Paeonol (BioDeep_00000017307)

 

Secondary id: BioDeep_00000003699, BioDeep_00000402993, BioDeep_00000860033

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product Volatile Flavor Compounds


代谢物信息卡片


2 inverted exclamation mark -Hydroxy-4 inverted exclamation mark -methoxyacetophenone

化学式: C9H10O3 (166.062991)
中文名称: 丹皮酚, 芍药醇, 牡丹酚
谱图信息: 最多检出来源 Viridiplantae(plant) 3.75%

分子结构信息

SMILES: CC(=O)C1=C(C=C(C=C1)OC)O
InChI: InChI=1S/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3

描述信息

Paeonol is a member of phenols and a member of methoxybenzenes. It has a role as a metabolite.
Paeonol is a natural product found in Vincetoxicum paniculatum, Vincetoxicum glaucescens, and other organisms with data available.
See also: Paeonia lactiflora root (part of); Paeonia X suffruticosa root (part of).
A natural product found in Paeonia rockii subspeciesrockii.
Paeonol is an active extraction from the root of Paeonia suffruticosa, Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.
Paeonol is an active extraction from the root of Paeonia suffruticosa, Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.

同义名列表

47 个代谢物同义名

2 inverted exclamation mark -Hydroxy-4 inverted exclamation mark -methoxyacetophenone; 2 inverted exclamation marka-Hydroxy-4 inverted exclamation marka-methoxyacetophenone; InChI=1/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H; quinuclidin-3-one oxime hydrochloride;Paeonol; 4-08-00-01793 (Beilstein Handbook Reference); Acetophenone, 2-hydroxy-4-methoxy-(7CI,8CI); 2-HYDROXY-4-METHOXYACETOPHENONE (4,4,4-D3); 1-[2-hydroxy-4-(methyloxy)phenyl]ethanone; 1-(2-hydroxy-4-methoxyphenyl)ethane-1-one; Ethanone, 1-(2-hydroxy-4-methoxyphenyl)-; 1-(2-hydroxy-4-methoxyphenyl)ethan-1-one; 1-(2-Hydroxy-4-methoxyphenyl)ethanone #; 1-(4-Methoxy-2-hydroxy-phenyl)-ethanone; 2-HYDROXY-4-METHOXYPHENYL METHYL KETONE; 1-(2-hydroxy-4-methoxy-phenyl)-ethanone; 1-(2-hydroxy-4-methoxy-phenyl)ethanone; 1-(2-hydroxy-4-methoxyphenyl)-ethanone; 1-(2-Hydroxy-4-methoxyphenyl)ethanone; 1-(4-METHOXY-2-HYDROXYPHENYL)ETHANONE; 2-Hydroxy-4-methoxyacetophenone, 99\\%; Acetophenone, 2-hydroxy-4-methoxy-; Resacetophenone, 4-O-methyl ester; 2`-Hydroxy-4`-methoxyacetophenone; 4-methoxy 2-hydroxy acetophenone; RESACETOPHENONE 4-O-METHYL ETHER; 2-Hydroxy-4-methoxyacetophenone; 4-Methoxy-2-hydroxyacetophenone; 2-hydroxy-4-methoxyacetophenone; Resacetophenone-4-methyl ether; 4-O-Methylresacetophenone; 2-Acetyl-5-methoxy-phenol; 2-acetyl-5-methoxyphenol; Spectrum2_001981; PAEONOL [WHO-DD]; Spectrum3_001686; Paeonol (Peonol); UNII-3R834EPI82; PAEONOL [INCI]; ICCB4_000282; KBio3_002432; 3R834EPI82; AI3-10581; Paeonal; Paeonol; peonol; Paeonol; Paeonol



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

129 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Guiming Yan, Luning Zhang, Daqiang Wu, Shengnan Jiang, Qifeng Wu, Min Dai. Paeonol attenuates nonalcoholic steatohepatitis by regulating intestinal flora and AhR/NLRP3/Caspase-1 metabolic pathway. Journal of ethnopharmacology. 2024 Jul; 329(?):118147. doi: 10.1016/j.jep.2024.118147. [PMID: 38574779]
  • Menglong Gao, Lishun Dong, Yulong Yang, Jinjin Yan, Yuning Liang, Xiaolin Ma, Min Zhou, Hongfei Wu, Yarong Liu, Min Dai. The anti-atherosclerotic effect of Paeonol against the lipid accumulation in macrophage-derived foam cells by inhibiting ferroptosis via the SIRT1/NRF2/GPX4 signaling pathway. Biochemical and biophysical research communications. 2024 May; 708(?):149788. doi: 10.1016/j.bbrc.2024.149788. [PMID: 38518720]
  • Yuzhen Niu, Yingying Jin, Yongxi Hao, Wei Liang, Fan Tang, Ziyi Qin, Tao Liang, Le Shi. Paeonol interferes with lupus nephritis by regulating M1/M2 polarization of macrophages. Molecular immunology. 2024 May; 169(?):66-77. doi: 10.1016/j.molimm.2024.03.004. [PMID: 38503139]
  • Jinjin Yan, Yulong Yang, Yarong Liu, Xiaoyan Shi, Hongfei Wu, Min Dai. MicroRNA let-7g links foam cell formation and adipogenic differentiation: A key regulator of Paeonol treating atherosclerosis-osteoporosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155447. doi: 10.1016/j.phymed.2024.155447. [PMID: 38394732]
  • Rong Li, Qingping Yi, Jinsong Wang, Yuanxin Miao, Qingchan Chen, Yan Xu, Mingfang Tao. Paeonol promotes longevity and fitness in Caenorhabditis elegans through activating the DAF-16/FOXO and SKN-1/Nrf2 transcription factors. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116368. doi: 10.1016/j.biopha.2024.116368. [PMID: 38471269]
  • Ling Meng, Yan Chen, Zhenjia Zheng, Lei Wang, Yahui Xu, Xiujun Li, Zhijian Xiao, Zheng Tang, Zhaosheng Wang. Ultrasound-Assisted Extraction of Paeonol from Moutan Cortex: Purification and Component Identification of Extract. Molecules (Basel, Switzerland). 2024 Jan; 29(3):. doi: 10.3390/molecules29030622. [PMID: 38338367]
  • Min Zhou, Xiaolin Ma, Menglong Gao, Hongfei Wu, Yarong Liu, Xiaoyan Shi, Min Dai. Paeonol Attenuates Atherosclerosis by Inhibiting Vascular Smooth Muscle Cells Senescence via SIRT1/P53/TRF2 Signaling Pathway. Molecules (Basel, Switzerland). 2024 Jan; 29(1):. doi: 10.3390/molecules29010261. [PMID: 38202844]
  • Enhua Wei, Aiying Gao, Xiaofei Mu, Songlin Qu, Caixing Yang, Fengling Li, Shujing Li, Xuehuan Liu, Chunhong Song, Yinghui Guo. Paeonol ameliorates hippocampal neuronal damage by inhibiting GRM5/GABBR2/β-arrestin2 and activating the cAMP-PKA signaling pathway in premenstrual irritability rats. Brain research bulletin. 2023 Dec; 205(?):110830. doi: 10.1016/j.brainresbull.2023.110830. [PMID: 38036272]
  • Minghui Zou, Qiqi Xue, Qiao Teng, Qiqi Zhang, Ting Liu, Yuanyuan Li, Jinhong Zhao. Acaricidal activities of paeonol from Moutan Cortex, dried bark of Paeonia × suffruticosa, against the grain pest mite Aleuroglyphus ovatus (Acari: Acaridae). Experimental & applied acarology. 2023 Dec; 91(4):615-628. doi: 10.1007/s10493-023-00861-9. [PMID: 37979065]
  • Rong-Qing Zhu, Chun-Fang Tian, Xiao-Yan Lan, Zi-Han Wang, Xiang Li, Li Zhou, Mei-Lan Chen, Li-Ping Kang. [Chemical and nutrient differences between medicinal material, residues, and residue compost of Moutan Cortex]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Dec; 48(23):6361-6370. doi: 10.19540/j.cnki.cjcmm.20231017.102. [PMID: 38211992]
  • Rui Wu, Yanfang Liu, Fang Zhang, Shu Dai, Xinyan Xue, Cheng Peng, Yan Li, Yunxia Li. Protective mechanism of Paeonol on central nervous system. Phytotherapy research : PTR. 2023 Oct; ?(?):. doi: 10.1002/ptr.8049. [PMID: 37872838]
  • Huan-Zheng Li, Xue-Fang Tang, Yu Lin, Fang-Fang Xu, Xin Zhang, Hui-Qing Ye, Wei Xiao, Zhen-Zhong Wang, Bing Xu. [Discrete element simulation study of mixing process of Guizhi Fuling Capsules: parameter calibration]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Aug; 48(15):4007-4014. doi: 10.19540/j.cnki.cjcmm.20230711.301. [PMID: 37802768]
  • Lixin Zhang, Lihua Wu, Xiangrui Zhu, Jian Mei, Yingli Chen. Paeonol represses A549 cell glycolytic reprogramming and proliferation by decreasing m6A modification of Acyl-CoA dehydrogenase. The Chinese journal of physiology. 2023 Jul; 66(4):248-256. doi: 10.4103/cjop.cjop-d-22-00166. [PMID: 37635484]
  • Shiqin Chen, Yingying Shan, Chunlin Liu, Chungui Du, Jiawei Zhu, Fei Yang, Yuran Shao, Qichao Bao, Yuting Wang, Ying Ran, Wenxiu Yin. Antimildew Effect of Three Phenolic Compounds and the Efficacy of Antimildew Sliced Bamboo Veneer. Molecules (Basel, Switzerland). 2023 Jun; 28(13):. doi: 10.3390/molecules28134941. [PMID: 37446603]
  • Yuanyuan Ding, Baowen Dang, Yonghui Zhang, Shiting Hu, Yuejin Wang, Chenrui Zhao, Tao Zhang, Zijun Gao. Paeonol attenuates Substance P-induced urticaria by inhibiting Src kinase phosphorylation in mast cells. Cellular immunology. 2023 May; 388-389(?):104728. doi: 10.1016/j.cellimm.2023.104728. [PMID: 37224634]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Xin Li, Huimei Shi, Di Zhang, Bei Jing, Zhenni Chen, Yachun Zheng, Shiquan Chang, Li Gao, Guoping Zhao. Paeonol alleviates neuropathic pain by modulating microglial M1 and M2 polarization via the RhoA/p38MAPK signaling pathway. CNS neuroscience & therapeutics. 2023 Apr; ?(?):. doi: 10.1111/cns.14211. [PMID: 37032648]
  • Yulong Yang, Yuning Liang, Xiaoyan Shi, Hongfei Wu, Yarong Liu, Tingting Jiang, Jinjin Yan, Min Zhou, Menglong Gao, Min Dai. Paeonol Attenuates the Endothelial-to-Mesenchymal Transition Induced by TGF-β1 in Human Umbilical Vein Endothelial Cells through ALK5-Smad2/3 Signaling Pathway. Current neurovascular research. 2023 Feb; ?(?):. doi: 10.2174/1567202620666230202124037. [PMID: 36733198]
  • Taotao Sun, Wenchao Xu, Jiaxin Wang, Jingyu Song, Tao Wang, Shaogang Wang, Kang Liu, Jihong Liu. Paeonol ameliorates diabetic erectile dysfunction by inhibiting HMGB1/RAGE/NF-kB pathway. Andrology. 2023 02; 11(2):344-357. doi: 10.1111/andr.13203. [PMID: 35678254]
  • Chunkun Yang, Jiawen Cheng, Qinwei Zhu, Qingquan Pan, Kui Ji, Jun Li. Review of the Protective Mechanism of Paeonol on Cardiovascular Disease. Drug design, development and therapy. 2023; 17(?):2193-2208. doi: 10.2147/dddt.s414752. [PMID: 37525853]
  • Wei Zhang, Manli Yu, Cenxi Zhang, Qing Yu, Sheng Xu, Qiongzhi Yan, Zhifu Guo, Yawei Xu. Active Ingredient Paeonol of Jijiu Huiyang Decoction Alleviates Isoproterenol-Induced Chronic Heart Failure via the GSK3A/PPARα Pathway. Oxidative medicine and cellular longevity. 2023; 2023(?):3271057. doi: 10.1155/2023/3271057. [PMID: 36785789]
  • Songjun Liu, Xinran Cao, Tao Zhang, Chenyang Zhang, Jiao Qu, Yang Sun, Wen Lv, Fan Qu. Paeonol ameliorates endometrial hyperplasia in mice via inhibiting PI3K/AKT pathway-related ferroptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jan; 109(?):154593. doi: 10.1016/j.phymed.2022.154593. [PMID: 36610113]
  • Yang Wang, Zheng Wang, Xiao Wu, Song Zhu, Qiru Guo, Zhong Jin, Zixian Chen, Delai Zhang, Wangming Hu, Huan Xu, Liangqin Shi, Lan Yang, Yong Wang. Paeonol Promotes Reendothelialization After Vascular Injury Through Activation of c-Myc/VEGFR2 Signaling Pathway. Drug design, development and therapy. 2023; 17(?):1567-1582. doi: 10.2147/dddt.s403134. [PMID: 37249931]
  • Cheng-Wen Jia, Ying-Dong Li, Hu-Gang Jiang, Guo-Wei Han, Xin-Ke Zhao. [Study on the mechanism of paeonol in improving low-density lipoprotein-induced human vascular endothelial cell injury]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 2022 Sep; 38(5):537-542. doi: 10.12047/j.cjap.6325.2022.100. [PMID: 37088766]
  • Zhiping Che, Xiaolong Guo, Yuanhao Li, Song Zhang, Lina Zhu, Jiaxuan He, Di Sun, Yihao Guo, Yibo Liu, Ruxue Wei, Xiaobo Huang, Shengming Liu, Genqiang Chen, Yuee Tian. Synthesis of paeonol ester derivatives and their insecticidal, nematicidal, and anti-oomycete activities. Pest management science. 2022 Aug; 78(8):3442-3455. doi: 10.1002/ps.6985. [PMID: 35567371]
  • Yuling Wang, Zeyan Tang, Xueping Guo, Yuqi Zhao, Shujing Ren, Zhenhai Zhang, Huixia Lv. Hyaluronic acid-cyclodextrin encapsulating paeonol for treatment of atopic dermatitis. International journal of pharmaceutics. 2022 Jul; 623(?):121916. doi: 10.1016/j.ijpharm.2022.121916. [PMID: 35714817]
  • Yipeng Gu, Kai Chen, Bingwen Xi, Jun Xie, Xuwen Bing. Protective effects of paeonol against lipopolysaccharide-induced liver oxidative stress and inflammation in gibel carp (Carassius auratus gibelio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Jul; 257(?):109339. doi: 10.1016/j.cbpc.2022.109339. [PMID: 35378299]
  • Jikun Du, Daibo Song, Jinwen Li, Yuanhua Li, Baohong Li, Li Li. Paeonol triggers apoptosis in HeLa cervical cancer cells: the role of mitochondria-related caspase pathway. Psychopharmacology. 2022 Jul; 239(7):2083-2092. doi: 10.1007/s00213-021-05811-0. [PMID: 33710373]
  • Jian-Hong Qi, Fang-Xu Dong, Xiao-Long Wang. Exploring targets and signaling pathways of paeonol involved in relieving inflammation based on modern technology. Molecular diversity. 2022 Jun; 26(3):1731-1742. doi: 10.1007/s11030-021-10301-8. [PMID: 34463943]
  • Wenjing Liu, Zhonggui Gong, Kanglei Zhang, Wenxuan Dong, Hui Zou, Ruilong Song, Jianchun Bian, Jiaqiao Zhu, Gang Liu, Zongping Liu. Paeonol protects renal tubular cells against cadmium-induced cytotoxicity via alleviating oxidative stress, inhibiting inflammatory responses and restoring autophagy. Journal of inorganic biochemistry. 2022 05; 230(?):111733. doi: 10.1016/j.jinorgbio.2022.111733. [PMID: 35131642]
  • Jing Lv, Shibing Zhu, Huiping Chen, Ying Xu, Qingyu Su, Guofen Yu, Wei Ma. Paeonol inhibits human lung cancer cell viability and metastasis in vitro via miR-126-5p/ZEB2 axis. Drug development research. 2022 04; 83(2):432-446. doi: 10.1002/ddr.21873. [PMID: 34636432]
  • Yipeng Gu, Kai Chen, Bingwen Xi, Jun Xie, Xuwen Bing. Paeonol increases the antioxidant and anti-inflammatory capacity of gibel carp (Carassius auratus gibelio) challenged with Aeromonas hydrophila. Fish & shellfish immunology. 2022 Apr; 123(?):479-488. doi: 10.1016/j.fsi.2022.03.005. [PMID: 35314333]
  • Min Pan, Qirui Wang, Yulong Liu, Nan Xiao, Xiaojia Niu, Daqiang Wu, Tianming Wang, Guiming Yan, Jing Shao. Paeonol enhances treatment of fluconazole and amphotericin B against oropharyngeal candidiasis through HIF-1α related IL-17 signaling. Medical mycology. 2022 Mar; 60(3):. doi: 10.1093/mmy/myac011. [PMID: 35099003]
  • Yajing Chen, Yuchen Jia, Yuxin Li, Yuanqiang Zheng, Guojiang Chen, Yanchun Shi. Investigation on the antitumor effects of paeonol against renal cell carcinoma based on network pharmacology and experimental validation. Journal of ethnopharmacology. 2022 Mar; 285(?):114857. doi: 10.1016/j.jep.2021.114857. [PMID: 34813895]
  • Huan Xu, Ziqiang Wu, Zhong Jin, Xiao Wu, Wangming Hu, Bing Liang, Guanhua Lou, Zixian Chen, Huan Yao, Xiongbing Chen, Xin Zhou, Han Xiao, Cenghao Yu, Delai Zhang, Daoying Gong, Lan Yang, Yaping Shi, Yiming Xu, Yong Wang. Paeonol Suppresses Vasculogenesis Through Regulating Vascular Smooth Muscle Phenotypic Switching. Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists. 2022 02; 29(1):117-131. doi: 10.1177/15266028211032956. [PMID: 34355606]
  • Ming Li, Ou Cai, Yuanjie Yu, Shiyun Tan. Paeonol inhibits the malignancy of Apatinib-resistant gastric cancer cells via LINC00665/miR-665/MAPK1 axis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Feb; 96(?):153903. doi: 10.1016/j.phymed.2021.153903. [PMID: 35026514]
  • Shengxi Meng, Bing Wang, Wentao Li. Paeonol administration alleviates cognitive deficits and attenuates neural pathological changes in APP/PS1 mice. Journal of integrative neuroscience. 2021 Dec; 20(4):1001-1010. doi: 10.31083/j.jin2004101. [PMID: 34997723]
  • Conghui Pang, Zhijuan Wu, Xiaoyan Xu, Wenxiu Yang, Xiaoxuan Wang, Yinghua Qi. Paeonol alleviates migration and invasion of endometrial stromal cells by reducing HIF-1α-regulated autophagy in endometriosis. Frontiers in bioscience (Landmark edition). 2021 09; 26(9):485-495. doi: 10.52586/4961. [PMID: 34590461]
  • Min Pan, Qirui Wang, Ting Cheng, Daqiang Wu, Tianming Wang, Guiming Yan, Jing Shao. Paeonol assists fluconazole and amphotericin B to inhibit virulence factors and pathogenicity of Candida albicans. Biofouling. 2021 09; 37(8):922-937. doi: 10.1080/08927014.2021.1985473. [PMID: 34615415]
  • Shanshan Guo, Qiang Zhang. Paeonol protects melanocytes against hydrogen peroxide-induced oxidative stress through activation of Nrf2 signaling pathway. Drug development research. 2021 09; 82(6):861-869. doi: 10.1002/ddr.21793. [PMID: 33491230]
  • Shalini Vellasamy, Dharmani Murugan, Razif Abas, Aspalilah Alias, Wu Yuan Seng, Choy Ker Woon. Biological Activities of Paeonol in Cardiovascular Diseases: A Review. Molecules (Basel, Switzerland). 2021 Aug; 26(16):. doi: 10.3390/molecules26164976. [PMID: 34443563]
  • Weidong Qian, Xinchen Li, Min Yang, Gennian Mao. Antibacterial and anti-biofilm activities of paeonol against Klebsiella pneumoniae and Enterobacter cloacae. Biofouling. 2021 07; 37(6):666-679. doi: 10.1080/08927014.2021.1955249. [PMID: 34320877]
  • Shao-Qin Sheng, Lei-Yuan Yu, Xian-Wei Zhou, Hong-Yi Pan, Feng-Ying Hu, Jia-Li Liu. Paeonol prevents migration and invasion, and promotes apoptosis of cervical cancer cells by inhibiting 5‑lipoxygenase. Molecular medicine reports. 2021 06; 23(6):. doi: 10.3892/mmr.2021.12040. [PMID: 33786614]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Kaveri M Adki, Yogesh A Kulkarni. Neuroprotective effect of paeonol in streptozotocin-induced diabetes in rats. Life sciences. 2021 Apr; 271(?):119202. doi: 10.1016/j.lfs.2021.119202. [PMID: 33577853]
  • Yuzhu Ge, Min Pan, Chuanfeng Zhang, Changzhong Wang, Kelong Ma, Guiming Yan, Tianming Wang, Daqiang Wu, Jing Shao. Paeonol alleviates dextran sodium sulfate induced colitis involving Candida albicans-associated dysbiosis. Medical mycology. 2021 Apr; 59(4):335-344. doi: 10.1093/mmy/myaa053. [PMID: 32598443]
  • J J Zhang, L J Cai, K Pang, Y Dong, Z G Zhang, B B Li, R Li, C H Han. Paeonol inhibits proliferation and induces cell apoptosis of human T24 and 5637 bladder cancer cells in vitro and in vivo. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2021 Mar; 23(3):601-611. doi: 10.1007/s12094-020-02455-y. [PMID: 32691366]
  • Jifei Miao, Jun Zhong, Jiao Lan, Sen Ye, Peng Ye, Siyan Li, Aijia You, Xianjie Chen, Xiaoyi Liu, Hui Li. Paeonol attenuates inflammation by confining HMGB1 to the nucleus. Journal of cellular and molecular medicine. 2021 03; 25(6):2885-2899. doi: 10.1111/jcmm.16319. [PMID: 33534963]
  • Yue-E Tian, Di Sun, Xiao-Xiao Han, Jin-Ming Yang, Song Zhang, Nan-Nan Feng, Li-Na Zhu, Zhong-Yuan Xu, Zhi-Ping Che, Sheng-Ming Liu, Xiao-Min Lin, Jia Jiang, Gen-Qiang Chen. Synthesis, anti-oomycete activity, and SAR studies of paeonol derivatives. Journal of Asian natural products research. 2021 Feb; 23(2):138-149. doi: 10.1080/10286020.2020.1718116. [PMID: 32009450]
  • Miao Sun, Yi-Zhou Wang, Yong Yang, Meng-Wen Lv, Shan-Shan Li, Jaime A Teixeira da Silva, Liang-Sheng Wang, Xiao-Nan Yu. Analysis of Chemical Components in the Roots of Eight Intersubgeneric Hybrids of Paeonia. Chemistry & biodiversity. 2021 Feb; 18(2):e2000848. doi: 10.1002/cbdv.202000848. [PMID: 33403807]
  • Zheng-Long Jin, Wen-Ying Gao, Shao-Jun Liao, Tao Yu, Qing Shi, Shang-Zhen Yu, Ye-Feng Cai. Paeonol inhibits the progression of intracerebral haemorrhage by mediating the HOTAIR/UPF1/ACSL4 axis. ASN neuro. 2021 Jan; 13(?):17590914211010647. doi: 10.1177/17590914211010647. [PMID: 33906483]
  • Asmita Gyawali, Myung-Hee Kim, Young-Sook Kang. A novel organic cation transporter involved in paeonol transport across the inner blood-retinal barrier and changes in uptake in high glucose conditions. Experimental eye research. 2021 01; 202(?):108387. doi: 10.1016/j.exer.2020.108387. [PMID: 33301773]
  • Yarong Liu, Aiwei Song, Hongfei Wu, Yin Sun, Min Dai. Paeonol inhibits apoptosis of vascular smooth muscle cells via up-regulation of autophagy by activating class III PI3K/Beclin-1 signaling pathway. Life sciences. 2021 Jan; 264(?):118714. doi: 10.1016/j.lfs.2020.118714. [PMID: 33157088]
  • Jifei Miao, Peng Ye, Jiao Lan, Sen Ye, Jun Zhong, Austin Gresham, Siyan Li, Aijia You, Xianjie Chen, Xiaoyi Liu, Hui Li. Paeonol promotes the phagocytic ability of macrophages through confining HMGB1 to the nucleus. International immunopharmacology. 2020 Dec; 89(Pt B):107068. doi: 10.1016/j.intimp.2020.107068. [PMID: 33091813]
  • Yilin Guo, Yaoyao Du, Lu Xie, Yiqiong Pu, Jianlong Yuan, Zhicheng Wang, Tong Zhang, Bing Wang. Effects of Paeonol and Gastroretention Tablets of Paeonol on Experimental Gastric Ulcers and Intestinal Flora in Rats. Inflammation. 2020 Dec; 43(6):2178-2190. doi: 10.1007/s10753-020-01285-y. [PMID: 32642910]
  • Xiaoyan Shi, Xianmei Xie, Ying Sun, Hai He, Hanwen Huang, Yarong Liu, Hongfei Wu, Min Dai. Paeonol inhibits NLRP3 mediated inflammation in rat endothelial cells by elevating hyperlipidemic rats plasma exosomal miRNA-223. European journal of pharmacology. 2020 Oct; 885(?):173473. doi: 10.1016/j.ejphar.2020.173473. [PMID: 32800809]
  • Kaveri M Adki, S Murugesan, Yogesh A Kulkarni. In Silico and In Vivo Toxicological Evaluation of Paeonol. Chemistry & biodiversity. 2020 Oct; 17(10):e2000422. doi: 10.1002/cbdv.202000422. [PMID: 32955165]
  • Haiyan Li, Jie Zhu, Caifen Wang, Wei Qin, Xiaoxiao Hu, Jiabin Tong, Lin Yu, Guoqing Zhang, Xiaohong Ren, Zegeng Li, Jiwen Zhang. Paeonol loaded cyclodextrin metal-organic framework particles for treatment of acute lung injury via inhalation. International journal of pharmaceutics. 2020 Sep; 587(?):119649. doi: 10.1016/j.ijpharm.2020.119649. [PMID: 32673767]
  • Yinlan Xu, Jiangang Zheng, Panpan Sun, Jianhua Guo, Xiaozhong Zheng, Yaogui Sun, Kuohai Fan, Wei Yin, Hongquan Li, Na Sun. Cepharanthine and Curcumin inhibited mitochondrial apoptosis induced by PCV2. BMC veterinary research. 2020 Sep; 16(1):345. doi: 10.1186/s12917-020-02568-0. [PMID: 32948186]
  • Zhaomin Dong, Xianmei Xie, Yin Sun, Hongfei Wu, Min Dai. Paeonol prevents lipid metabolism dysfunction in palmitic acid-induced HepG2 injury through promoting SIRT1-FoxO1-ATG14-dependent autophagy. European journal of pharmacology. 2020 Aug; 880(?):173145. doi: 10.1016/j.ejphar.2020.173145. [PMID: 32343969]
  • Jiadi Wu, Daqiang Wu, Kelong Ma, Tianming Wang, Gaoxiang Shi, Jing Shao, Changzhong Wang, Guiming Yan. Paeonol ameliorates murine alcohol liver disease via mycobiota-mediated Dectin-1/IL-1β signaling pathway. Journal of leukocyte biology. 2020 07; 108(1):199-214. doi: 10.1002/jlb.3ma0120-325rr. [PMID: 32129526]
  • Mervat Z Mohamed, Mohamed A Morsy, Hanaa H Mohamed, Heba M Hafez. Paeonol protects against testicular ischaemia-reperfusion injury in rats through inhibition of oxidative stress and inflammation. Andrologia. 2020 Jul; 52(6):e13599. doi: 10.1111/and.13599. [PMID: 32314822]
  • Ya-Rong Liu, Qian Shao, Hui-Hui Zhang, Ying Jia, Min Dai. [Inhibitory effect of paeonol on aortic endothelial inflammation in atherosclerotic rats by up-regulation of caveolin-1 expression and suppression of NF-κB pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2020 Jun; 45(11):2578-2585. doi: 10.19540/j.cnki.cjcmm.20200210.408. [PMID: 32627492]
  • Kaveri M Adki, Yogesh A Kulkarni. Chemistry, pharmacokinetics, pharmacology and recent novel drug delivery systems of paeonol. Life sciences. 2020 Jun; 250(?):117544. doi: 10.1016/j.lfs.2020.117544. [PMID: 32179072]
  • Qianghua Lv, Shufang Li, Hanlu Wei, Zhongmei Wen, Yanling Wang, Tianzhong Tang, Jianfeng Wang, Lining Xia, Xuming Deng. Identification of the natural product paeonol derived from peony bark as an inhibitor of the Salmonella enterica serovar Typhimurium type III secretion system. Applied microbiology and biotechnology. 2020 Feb; 104(4):1673-1682. doi: 10.1007/s00253-019-10290-7. [PMID: 31897522]
  • Masayuki Izumi, Takashi Yoshida, Takashi Nakamura, And Minoru Wakamori. Paeonol, an Ingredient of Kamishoyosan, Reduces Intracellular Lipid Accumulation by Inhibiting Glucocorticoid Receptor Activity in 3T3-L1 Cells. Nutrients. 2020 Jan; 12(2):. doi: 10.3390/nu12020309. [PMID: 31991567]
  • Yue Sun, Lingjun Li, Huichao Xie, Yuzhen Wang, Shuang Gao, Li Zhang, Fumin Bo, Shanjing Yang, Anjie Feng. Primary Studies on Construction and Evaluation of Ion-Sensitive in situ Gel Loaded with Paeonol-Solid Lipid Nanoparticles for Intranasal Drug Delivery. International journal of nanomedicine. 2020; 15(?):3137-3160. doi: 10.2147/ijn.s247935. [PMID: 32440115]
  • Haiyan Jin, Minyan Wang, Jiangmei Wang, Hongmin Cao, Wanting Niu, Lizhong Du. Paeonol attenuates isoflurane anesthesia-induced hippocampal neurotoxicity via modulation of JNK/ERK/P38MAPK pathway and regulates histone acetylation in neonatal rat. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2020 Jan; 33(1):81-91. doi: 10.1080/14767058.2018.1487396. [PMID: 29886761]
  • Jilei Wang, Guiying Wu, Haiping Chu, Zhongyu Wu, Jingyong Sun. Paeonol Derivatives and Pharmacological Activities: A Review of Recent Progress. Mini reviews in medicinal chemistry. 2020; 20(6):466-482. doi: 10.2174/1389557519666191015204223. [PMID: 31644406]
  • Zhi-Ping Che, Jin-Ming Yang, Di Sun, Yue-E Tian, Sheng-Ming Liu, Xiao-Min Lin, Jia Jiang, Gen-Qiang Chen. Combinatorial Synthesis of A Series of Paeonol-based Phenylsulfonyl hydrazone Derivatives as Insecticidal Agents. Combinatorial chemistry & high throughput screening. 2020; 23(3):232-238. doi: 10.2174/1386207323666200127121129. [PMID: 31985371]
  • Liyan Mei, Meihong He, Chaoying Zhang, Jifei Miao, Quan Wen, Xia Liu, Qin Xu, Sen Ye, Peng Ye, Huina Huang, Junli Lin, Xiaojing Zhou, Kai Zhao, Dongfeng Chen, Jianhong Zhou, Chun Li, Hui Li. Paeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p. Scientific reports. 2019 12; 9(1):19370. doi: 10.1038/s41598-019-55980-4. [PMID: 31852965]
  • Da Qing Yu, Xiao Jing Han, Ting Yu Shan, Rui Xu, Jin Hu, Wang Xing Cheng, Liang Ping Zha, Hua Sheng Peng. Microscopic Characteristic and Chemical Composition Analysis of Three Medicinal Plants and Surface Frosts. Molecules (Basel, Switzerland). 2019 Dec; 24(24):. doi: 10.3390/molecules24244548. [PMID: 31842368]
  • Xiaoxiao Zhang, Yuhui Zhai, Junhui Yuan, Yonghong Hu. New insights into Paeoniaceae used as medicinal plants in China. Scientific reports. 2019 12; 9(1):18469. doi: 10.1038/s41598-019-54863-y. [PMID: 31804561]
  • Zhonghui Gai, Zhenxing Wang, Lei Zhang, Jun Ma, Qiao Zhu. Paeonol protects against hypertension in spontaneously hypertensive rats by restoring vascular endothelium. Bioscience, biotechnology, and biochemistry. 2019 Nov; 83(11):1992-1999. doi: 10.1080/09168451.2019.1648203. [PMID: 31362597]
  • Dong-Hai Liu, Elvis Agbo, Shu-Hong Zhang, Jin-Ling Zhu. Anticonvulsant and Neuroprotective Effects of Paeonol in Epileptic Rats. Neurochemical research. 2019 Nov; 44(11):2556-2565. doi: 10.1007/s11064-019-02874-6. [PMID: 31520267]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Gang Chen, Ping Jia, Zhong-Yi Yin, Shu-Zhen Kong, Zhao-Bao Xiang, Xu-Xu Zheng. Paeonol ameliorates monosodium urate-induced arthritis in rats through inhibiting nuclear factor-κB-mediated proinflammatory cytokine production. Phytotherapy research : PTR. 2019 Nov; 33(11):2971-2978. doi: 10.1002/ptr.6472. [PMID: 31407455]
  • Si-Yi Guo, Gui-Tian Chen, Jun Shi, Yan-Ting Wu, Jian-Hui Lai, Xiao-Qi Xu. [Study on physicochemical properties of paeonol-Helix aspersa muller nanogel and its inhibitory effects on hypertrophic scar tissue in rabbit ear]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Nov; 44(22):4857-4863. doi: 10.19540/j.cnki.cjcmm.20190901.301. [PMID: 31872593]
  • Hao Zhou, Zhen-Zhen Qiu, Zuo-Hua Yu, Lin Gao, Ji-Ming He, Zhi-Wei Zhang, Jian Zheng. Paeonol reverses promoting effect of the HOTAIR/miR-124/Notch1 axis on renal interstitial fibrosis in a rat model. Journal of cellular physiology. 2019 08; 234(8):14351-14363. doi: 10.1002/jcp.28137. [PMID: 30714138]
  • Xu Jing, Chao Sun, Huigang Chen, Jing Sun, Ying Zhang, Jing Wu. Protection of paeonol against epirubicin-induced hepatotoxicity: A metabolomic study. Bioscience trends. 2019 Jul; 13(3):253-260. doi: 10.5582/bst.2019.01105. [PMID: 31231109]
  • Liang Zhang, Deng-Chang Li, Li-Fang Liu. Paeonol: pharmacological effects and mechanisms of action. International immunopharmacology. 2019 Jul; 72(?):413-421. doi: 10.1016/j.intimp.2019.04.033. [PMID: 31030097]
  • Yujiao Meng, Zhengrong Liu, Chunyan Zhai, Tingting Di, Lu Zhang, Lei Zhang, Xinran Xie, Yan Lin, Ning Wang, Jingxia Zhao, Yan Wang, Ping Li. Paeonol inhibits the development of 1‑chloro‑2,4‑dinitrobenzene‑induced atopic dermatitis via mast and T cells in BALB/c mice. Molecular medicine reports. 2019 Apr; 19(4):3217-3229. doi: 10.3892/mmr.2019.9985. [PMID: 30816506]
  • Fujing Wang, Maomao Zhu, Nan Jiang, Minghua Zhang, Liang Feng, Xiaobin Jia. Paeonol ameliorates lipopolysaccharides-induced acute lung injury by regulating TLR4/MyD88/ NF-κB signaling pathway. Die Pharmazie. 2019 02; 74(2):101-106. doi: 10.1691/ph.2019.8860. [PMID: 30782259]
  • Duraisamy Ramachandhiran, Veerasamy Vinothkumar, Sukumar Babukumar. Paeonol exhibits anti-tumor effects by apoptotic and anti-inflammatory activities in 7,12-dimethylbenz(a)anthracene induced oral carcinogenesis. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2019 Jan; 94(1):10-25. doi: 10.1080/10520295.2018.1493221. [PMID: 30101628]
  • Chan-Min Liu, Hui-Xin Yang, Jie-Qiong Ma, Wei Yang, Zhao-Jun Feng, Jian-Mei Sun, Chao Cheng, Jun Li, Hong Jiang. Role of AMPK pathway in lead-induced endoplasmic reticulum stress in kidney and in paeonol-induced protection in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Dec; 122(?):87-94. doi: 10.1016/j.fct.2018.10.024. [PMID: 30296514]
  • ZhengWang Sun, Juan Du, Eunson Hwang, Tae-Hoo Yi. Paeonol extracted from Paeonia suffruticosa Andr. ameliorated UVB-induced skin photoaging via DLD/Nrf2/ARE and MAPK/AP-1 pathway. Phytotherapy research : PTR. 2018 Sep; 32(9):1741-1749. doi: 10.1002/ptr.6100. [PMID: 29748977]
  • Xia Liu, Qin Xu, Liyan Mei, Hang Lei, Quan Wen, Jifei Miao, Huina Huang, Dongfeng Chen, Shaohui Du, Saixia Zhang, Jianhong Zhou, Rudong Deng, Yiwei Li, Chun Li, Hui Li. Paeonol attenuates acute lung injury by inhibiting HMGB1 in lipopolysaccharide-induced shock rats. International immunopharmacology. 2018 Aug; 61(?):169-177. doi: 10.1016/j.intimp.2018.05.032. [PMID: 29883962]
  • Yilin Guo, Shiyu Zong, Yiqiong Pu, Benliang Xu, Tong Zhang, Bing Wang. Advances in Pharmaceutical Strategies Enhancing the Efficiencies of Oral Colon-Targeted Delivery Systems in Inflammatory Bowel Disease. Molecules (Basel, Switzerland). 2018 Jul; 23(7):. doi: 10.3390/molecules23071622. [PMID: 29973488]
  • Xing Sun, Peng Wang, Li-Ping Yao, Wei Wang, Yi-Meng Gao, Jing Zhang, Yu-Jie Fu. Paeonol alleviated acute alcohol-induced liver injury via SIRT1/Nrf2/NF-κB signaling pathway. Environmental toxicology and pharmacology. 2018 Jun; 60(?):110-117. doi: 10.1016/j.etap.2018.04.016. [PMID: 29704732]
  • Zhaojun Sheng, Siyuan Ge, Ximing Xu, Yan Zhang, Panpan Wu, Kun Zhang, Xuetao Xu, Chen Li, Denggao Zhao, Xiaowen Tang. Design, synthesis and evaluation of cinnamic acid ester derivatives as mushroom tyrosinase inhibitors. MedChemComm. 2018 May; 9(5):853-861. doi: 10.1039/c8md00099a. [PMID: 30108974]
  • Na Zhu, Xiao-Xiang Wu, Yong Tian, Jin-Xiu Zhu, Jian-Chun Li. Pharmacokinetic and Pharmacodynamics of Self-Assembled Cubic Liquid Crystalline Nanoparticle Gel After Transdermal Administration. Medical science monitor : international medical journal of experimental and clinical research. 2018 Apr; 24(?):2330-2338. doi: 10.12659/msm.906140. [PMID: 29666359]
  • Xiaogang He, Qiufang Cai, Jianxiang Li, Weifeng Guo. Involvement of brain-gut axis in treatment of cerebral infarction by β-asaron and paeonol. Neuroscience letters. 2018 02; 666(?):78-84. doi: 10.1016/j.neulet.2017.12.036. [PMID: 29258757]
  • Shiyu Zong, Yiqiong Pu, Suyun Li, Benliang Xu, Yong Zhang, Tong Zhang, Bing Wang. Beneficial anti-inflammatory effect of paeonol self-microemulsion-loaded colon-specific capsules on experimental ulcerative colitis rats. Artificial cells, nanomedicine, and biotechnology. 2018; 46(sup1):324-335. doi: 10.1080/21691401.2017.1423497. [PMID: 29316822]
  • Li Lu, Yating Qin, Chen Chen, Xiaomei Guo. Beneficial Effects Exerted by Paeonol in the Management of Atherosclerosis. Oxidative medicine and cellular longevity. 2018; 2018(?):1098617. doi: 10.1155/2018/1098617. [PMID: 30524649]
  • Mi Hye Kwon, Jin Seok Jeong, Jayoung Ryu, Young Woong Cho, Hee Eun Kang. Simultaneous determination of saikosaponin a, paeonol, and imperatorin, components of DA-9805, in rat plasma by LC-MS/MS and application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Nov; 1068-1069(?):289-296. doi: 10.1016/j.jchromb.2017.10.059. [PMID: 29128276]
  • Mingran Liu, Shuqiang Zhong, Ruifeng Kong, Hong Shao, Chunyan Wang, Hongying Piao, Wentao Lv, Xiaojie Chu, Yan Zhao. Paeonol alleviates interleukin-1β-induced inflammatory responses in chondrocytes during osteoarthritis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Nov; 95(?):914-921. doi: 10.1016/j.biopha.2017.09.011. [PMID: 28910961]
  • Zhong-Kuan Lyu, Chang-Ling Li, Yan Jin, Yu-Zhao Liu, Xi Zhang, Fang Zhang, Lu-Ning Ning, Er-Shun Liang, Min Ma, Wei Gao, Ming-Xiang Zhang, De-Shan Liu. Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells via downregulating MMP‑2 and MMP‑9. Molecular medicine reports. 2017 Nov; 16(5):7513-7519. doi: 10.3892/mmr.2017.7576. [PMID: 28944890]
  • Li-Qin Ding, Tian-Yi Qiu, Zhao-Xi Liu, Li-Xia Chen, Mahmood Brobbey Oppong, De-Qin Zhang, Bo-Li Zhang, Gang Bai, Feng Qiu. Systematic characterization of the metabolites of paeonol in rats using ultra performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry with an integrative strategy. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Oct; 1065-1066(?):70-78. doi: 10.1016/j.jchromb.2017.09.015. [PMID: 28946128]
  • Pin-Kuei Fu, Chi-Yu Yang, Su-Chin Huang, Yu-Wen Hung, Kee-Ching Jeng, Ying-Pei Huang, Hong Chuang, Nai-Chun Huang, Jui-Ping Li, Ming-Hua Hsu, Jen-Kun Chen. Evaluation of LPS-Induced Acute Lung Injury Attenuation in Rats by Aminothiazole-Paeonol Derivatives. Molecules (Basel, Switzerland). 2017 Sep; 22(10):. doi: 10.3390/molecules22101605. [PMID: 28946699]