Erythrit (BioDeep_00000408246)

Main id: BioDeep_00000001731

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


rel-(2R,3S)-1,2,3,4-Butanetetrol

化学式: C4H10O4 (122.0579)
中文名称: 赤藓糖醇
谱图信息: 最多检出来源 Homo sapiens(blood) 39.03%

Reviewed

Last reviewed on 2024-08-08.

Cite this Page

Erythrit. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/erythrit (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000408246). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(C(CO)O)O)O
InChI: InChI=1S/C4H10O4/c5-1-3(7)4(8)2-6/h3-8H,1-2H2/t3-,4+

描述信息

D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
The meso-diastereomer of butane-1,2,3,4-tetrol.
meso-Erythritol is a sugar alcohol that occurs naturally in a variety of foods (e.g., pear, watermelon), is 60-80\\% as sweet as sucrose, and is an approved low-calorie sweetener food additive[1].
meso-Erythritol is a sugar alcohol that occurs naturally in a variety of foods (e.g., pear, watermelon), is 60-80\% as sweet as sucrose, and is an approved low-calorie sweetener food additive[1].

同义名列表

4 个代谢物同义名

Erythritol; meso-Erythritol; Erythritol; Erythritol



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

31 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 AKR1B1, ALB, G6PD, GK, SHPK
Peripheral membrane protein 4 G6PD, GBA1, HSD17B6, SORD
Endoplasmic reticulum membrane 1 TKT
Mitochondrion membrane 1 SORD
Nucleus 3 ALB, GK, TAL1
cytosol 8 AKR1B1, ALB, G6PD, GK, LIPE, SHPK, SORD, TKT
mitochondrial membrane 1 SORD
nuclear body 1 TKT
trans-Golgi network 1 GBA1
centrosome 1 ALB
nucleoplasm 3 AKR1B1, TAL1, TKT
Cell membrane 3 LIPE, TKT, TNF
Early endosome membrane 1 HSD17B6
cell surface 1 TNF
glutamatergic synapse 1 GHRL
Golgi apparatus 2 ALB, GBA1
Golgi membrane 1 INS
lysosomal membrane 2 GAA, GBA1
neuronal cell body 1 TNF
postsynapse 1 GHRL
Cytoplasm, cytosol 3 G6PD, GK, LIPE
Lysosome 2 GAA, GBA1
plasma membrane 4 GAA, GCG, TKT, TNF
Membrane 4 G6PD, GAA, LIPE, SORD
apical plasma membrane 1 TKT
axon 2 CCK, GHRL
caveola 1 LIPE
extracellular exosome 8 AKR1B1, ALB, G6PD, GAA, GBA1, GK, SORD, TKT
Lysosome membrane 2 GAA, GBA1
Lumenal side 2 GBA1, HSD17B6
endoplasmic reticulum 3 ALB, GBA1, HSD17B6
extracellular space 11 AKR1B1, ALB, CCK, GCG, GHRL, INS, OSM, PYY, SCT, SORD, TNF
lysosomal lumen 2 GAA, GBA1
Schaffer collateral - CA1 synapse 1 GHRL
mitochondrion 2 AKR1B1, GK
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 3 G6PD, GAA, HSD17B6
Microsome membrane 1 HSD17B6
Single-pass type I membrane protein 1 TKT
Secreted 7 ALB, CCK, GAA, GCG, GHRL, INS, OSM
extracellular region 10 ALB, CCK, GAA, GCG, GHRL, INS, OSM, PYY, SCT, TNF
cytoplasmic side of plasma membrane 1 G6PD
Mitochondrion outer membrane 1 GK
Single-pass membrane protein 1 GK
mitochondrial outer membrane 1 GK
anchoring junction 1 ALB
transcription regulator complex 1 TAL1
centriolar satellite 1 G6PD
motile cilium 1 SORD
external side of plasma membrane 1 TNF
actin cytoskeleton 1 TKT
neuronal dense core vesicle lumen 1 GHRL
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 TKT
Membrane raft 1 TNF
focal adhesion 1 TKT
Peroxisome 1 TKT
receptor complex 1 TKT
ciliary basal body 1 ALB
chromatin 1 TAL1
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Cell projection, cilium, flagellum 1 SORD
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
tertiary granule membrane 1 GAA
[Isoform 4]: Cytoplasm, cytosol 1 GK
secretory granule lumen 3 GCG, GHRL, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, GCG, GHRL, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
ficolin-1-rich granule membrane 1 GAA
[Glucagon-like peptide 1]: Secreted 1 GCG
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
autolysosome lumen 1 GAA
[Isoform 3]: Mitochondrion outer membrane 1 GK
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Fangmei Liu, Kai Xia, Yuqing Chen, Ling Zhu, Lingzhi Zhu, Xuequn Zhao, Ruyi Sha, Jun Huang. Inhibition of hyphal formation together with biochar addition promotes erythritol production by Yarrowia lipolytica. Biotechnology and bioengineering. 2024 Jun; 121(6):1937-1949. doi: 10.1002/bit.28704. [PMID: 38548668]
  • Diego González-Cabanelas, Erica Perreca, Johann M Rohwer, Axel Schmidt, Tobias Engl, Bettina Raguschke, Jonathan Gershenzon, Louwrance P Wright. Deoxyxylulose 5-Phosphate Synthase Does Not Play a Major Role in Regulating the Methylerythritol 4-Phosphate Pathway in Poplar. International journal of molecular sciences. 2024 Apr; 25(8):. doi: 10.3390/ijms25084181. [PMID: 38673766]
  • Ewa Raczkowska, Aneta Wojdyło, Paulina Nowicka. The use of blackcurrant pomace and erythritol to optimise the functional properties of shortbread cookies. Scientific reports. 2024 02; 14(1):3788. doi: 10.1038/s41598-024-54461-7. [PMID: 38361029]
  • Kai Xia, Fang-Mei Liu, Yu-Qing Chen, Shan-Shan Chen, Chun-Ying Huang, Xue-Qun Zhao, Ru-Yi Sha, Jun Huang. Mechanism and evolutionary analysis of Yarrowia lipolytica CA20 capable of producing erythritol with a high yield based on comparative genomics. Yi chuan = Hereditas. 2023 Oct; 45(10):904-921. doi: 10.16288/j.yczz.23-139. [PMID: 37872113]
  • Xin Wu, Mengwei Bu, Zili Yang, Hongrui Ping, Chunlin Song, Jiang Duan, Aidong Zhang. Design and Synthesis of Fosmidomycin Analogs containing aza-Linkers and Their Biological Activity Evaluation. Pest management science. 2023 Oct; ?(?):. doi: 10.1002/ps.7810. [PMID: 37794283]
  • Anil B Khatape, Vidhya Rangaswamy, Syed G Dastager. Strain improvement for enhanced erythritol production by Moniliella pollinis Mutant-58 using jaggery as a cost-effective substrate. International microbiology : the official journal of the Spanish Society for Microbiology. 2023 Jul; ?(?):. doi: 10.1007/s10123-023-00411-8. [PMID: 37525085]
  • Fan Jiang, Dongying Liu, Jingqi Dai, Tao Yang, Jinzhu Zhang, Daidi Che, Jinping Fan. Cloning and Functional Characterization of 2-C-methyl-D-erythritol-4-phosphate cytidylyltransferase (LiMCT) Gene in Oriental Lily (Lilium 'Sorbonne'). Molecular biotechnology. 2023 Apr; ?(?):. doi: 10.1007/s12033-023-00729-8. [PMID: 37014586]
  • Yueyang Wang, Yue Li, Huiyun Song, Zhi Wang, Pei Li. Characterization of the 1-Deoxy-D-xylulose 5-Phosphate synthase Genes in Toona ciliata Suggests Their Role in Insect Defense. International journal of molecular sciences. 2023 Jan; 24(3):. doi: 10.3390/ijms24032339. [PMID: 36768662]
  • Lea Vidal, Esteban Lebrun, Young-Kyoung Park, Guillaume Mottet, Jean-Marc Nicaud. Bidirectional hybrid erythritol-inducible promoter for synthetic biology in Yarrowia lipolytica. Microbial cell factories. 2023 Jan; 22(1):7. doi: 10.1186/s12934-023-02020-6. [PMID: 36635727]
  • Takanori Kondo, Chihiro Yasui, Ikkei Miyajima, Taisuke Banno, Kouichi Asakura, Tokuma Fukuoka, Kazunori Ushimaru, Maito Koga, Azusa Saika, Tomotake Morita, Yoshiaki Takahashi, Chigusa Hayashi, Masayuki Igarashi, Daisuke Takahashi, Kazunobu Toshima. Synthesis of Mannosylerythritol Lipid Analogues and their Self-Assembling Properties, Recovery Effects on Damaged Skin Cells, and Antibacterial Activity. Chemistry (Weinheim an der Bergstrasse, Germany). 2022 Oct; 28(55):e202201733. doi: 10.1002/chem.202201733. [PMID: 35761481]
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  • Yong Yuan, Siyan Ren, Xiaofeng Liu, Liyang Su, Yu Wu, Wen Zhang, Yan Li, Yidan Jiang, Hsihua Wang, Rao Fu, Mondher Bouzayen, Mingchun Liu, Yang Zhang. SlWRKY35 positively regulates carotenoid biosynthesis by activating the MEP pathway in tomato fruit. The New phytologist. 2022 04; 234(1):164-178. doi: 10.1111/nph.17977. [PMID: 35048386]
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  • Bin Liu, Lu Zhang, Linda Rusalepp, Eve Kaurilind, Hassan Yusuf Sulaiman, Tõnu Püssa, Ülo Niinemets. Heat priming improved heat tolerance of photosynthesis, enhanced terpenoid and benzenoid emission and phenolics accumulation in Achillea millefolium. Plant, cell & environment. 2021 07; 44(7):2365-2385. doi: 10.1111/pce.13830. [PMID: 32583881]
  • Laura Daza-Serna, Sebastián Serna-Loaiza, Audrey Masi, Robert Ludwig Mach, Astrid Rosa Mach-Aigner, Anton Friedl. From the culture broth to the erythritol crystals: an opportunity for circular economy. Applied microbiology and biotechnology. 2021 Jun; 105(11):4467-4486. doi: 10.1007/s00253-021-11355-2. [PMID: 34043080]
  • Bettina K Wölnerhanssen, Jürgen Drewe, Wout Verbeure, Carel W le Roux, Ludmilla Dellatorre-Teixeira, Jens F Rehfeld, Jens J Holst, Bolette Hartmann, Jan Tack, Ralph Peterli, Christoph Beglinger, Anne C Meyer-Gerspach. Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study. Diabetes, obesity & metabolism. 2021 06; 23(6):1311-1321. doi: 10.1111/dom.14342. [PMID: 33565706]
  • Rena Kawano, Takuro Okamura, Yoshitaka Hashimoto, Saori Majima, Takafumi Senmaru, Emi Ushigome, Mai Asano, Masahiro Yamazaki, Hiroshi Takakuwa, Ryoichi Sasano, Naoko Nakanishi, Masahide Hamaguchi, Michiaki Fukui. Erythritol Ameliorates Small Intestinal Inflammation Induced by High-Fat Diets and Improves Glucose Tolerance. International journal of molecular sciences. 2021 May; 22(11):. doi: 10.3390/ijms22115558. [PMID: 34074061]
  • Liping Zeng, Katayoon Dehesh. The eukaryotic MEP-pathway genes are evolutionarily conserved and originated from Chlaymidia and cyanobacteria. BMC genomics. 2021 Feb; 22(1):137. doi: 10.1186/s12864-021-07448-x. [PMID: 33637041]
  • Wu Wang, Jiao Feng, Lingling Wei, Muhammad Khalil-Ur-Rehman, Niels J Nieuwenhuizen, Lina Yang, Huan Zheng, Jianmin Tao. Transcriptomics Integrated with Free and Bound Terpenoid Aroma Profiling during 'Shine Muscat' (Vitis labrusca × V. vinifera) Grape Berry Development Reveals Coordinate Regulation of MEP Pathway and Terpene Synthase Gene Expression. Journal of agricultural and food chemistry. 2021 Feb; 69(4):1413-1429. doi: 10.1021/acs.jafc.0c06591. [PMID: 33481572]
  • Kuo Xu, Xu-Lun Wei, Lin Xue, Zhong-Feng Zhang, Peng Zhang. Antimicrobial Meroterpenoids and Erythritol Derivatives Isolated from the Marine-Algal-Derived Endophytic Fungus Penicillium chrysogenum XNM-12. Marine drugs. 2020 Nov; 18(11):. doi: 10.3390/md18110578. [PMID: 33233849]
  • Karley K Mahalak, Jenni Firrman, Peggy M Tomasula, Alberto Nuñez, Jung-Jin Lee, Kyle Bittinger, William Rinaldi, Lin Shu Liu. Impact of Steviol Glycosides and Erythritol on the Human and Cebus apella Gut Microbiome. Journal of agricultural and food chemistry. 2020 Nov; 68(46):13093-13101. doi: 10.1021/acs.jafc.9b06181. [PMID: 31869223]
  • Rui Xiong, Zhu Chen, Weiyu Wang, Li Jiang, Yan Xiang, Jun Fan. Combined transcriptome sequencing and prokaryotic expression to investigate the key enzyme in the 2-C-methylerythritol-4-phosphate pathway of Osmanthus fragrans. Functional plant biology : FPB. 2020 09; 47(10):945-958. doi: 10.1071/fp19365. [PMID: 32527366]
  • Semira R Ortiz, Martha S Field. Mammalian metabolism of erythritol: a predictive biomarker of metabolic dysfunction. Current opinion in clinical nutrition and metabolic care. 2020 09; 23(5):296-301. doi: 10.1097/mco.0000000000000665. [PMID: 32412980]
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  • Naoto Katakami, Kazuo Omori, Naohiro Taya, Shoya Arakawa, Mitsuyoshi Takahara, Taka-Aki Matsuoka, Hiroshi Tsugawa, Masahiro Furuno, Takeshi Bamba, Eiichiro Fukusaki, Iichiro Shimomura. Plasma metabolites associated with arterial stiffness in patients with type 2 diabetes. Cardiovascular diabetology. 2020 06; 19(1):75. doi: 10.1186/s12933-020-01057-w. [PMID: 32527273]
  • Yifeng Zhang, Yujun Zhao, Jiadian Wang, Tianyuan Hu, Yuru Tong, Jiawei Zhou, Jie Gao, Luqi Huang, Wei Gao. The expression of TwDXS in the MEP pathway specifically affects the accumulation of triptolide. Physiologia plantarum. 2020 May; 169(1):40-48. doi: 10.1111/ppl.13051. [PMID: 31758560]
  • M K You, Y J Lee, J K Kim, S A Baek, Y A Jeon, S H Lim, S H Ha. The organ-specific differential roles of rice DXS and DXR, the first two enzymes of the MEP pathway, in carotenoid metabolism in Oryza sativa leaves and seeds. BMC plant biology. 2020 Apr; 20(1):167. doi: 10.1186/s12870-020-02357-9. [PMID: 32293285]
  • Arvind Sharma, Jeremiah Reyes, David Borgmeyer, Cuauhtemoc Ayala-Chavez, Katie Snow, Fiza Arshad, Andrew Nuss, Monika Gulia-Nuss. The sugar substitute erythritol shortens the lifespan of Aedes aegypti potentially by N-linked protein glycosylation. Scientific reports. 2020 04; 10(1):6195. doi: 10.1038/s41598-020-63050-3. [PMID: 32277123]
  • Jili Wang, Yaqing Zhou, Xiuwen Wang, Lixia Duan, Jiang Duan, Weiguo Li, Aidong Zhang. Synthesis and Evaluation of Halogenated 5-(2-Hydroxyphenyl)pyrazoles as Pseudilin Analogues Targeting the Enzyme IspD in the Methylerythritol Phosphate Pathway. Journal of agricultural and food chemistry. 2020 Mar; 68(10):3071-3078. doi: 10.1021/acs.jafc.9b08057. [PMID: 32078770]
  • Jin-Zheng Wang, Yongxing Lei, Yanmei Xiao, Xiang He, Jiubo Liang, Jishan Jiang, Shangzhi Dong, Haiyan Ke, Patricia Leon, Philipp Zerbe, Youli Xiao, Katayoon Dehesh. Uncovering the functional residues of Arabidopsis isoprenoid biosynthesis enzyme HDS. Proceedings of the National Academy of Sciences of the United States of America. 2020 01; 117(1):355-361. doi: 10.1073/pnas.1916434117. [PMID: 31879352]
  • Enrico Orsi, Jules Beekwilder, Siebe Peek, Gerrit Eggink, Servé W M Kengen, Ruud A Weusthuis. Metabolic flux ratio analysis by parallel 13C labeling of isoprenoid biosynthesis in Rhodobacter sphaeroides. Metabolic engineering. 2020 01; 57(?):228-238. doi: 10.1016/j.ymben.2019.12.004. [PMID: 31843486]
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  • Garima Ayachit, Inayatullah Shaikh, Preeti Sharma, Bhavika Jani, Labdhi Shukla, Priyanka Sharma, Shivarudrappa B Bhairappanavar, Chaitanya Joshi, Jayashankar Das. De novo transcriptome of Gymnema sylvestre identified putative lncRNA and genes regulating terpenoid biosynthesis pathway. Scientific reports. 2019 10; 9(1):14876. doi: 10.1038/s41598-019-51355-x. [PMID: 31619732]
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  • Nawaporn Onkokesung, Michael Reichelt, Louwrance P Wright, Michael A Phillips, Jonathan Gershenzon, Marcel Dicke. The plastidial metabolite 2-C-methyl-D-erythritol-2,4-cyclodiphosphate modulates defence responses against aphids. Plant, cell & environment. 2019 07; 42(7):2309-2323. doi: 10.1111/pce.13538. [PMID: 30786032]
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