jing Yu, Xiaoyan Gao, Lijun Zhang, Hang Shi, Yingxuan Yan, Yongli Han, Chengyuan Wu, Ying Liu, Minglv Fang, Cheng Huang, Shengjie Fan. Magnolol extends lifespan and improves age-related neurodegeneration in Caenorhabditis elegans via increase of stress resistance. Scientific reports. 2024 02; 14(1):3158. doi: 10.1038/s41598-024-53374-9. [PMID: 38326350]
  • Jian Jiang, Xuefeng Hou, Kangjie Xu, Kangkang Ji, Zhongkai Ji, Juqun Xi, Xin Wang. Bacteria-targeted magnolol-loaded multifunctional nanocomplexes for antibacterial and anti-inflammatory treatment. Biomedical materials (Bristol, England). 2024 Jan; ?(?):. doi: 10.1088/1748-605x/ad2406. [PMID: 38290149]
  • Yue Yang, Zihe Li, Hang Zong, Shimeng Liu, Qiuhui Du, Hao Wu, Zhenzhu Li, Xiao Wang, Lihui Huang, Changlong Lai, Meide Zhang, Wen Wang, Xianqing Chen. Identification and Validation of Magnolol Biosynthesis Genes in Magnolia officinalis. Molecules (Basel, Switzerland). 2024 Jan; 29(3):. doi: 10.3390/molecules29030587. [PMID: 38338333]
  • Xi Fan, Zhuangzhuang Zhang, Wenxia Gao, Qingqing Pan, Kui Luo, Bin He, Yuji Pu. An Engineered Butyrate-Derived Polymer Nanoplatform as a Mucosa-Healing Enhancer Potentiates the Therapeutic Effect of Magnolol in Inflammatory Bowel Disease. ACS nano. 2024 Jan; 18(1):229-244. doi: 10.1021/acsnano.3c05732. [PMID: 38112525]
  • Yi Chu, Yazhen Zheng, Yingying Li, Sisi Gui, Jingwu Zhao, Yaxiang Zhao, Xiaodong Chen. Dietary supplementation of magnolol alleviates fatty liver hemorrhage syndrome in postpeak Xinhua laying hens via regulation of liver lipid metabolism. Poultry science. 2023 Dec; 103(3):103378. doi: 10.1016/j.psj.2023.103378. [PMID: 38228060]
  • Jintao Wang, Huan Liu, Zhuolin Sun, Xinyi Zou, Zixuan Zhang, Xiaofeng Wei, Lanying Pan, Antony Stalin, Wei Zhao, Yuan Chen. The Inhibitory Effect of Magnolol on the Human TWIK1 Channel Is Related to G229 and T225 Sites. Molecules (Basel, Switzerland). 2023 Sep; 28(19):. doi: 10.3390/molecules28196815. [PMID: 37836658]
  • Lin Niu, Yu-Jie Lu, Xing-Wang Zu, Wen Yang, Fu-Kui Shen, Yan-Yan Xu, Min Jiang, Yang Xie, Su-Yun Li, Jie Gao, Gang Bai. Magnolol alleviates pulmonary fibrosis inchronic obstructive pulmonary disease by targeting transient receptor potential vanilloid 4-ankyrin repeat domain. Phytotherapy research : PTR. 2023 Sep; 37(9):4282-4297. doi: 10.1002/ptr.7907. [PMID: 37282760]
  • Jian-Yu Chen, Xiao-Yun Tian, Shan-Shan Wei, Wen Xu, Rong-Rong Pan, Lin-Lin Chen, Lang-Dong Chen, Li-Hong Nan, Yao-Lin, Shan-Deng, Qian-Qian Wang, Xue-Qin Ma, Ming-Qing Huang. Magnolol as STAT3 inhibitor for treating multiple sclerosis by restricting Th17 cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Aug; 117(?):154917. doi: 10.1016/j.phymed.2023.154917. [PMID: 37301184]
  • Riccardo Fontana, Laura Beatrice Mattioli, Giulia Biotti, Roberta Budriesi, Roberto Gotti, Matteo Micucci, Ivan Corazza, Peggy Marconi, Maria Frosini, Stefano Manfredini, Raissa Buzzi, Silvia Vertuani. Magnolia officinalis L. bark extract and respiratory diseases: From traditional Chinese medicine to western medicine via network target. Phytotherapy research : PTR. 2023 Jul; 37(7):2915-2938. doi: 10.1002/ptr.7786. [PMID: 36879409]
  • Ge Gao, Shaofang Niu, Tongtong Liu, Yan Zhang, Xueqing Zhao, Zhishang Shi, Shuai Chen, Mengmeng Wu, Guoqiang Li, Ting Ma. Fabrication of bacterial cellulose composites with antimicrobial properties by in situ modification utilizing the specific function-suspension containing water-insoluble magnolol. International journal of biological macromolecules. 2023 Apr; 239(?):124329. doi: 10.1016/j.ijbiomac.2023.124329. [PMID: 37019196]
  • Jia Cao, Shixia Zhang, Yanshuang Hao, Kai Fan, Lingling Wang, Xinghua Zhao, Xin He. Amorphous solid dispersion preparation via coprecipitation improves the dissolution, oral bioavailability, and intestinal health enhancement properties of magnolol. Poultry science. 2023 Apr; 102(6):102676. doi: 10.1016/j.psj.2023.102676. [PMID: 37104903]
  • Hu Qiao, Zhang Tengfei, Zhang Wenting, Lu Qin, Guo Yunqing, Cao Xiaoyi, Shao Huabin, Zhai Xinguo, Luo Qingping. Mechanistic insights of magnolol antimicrobial activity against Mycoplasma using untargeted metabolomic analyses. Frontiers in cellular and infection microbiology. 2023; 13(?):1325347. doi: 10.3389/fcimb.2023.1325347. [PMID: 38152121]
  • Juanzhen Yang, Yuxi Wei, Tong Zhao, Xiaoqian Li, Xuejian Zhao, Xingnan Ouyang, Lihua Zhou, Xiuqin Zhan, Minyi Qian, Jiaying Wang, Xu Shen. Magnolol effectively ameliorates diabetic peripheral neuropathy in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Dec; 107(?):154434. doi: 10.1016/j.phymed.2022.154434. [PMID: 36122436]
  • Jidan Zhang, Hongmei Li, Liwei Hou, Jianhui Sun, Weihao Wang, Hua Li, Weipeng Yang, Peijing Rong, Tiegui Nan, Liping Kang, Bin Yang. Pharmacokinetics and metabolites of glycosides and lignans of the stem bark of Magnolia officinalis in functional dyspepsia and normal rats using liquid chromatography-tandem mass spectrometry. Journal of separation science. 2022 Oct; 45(19):3663-3678. doi: 10.1002/jssc.202100982. [PMID: 35908283]
  • Fang Chen, Hao Zhang, Na Zhao, Encun Du, Feng Jin, Qiwen Fan, Wanzheng Guo, Shaowen Huang, Jintao Wei. Effects of magnolol and honokiol blend on performance, egg quality, hepatic lipid metabolism, and intestinal morphology of hens at late laying cycle. Animal : an international journal of animal bioscience. 2022 Jun; 16(6):100532. doi: 10.1016/j.animal.2022.100532. [PMID: 35576638]
  • Lin Niu, Jie Wang, Fukui Shen, Jie Gao, Min Jiang, Gang Bai. Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle. Journal of ethnopharmacology. 2022 May; 290(?):115105. doi: 10.1016/j.jep.2022.115105. [PMID: 35157953]
  • Chia-Yu Tang, Chang-Chi Lai, Po-Hsun Huang, An-Han Yang, Shu-Chiung Chiang, Po-Chao Huang, Kuo-Wei Tseng, Cheng-Hsiung Huang. Magnolol reduces myocardial injury induced by renal ischemia and reperfusion. Journal of the Chinese Medical Association : JCMA. 2022 05; 85(5):584-596. doi: 10.1097/jcma.0000000000000727. [PMID: 35385419]
  • Jing Zhao, Pan Gao, Chengqiao Mu, Jingqi Ning, Wenbin Deng, Dongxu Ji, Haowei Sun, Xiangrong Zhang, Xinggang Yang. Preparation and Evaluation of Novel Supersaturated Solid Dispersion of Magnolol : Theme: Advancements in Amorphous Solid Dispersions to Improve Bioavailability. AAPS PharmSciTech. 2022 Mar; 23(4):97. doi: 10.1208/s12249-022-02251-7. [PMID: 35332440]
  • Xiaolin Dai, Long Xie, Kai Liu, Youdan Liang, Yi Cao, Jing Lu, Xian Wang, Xumin Zhang, Xiaofang Li. The neuropharmacological effects of magnolol and honokiol：a review of signal pathways and molecular mechanisms. Current molecular pharmacology. 2022 Feb; ?(?):. doi: 10.2174/1874467215666220223141101. [PMID: 35196977]
  • Sayeh Mottaghi, Hassan Abbaszadeh. Natural Lignans Honokiol and Magnolol as Potential Anticarcinogenic and Anticancer Agents. A Comprehensive Mechanistic Review. Nutrition and cancer. 2022; 74(3):761-778. doi: 10.1080/01635581.2021.1931364. [PMID: 34047218]
  • Ting Chen, Lan Shou, Xiaowen Guo, Mingyang Wei, Hui Zheng, Tao Tao. Magnolol attenuates the locomotor impairment, cognitive deficit, and neuroinflammation in Alzheimer's disease mice with brain insulin resistance via up-regulating miR-200c. Bioengineered. 2022 01; 13(1):531-543. doi: 10.1080/21655979.2021.2009975. [PMID: 34968163]
  • Min Young Kim, Jae Woo Han, Quang Le Dang, Jin-Cheol Kim, Hun Kim, Gyung Ja Choi. Characterization of Alternaria porri causing onion purple blotch and its antifungal compound magnolol identified from Caryodaphnopsis baviensis. PloS one. 2022; 17(1):e0262836. doi: 10.1371/journal.pone.0262836. [PMID: 35051224]
  • Feng-Ling Zhang, Xiao-Jie Yin, Yun-Liang Yan, Qiao-Feng Wu. Pharmacokinetics and Pharmacodynamics of Huanglian-Houpo Decoction Based on Berberine Hydrochloride and Magnolol Against H1N1 Influenza Virus. European journal of drug metabolism and pharmacokinetics. 2022 Jan; 47(1):57-67. doi: 10.1007/s13318-021-00724-x. [PMID: 34635990]
  • Chung-Ping Yu, Pei-Ying Li, Szu-Yu Chen, Shiuan-Pey Lin, Yu-Chi Hou. Magnolol and Honokiol Inhibited the Function and Expression of BCRP with Mechanism Exploration. Molecules (Basel, Switzerland). 2021 Dec; 26(23):. doi: 10.3390/molecules26237390. [PMID: 34885972]
  • Qiwen Fan, Fang Chen, Wei Zhang, Encun Du, Na Zhao, Shaowen Huang, Wanzheng Guo, Xianghua Yan, Mingxin Chen, Jintao Wei. Maternal magnolol supplementation alters placental morphology, promotes placental angiogenesis during mid-gestation and improves offspring growth in a pregnant mouse model. Reproductive biology. 2021 Dec; 21(4):100567. doi: 10.1016/j.repbio.2021.100567. [PMID: 34653815]
  • Encun Du, Qiwen Fan, Na Zhao, Wei Zhang, Jintao Wei, Fang Chen, Shaowen Huang, Wanzheng Guo. Supplemental magnolol improves the antioxidant capacity and intestinal health of broiler chickens. Animal science journal = Nihon chikusan Gakkaiho. 2021 Dec; 92(1):e13665. doi: 10.1111/asj.13665. [PMID: 34874084]
  • Georgiana Ioana Potra Cicalău, Petru Aurel Babes, Horia Calniceanu, Adelina Popa, Gabriela Ciavoi, Gilda Mihaela Iova, Mariana Ganea, Ioana Scrobotă. Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26226899. [PMID: 34833990]
  • Ting Wang, Kaiju Xu, Liyun Zhao, Rongsheng Tong, Liang Xiong, Jianyou Shi. Recent research and development of NDM-1 inhibitors. European journal of medicinal chemistry. 2021 Nov; 223(?):113667. doi: 10.1016/j.ejmech.2021.113667. [PMID: 34225181]
  • Hu Li, Ying-Hui He, Yong-Mei Hu, Qing-Ru Chu, Yong-Jia Chen, Zhen-Rong Wu, Zhi-Jun Zhang, Ying-Qian Liu, Cheng-Jie Yang, Hong-Jie Liang, Yin-Fang Yan. Design, Synthesis, and Structure-Activity Relationship Studies of Magnolol Derivatives as Antifungal Agents. Journal of agricultural and food chemistry. 2021 Oct; 69(40):11781-11793. doi: 10.1021/acs.jafc.1c01838. [PMID: 34582205]
  • Feixu Mo, Xianfeng Hu, Yi Ding, Rongyu Li, Youhua Long, Xiaomao Wu, Ming Li. Naturally produced magnolol can significantly damage the plasma membrane of Rhizoctonia solani. Pesticide biochemistry and physiology. 2021 Oct; 178(?):104942. doi: 10.1016/j.pestbp.2021.104942. [PMID: 34446208]
  • Katarzyna Szałabska-Rąpała, Weronika Borymska, Ilona Kaczmarczyk-Sedlak. Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its Complications and Comorbidities-A Review. International journal of molecular sciences. 2021 Sep; 22(18):. doi: 10.3390/ijms221810050. [PMID: 34576213]
  • Xiao Wang, Huan Gu, Huan Zhang, Jing Xian, Jingjing Li, Chaomei Fu, Chen Zhang, Jinming Zhang. Oral Core-Shell Nanoparticles Embedded in Hydrogel Microspheres for the Efficient Site-Specific Delivery of Magnolol and Enhanced Antiulcerative Colitis Therapy. ACS applied materials & interfaces. 2021 Jul; 13(29):33948-33961. doi: 10.1021/acsami.1c09804. [PMID: 34261306]
  • Ling Chen, Yu-Ting Wu, Xuan-Ye Gu, Ling-Peng Xie, Hui-Jie Fan, Zhang-Bin Tan, Wen-Tong Zhang, Hong-Mei Chen, Jun Li, Gui-Qiong Huang, Bin Liu, Ying-Chun Zhou, Xiao-Min Sun. Magnolol, a natural aldehyde dehydrogenase-2 agonist, inhibits the proliferation and collagen synthesis of cardiac fibroblasts. Bioorganic & medicinal chemistry letters. 2021 07; 43(?):128045. doi: 10.1016/j.bmcl.2021.128045. [PMID: 33865968]
  • Chenxia Han, Dan Du, Yongjian Wen, Jiawang Li, Rui Wang, Tao Jin, Jingyu Yang, Na Shi, Kun Jiang, Lihui Deng, Xianghui Fu, Rajarshi Mukherjee, John A Windsor, Jiwon Hong, Anthony R Phillips, Robert Sutton, Wei Huang, Tingting Liu, Qing Xia. Chaiqin chengqi decoction ameliorates acute pancreatitis in mice via inhibition of neuron activation-mediated acinar cell SP/NK1R signaling pathways. Journal of ethnopharmacology. 2021 Jun; 274(?):114029. doi: 10.1016/j.jep.2021.114029. [PMID: 33731310]
  • Jing An, Chaoxing He, Caihui Guo, Zhanjun Dong. Application of hollow fiber centrifugal ultrafiltrate purification as the pretreatment technology for traditional Chinese medicine: its application for analysis of honokiol and magnolol in TCM preparations containing Cortex Magnoliae Officinalis. Annals of palliative medicine. 2021 Jun; 10(6):6359-6366. doi: 10.21037/apm-21-242. [PMID: 33752432]
  • Dongmei Jiang, Dizhe Wei, Hongtao Li, Liuqing Wang, Nan Jiang, Yunchao Li, Meng Wang. Natural occurrence of Alternaria mycotoxins in wheat and potential of reducing associated risks using magnolol. Journal of the science of food and agriculture. 2021 May; 101(7):3071-3077. doi: 10.1002/jsfa.10901. [PMID: 33124688]
  • Weimei Jin, Xiaoli Wang, Yuxiao Zeng, Yifen Lan, Xiaoqiu Wang. Magnolol suppressed cell migration and invasion and induced cell apoptosis via inhibition of the NF-κB signaling pathway by upregulating microRNA-129 in multiple myeloma. Neoplasma. 2021 Mar; 68(2):404-415. doi: 10.4149/neo_2020_200923n1010. [PMID: 33440989]
  • Yuhong Cao, Yan Cao, Yiwei Shi, Ying Cai, Langdong Chen, Dongyao Wang, Yue Liu, Xiaofei Chen, Zhenyu Zhu, Zhanying Hong, Yifeng Chai. Surface plasmon resonance biosensor combined with lentiviral particle stabilization strategy for rapid and specific screening of P-Glycoprotein ligands. Analytical and bioanalytical chemistry. 2021 Mar; 413(7):2021-2031. doi: 10.1007/s00216-021-03170-5. [PMID: 33528601]
  • Yu Chen, Xiuyun He, Dagang Feng, Shijie Li. Compare the Effects of Magnolol on Gastric Cancer Cells Through c-Jun N-Terminal Kinase Signaling Pathway and Gold Magnetic. Journal of nanoscience and nanotechnology. 2021 Feb; 21(2):943-948. doi: 10.1166/jnn.2021.18688. [PMID: 33183428]
  • Kuo-Chou Chiu, Yin-Hwa Shih, Tong-Hong Wang, Wan-Chen Lan, Po-Jung Li, Hong-Syu Jhuang, Shih-Min Hsia, Yen-Wen Shen, Michael Yuan-Chien Chen, Tzong-Ming Shieh. In vitro antimicrobial and antipro-inflammation potential of honokiol and magnolol against oral pathogens and macrophages. Journal of the Formosan Medical Association = Taiwan yi zhi. 2021 Feb; 120(2):827-837. doi: 10.1016/j.jfma.2020.09.002. [PMID: 32978046]
  • Fang Chen, Hao Zhang, Encun Du, Feng Jin, Chao Zheng, Qiwen Fan, Na Zhao, Wanzheng Guo, Wei Zhang, Shaowen Huang, Jintao Wei. Effects of magnolol on egg production, egg quality, antioxidant capacity, and intestinal health of laying hens in the late phase of the laying cycle. Poultry science. 2021 Feb; 100(2):835-843. doi: 10.1016/j.psj.2020.10.047. [PMID: 33518137]
  • Min Zhao, Yun-Hua Zheng, Qi-Yuan Zhao, Wei Zheng, Jian-Hong Yang, He-Ying Pei, Ling Liu, Kong-Jun Liu, Lin-Lin Xue, De-Xin Deng, Lun Wang, Xu Ma, Su-Hong Fu, Ai-Hua Peng, Ming-Hai Tang, Yun-Zi Luo, Hao-Yu Ye, Li-Juan Chen. Synthesis and evaluation of new compounds bearing 3-(4-aminopiperidin-1-yl)methyl magnolol scaffold as anticancer agents for the treatment of non-small cell lung cancer via targeting autophagy. European journal of medicinal chemistry. 2021 Jan; 209(?):112922. doi: 10.1016/j.ejmech.2020.112922. [PMID: 33069436]
  • Qian Lin, Yang Liu, Simin Peng, Chunjie Liu, Tuo Lv, Liping Liao, Yinghui Li, Yanzhou Wang, Zhiyong Fan, Weiguo Wu, Jianguo Zeng, Huajiao Qiu, Xi He, Qiuzhong Dai. Magnolol additive improves growth performance of Linwu ducklings by modulating antioxidative status. PloS one. 2021; 16(12):e0259896. doi: 10.1371/journal.pone.0259896. [PMID: 34972101]
  • Hyojin Kim, Chae Yeon Lim, Mi Sook Chung. Magnolia officinalis and Its Honokiol and Magnolol Constituents Inhibit Human Norovirus Surrogates. Foodborne pathogens and disease. 2021 01; 18(1):24-30. doi: 10.1089/fpd.2020.2805. [PMID: 32716659]
  • Hong-Liang Lin, Wen-Ting Cheng, Ling-Chun Chen, Hsiu-O Ho, Shyr-Yi Lin, Chien-Ming Hsieh. Honokiol/Magnolol-Loaded Self-Assembling Lecithin-Based Mixed Polymeric Micelles (lbMPMs) for Improving Solubility to Enhance Oral Bioavailability. International journal of nanomedicine. 2021; 16(?):651-665. doi: 10.2147/ijn.s290444. [PMID: 33536753]
  • Guoyuan Li, Yuting Lu, Yongchun Fan, Qing Ning, Weiguang Li. Enhanced oral bioavailability of magnolol via mixed micelles and nanosuspensions based on Soluplus®-Poloxamer 188. Drug delivery. 2020 Dec; 27(1):1010-1017. doi: 10.1080/10717544.2020.1785582. [PMID: 32631085]
  • Ting Xu, Zhiyuan Zheng, Yong Guo, Li-Ping Bai. Semisynthesis of novel magnolol-based Mannich base derivatives that suppress cancer cells via inducing autophagy. European journal of medicinal chemistry. 2020 Nov; 205(?):112663. doi: 10.1016/j.ejmech.2020.112663. [PMID: 32791403]
  • Eliza Łata, Agnieszka Fulczyk, Péter G Ott, Teresa Kowalska, Mieczysław Sajewicz, Ágnes M Móricz. Thin-layer chromatographic quantification of magnolol and honokiol in dietary supplements and selected biological properties of these preparations. Journal of chromatography. A. 2020 Aug; 1625(?):461230. doi: 10.1016/j.chroma.2020.461230. [PMID: 32709311]
  • Jingwei Zhou, Yaoyao Hu, Peichun Chen, Hongwu Zhang. Preparation of restricted access monolithic tip via unidirectional freezing and atom transfer radical polymerization for directly extracting magnolol and honokiol from rat plasma followed by liquid chromatography analysis. Journal of chromatography. A. 2020 Aug; 1625(?):461238. doi: 10.1016/j.chroma.2020.461238. [PMID: 32709314]
  • Cheng Tao, Jian Chen, Xiaofei Huang, Zide Chen, Xinping Li, Yinghong Li, Youqin Xu, Min Ma, Zhengzhi Wu. CT1-3, a novel magnolol-sulforaphane hybrid suppresses tumorigenesis through inducing mitochondria-mediated apoptosis and inhibiting epithelial mesenchymal transition. European journal of medicinal chemistry. 2020 Aug; 199(?):112441. doi: 10.1016/j.ejmech.2020.112441. [PMID: 32416457]
  • Danting Li, Bo Lv, Di Wang, Doudou Xu, Siyuan Qin, Ying Zhang, Jie Chen, Wei Zhang, Zunjian Zhang, Fengguo Xu. Network Pharmacology and Bioactive Equivalence Assessment Integrated Strategy Driven Q-markers Discovery for Da-Cheng-Qi Decoction to Attenuate Intestinal Obstruction. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Jul; 72(?):153236. doi: 10.1016/j.phymed.2020.153236. [PMID: 32464544]
  • Dinh Bui, Li Li, Taijun Yin, Xinli Wang, Song Gao, Ming You, Rashim Singh, Ming Hu. Pharmacokinetic and Metabolic Profiling of Key Active Components of Dietary Supplement Magnolia officinalis Extract for Prevention against Oral Carcinoma. Journal of agricultural and food chemistry. 2020 Jun; 68(24):6576-6587. doi: 10.1021/acs.jafc.0c01475. [PMID: 32348135]
  • Mona Elhabak, Rihab Osman, Mona Mohamed, Ola M El-Borady, Gehanne A S Awad, Nahed Mortada. Near IR responsive targeted integrated lipid polymer nanoconstruct for enhanced magnolol cytotoxicity in breast cancer. Scientific reports. 2020 05; 10(1):8771. doi: 10.1038/s41598-020-65521-z. [PMID: 32472087]
  • Chun-Min Su, Yueh-Shan Weng, Lin-Yen Kuan, Jiann-Hwa Chen, Fei-Ting Hsu. Suppression of PKCδ/NF-κB Signaling and Apoptosis Induction through Extrinsic/Intrinsic Pathways Are Associated Magnolol-Inhibited Tumor Progression in Colorectal Cancer In Vitro and In Vivo. International journal of molecular sciences. 2020 May; 21(10):. doi: 10.3390/ijms21103527. [PMID: 32429376]
  • Qi Zhang, Gang Cheng, Jing Pan, Jacek Zielonka, Donghai Xiong, Charles R Myers, Liang Feng, Song Seok Shin, Young Heui Kim, Dinh Bui, Ming Hu, Brian Bennett, Kathleen Schmainda, Yian Wang, Balaraman Kalyanaraman, Ming You. Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I. Cell communication and signaling : CCS. 2020 04; 18(1):58. doi: 10.1186/s12964-020-0524-2. [PMID: 32264893]
  • Jian Chen, Cheng Tao, Xiaofei Huang, Zide Chen, Li Wang, Xinping Li, Min Ma, Zhengzhi Wu. CT2-3, a novel magnolol analogue suppresses NSCLC cells through triggering cell cycle arrest and apoptosis. Bioorganic & medicinal chemistry. 2020 03; 28(6):115352. doi: 10.1016/j.bmc.2020.115352. [PMID: 32044229]
  • Jing Li, Daniëlle Copmans, Michèle Partoens, Borbála Hunyadi, Walter Luyten, Peter de Witte. Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine: Magnolia officinalis Extract and Its Constituents Magnolol and Honokiol Exhibit Potent Anticonvulsant Activity in a Therapy-Resistant Epilepsy Model. ACS chemical neuroscience. 2020 03; 11(5):730-742. doi: 10.1021/acschemneuro.9b00610. [PMID: 32083464]
  • Jai-Jen Tsai, Jiann-Hwa Chen, Cheng Hsien Chen, Jing-Gung Chung, Fei-Ting Hsu. Apoptosis induction and ERK/NF-κB inactivation are associated with magnolol-inhibited tumor progression in hepatocellular carcinoma in vivo. Environmental toxicology. 2020 Feb; 35(2):167-175. doi: 10.1002/tox.22853. [PMID: 31714653]
  • Qian Lin, Simin Peng, Yinghui Li, Guitao Jiang, Zhenzhang Liao, Zhiyong Fan, Xi He, Qiuzhong Dai. Magnolol additive improves carcass and meat quality of Linwu ducks by modulating antioxidative status. Animal science journal = Nihon chikusan Gakkaiho. 2020 Jan; 91(1):e13301. doi: 10.1111/asj.13301. [PMID: 31729108]
  • Yuan Yuan, Xiaocui Zhou, Yuanyuan Wang, Yan Wang, Xiangyan Teng, Shuaiyu Wang. Cardiovascular Modulating Effects of Magnolol and Honokiol, Two Polyphenolic Compounds from Traditional Chinese Medicine-Magnolia Officinalis. Current drug targets. 2020; 21(6):559-572. doi: 10.2174/1389450120666191024175727. [PMID: 31749425]
  • Da Qing Yu, Xiao Jing Han, Ting Yu Shan, Rui Xu, Jin Hu, Wang Xing Cheng, Liang Ping Zha, Hua Sheng Peng. Microscopic Characteristic and Chemical Composition Analysis of Three Medicinal Plants and Surface Frosts. Molecules (Basel, Switzerland). 2019 Dec; 24(24):. doi: 10.3390/molecules24244548. [PMID: 31842368]
  • Yongtao Bai, Lihua Song, Yongheng Zhang, Guoliang Dai, Weidong Zhang, Shanshan Song, Hong Sun, Wen Jing, Meijuan Xu, Wenzheng Ju. Comparative pharmacokinetic study of four major bioactive components after oral administration of Zhi-Zi-Hou-Po decoction in normal and corticosterone-induced depressive rats. Biomedical chromatography : BMC. 2019 Sep; 33(9):e4542. doi: 10.1002/bmc.4542. [PMID: 30947404]
  • Ding Lin, Zhongzhong Yan, Aiyu Chen, Jiao Ye, Aixi Hu, Juan Liu, Junmei Peng, Xiaoyun Wu. Anti-proliferative activity and structure-activity relationship of honokiol derivatives. Bioorganic & medicinal chemistry. 2019 08; 27(16):3729-3734. doi: 10.1016/j.bmc.2019.06.042. [PMID: 31278004]
  • Maria Teresa Faleschini, Anne Maier, Sarah Fankhauser, Katharina Thasis, Simon Hebeisen, Matthias Hamburger, Veronika Butterweck. A FLIPR Assay for Discovery of GABAA Receptor Modulators of Natural Origin. Planta medica. 2019 Aug; 85(11-12):925-933. doi: 10.1055/a-0921-7602. [PMID: 31127604]
  • Yun-Qing Song, Zi-Miao Weng, Tong-Yi Dou, Moshe Finel, Ya-Qiao Wang, Le-Le Ding, Qiang Jin, Dan-Dan Wang, Sheng-Quan Fang, Yun-Feng Cao, Jie Hou, Guang-Bo Ge. Inhibition of human carboxylesterases by magnolol: Kinetic analyses and mechanism. Chemico-biological interactions. 2019 Aug; 308(?):339-349. doi: 10.1016/j.cbi.2019.06.003. [PMID: 31170387]
  • Lan Tang, Zhuanfeng Zhu, Miao Xie, Lipeng Cao, Xiao Lan Yu, Ran Zhang, Zhimin Ou, Weiguang Shan, Zhenhai Zhang. Effects of β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin Inclusions on the Degradation of Magnolol by Intestinal Bacteria. AAPS PharmSciTech. 2019 Jul; 20(6):244. doi: 10.1208/s12249-019-1397-9. [PMID: 31286296]
  • Ya-Han Chen, Mei-Huan Lu, Dong-Sheng Guo, Ying-Yan Zhai, Dan Miao, Jian-Ying Yue, Chen-Hong Yuan, Ming-Min Zhao, De-Rong An. Antifungal Effect of Magnolol and Honokiol from Magnolia officinalis on Alternaria alternata Causing Tobacco Brown Spot. Molecules (Basel, Switzerland). 2019 Jun; 24(11):. doi: 10.3390/molecules24112140. [PMID: 31174300]
  • Wen Zhou, Xuemei Lin, Jun Chu, Tao Jiang, Huiyu Zhao, Bo Yan, Zhongmin Zhang. Magnolol prevents ossified tendinopathy by inhibiting PGE2-induced osteogenic differentiation of TDSCs. International immunopharmacology. 2019 May; 70(?):117-124. doi: 10.1016/j.intimp.2019.02.010. [PMID: 30798160]
  • Subasri Subramaniyan, Phaniendra Alugoju, Sudharshan Sj, Bhavana Veerabhadrappa, Madhu Dyavaiah. Magnolol protects Saccharomyces cerevisiae antioxidant-deficient mutants from oxidative stress and extends yeast chronological life span. FEMS microbiology letters. 2019 04; 366(8):. doi: 10.1093/femsle/fnz065. [PMID: 30924879]
  • Wen-Yong Fei, Qiang Huo, Pei-Qing Zhao, Long-Juan Qin, Tao Li. Magnolol prevents ovariectomy‑induced bone loss by suppressing osteoclastogenesis via inhibition of the nuclear factor‑κB and mitogen‑activated protein kinase pathways. International journal of molecular medicine. 2019 Apr; 43(4):1669-1678. doi: 10.3892/ijmm.2019.4099. [PMID: 30816431]
  • Abdullah Al Emran, Brinda Reddy Chinna Chowdary, Farzana Ahmed, Heinz Hammerlindl, Antje Huefner, Nikolas K Haass, Wolfgang Schuehly, Helmut Schaider. Magnolol induces cell death through PI3K/Akt-mediated epigenetic modifications boosting treatment of BRAF- and NRAS-mutant melanoma. Cancer medicine. 2019 03; 8(3):1186-1196. doi: 10.1002/cam4.1978. [PMID: 30793515]
  • Yang Hu, Yufeng Shen, Xiao Tu, Xiaohu Wu, Gao-Xue Wang, Fei Ling. Isolation of anti-Saprolegnia lignans from Magnolia officinalis and SAR evaluation of honokiol/magnolol analogs. Bioorganic & medicinal chemistry letters. 2019 02; 29(3):389-395. doi: 10.1016/j.bmcl.2018.12.038. [PMID: 30579792]
  • Haiyan Wen, Siqi Zhou, Jinchun Song. Induction of apoptosis by magnolol via the mitochondrial pathway and cell cycle arrest in renal carcinoma cells. Biochemical and biophysical research communications. 2019 01; 508(4):1271-1278. doi: 10.1016/j.bbrc.2018.12.087. [PMID: 30573364]
  • Safa Oufensou, Barbara Scherm, Giovanna Pani, Virgilio Balmas, Davide Fabbri, Maria Antonietta Dettori, Paola Carta, Ismael Malbrán, Quirico Migheli, Giovanna Delogu. Honokiol, magnolol and its monoacetyl derivative show strong anti-fungal effect on Fusarium isolates of clinical relevance. PloS one. 2019; 14(9):e0221249. doi: 10.1371/journal.pone.0221249. [PMID: 31483823]
  • Hongce Chen, Wuyu Fu, Hongyuan Chen, Siyuan You, Xiawan Liu, Yujiao Yang, Yao Wei, Jun Huang, Wen Rui. Magnolol attenuates the inflammation and enhances phagocytosis through the activation of MAPK, NF-κB signal pathways in vitro and in vivo. Molecular immunology. 2019 01; 105(?):96-106. doi: 10.1016/j.molimm.2018.11.008. [PMID: 30500626]
  • Jianhong Zhang, Zhixi Chen, Xianhua Huang, Weimei Shi, Rui Zhang, Meiling Chen, Hao Huang, Longhuo Wu. Insights on the Multifunctional Activities of Magnolol. BioMed research international. 2019; 2019(?):1847130. doi: 10.1155/2019/1847130. [PMID: 31240205]
  • Andrea Sarrica, Natalja Kirika, Margherita Romeo, Mario Salmona, Luisa Diomede. Safety and Toxicology of Magnolol and Honokiol. Planta medica. 2018 Nov; 84(16):1151-1164. doi: 10.1055/a-0642-1966. [PMID: 29925102]
  • Kristen Stout, Marketa Bernaskova, Gary W Miller, Antje Hufner, Wolfgang Schuehly. Bioinspired Honokiol Analogs and Their Evaluation for Activity on the Norepinephrine Transporter. Molecules (Basel, Switzerland). 2018 Oct; 23(10):. doi: 10.3390/molecules23102536. [PMID: 30287800]
  • Tong-Hua Yang, Yun-Bao Ma, Chang-An Geng, De-Xiu Yan, Xiao-Yan Huang, Tian-Ze Li, Xue-Mei Zhang, Ji-Jun Chen. Synthesis and biological evaluation of magnolol derivatives as melatonergic receptor agonists with potential use in depression. European journal of medicinal chemistry. 2018 Aug; 156(?):381-393. doi: 10.1016/j.ejmech.2018.07.027. [PMID: 30015074]
  • Sang-Bum Kim, Kyu-Sang Kim, Heon-Min Ryu, Seong-Ho Hong, Bo-Kyoung Kim, Dae-Duk Kim, Jin Woo Park, In-Soo Yoon. Modulation of Rat Hepatic CYP1A and 2C Activity by Honokiol and Magnolol: Differential Effects on Phenacetin and Diclofenac Pharmacokinetics In Vivo. Molecules (Basel, Switzerland). 2018 06; 23(6):. doi: 10.3390/molecules23061470. [PMID: 29914211]
  • Jie Cheng, Shuqi Dong, Litao Yi, Di Geng, Qing Liu. Magnolol abrogates chronic mild stress-induced depressive-like behaviors by inhibiting neuroinflammation and oxidative stress in the prefrontal cortex of mice. International immunopharmacology. 2018 Jun; 59(?):61-67. doi: 10.1016/j.intimp.2018.03.031. [PMID: 29627576]
  • Yanli Deng, Xuefeng Han, Shaoxun Tang, Chengjian Li, Wenjun Xiao, Zhiliang Tan. Magnolol and Honokiol Attenuate Apoptosis of Enterotoxigenic Escherichia Coli-Induced Intestinal Epithelium by Maintaining Secretion and Absorption Homeostasis and Protecting Mucosal Integrity. Medical science monitor : international medical journal of experimental and clinical research. 2018 May; 24(?):3348-3356. doi: 10.12659/msm.910350. [PMID: 29782483]
  • Wei Liu, Xiashi Zhu. Simultaneous determination of Magnolol and Honokiol by amino acid ionic liquid synchronous fluorescence spectrometry. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2018 May; 196(?):141-147. doi: 10.1016/j.saa.2018.01.067. [PMID: 29448168]
  • Ling Xiao, Liangliang Zhu, Wenjuan Li, Conghu Li, Yunfeng Cao, Guangbo Ge, Xiaoyu Sun. New Insights into SN-38 Glucuronidation: Evidence for the Important Role of UDP Glucuronosyltransferase 1A9. Basic & clinical pharmacology & toxicology. 2018 Apr; 122(4):424-428. doi: 10.1111/bcpt.12929. [PMID: 29076612]
  • Hongxue Shen, Sheng Liu, Pinggang Ding, Lulu Wang, Jianming Ju, Guohui Liang. Enhancement of oral bioavailability of magnolol by encapsulation in mixed micelles containing pluronic F127 and L61. The Journal of pharmacy and pharmacology. 2018 Apr; 70(4):498-506. doi: 10.1111/jphp.12887. [PMID: 29433156]
  • Yong Zhang, Li-Tang Fu, Fang Tang. The protective effects of magnolol on acute trinitrobenzene sulfonic acid‑induced colitis in rats. Molecular medicine reports. 2018 03; 17(3):3455-3464. doi: 10.3892/mmr.2017.8321. [PMID: 29286109]
  • Xiaohui Chen, Kai Hao, Xiaobo Yu, Aiguo Huang, Bin Zhu, Gao-Xue Wang, Fei Ling. Magnolol protects Ctenopharyngodon idella kidney cells from apoptosis induced by grass carp reovirus. Fish & shellfish immunology. 2018 Mar; 74(?):426-435. doi: 10.1016/j.fsi.2017.12.035. [PMID: 29277695]
  • Chun-Kai Chang, Xiu-Ru Lin, Yen-Lin Lin, Woei-Horng Fang, Shu-Wha Lin, Sui-Yuan Chang, Jau-Tsuen Kao. Magnolol-mediated regulation of plasma triglyceride through affecting lipoprotein lipase activity in apolipoprotein A5 knock-in mice. PloS one. 2018; 13(2):e0192740. doi: 10.1371/journal.pone.0192740. [PMID: 29425239]
  • Ye Tian, Haihua Feng, Lu Han, Lin Wu, Hongming Lv, Bingyu Shen, Zheng Li, Qiaoling Zhang, Guowen Liu. Magnolol Alleviates Inflammatory Responses and Lipid Accumulation by AMP-Activated Protein Kinase-Dependent Peroxisome Proliferator-Activated Receptor α Activation. Frontiers in immunology. 2018; 9(?):147. doi: 10.3389/fimmu.2018.00147. [PMID: 29467759]
  • Pinggang Ding, Hongxue Shen, Jianan Wang, Jianming Ju. Improved oral bioavailability of magnolol by using a binary mixed micelle system. Artificial cells, nanomedicine, and biotechnology. 2018; 46(sup2):668-674. doi: 10.1080/21691401.2018.1468339. [PMID: 30183380]
  • Jawad Behbehani, Sheikh Shreaz, Mohammad Irshad, Maribassapa Karched. The natural compound magnolol affects growth, biofilm formation, and ultrastructure of oral Candida isolates. Microbial pathogenesis. 2017 Dec; 113(?):209-217. doi: 10.1016/j.micpath.2017.10.040. [PMID: 29074435]
  • Feng Huang, Rui-Yun Zhang, Lei Song. Beneficial effect of magnolol on lupus nephritis in MRL/lpr mice by attenuating the NLRP3 inflammasome and NF‑κB signaling pathway: A mechanistic analysis. Molecular medicine reports. 2017 Oct; 16(4):4817-4822. doi: 10.3892/mmr.2017.7154. [PMID: 28791390]
  • Xiaoyan Liu, Xiaoling Chen, Yuanjun Zhu, Kewei Wang, Yinye Wang. Effect of magnolol on cerebral injury and blood brain barrier dysfunction induced by ischemia-reperfusion in vivo and in vitro. Metabolic brain disease. 2017 08; 32(4):1109-1118. doi: 10.1007/s11011-017-0004-6. [PMID: 28378105]
  • Ling Zhao, Hai-Tao Xiao, Huai-Xue Mu, Tao Huang, Ze-Si Lin, Linda L D Zhong, Guang-Zhi Zeng, Bao-Min Fan, Cheng-Yuan Lin, Zhao-Xiang Bian. Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice. Molecules (Basel, Switzerland). 2017 Jul; 22(7):. doi: 10.3390/molecules22071218. [PMID: 28726741]
  • Fahimeh Moradi-Afrapoli, Samad Nejad Ebrahimi, Martin Smiesko, Matthias Hamburger. HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a Larval Zebrafish Locomotor Assay. Journal of natural products. 2017 05; 80(5):1548-1557. doi: 10.1021/acs.jnatprod.7b00081. [PMID: 28485933]
  • Fabrizio Schifano, Valentina Guarino, Duccio G Papanti, Jacopo Baccarin, Laura Orsolini, John M Corkery. Is there a potential of misuse for Magnolia officinalis compounds/metabolites?. Human psychopharmacology. 2017 05; 32(3):. doi: 10.1002/hup.2595. [PMID: 28517911]