Erythritol (BioDeep_00000001731)

 

Secondary id: BioDeep_00000408246

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


1,2,3,4-Butanetetrol,(2R,3R)-rel-

化学式: C4H10O4 (122.057906)
中文名称: DL-苏糖醇, 赤藓糖醇
谱图信息: 最多检出来源 Homo sapiens(blood) 0.69%

Reviewed

Last reviewed on 2024-07-16.

Cite this Page

Erythritol. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/erythritol (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000001731). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(C(CO)O)O)O
InChI: InChI=1S/C4H10O4/c5-1-3(7)4(8)2-6/h3-8H,1-2H2

描述信息

Erythritol is a sugar alcohol (or polyol), used as a food additive and sugar substitute. It is naturally occurring and is made from corn using enzymes and fermentation. Its formula is C4H10O4, or HO(CH2)(CHOH)2(CH2)OH; specifically, one particular stereoisomer with that formula. Erythritol is 60–70\\\\\% as sweet as sucrose (table sugar), yet it is almost noncaloric and does not affect blood sugar or cause tooth decay. Erythritol occurs widely in nature and has been found to occur naturally in several foods including wine, sake, beer, watermelon, pear, grape, and soy sauce. Evidence indicates that erythritol also exists endogenously in the tissues and body fluids of humans and animals. Erythritol is absorbed from the proximal intestine by passive diffusion in a manner similar to that of many low molecular weight organic molecules which do not have associated active transport systems. The rate of absorption is related to their molecular size. It passes through the intestinal membranes at a faster rate than larger molecules such as mannitol or glucose. In diabetics, erythritol has also been shown to be rapidly absorbed and excreted unchanged in the urine. Following absorption, ingested erythritol is rapidly distributed throughout the body and has been reported to occur in hepatocytes, pancreatic cells, and vascular smooth muscle cells. Erythritol also has been reported to cross the human placenta and to pass slowly from the plasma into the brain and cerebrospinal fluid (PMID:9862657). Erythritol is found to be associated with ribose-5-phosphate isomerase deficiency, which is an inborn error of metabolism.
Bulk sweetener with good taste props. Not metabolised, excreted unchanged in urine. Less sweet than sucrose. Use not yet permitted in most countries (1997). GRAS status for use as a sweetener, thickener, stabiliser, humectant, etc. in food
meso-Erythritol is a sugar alcohol that occurs naturally in a variety of foods (e.g., pear, watermelon), is 60-80\\% as sweet as sucrose, and is an approved low-calorie sweetener food additive[1].
meso-Erythritol is a sugar alcohol that occurs naturally in a variety of foods (e.g., pear, watermelon), is 60-80\% as sweet as sucrose, and is an approved low-calorie sweetener food additive[1].

同义名列表

28 个代谢物同义名

1,2,3,4-Butanetetrol,(2R,3R)-rel-; (2S,3R)-butane-1,2,3,4-tetrol; (2R,3S)-Butane-1,2,3,4-tetrol; 1,2,3,4-Tetrahydroxybutane; Butane-1,2,3,4-tetrol; 1,2,3,4-Butanetetrol; Tetrahydroxybutane; Erythro-tetritol; MESO-erythritol; Mesoerythritol; L-(-)-Threitol; Meso-eythritol; Erythroglucin; Antierythrite; L-Erythritol; Lichen sugar; Butanetetrol; I-erythritol; Erythritol; L-Threitol; Erythrite; Phycitol; Erythrit; Erythrol; C*Eridex; Paycite; Phycite; Erythritol



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

65 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fangmei Liu, Kai Xia, Yuqing Chen, Ling Zhu, Lingzhi Zhu, Xuequn Zhao, Ruyi Sha, Jun Huang. Inhibition of hyphal formation together with biochar addition promotes erythritol production by Yarrowia lipolytica. Biotechnology and bioengineering. 2024 Jun; 121(6):1937-1949. doi: 10.1002/bit.28704. [PMID: 38548668]
  • Diego González-Cabanelas, Erica Perreca, Johann M Rohwer, Axel Schmidt, Tobias Engl, Bettina Raguschke, Jonathan Gershenzon, Louwrance P Wright. Deoxyxylulose 5-Phosphate Synthase Does Not Play a Major Role in Regulating the Methylerythritol 4-Phosphate Pathway in Poplar. International journal of molecular sciences. 2024 Apr; 25(8):. doi: 10.3390/ijms25084181. [PMID: 38673766]
  • Ewa Raczkowska, Aneta Wojdyło, Paulina Nowicka. The use of blackcurrant pomace and erythritol to optimise the functional properties of shortbread cookies. Scientific reports. 2024 02; 14(1):3788. doi: 10.1038/s41598-024-54461-7. [PMID: 38361029]
  • Kai Xia, Fang-Mei Liu, Yu-Qing Chen, Shan-Shan Chen, Chun-Ying Huang, Xue-Qun Zhao, Ru-Yi Sha, Jun Huang. Mechanism and evolutionary analysis of Yarrowia lipolytica CA20 capable of producing erythritol with a high yield based on comparative genomics. Yi chuan = Hereditas. 2023 Oct; 45(10):904-921. doi: 10.16288/j.yczz.23-139. [PMID: 37872113]
  • Xin Wu, Mengwei Bu, Zili Yang, Hongrui Ping, Chunlin Song, Jiang Duan, Aidong Zhang. Design and Synthesis of Fosmidomycin Analogs containing aza-Linkers and Their Biological Activity Evaluation. Pest management science. 2023 Oct; ?(?):. doi: 10.1002/ps.7810. [PMID: 37794283]
  • Anil B Khatape, Vidhya Rangaswamy, Syed G Dastager. Strain improvement for enhanced erythritol production by Moniliella pollinis Mutant-58 using jaggery as a cost-effective substrate. International microbiology : the official journal of the Spanish Society for Microbiology. 2023 Jul; ?(?):. doi: 10.1007/s10123-023-00411-8. [PMID: 37525085]
  • Fan Jiang, Dongying Liu, Jingqi Dai, Tao Yang, Jinzhu Zhang, Daidi Che, Jinping Fan. Cloning and Functional Characterization of 2-C-methyl-D-erythritol-4-phosphate cytidylyltransferase (LiMCT) Gene in Oriental Lily (Lilium 'Sorbonne'). Molecular biotechnology. 2023 Apr; ?(?):. doi: 10.1007/s12033-023-00729-8. [PMID: 37014586]
  • Yueyang Wang, Yue Li, Huiyun Song, Zhi Wang, Pei Li. Characterization of the 1-Deoxy-D-xylulose 5-Phosphate synthase Genes in Toona ciliata Suggests Their Role in Insect Defense. International journal of molecular sciences. 2023 Jan; 24(3):. doi: 10.3390/ijms24032339. [PMID: 36768662]
  • Lea Vidal, Esteban Lebrun, Young-Kyoung Park, Guillaume Mottet, Jean-Marc Nicaud. Bidirectional hybrid erythritol-inducible promoter for synthetic biology in Yarrowia lipolytica. Microbial cell factories. 2023 Jan; 22(1):7. doi: 10.1186/s12934-023-02020-6. [PMID: 36635727]
  • Takanori Kondo, Chihiro Yasui, Ikkei Miyajima, Taisuke Banno, Kouichi Asakura, Tokuma Fukuoka, Kazunori Ushimaru, Maito Koga, Azusa Saika, Tomotake Morita, Yoshiaki Takahashi, Chigusa Hayashi, Masayuki Igarashi, Daisuke Takahashi, Kazunobu Toshima. Synthesis of Mannosylerythritol Lipid Analogues and their Self-Assembling Properties, Recovery Effects on Damaged Skin Cells, and Antibacterial Activity. Chemistry (Weinheim an der Bergstrasse, Germany). 2022 Oct; 28(55):e202201733. doi: 10.1002/chem.202201733. [PMID: 35761481]
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  • Laura Daza-Serna, Sebastián Serna-Loaiza, Audrey Masi, Robert Ludwig Mach, Astrid Rosa Mach-Aigner, Anton Friedl. From the culture broth to the erythritol crystals: an opportunity for circular economy. Applied microbiology and biotechnology. 2021 Jun; 105(11):4467-4486. doi: 10.1007/s00253-021-11355-2. [PMID: 34043080]
  • Bettina K Wölnerhanssen, Jürgen Drewe, Wout Verbeure, Carel W le Roux, Ludmilla Dellatorre-Teixeira, Jens F Rehfeld, Jens J Holst, Bolette Hartmann, Jan Tack, Ralph Peterli, Christoph Beglinger, Anne C Meyer-Gerspach. Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study. Diabetes, obesity & metabolism. 2021 06; 23(6):1311-1321. doi: 10.1111/dom.14342. [PMID: 33565706]
  • Rena Kawano, Takuro Okamura, Yoshitaka Hashimoto, Saori Majima, Takafumi Senmaru, Emi Ushigome, Mai Asano, Masahiro Yamazaki, Hiroshi Takakuwa, Ryoichi Sasano, Naoko Nakanishi, Masahide Hamaguchi, Michiaki Fukui. Erythritol Ameliorates Small Intestinal Inflammation Induced by High-Fat Diets and Improves Glucose Tolerance. International journal of molecular sciences. 2021 May; 22(11):. doi: 10.3390/ijms22115558. [PMID: 34074061]
  • Liping Zeng, Katayoon Dehesh. The eukaryotic MEP-pathway genes are evolutionarily conserved and originated from Chlaymidia and cyanobacteria. BMC genomics. 2021 Feb; 22(1):137. doi: 10.1186/s12864-021-07448-x. [PMID: 33637041]
  • Wu Wang, Jiao Feng, Lingling Wei, Muhammad Khalil-Ur-Rehman, Niels J Nieuwenhuizen, Lina Yang, Huan Zheng, Jianmin Tao. Transcriptomics Integrated with Free and Bound Terpenoid Aroma Profiling during 'Shine Muscat' (Vitis labrusca × V. vinifera) Grape Berry Development Reveals Coordinate Regulation of MEP Pathway and Terpene Synthase Gene Expression. Journal of agricultural and food chemistry. 2021 Feb; 69(4):1413-1429. doi: 10.1021/acs.jafc.0c06591. [PMID: 33481572]
  • Kuo Xu, Xu-Lun Wei, Lin Xue, Zhong-Feng Zhang, Peng Zhang. Antimicrobial Meroterpenoids and Erythritol Derivatives Isolated from the Marine-Algal-Derived Endophytic Fungus Penicillium chrysogenum XNM-12. Marine drugs. 2020 Nov; 18(11):. doi: 10.3390/md18110578. [PMID: 33233849]
  • Karley K Mahalak, Jenni Firrman, Peggy M Tomasula, Alberto Nuñez, Jung-Jin Lee, Kyle Bittinger, William Rinaldi, Lin Shu Liu. Impact of Steviol Glycosides and Erythritol on the Human and Cebus apella Gut Microbiome. Journal of agricultural and food chemistry. 2020 Nov; 68(46):13093-13101. doi: 10.1021/acs.jafc.9b06181. [PMID: 31869223]
  • Semira R Ortiz, Martha S Field. Mammalian metabolism of erythritol: a predictive biomarker of metabolic dysfunction. Current opinion in clinical nutrition and metabolic care. 2020 09; 23(5):296-301. doi: 10.1097/mco.0000000000000665. [PMID: 32412980]
  • Rui Xiong, Zhu Chen, Weiyu Wang, Li Jiang, Yan Xiang, Jun Fan. Combined transcriptome sequencing and prokaryotic expression to investigate the key enzyme in the 2-C-methylerythritol-4-phosphate pathway of Osmanthus fragrans. Functional plant biology : FPB. 2020 09; 47(10):945-958. doi: 10.1071/fp19365. [PMID: 32527366]
  • Xueliang Qiu, Peng Xu, Xinrui Zhao, Guocheng Du, Juan Zhang, Jianghua Li. Combining genetically-encoded biosensors with high throughput strain screening to maximize erythritol production in Yarrowia lipolytica. Metabolic engineering. 2020 07; 60(?):66-76. doi: 10.1016/j.ymben.2020.03.006. [PMID: 32224262]
  • Naoto Katakami, Kazuo Omori, Naohiro Taya, Shoya Arakawa, Mitsuyoshi Takahara, Taka-Aki Matsuoka, Hiroshi Tsugawa, Masahiro Furuno, Takeshi Bamba, Eiichiro Fukusaki, Iichiro Shimomura. Plasma metabolites associated with arterial stiffness in patients with type 2 diabetes. Cardiovascular diabetology. 2020 06; 19(1):75. doi: 10.1186/s12933-020-01057-w. [PMID: 32527273]
  • Yifeng Zhang, Yujun Zhao, Jiadian Wang, Tianyuan Hu, Yuru Tong, Jiawei Zhou, Jie Gao, Luqi Huang, Wei Gao. The expression of TwDXS in the MEP pathway specifically affects the accumulation of triptolide. Physiologia plantarum. 2020 May; 169(1):40-48. doi: 10.1111/ppl.13051. [PMID: 31758560]
  • M K You, Y J Lee, J K Kim, S A Baek, Y A Jeon, S H Lim, S H Ha. The organ-specific differential roles of rice DXS and DXR, the first two enzymes of the MEP pathway, in carotenoid metabolism in Oryza sativa leaves and seeds. BMC plant biology. 2020 Apr; 20(1):167. doi: 10.1186/s12870-020-02357-9. [PMID: 32293285]
  • Arvind Sharma, Jeremiah Reyes, David Borgmeyer, Cuauhtemoc Ayala-Chavez, Katie Snow, Fiza Arshad, Andrew Nuss, Monika Gulia-Nuss. The sugar substitute erythritol shortens the lifespan of Aedes aegypti potentially by N-linked protein glycosylation. Scientific reports. 2020 04; 10(1):6195. doi: 10.1038/s41598-020-63050-3. [PMID: 32277123]
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  • Jin-Zheng Wang, Yongxing Lei, Yanmei Xiao, Xiang He, Jiubo Liang, Jishan Jiang, Shangzhi Dong, Haiyan Ke, Patricia Leon, Philipp Zerbe, Youli Xiao, Katayoon Dehesh. Uncovering the functional residues of Arabidopsis isoprenoid biosynthesis enzyme HDS. Proceedings of the National Academy of Sciences of the United States of America. 2020 01; 117(1):355-361. doi: 10.1073/pnas.1916434117. [PMID: 31879352]
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