Taxifolin (BioDeep_00000017305)

 

Secondary id: BioDeep_00000000348, BioDeep_00000018141, BioDeep_00000398609

human metabolite PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, trans-(+/-)-

化学式: C15H12O7 (304.05830019999996)
中文名称: (±)-二氢槲皮素, (+)-花旗松素, (±)-花旗松素, (±)-紫杉叶素, (±)-黄杉素, 二氢槲皮素, 花旗松素, 紫杉叶素, 黄杉素
谱图信息: 最多检出来源 Viridiplantae(plant) 0.26%

分子结构信息

SMILES: C1(O)C=C(O)C2C(=O)[C@@H]([C@@H](C3=CC=C(O)C(O)=C3)OC=2C=1)O
InChI: InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1

描述信息

(+)-taxifolin is a taxifolin that has (2R,3R)-configuration. It has a role as a metabolite. It is a conjugate acid of a (+)-taxifolin(1-). It is an enantiomer of a (-)-taxifolin.
Taxifolin is a natural product found in Austrocedrus chilensis, Smilax corbularia, and other organisms with data available.
See also: Milk Thistle (part of); Maritime Pine (part of).
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
A taxifolin that has (2R,3R)-configuration.
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].
Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].

同义名列表

76 个代谢物同义名

4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, trans-(+/-)-; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R-trans)-; 4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-,(2R,3R)-rel-; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-; 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one, (2R-trans)-; (2R,3R)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one; rel-(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one; (2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE; (2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyrone; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-; (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one; rel-(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one; (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chroman-4-one; (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one; Taxifolin, primary pharmaceutical reference standard; (+)-TAXIFOLIN (CONSTITUENT OF MARITIME PINE) [DSC]; (+)-TAXIFOLIN (CONSTITUENT OF MILK THISTLE) [DSC]; Flavanone, 3,3,4,5,7-pentahydroxy-, (2R,3R)-(+)-; Flavanone, 3,3,4,5,7-pentahydroxy-, (2R)-trans-; Flavanone, 3,3,4,5,7-pentahydroxy-, trans-(+)-; (+)-TAXIFOLIN (CONSTITUENT OF MARITIME PINE); 5-18-05-00451 (Beilstein Handbook Reference); Flavone, 2,3-dihydro-3,3,4,5,7-pentahydroxy-; (+)-TAXIFOLIN (CONSTITUENT OF MILK THISTLE); Flavanone, 3,3,4,5,7-pentahydroxy-, (R,R)-; (2R,3R)-3,3,4,5,7-Pentahydroxyflavanone; (2R,3R)-3,5,7,3,4-Pentahydroxyflavanone; F40AB773-26FA-4112-A46D-DC970AF64BC1; (+)-Dihydroquercetin; (+)-Taxifolin; Flavanone, 3,3,4,5,7-pentahydroxy-; 3,5,7,3,4-Pentahydroxyflavanone; 3,3,4,5,7-Pentahydroxyflavanone; a cis or trans dihydroquercetin; Taxifolin, analytical standard; DIHYDROQUERCETIN, (+)-(2R,3R)-; (2R,3R)-TRANS-DIHYDROQUERCETIN; taxifolin (dihydroquercetin); (+)-(2R,3R)-dihydroquercetin; DIHYDROQUERCETIN [WHO-DD]; (2R,3R)-Dihydroquercetin; Dihydroquercetin, (+/-)-; DIHYDROQUERCETIN [INCI]; (+/-)-Taxifolin hydrate; trans dihydroquercetin; (+/-)-dihydroquercetin; trans-Dihydroquercetin; (+/-)-trans Taxifolin; (2R,3R)-(+)-Taxifolin; 2,3-Dihydroquercetin; (+)-Dihydroquercetin; (+)-trans Taxifolin; (+)-trans-Taxifolin; Taxifolin, (+/-)-; dihydroquercetin; UNII-9SOB9E3987; UNII-EAS93SC1VS; Taxifolin (Tax); (+/-)-Taxifolin; (±)-Taxifolin; (?)-Taxifolin; TAXIFOLIN-(+); MEGxp0_000741; (+)-Taxifolin; ACon1_000239; ()-Taxifolin; Taxifoliol; 9SOB9E3987; EAS93SC1VS; Flamena D; Taxifolin; Diquertin; Lariksin; Distylin; Lavitol; FLAMENA; DQH



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

181 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qiteng Ding, Wencong Liu, Shuai Zhang, Shuwen Sun, Jiali Yang, Lifeng Zhang, Ning Wang, Shuang Ma, Guodong Chai, Liqian Shen, Yang Gao, Chuanbo Ding, Xinglong Liu. Hydrogel loaded with thiolated chitosan modified taxifolin liposome promotes osteoblast proliferation and regulates Wnt signaling pathway to repair rat skull defects. Carbohydrate polymers. 2024 Jul; 336(?):122115. doi: 10.1016/j.carbpol.2024.122115. [PMID: 38670750]
  • Marija Bruić, Andrea Pirković, Sunčica Borozan, Mirjana Nacka Aleksić, Milica Jovanović Krivokuća, Biljana Spremo-Potparević. Antioxidative and anti-inflammatory effects of taxifolin in H2O2-induced oxidative stress in HTR-8/SVneo trophoblast cell line. Reproductive toxicology (Elmsford, N.Y.). 2024 Jun; 126(?):108585. doi: 10.1016/j.reprotox.2024.108585. [PMID: 38574953]
  • Yuqiao Zeng, Yiyu He, Li Wang, Hao Xu, Qianwen Zhang, Yanjun Wang, Jianhua Zhang, Likun Wang. Dihydroquercetin improves experimental acute liver failure by targeting ferroptosis and mitochondria-mediated apoptosis through the SIRT1/p53 axis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155533. doi: 10.1016/j.phymed.2024.155533. [PMID: 38552433]
  • Qiteng Ding, Xinglong Liu, Xuexia Liu, Guodong Chai, Ning Wang, Shuang Ma, Lifeng Zhang, Shuai Zhang, Jiali Yang, Yanjun Wang, Liqian Shen, Chuanbo Ding, Wencong Liu. Polyvinyl alcohol/carboxymethyl chitosan-based hydrogels loaded with taxifolin liposomes promote diabetic wound healing by inhibiting inflammation and regulating autophagy. International journal of biological macromolecules. 2024 Apr; 263(Pt 1):130226. doi: 10.1016/j.ijbiomac.2024.130226. [PMID: 38368971]
  • Yang Lu, Xinglong Liu, Ting Zhao, Chuanbo Ding, Qiteng Ding, Ning Wang, Shuang Ma, Lina Ma, Wencong Liu. Synthesis of Taxifolin-Loaded Polydopamine for Chemo-Photothermal-Synergistic Therapy of Ovarian Cancer. Molecules (Basel, Switzerland). 2024 Feb; 29(5):. doi: 10.3390/molecules29051042. [PMID: 38474556]
  • Ziyang Liu, Dengjun Qiu, Tong Yang, Jingxu Su, Chengyuan Liu, Xinyue Su, Anning Li, Pingping Sun, Jianguo Li, Li Yan, Chuanbo Ding, Shuai Zhang. Research Progress of Dihydroquercetin in the Treatment of Skin Diseases. Molecules (Basel, Switzerland). 2023 Oct; 28(19):. doi: 10.3390/molecules28196989. [PMID: 37836832]
  • Yue Wang, Chuanbo Ding, Yingchun Zhao, Jinping Zang, Qiteng Ding, Shuai Zhang, Ning Wang, Jiali Yang, Siyu Xi, Ting Zhao, Chunli Zhao, Wencong Liu. Sodium alginate/poly(vinyl alcohol)/taxifolin nanofiber mat promoting diabetic wound healing by modulating the inflammatory response, angiogenesis, and skin flora. International journal of biological macromolecules. 2023 Aug; ?(?):126530. doi: 10.1016/j.ijbiomac.2023.126530. [PMID: 37634780]
  • Amir Taldaev, Anastasiya D Savina, Vera V Olicheva, Sergey V Ivanov, Roman P Terekhov, Igor R Ilyasov, Anastasiya K Zhevlakova, Irina A Selivanova. Protective Properties of Spheroidal Taxifolin Form in Streptozotocin-Induced Diabetic Rats. International journal of molecular sciences. 2023 Jul; 24(15):. doi: 10.3390/ijms241511962. [PMID: 37569337]
  • Ipek Bayram, Artiona Laze, Eric A Decker. Synergistic Mechanisms of Interactions between Myricetin or Taxifolin with α-Tocopherol in Oil-in-Water Emulsions. Journal of agricultural and food chemistry. 2023 Jun; ?(?):. doi: 10.1021/acs.jafc.3c01226. [PMID: 37279160]
  • J N Caamaño, J Santiago-Moreno, F Martínez-Pastor, C Tamargo, A Salman, Á Fernández, M J Merino, E Lacalle, A Toledano-Díaz, C O Hidalgo. Use of the flavonoid taxifolin for sperm cryopreservation from the threatened Bermeya goat breed. Theriogenology. 2023 May; 206(?):18-27. doi: 10.1016/j.theriogenology.2023.05.004. [PMID: 37172535]
  • Qiteng Ding, Chuanbo Ding, Xinglong Liu, Yinan Zheng, Yingchun Zhao, Shuai Zhang, Shuwen Sun, Zanwen Peng, Wencong Liu. Preparation of nanocomposite membranes loaded with taxifolin liposome and its mechanism of wound healing in diabetic mice. International journal of biological macromolecules. 2023 Apr; 241(?):124537. doi: 10.1016/j.ijbiomac.2023.124537. [PMID: 37086765]
  • Shalini Gurumayum, Simanta Bharadwaj, Yunus Sheikh, Sagar R Barge, Kangkon Saikia, Deepsikha Swargiary, Semim Akhtar Ahmed, Debajit Thakur, Jagat C Borah. Taxifolin-3-O-glucoside from Osbeckia nepalensis Hook. mediates antihyperglycemic activity in CC1 hepatocytes and in diabetic Wistar rats via regulating AMPK/G6Pase/PEPCK signaling axis. Journal of ethnopharmacology. 2023 Mar; 303(?):115936. doi: 10.1016/j.jep.2022.115936. [PMID: 36403743]
  • Takayuki Inoue, Bin Fu, Miwako Nishio, Miyako Tanaka, Hisashi Kato, Masashi Tanaka, Michiko Itoh, Hajime Yamakage, Kozue Ochi, Ayaka Ito, Yukihiro Shiraki, Satoshi Saito, Masafumi Ihara, Hideo Nishimura, Atsuhiko Kawamoto, Shian Inoue, Kumiko Saeki, Atsushi Enomoto, Takayoshi Suganami, Noriko Satoh-Asahara. Novel Therapeutic Potentials of Taxifolin for Obesity-Induced Hepatic Steatosis, Fibrogenesis, and Tumorigenesis. Nutrients. 2023 Jan; 15(2):. doi: 10.3390/nu15020350. [PMID: 36678220]
  • A B Katasonov. [Dihydroquercetin as a systemic neuroprotector for the prevention and treatment of β-amyloid-associated brain diseases]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2023; 123(7):136-142. doi: 10.17116/jnevro2023123071136. [PMID: 37490679]
  • Mengyu Wang, Hui Han, Fan Wan, Ruqing Zhong, Yoon Jung Do, Sang-Ik Oh, Xuemeng Lu, Lei Liu, Bao Yi, Hongfu Zhang. Dihydroquercetin Supplementation Improved Hepatic Lipid Dysmetabolism Mediated by Gut Microbiota in High-Fat Diet (HFD)-Fed Mice. Nutrients. 2022 Dec; 14(24):. doi: 10.3390/nu14245214. [PMID: 36558373]
  • Jinping Zhang, Yongchun Zheng, Bo Hong, Lina Ma, Yingchun Zhao, Shuai Zhang, Shuwen Sun, Qiteng Ding, Yue Wang, Wencong Liu, Chuanbo Ding. Dihydroquercetin composite nanofibrous membrane prevents UVA radiation-mediated inflammation, apoptosis and oxidative stress by modulating MAPKs/Nrf2 signaling in human epidermal keratinocytes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Nov; 155(?):113727. doi: 10.1016/j.biopha.2022.113727. [PMID: 36156260]
  • Shiqin Yu, Mingjia Li, Song Gao, Jingwen Zhou. Engineering Saccharomyces cerevisiae for the production of dihydroquercetin from naringenin. Microbial cell factories. 2022 Oct; 21(1):213. doi: 10.1186/s12934-022-01937-8. [PMID: 36243863]
  • R Ozyurt, N Celik, Z Suleyman, F Cagiran, Z Kali, N Gurkan, F Altindag, S Bulut, C Sarigul, K Dinc, H Suleyman. Fertility protective effect of taxifolin in cisplatin-induced ovarian damage. European review for medical and pharmacological sciences. 2022 10; 26(19):7195-7203. doi: 10.26355/eurrev_202210_29909. [PMID: 36263529]
  • Mei-Hua Piao, Hui Wang, Yin-Jing Jiang, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian. Taxifolin blocks monosodium urate crystal-induced gouty inflammation by regulating phagocytosis and autophagy. Inflammopharmacology. 2022 Aug; 30(4):1335-1349. doi: 10.1007/s10787-022-01014-x. [PMID: 35708797]
  • Ying Li, Hang Su, Zhong-Ping Yin, Jing-En Li, En Yuan, Qing-Feng Zhang. Metabolism, tissue distribution and excretion of taxifolin in rat. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):112959. doi: 10.1016/j.biopha.2022.112959. [PMID: 35430392]
  • Jinping Zhang, Kecheng Chen, Chuanbo Ding, Shuwen Sun, Yinan Zheng, Qiteng Ding, Bo Hong, Wencong Liu. Fabrication of chitosan/PVP/dihydroquercetin nanocomposite film for in vitro and in vivo evaluation of wound healing. International journal of biological macromolecules. 2022 May; 206(?):591-604. doi: 10.1016/j.ijbiomac.2022.02.110. [PMID: 35217084]
  • Yiming Zhang, Lanlan Zhan, Quan Wen, Yulin Feng, Yun Luo, Ting Tan. Trapping Methylglyoxal by Taxifolin and Its Metabolites in Mice. Journal of agricultural and food chemistry. 2022 Apr; 70(16):5026-5038. doi: 10.1021/acs.jafc.2c02189. [PMID: 35420027]
  • Nguyen Huy Thuan, Anil Shrestha, Nguyen Thanh Trung, Vinay Bharadwaj Tatipamula, Duong Van Cuong, Nguyen Xuan Canh, Nguyen Van Giang, Tae-Su Kim, Jae Kyung Sohng, Dipesh Dhakal. Advances in biochemistry and the biotechnological production of taxifolin and its derivatives. Biotechnology and applied biochemistry. 2022 Apr; 69(2):848-861. doi: 10.1002/bab.2156. [PMID: 33797804]
  • Murat Alay, Miyase Gulcin Sonmez, Aysegul Sakin, Murat Atmaca, Halis Suleyman, Gulce Naz Yazici, Abdulkadir Coban, Bahadir Suleyman, Seval Bulut, Durdu Altuner. The effects of taxifolin on neuropathy related with hyperglycemia and neuropathic pain in rats: A biochemical and histopathological evaluation. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2022 Apr; 31(4):427-435. doi: 10.17219/acem/144002. [PMID: 35178903]
  • Hang Su, Wen-Jun Wang, Guo-Dong Zheng, Zhong-Ping Yin, Jing-En Li, Ling-Li Chen, Qing-Feng Zhang. The anti-obesity and gut microbiota modulating effects of taxifolin in C57BL/6J mice fed with a high-fat diet. Journal of the science of food and agriculture. 2022 Mar; 102(4):1598-1608. doi: 10.1002/jsfa.11496. [PMID: 34409603]
  • Wei Li, Le Zhang, Qingbiao Xu, Wenbo Yang, Jianan Zhao, Ying Ren, Zhendong Yu, Libao Ma. Taxifolin Alleviates DSS-Induced Ulcerative Colitis by Acting on Gut Microbiome to Produce Butyric Acid. Nutrients. 2022 Mar; 14(5):. doi: 10.3390/nu14051069. [PMID: 35268045]
  • Xiangming Liu, Yiming Ma, Lijuan Luo, Dandan Zong, Herui Li, Zihang Zeng, Yanan Cui, Weiwei Meng, Yan Chen. Dihydroquercetin suppresses cigarette smoke induced ferroptosis in the pathogenesis of chronic obstructive pulmonary disease by activating Nrf2-mediated pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Feb; 96(?):153894. doi: 10.1016/j.phymed.2021.153894. [PMID: 34942457]
  • Youhua Chen, Yan Mei, Lu Yang, Weibin Li, Yu Zhou, Surong He, Jie Liang. Taxifolin improves inflammatory injury of human bronchial epithelial cells by inhibiting matrix metalloproteinase (MMP) 10 via Wnt/β-catenin pathway. Bioengineered. 2022 01; 13(1):1198-1208. doi: 10.1080/21655979.2021.2018384. [PMID: 35000533]
  • Mengwen Shen, Baibai Lin, Fenghua Qian, Lei Zhao, Yao Xi, Yiming Qian. Taxifolin ameliorates sepsis-induced lung capillary leak through inhibiting the JAK/STAT3 pathway. Allergologia et immunopathologia. 2022; 50(2):7-15. doi: 10.15586/aei.v50i2.550. [PMID: 35257540]
  • Ceyda Tanoğlu, Alevtina Ersoy, Taha Abdulkadir Çoban, Gülce Naz Yazıcı, Renad Mammadov, Bahadır Süleyman. The effect of taxifolin on oxidative sciatic nerve damage induced by cobalt chloride in rats: a biochemical and histopathological evaluation. Acta neurobiologiae experimentalis. 2022; 82(3):254-262. doi: 10.55782/ane-2022-024. [PMID: 36214708]
  • Alena Rajnochová Svobodová, Alena Ryšavá, Kateřina Čížková, Lenka Roubalová, Jitka Ulrichová, Jiří Vrba, Bohumil Zálešák, Jitka Vostálová. Effect of the flavonoids quercetin and taxifolin on UVA-induced damage to human primary skin keratinocytes and fibroblasts. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2022 Jan; 21(1):59-75. doi: 10.1007/s43630-021-00140-9. [PMID: 34837635]
  • Xiaoying Yu, Saddam Hussein, Lijia Li, Qingyu Liu, Zhibin Ban, Hailong Jiang. Effect of Dihydroquercetin on Energy Metabolism in LPS-Induced Inflammatory Mice. BioMed research international. 2022; 2022(?):6491771. doi: 10.1155/2022/6491771. [PMID: 35832840]
  • Sahin Yuceli, Bahadir Suleyman, Gulce Naz Yazici, Renad Mammadov, Murat Cankaya, Celaleddin Semih Kunak, Seval Bulut, Halis Suleyman, Durdu Altuner. Effect of Taxifolin on Ischemia/Reperfusion-Induced Oxidative Injury of Sciatic Nerve in Rats. Transplantation proceedings. 2021 Dec; 53(10):3087-3092. doi: 10.1016/j.transproceed.2021.09.041. [PMID: 34772492]
  • Xing-Long Liu, Ying-Chun Zhao, Hong-Yan Zhu, Ming Wu, Yi-Nan Zheng, Min Yang, Zhi-Qiang Cheng, Chuan-Bo Ding, Wen-Cong Liu. Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice. Food & function. 2021 Nov; 12(23):12142-12158. doi: 10.1039/d1fo01349a. [PMID: 34788354]
  • Fan Wan, Hui Han, Ruqing Zhong, Mengyu Wang, Shanlong Tang, Shunfen Zhang, Fujiang Hou, Bao Yi, Hongfu Zhang. Dihydroquercetin supplement alleviates colonic inflammation potentially through improved gut microbiota community in mice. Food & function. 2021 Nov; 12(22):11420-11434. doi: 10.1039/d1fo01422f. [PMID: 34673859]
  • Ahmed A Al-Karmalawy, Mai M Farid, Ahmed Mostafa, Alia Y Ragheb, Sara H Mahmoud, Mahmoud Shehata, Noura M Abo Shama, Mohamed GabAllah, Gomaa Mostafa-Hedeab, Mona M Marzouk. Naturally Available Flavonoid Aglycones as Potential Antiviral Drug Candidates against SARS-CoV-2. Molecules (Basel, Switzerland). 2021 Oct; 26(21):. doi: 10.3390/molecules26216559. [PMID: 34770969]
  • Tingting Di, Chunyan Zhai, Jingxia Zhao, Yan Wang, Zhaoxia Chen, Ping Li. Taxifolin inhibits keratinocyte proliferation and ameliorates imiquimod-induced psoriasis-like mouse model via regulating cytoplasmic phospholipase A2 and PPAR-γ pathway. International immunopharmacology. 2021 Oct; 99(?):107900. doi: 10.1016/j.intimp.2021.107900. [PMID: 34233233]
  • Mengyun Xing, Yunlin Cao, Chuanhong Ren, Yilong Liu, Jiajia Li, Donald Grierson, Cathie Martin, Chongde Sun, Kunsong Chen, Changjie Xu, Xian Li. Elucidation of myricetin biosynthesis in Morella rubra of the Myricaceae. The Plant journal : for cell and molecular biology. 2021 10; 108(2):411-425. doi: 10.1111/tpj.15449. [PMID: 34331782]
  • A M Kabel, H H Arab, M A Abd Elmaaboud. Attenuation of diethyl nitrosamine-induced hepatocellular carcinoma by taxifolin and/or alogliptin: The interplay between toll-like receptor 4, transforming growth factor beta-1, and apoptosis. Human & experimental toxicology. 2021 Oct; 40(10):1710-1720. doi: 10.1177/09603271211008496. [PMID: 33840231]
  • A M Kabel, S A Salama. Effect of taxifolin/dapagliflozin combination on colistin-induced nephrotoxicity in rats. Human & experimental toxicology. 2021 Oct; 40(10):1767-1780. doi: 10.1177/09603271211010906. [PMID: 33882723]
  • Shinji Kondo, Shin-Ichi Adachi, Fumiaki Yoshizawa, Kazumi Yagasaki. Antidiabetic Effect of Taxifolin in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Hyperglycemia and Hyperuricemia. Current issues in molecular biology. 2021 Sep; 43(3):1293-1306. doi: 10.3390/cimb43030092. [PMID: 34698101]
  • Zheng-Wen Yu, Ni Zhang, Chun-Yan Jiang, Shao-Xiong Wu, Xia-Yu Feng, Xiao-Ying Feng. Exploring the genes involved in biosynthesis of dihydroquercetin and dihydromyricetin in Ampelopsis grossedentata. Scientific reports. 2021 08; 11(1):15596. doi: 10.1038/s41598-021-95071-x. [PMID: 34341423]
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