Diosgenin (BioDeep_00000171853)

Main id: BioDeep_00000000107

 

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


5,7,9,13-tetramethyl-5-oxaspiro[oxane-2,6-pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosan]-18-en-16-ol

化学式: C27H42O3 (414.3133782)
中文名称: 薯蓣皂素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C2C(CC3C4CC=C5CC(O)CCC5(C)C4CCC23C)OC11CCC(C)CO1
InChI: InChI=1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3

描述信息

Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway[1]. Diosgenin is an exogenous activator of Pdia3/ERp57[2]. Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression[5].
Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway[1]. Diosgenin is an exogenous activator of Pdia3/ERp57[2]. Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression[5].

同义名列表

3 个代谢物同义名

5,7,9,13-tetramethyl-5-oxaspiro[oxane-2,6-pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosan]-18-en-16-ol; Spirost-5-en-3-ol; Diosgenin



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

193 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Liwei Fan, Runfeng Ni, Haijin Wang, Le Zhang, Aidi Wang, Baoshan Liu. Dioscin alleviates aplastic anemia through regulatory T cells promotion. Hematology (Amsterdam, Netherlands). 2024 Dec; 29(1):2326389. doi: 10.1080/16078454.2024.2326389. [PMID: 38466633]
  • Xinyu Zhou, Duanna Zhang, Jieting Lei, Jixia Ren, Bo Yang, Zhixing Cao, Chuanjie Guo, Yuzhi Li. Polyphyllin I induces rapid ferroptosis in acute myeloid leukemia through simultaneous targeting PI3K/SREBP-1/SCD1 axis and triggering of lipid peroxidation. Journal of natural medicines. 2024 Jun; 78(3):618-632. doi: 10.1007/s11418-024-01811-4. [PMID: 38668832]
  • Ya-Xin Shi, Li Xu, Xin Wang, Ke-Ke Zhang, Cheng-Yuan Zhang, Hong-Yun Liu, Ping-Ping Ding, Wei Shi, Zhi-Yong Liu. Paris polyphylla ethanol extract and polyphyllin I ameliorate adenomyosis by inhibiting epithelial-mesenchymal transition. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 May; 127(?):155461. doi: 10.1016/j.phymed.2024.155461. [PMID: 38452697]
  • Shuli Man, Xinghao Zhang, Lu Xie, Yaxue Zhou, Genbei Wang, Ruijia Hao, Wenyuan Gao. A new insight into material basis of rhizoma Paridis saponins in alleviating pain. Journal of ethnopharmacology. 2024 Apr; 323(?):117642. doi: 10.1016/j.jep.2023.117642. [PMID: 38151180]
  • Chang Junli, Zhao Fulai, Sun Xingyuan, M A Xiaoping, Zhao Peng, Zhou Chujie, Shi Binhao, G U Wenchao, Wang Yongjun, Yang Yanping. Polyphyllin I enhances tumor necrosis factor-related apoptosis-inducing ligand-induced inhibition of human osteosarcoma cell growth downregulating the Wnt/β-catenin pathway. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Apr; 44(2):251-259. doi: 10.19852/j.cnki.jtcm.2024.02.002. [PMID: 38504531]
  • Jia Liu, Honglin Liu, Liangyan Deng, Tao Wang, Luyao Li, Yuanyuan Chen, Liping Qu, Wenjun Zou. Protective Role of Dioscin against Doxorubicin-Induced Chronic Cardiotoxicity: Insights from Nrf2-GPX4 Axis-Mediated Cardiac Ferroptosis. Biomolecules. 2024 Mar; 14(4):. doi: 10.3390/biom14040422. [PMID: 38672439]
  • Shangni Dang, Jiang Geng, Ran Wang, Yumei Feng, Youzhi Han, Runmei Gao. Isolation of endophytes from Dioscorea nipponica Makino for stimulating diosgenin production and plant growth. Plant cell reports. 2024 Mar; 43(4):95. doi: 10.1007/s00299-024-03164-4. [PMID: 38472393]
  • Parul Tyagi, Mrinalini Prasad, Shivangi Mathur, Rajiv Ranjan. Diosgenin biosynthesis investigation in medicinal herb (Tribulus terrestris) by transcriptome analysis. Gene. 2024 Jan; 893(?):147937. doi: 10.1016/j.gene.2023.147937. [PMID: 38381509]
  • Juliana Caroline Santos Santana, Gelson Dos Santos Difante, Jéssica Gomes Rodrigues, Marislayne de Gusmão Pereira, Henrique Jorge Fernandes, Camila Celeste Brandão Ferreira Ítavo, Vanessa Zirondi Longhini, Alexandre Menezes Dias, Luís Carlos Vinhas Ítavo. Mathematical models for predicting protodioscin in tropical forage grasses. Toxicon : official journal of the International Society on Toxinology. 2024 Jan; 240(?):107628. doi: 10.1016/j.toxicon.2024.107628. [PMID: 38278421]
  • Mehdi Arabasadi, Amin Ebrahimi, Mohammad-Reza Amerian, Ehsan Ebrahimibasabi, Elham Azadvari. The amelioration of salt stress-induced damage in fenugreek through the application of cold plasma and melatonin. Plant physiology and biochemistry : PPB. 2024 Jan; 207(?):108382. doi: 10.1016/j.plaphy.2024.108382. [PMID: 38271864]
  • Mengyao Yan, Yixin Zhao, Shuli Man, Yujie Dai, Long Ma, Wenyuan Gao. Diosgenin as a substitute for cholesterol alleviates NAFLD by affecting CYP7A1 and NPC1L1-related pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 125(?):155299. doi: 10.1016/j.phymed.2023.155299. [PMID: 38301301]
  • Mengfei Wang, Chenyue Yuan, Zong Wu, Meng Xu, Ziqi Chen, Jialiang Yao, Zujun Que, Jianhui Tian, Elaine Lai-Han Leung, Ziliang Wang. Paris saponin VII reverses resistance to PARP inhibitors by regulating ovarian cancer tumor angiogenesis and glycolysis through the RORα/ECM1/VEGFR2 signaling axis. International journal of biological sciences. 2024; 20(7):2454-2475. doi: 10.7150/ijbs.91861. [PMID: 38725854]
  • Yan Lin, Qiuyan Hu, Qiang Ye, Haohua Zhang, Ziyu Bao, Yongping Li, Luo Jian Mo. Diosgenin biosynthesis pathway and its regulation in Dioscorea cirrhosa L. PeerJ. 2024; 12(?):e16702. doi: 10.7717/peerj.16702. [PMID: 38282859]
  • Haoyang Gao, Ze Wang, Danlin Zhu, Linlin Zhao, Weihua Xiao. Dioscin: Therapeutic potential for diabetes and complications. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 170(?):116051. doi: 10.1016/j.biopha.2023.116051. [PMID: 38154275]
  • Shirong Feng, Lintao Pan, Quanshun Li, Yi Zhang, Fangyuan Mou, Zhao Liu, Yuanyuan Zhang, Longfei Duan, Baofu Qin, Zhongqiu Hu. The Isolation, Identification and Immobilization Method of Three Novel Enzymes with Diosgenin-Producing Activity Derived from an Aspergillus flavus. International journal of molecular sciences. 2023 Dec; 24(24):. doi: 10.3390/ijms242417611. [PMID: 38139441]
  • Yifan Cui, Yingzhuo Zhou, Yan Li, Jieying Wang, Daotong Li, Fang Chen. Chinese Yam and Its Active Components Regulate the Structure of Gut Microbiota and Indole-like Metabolites in Anaerobic Fermentation In Vitro. Nutrients. 2023 Dec; 15(24):. doi: 10.3390/nu15245112. [PMID: 38140371]
  • Su-Wen Chen, Guo-Liang Yin, Chao-Yuan Song, De-Cheng Meng, Wen-Fei Yu, Xin Zhang, Ya-Nan Feng, Peng-Peng Liang, Feng-Xia Zhang. [Diosgenin alleviates NAFLD induced by a high-fat diet in rats via mTOR/SREBP-1c/HSP60/MCAD/SCAD signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Oct; 48(19):5304-5314. doi: 10.19540/j.cnki.cjcmm.20230601.705. [PMID: 38114120]
  • Jingyuan Zeng, Xican Li, Rongxin Cai, Ban Chen, Chunhou Li, Qingzhong Hu, Yue Sun. Proposing anti-counterfeiting pharmacopoeia quality markers for Shenlingbaizhu granule based on UHPLC-Q-orbitrap-MS identification. Phytochemical analysis : PCA. 2023 Sep; ?(?):. doi: 10.1002/pca.3284. [PMID: 37735858]
  • Yang Liu, Weitao Zhang, Haoyan Zhou, Jun Chen. Steroidal saponins PPI/CCRIS/PSV induce cell death in pancreatic cancer cell through GSDME-dependent pyroptosis. Biochemical and biophysical research communications. 2023 09; 673(?):51-58. doi: 10.1016/j.bbrc.2023.06.062. [PMID: 37356145]
  • Pei-Lu Chen, Guang-Hui Xu, Ming Li, Jia-Yuan Zhang, Jie Cheng, Cheng-Fu Li, Li-Tao Yi. Yamogenin Exhibits Antidepressant-like Effects via Inhibition of ER Stress and Microglial Activation in LPS-Induced Mice. ACS chemical neuroscience. 2023 Aug; ?(?):. doi: 10.1021/acschemneuro.3c00306. [PMID: 37579249]
  • Yi Xiao, Fang Liu, Qinyi Wu, Xinting Zhu, Changyan Yu, Nian Jiang, Sanhua Li, Yun Liu. Dioscin activates endoplasmic reticulum UPR for defense against pathogen bacteria in Caenorhabditis elegans via IRE-1/XBP-1 pathway. The Journal of infectious diseases. 2023 Jul; ?(?):. doi: 10.1093/infdis/jiad294. [PMID: 37499184]
  • Min He, Si-Yuan Guo, Yan Yin, Chi Zhang, Xia-Nan Zhang. [Gene clone and functional identification of sterol glycosyltransferases from Paris polyphylla var. yunnanensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Jul; 48(14):3774-3785. doi: 10.19540/j.cnki.cjcmm.20230413.101. [PMID: 37475069]
  • Weiyi Shen, Wentao Shao, Qihan Wang, Bo Wang, Gang Zhao, Aihua Gu, Zhaoyan Jiang, Hai Hu. Dietary diosgenin transcriptionally down-regulated intestinal NPC1L1 expression to prevent cholesterol gallstone formation in mice. Journal of biomedical science. 2023 Jun; 30(1):44. doi: 10.1186/s12929-023-00933-3. [PMID: 37370162]
  • Michael Yu-Chih Chen, Bruce Chi-Kang Tsai, Wei-Wen Kuo, Chia-Hua Kuo, Yueh-Min Lin, Dennis Jine-Yuan Hsieh, Pei-Ying Pai, Shih-Chieh Liao, Shang-En Huang, Shin-Da Lee, Chih-Yang Huang. Diosgenin Attenuates Myocardial Cell Apoptosis Triggered by Oxidative Stress through Estrogen Receptor to Activate the PI3K/Akt and ERK Axes. The American journal of Chinese medicine. 2023 Jun; ?(?):1-22. doi: 10.1142/s0192415x23500556. [PMID: 37335210]
  • Suwen Chen, Shangwen Sun, Yanan Feng, Xiu Li, Guoliang Yin, Pengpeng Liang, Wenfei Yu, Decheng Meng, Xin Zhang, Hongshuai Liu, Fengxia Zhang. Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic FXR-SHP-SREBP1C/PPARα/CD36 pathway. European journal of pharmacology. 2023 May; ?(?):175808. doi: 10.1016/j.ejphar.2023.175808. [PMID: 37263401]
  • Weipeng Wang, Lixiu Hou, Song Li, Jiaru Li. The Functional Characterization of DzCYP72A12-4 Related to Diosgenin Biosynthesis and Drought Adaptability in Dioscorea zingiberensis. International journal of molecular sciences. 2023 May; 24(9):. doi: 10.3390/ijms24098430. [PMID: 37176134]
  • Shahla Sheikhi, Amin Ebrahimi, Parviz Heidari, Mohamad Reza Amerian, Sajad Rashidi-Monfared, Hadi Alipour. Exogenous 24-epibrassinolide ameliorates tolerance to high-temperature by adjusting the biosynthesis of pigments, enzymatic, non-enzymatic antioxidants, and diosgenin content in fenugreek. Scientific reports. 2023 Apr; 13(1):6661. doi: 10.1038/s41598-023-33913-6. [PMID: 37095206]
  • Xinxin Zhang, Yu Zhang, Yuting Guo, Peiyun Xue, Zhaowei Xue, Yan Zhang, Hong Zhang, Yoichiro Ito, Jianwei Dou, Zengjun Guo. Research progress of diosgenin extraction from Dioscorea zingiberensis C. H. Wright: Inspiration of novel method with environmental protection and efficient characteristics. Steroids. 2023 04; 192(?):109181. doi: 10.1016/j.steroids.2023.109181. [PMID: 36642106]
  • Yanjie Li, Chengyu Zhang, Kexin Kong, Xiaohui Yan. Characterization and Biological Activities of Four Biotransformation Products of Diosgenin from Rhodococcus erythropolis. Molecules (Basel, Switzerland). 2023 Mar; 28(7):. doi: 10.3390/molecules28073093. [PMID: 37049855]
  • Joan Candice Ondevilla, Shinya Hanashima, Akane Mukogawa, Darcy Garza Miyazato, Yuichi Umegawa, Michio Murata. Effect of the number of sugar units on the interaction between diosgenyl saponin and membrane lipids. Biochimica et biophysica acta. Biomembranes. 2023 Mar; 1865(5):184145. doi: 10.1016/j.bbamem.2023.184145. [PMID: 36914020]
  • Lubomir Petrov, Olya Stoilova, Georgi Pramatarov, Hristiyana Kanzova, Elina Tsvetanova, Madlena Andreeva, Almira Georgieva, Dimitrinka Atanasova, Stanislav Philipov, Albena Alexandrova. Effect of Chitosan-Diosgenin Combination on Wound Healing. International journal of molecular sciences. 2023 Mar; 24(5):. doi: 10.3390/ijms24055049. [PMID: 36902475]
  • Kexin Nie, Yang Gao, Shen Chen, Zhi Wang, Hongzhan Wang, Yueheng Tang, Hao Su, Fuer Lu, Hui Dong, Ke Fang. Diosgenin attenuates non-alcoholic fatty liver disease in type 2 diabetes through regulating SIRT6-related fatty acid uptake. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 111(?):154661. doi: 10.1016/j.phymed.2023.154661. [PMID: 36682299]
  • Wen-Ling Liao, Chun-Ping Huang, Hao-Pei Wang, Yu-Jie Lei, Hui-Ju Lin, Yu-Chuen Huang. Diosgenin, a Natural Steroidal Sapogenin, Alleviates the Progression of Diabetic Retinopathy in Diabetic Mice. In vivo (Athens, Greece). 2023 Mar; 37(2):661-666. doi: 10.21873/invivo.13126. [PMID: 36881067]
  • Xue Yin, Jia Liu, Chengxi Kou, Jiaojiao Lu, He Zhang, Wei Song, Yuhua Li, Zheyong Xue, Xin Hua. Deciphering the network of cholesterol biosynthesis in Paris polyphylla laid a base for efficient diosgenin production in plant chassis. Metabolic engineering. 2023 Feb; 76(?):232-246. doi: 10.1016/j.ymben.2023.02.009. [PMID: 36849090]
  • Jun-Ji Cui, Ze-Yun Huang, Yi-Hang Xie, Jun-Bin Wu, Guang-Hui Xu, Cheng-Fu Li, Man-Man Zhang, Li-Tao Yi. Gut microbiota mediated inflammation, neuroendocrine and neurotrophic functions involved in the antidepressant-like effects of diosgenin in chronic restraint stress. Journal of affective disorders. 2023 01; 321(?):242-252. doi: 10.1016/j.jad.2022.10.045. [PMID: 36349650]
  • Bharathi Nathan, Archana Prabahar, M M Sudheer Mohammed. Network analysis of anti-inflammatory phytochemicals and omics data for Rheumatoid arthritis. Current computer-aided drug design. 2023 Jan; ?(?):. doi: 10.2174/1573409919666230106125058. [PMID: 36617711]
  • Shi-Zhao Zhang, Peng-Peng Liang, Ya-Nan Feng, Guo-Liang Yin, Feng-Cui Sun, Chao-Qun Ma, Feng-Xia Zhang. Therapeutic potential and research progress of diosgenin for lipid metabolism diseases. Drug development research. 2022 12; 83(8):1725-1738. doi: 10.1002/ddr.21991. [PMID: 36126194]
  • Olga Michalak, Piotr Krzeczyński, Anna Jaromin, Piotr Cmoch, Marcin Cybulski, Kinga Trzcińska, Przemysław Miszta, Pakhuri Mehta, Jerzy Gubernator, Sławomir Filipek. Antioxidant activity of novel diosgenin derivatives: Synthesis, biological evaluation, and in silico ADME prediction. Steroids. 2022 12; 188(?):109115. doi: 10.1016/j.steroids.2022.109115. [PMID: 36154831]
  • Jinling Zhang, Wenbao Wang, Yanzhao Tian, Liwei Ma, Lin Zhou, Hao Sun, Yukun Ma, Huiling Hou, Xiaoli Wang, Jin Ye, Xiaobo Wang. Design, synthesis and biological evaluation of novel diosgenin-benzoic acid mustard hybrids with potential anti-proliferative activities in human hepatoma HepG2 cells. Journal of enzyme inhibition and medicinal chemistry. 2022 Dec; 37(1):1299-1314. doi: 10.1080/14756366.2022.2070161. [PMID: 35652316]
  • Yujie Zhong, Zhiman Li, Ruyi Jin, Yanpeng Yao, Silan He, Min Lei, Xin Wang, Chao Shi, Li Gao, Xiaoli Peng. Diosgenin Ameliorated Type II Diabetes-Associated Nonalcoholic Fatty Liver Disease through Inhibiting De Novo Lipogenesis and Improving Fatty Acid Oxidation and Mitochondrial Function in Rats. Nutrients. 2022 Nov; 14(23):. doi: 10.3390/nu14234994. [PMID: 36501024]
  • Soledad García-Morales, Ilenia Janeth Corzo-Jiménez, Natalina Frine Silva-Córdova, Andrés Michelle Soto-Cordero, Diego Iván Rodríguez-Mejía, Joaliné Pardo-Núñez, Janet María León-Morales. Comparative study of steroidal sapogenins content in leaves of five Agave species. Journal of the science of food and agriculture. 2022 Oct; 102(13):5653-5659. doi: 10.1002/jsfa.11912. [PMID: 35368099]
  • Ahmad Nasiri, Sajad Rashidi-Monfared, Amin Ebrahimi, Nargues Falahi Charkhabi, Ahmad Moieni. Metabolic engineering of the diosgenin biosynthesis pathway in Trigonella foenum-graceum hairy root cultures. Plant science : an international journal of experimental plant biology. 2022 Oct; 323(?):111410. doi: 10.1016/j.plantsci.2022.111410. [PMID: 35944746]
  • Zhi Wang, Qiao Wu, Hongzhan Wang, Yang Gao, Kexin Nie, Yueheng Tang, Hao Su, Meilin Hu, Jing Gong, Ke Fang, Hui Dong. Diosgenin protects against podocyte injury in early phase of diabetic nephropathy through regulating SIRT6. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Sep; 104(?):154276. doi: 10.1016/j.phymed.2022.154276. [PMID: 35728388]
  • Shofiul Azam, Yon-Suk Kim, Md Jakaria, Ye-Ji Yu, Jae-Yong Ahn, In-Su Kim, Dong-Kug Choi. Dioscorea nipponica Makino Rhizome Extract and Its Active Compound Dioscin Protect against Neuroinflammation and Scopolamine-Induced Memory Deficits. International journal of molecular sciences. 2022 Sep; 23(17):. doi: 10.3390/ijms23179923. [PMID: 36077321]
  • Lixiu Hou, Song Li, Furui Zhang, Yongbin Gu, Jiaru Li. Effect of exogenous jasmonic acid on physiology and steroidal saponin accumulation in Dioscorea zingiberensis. Plant physiology and biochemistry : PPB. 2022 Sep; 186(?):1-10. doi: 10.1016/j.plaphy.2022.06.025. [PMID: 35792454]
  • Nguyen Thi Duyen, Le Ba Vinh, Nguyen Viet Phong, Nguyen Minh Khoi, Do Thi Ha, Pham Quoc Long, Le Viet Dung, Tran Thi Hien, Nguyen Tien Dat, Ki Yong Lee. Steroid glycosides isolated from Paris polyphylla var. chinensis aerial parts and paris saponin II induces G1/S-phase MCF-7 cell cycle arrest. Carbohydrate research. 2022 Sep; 519(?):108613. doi: 10.1016/j.carres.2022.108613. [PMID: 35752103]
  • Mahantesha B N Naika, Nitish Sathyanarayanan, Radha Sivarajan Sajeevan, Teerna Bhattacharyya, Pritha Ghosh, Meenakshi S Iyer, Mahita Jarjapu, Adwait G Joshi, K Harini, K Mohamed Shafi, Neha Kalmankar, Snehal D Karpe, Bhavika Mam, Shaik Naseer Pasha, Ramanathan Sowdhamini. Exploring the medicinally important secondary metabolites landscape through the lens of transcriptome data in fenugreek (Trigonella foenum graecum L.). Scientific reports. 2022 08; 12(1):13534. doi: 10.1038/s41598-022-17779-8. [PMID: 35941189]
  • Linshu Guan, Zhang Mao, Sen Yang, Guanlin Wu, Yurong Chen, Lianhong Yin, Yan Qi, Lan Han, Lina Xu. Dioscin alleviates Alzheimer's disease through regulating RAGE/NOX4 mediated oxidative stress and inflammation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Aug; 152(?):113248. doi: 10.1016/j.biopha.2022.113248. [PMID: 35691153]
  • Zhe Zhang, Xuerong Zhao, Meng Gao, Lina Xu, Yan Qi, Jinhong Wang, Lianhong Yin. Dioscin alleviates myocardial infarction injury via regulating BMP4/NOX1-mediated oxidative stress and inflammation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Aug; 103(?):154222. doi: 10.1016/j.phymed.2022.154222. [PMID: 35675750]
  • Jude E Okokon, Idongesit C Etuk, Paul S Thomas, Falko P Drijfhout, Tim D W Claridge, Wen-Wu Li. In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jul; 151(?):113153. doi: 10.1016/j.biopha.2022.113153. [PMID: 35598372]
  • Ruixia Bao, Wei Wang, Beibei Chen, Jujie Pan, Qian Chen, Mengyang Liu, Dan Wang, Yuzheng Wu, Haiyang Yu, Lifeng Han, Yi Zhang, Tao Wang. Dioscin Ameliorates Hyperuricemia-Induced Atherosclerosis by Modulating of Cholesterol Metabolism through FXR-Signaling Pathway. Nutrients. 2022 May; 14(9):. doi: 10.3390/nu14091983. [PMID: 35565954]
  • Monisha Prasad, Selvaraj Jayaraman, Ponnulakshmi Rajagopal, Vishnu Priya Veeraraghavan, Praveen Kumar Kumar, Shanmughavel Piramanayagam, Leelavinothan Pari. Diosgenin inhibits ER stress-induced inflammation in aorta via iRhom2/TACE mediated signaling in experimental diabetic rats: An in vivo and in silico approach. Chemico-biological interactions. 2022 May; 358(?):109885. doi: 10.1016/j.cbi.2022.109885. [PMID: 35305976]
  • Ruolan Fan, Weishen He, Yong Fan, Wen Xu, Wei Xu, Guohong Yan, Shaohua Xu. Recent advances in chemical synthesis, biocatalysis, and biological evaluation of diosgenin derivatives - A review. Steroids. 2022 04; 180(?):108991. doi: 10.1016/j.steroids.2022.108991. [PMID: 35217033]
  • Lili Song, Congjun Li, Fei Wu, Shicui Zhang. Dietary intake of diosgenin delays aging of male fish Nothobranchius guentheri through modulation of multiple pathways that play prominent roles in ROS production. Biogerontology. 2022 04; 23(2):201-213. doi: 10.1007/s10522-022-09955-0. [PMID: 35102470]
  • Yujie Zhong, Jiayu Liu, Dianjun Sun, Tianmin Guo, Yanpeng Yao, Xiaodong Xia, Chao Shi, Xiaoli Peng. Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis, and improving mitochondrial quality and quantity control. Food & function. 2022 Mar; 13(6):3660-3673. doi: 10.1039/d1fo02733f. [PMID: 35262539]
  • Xu-Bo Wu, Chin-Hu Lai, Ying-Jui Ho, Chia-Hua Kuo, Pei-Fang Lai, Ching-Yi Tasi, Guohua Jin, Minqian Wei, Marthandam Asokan Shibu, Chih-Yang Huang, Shin-Da Lee. Anti-apoptotic effects of diosgenin on ovariectomized hearts. Steroids. 2022 03; 179(?):108980. doi: 10.1016/j.steroids.2022.108980. [PMID: 35157911]
  • Yujie Zhong, Dianjun Sun, Yanpeng Yao, Qi Liu, Tianmin Guo, Xin Wang, Xiaoli Peng. Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury. Chemico-biological interactions. 2022 Mar; 355(?):109850. doi: 10.1016/j.cbi.2022.109850. [PMID: 35149085]
  • Yaoyao Cai, Fengfeng Xie, Haiou Wang, Qi Zhai, Feng Lin, Shishi Pan. Polyphyllin I alleviates inflammatory injury in mice with gestational diabetes through AMPK pathway. General physiology and biophysics. 2022 Mar; 41(2):159-164. doi: 10.4149/gpb_2022006. [PMID: 35416179]
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  • Romaan Nazir, Vijay Kumar, Suphala Gupta, Padmanabh Dwivedi, Devendra Kumar Pandey, Abhijit Dey. Biotechnological strategies for the sustainable production of diosgenin from Dioscorea spp. Applied microbiology and biotechnology. 2021 Jan; 105(2):569-585. doi: 10.1007/s00253-020-11055-3. [PMID: 33404834]
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  • Yao Tan, Liming Wang, Jian Gao, Junhong Ma, Haiyang Yu, Yi Zhang, Tao Wang, Lifeng Han. Multiomics Integrative Analysis for Discovering the Potential Mechanism of Dioscin against Hyperuricemia Mice. Journal of proteome research. 2021 01; 20(1):645-660. doi: 10.1021/acs.jproteome.0c00584. [PMID: 33107303]