Diosgenin (BioDeep_00000000107)

 

Secondary id: BioDeep_00000000533, BioDeep_00000171853

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(2R,4S,5R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-5,6a,8a,9-Tetramethyl-1,3,3,4,4,5,5,6,6a,6b,6,7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2,1:4,5]indeno[2,1-b]furan-10,2-pyran]-4-ol

化学式: C27H42O3 (414.3133782)
中文名称: 薯芋皂苷配基, 薯蓣皂苷元, 薯蓣皂素, 薯芋皂素, 地奥配质, 薯蓣皂甙元
谱图信息: 最多检出来源 Viridiplantae(plant) 8.93%

分子结构信息

SMILES: C1[C@H](O)CC2[C@@](C)([C@@]3([H])CC[C@]4(C)[C@H]5[C@@H]([C@]6(O[C@H]5C[C@@]4([H])[C@]3([H])CC=2)CC[C@@H](C)CO6)C)C1
InChI: InChI=1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3

描述信息

Diosgenin is a sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25. A natural product found in Dioscorea (wild yam) species, it is used as the starting point for the commercial synthesis of a number of steroids, including cortisone, pregnenolone and progesterone. It has a role as an apoptosis inducer, an antiviral agent, an antineoplastic agent and a metabolite. It is a 3beta-sterol, a spiroketal, a hexacyclic triterpenoid and a sapogenin. It derives from a hydride of a spirostan.
Diosgenin is a natural product found in Ophiopogon intermedius, Dracaena draco, and other organisms with data available.
A spirostan found in DIOSCOREA and other plants. The 25S isomer is called yamogenin. Solasodine is a natural derivative formed by replacing the spiro-ring with a nitrogen, which can rearrange to SOLANINE.
See also: Fenugreek seed (part of); Dioscorea polystachya tuber (part of).
A sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25. A natural product found in Dioscorea (wild yam) species, it is used as the starting point for the commercial synthesis of a number of steroids, including cortisone, pregnenolone and progesterone.
Diosgenin is a member of the class of compounds known as triterpenoids. Triterpenoids are terpene molecules containing six isoprene units. Diosgenin is practically insoluble (in water) and an extremely weak acidic compound (based on its pKa). Diosgenin can be found in a number of food items such as carrot, wild carrot, yam, and bitter gourd, which makes diosgenin a potential biomarker for the consumption of these food products. Diosgenin, a phytosteroid sapogenin, is the product of hydrolysis by acids, strong bases, or enzymes of saponins, extracted from the tubers of Dioscorea wild yam, such as the Kokoro. The sugar-free (aglycone) product of such hydrolysis, diosgenin is used for the commercial synthesis of cortisone, pregnenolone, progesterone, and other steroid products .
Bottle Name:Diosgenin; Origin: Plant; Formula(Parent): C27H42O3; PRIME Parent Name:Diosgenin; PRIME in-house No.:T0108; SubCategory_DNP: The sterols, Cholestanes
Origin: Plant; Formula(Parent): C27H42O3; Bottle Name:Diosgenin; PRIME Parent Name:Diosgenin; PRIME in-house No.:T0108; SubCategory_DNP: The sterols, Cholestanes
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2260
Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway[1]. Diosgenin is an exogenous activator of Pdia3/ERp57[2]. Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression[5].
Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway[1]. Diosgenin is an exogenous activator of Pdia3/ERp57[2]. Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression[5].

同义名列表

42 个代谢物同义名

(2R,4S,5R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-5,6a,8a,9-Tetramethyl-1,3,3,4,4,5,5,6,6a,6b,6,7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2,1:4,5]indeno[2,1-b]furan-10,2-pyran]-4-ol; (1S,2R,2S,4S,5R,7S,8R,9S,12S,13R,16S)-5,7,9,13-tetramethyl-5-oxaspiro[oxane-2,6-pentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosan]-18-en-16-ol; (25R)-5-Spirosten-3(1/4)?-ol ; 3(1/4)?-Hydroxy-5-spirostene; Diosgenin, European Pharmacopoeia (EP) Reference Standard; (2R,5R)-5-tetramethylspiro[[?]-2,2-tetrahydropyran]ol; DIOSGENIN (CONSTITUENT OF FENUGREEK SEED) [DSC]; 5-19-03-00030 (Beilstein Handbook Reference); DIOSGENIN (CONSTITUENT OF FENUGREEK SEED); (25R)-14beta,17beta-spirost-5-en-3beta-ol; Spirost-5-en-3-ol, (3-beta,25R)-; (3.BETA.,25R)-SPIROST-5-EN-3-OL; Spirost-5-en-3-ol, (3beta,25R)-; (20R,25R)-Spirost-5-en-3beta-ol; Spirost-5-en-3-beta-ol, (25R)-; Spirost-5-en-3beta-ol, (25R)-; 22alpha-Spirost-5-en-3beta-ol; (25R)-spirost-5-en-3beta-diol; (3beta,25R)-spirost-5-en-3-ol; Spirost-5-en-3-ol, (3b,25R)-; WQLVFSAGQJTQCK-VKROHFNGSA-N; (25R)-Spirost-5-en-3beta-ol; 3beta-Hydroxy-5-spirostene; (25R)-5-Spirosten-3beta-ol; 3A-Hydroxy-5-spirostene; (25R)-5-Spirosten-3A-ol; Dioscorea sapogenin; DIOSGENIN [WHO-DD]; Diosgenin, >=93\\%; DIOSGENIN [INCI]; UNII-K49P2K8WLX; DIOSGENIN [MI]; Diosgenin,(S); nitrogen in; ST 27:3;O3; K49P2K8WLX; Diosgenin; Nitogenin; DISOGENIN; SP 37; YUV; NCGC00386027-01_C27H42O3_Spirost-5-en-3-ol, (3beta,25R)-; Diosgenin



数据库引用编号

56 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

446 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Liwei Fan, Runfeng Ni, Haijin Wang, Le Zhang, Aidi Wang, Baoshan Liu. Dioscin alleviates aplastic anemia through regulatory T cells promotion. Hematology (Amsterdam, Netherlands). 2024 Dec; 29(1):2326389. doi: 10.1080/16078454.2024.2326389. [PMID: 38466633]
  • Xinyu Zhou, Duanna Zhang, Jieting Lei, Jixia Ren, Bo Yang, Zhixing Cao, Chuanjie Guo, Yuzhi Li. Polyphyllin I induces rapid ferroptosis in acute myeloid leukemia through simultaneous targeting PI3K/SREBP-1/SCD1 axis and triggering of lipid peroxidation. Journal of natural medicines. 2024 Jun; 78(3):618-632. doi: 10.1007/s11418-024-01811-4. [PMID: 38668832]
  • Ya-Xin Shi, Li Xu, Xin Wang, Ke-Ke Zhang, Cheng-Yuan Zhang, Hong-Yun Liu, Ping-Ping Ding, Wei Shi, Zhi-Yong Liu. Paris polyphylla ethanol extract and polyphyllin I ameliorate adenomyosis by inhibiting epithelial-mesenchymal transition. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 May; 127(?):155461. doi: 10.1016/j.phymed.2024.155461. [PMID: 38452697]
  • Shuli Man, Xinghao Zhang, Lu Xie, Yaxue Zhou, Genbei Wang, Ruijia Hao, Wenyuan Gao. A new insight into material basis of rhizoma Paridis saponins in alleviating pain. Journal of ethnopharmacology. 2024 Apr; 323(?):117642. doi: 10.1016/j.jep.2023.117642. [PMID: 38151180]
  • Chang Junli, Zhao Fulai, Sun Xingyuan, M A Xiaoping, Zhao Peng, Zhou Chujie, Shi Binhao, G U Wenchao, Wang Yongjun, Yang Yanping. Polyphyllin I enhances tumor necrosis factor-related apoptosis-inducing ligand-induced inhibition of human osteosarcoma cell growth downregulating the Wnt/β-catenin pathway. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Apr; 44(2):251-259. doi: 10.19852/j.cnki.jtcm.2024.02.002. [PMID: 38504531]
  • Jia Liu, Honglin Liu, Liangyan Deng, Tao Wang, Luyao Li, Yuanyuan Chen, Liping Qu, Wenjun Zou. Protective Role of Dioscin against Doxorubicin-Induced Chronic Cardiotoxicity: Insights from Nrf2-GPX4 Axis-Mediated Cardiac Ferroptosis. Biomolecules. 2024 Mar; 14(4):. doi: 10.3390/biom14040422. [PMID: 38672439]
  • Shangni Dang, Jiang Geng, Ran Wang, Yumei Feng, Youzhi Han, Runmei Gao. Isolation of endophytes from Dioscorea nipponica Makino for stimulating diosgenin production and plant growth. Plant cell reports. 2024 Mar; 43(4):95. doi: 10.1007/s00299-024-03164-4. [PMID: 38472393]
  • Parul Tyagi, Mrinalini Prasad, Shivangi Mathur, Rajiv Ranjan. Diosgenin biosynthesis investigation in medicinal herb (Tribulus terrestris) by transcriptome analysis. Gene. 2024 Jan; 893(?):147937. doi: 10.1016/j.gene.2023.147937. [PMID: 38381509]
  • Juliana Caroline Santos Santana, Gelson Dos Santos Difante, Jéssica Gomes Rodrigues, Marislayne de Gusmão Pereira, Henrique Jorge Fernandes, Camila Celeste Brandão Ferreira Ítavo, Vanessa Zirondi Longhini, Alexandre Menezes Dias, Luís Carlos Vinhas Ítavo. Mathematical models for predicting protodioscin in tropical forage grasses. Toxicon : official journal of the International Society on Toxinology. 2024 Jan; 240(?):107628. doi: 10.1016/j.toxicon.2024.107628. [PMID: 38278421]
  • Mehdi Arabasadi, Amin Ebrahimi, Mohammad-Reza Amerian, Ehsan Ebrahimibasabi, Elham Azadvari. The amelioration of salt stress-induced damage in fenugreek through the application of cold plasma and melatonin. Plant physiology and biochemistry : PPB. 2024 Jan; 207(?):108382. doi: 10.1016/j.plaphy.2024.108382. [PMID: 38271864]
  • Mengyao Yan, Yixin Zhao, Shuli Man, Yujie Dai, Long Ma, Wenyuan Gao. Diosgenin as a substitute for cholesterol alleviates NAFLD by affecting CYP7A1 and NPC1L1-related pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 125(?):155299. doi: 10.1016/j.phymed.2023.155299. [PMID: 38301301]
  • Mengfei Wang, Chenyue Yuan, Zong Wu, Meng Xu, Ziqi Chen, Jialiang Yao, Zujun Que, Jianhui Tian, Elaine Lai-Han Leung, Ziliang Wang. Paris saponin VII reverses resistance to PARP inhibitors by regulating ovarian cancer tumor angiogenesis and glycolysis through the RORα/ECM1/VEGFR2 signaling axis. International journal of biological sciences. 2024; 20(7):2454-2475. doi: 10.7150/ijbs.91861. [PMID: 38725854]
  • Yan Lin, Qiuyan Hu, Qiang Ye, Haohua Zhang, Ziyu Bao, Yongping Li, Luo Jian Mo. Diosgenin biosynthesis pathway and its regulation in Dioscorea cirrhosa L. PeerJ. 2024; 12(?):e16702. doi: 10.7717/peerj.16702. [PMID: 38282859]
  • Haoyang Gao, Ze Wang, Danlin Zhu, Linlin Zhao, Weihua Xiao. Dioscin: Therapeutic potential for diabetes and complications. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 170(?):116051. doi: 10.1016/j.biopha.2023.116051. [PMID: 38154275]
  • Shirong Feng, Lintao Pan, Quanshun Li, Yi Zhang, Fangyuan Mou, Zhao Liu, Yuanyuan Zhang, Longfei Duan, Baofu Qin, Zhongqiu Hu. The Isolation, Identification and Immobilization Method of Three Novel Enzymes with Diosgenin-Producing Activity Derived from an Aspergillus flavus. International journal of molecular sciences. 2023 Dec; 24(24):. doi: 10.3390/ijms242417611. [PMID: 38139441]
  • Yifan Cui, Yingzhuo Zhou, Yan Li, Jieying Wang, Daotong Li, Fang Chen. Chinese Yam and Its Active Components Regulate the Structure of Gut Microbiota and Indole-like Metabolites in Anaerobic Fermentation In Vitro. Nutrients. 2023 Dec; 15(24):. doi: 10.3390/nu15245112. [PMID: 38140371]
  • Su-Wen Chen, Guo-Liang Yin, Chao-Yuan Song, De-Cheng Meng, Wen-Fei Yu, Xin Zhang, Ya-Nan Feng, Peng-Peng Liang, Feng-Xia Zhang. [Diosgenin alleviates NAFLD induced by a high-fat diet in rats via mTOR/SREBP-1c/HSP60/MCAD/SCAD signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Oct; 48(19):5304-5314. doi: 10.19540/j.cnki.cjcmm.20230601.705. [PMID: 38114120]
  • Jingyuan Zeng, Xican Li, Rongxin Cai, Ban Chen, Chunhou Li, Qingzhong Hu, Yue Sun. Proposing anti-counterfeiting pharmacopoeia quality markers for Shenlingbaizhu granule based on UHPLC-Q-orbitrap-MS identification. Phytochemical analysis : PCA. 2023 Sep; ?(?):. doi: 10.1002/pca.3284. [PMID: 37735858]
  • Yang Liu, Weitao Zhang, Haoyan Zhou, Jun Chen. Steroidal saponins PPI/CCRIS/PSV induce cell death in pancreatic cancer cell through GSDME-dependent pyroptosis. Biochemical and biophysical research communications. 2023 09; 673(?):51-58. doi: 10.1016/j.bbrc.2023.06.062. [PMID: 37356145]
  • Pei-Lu Chen, Guang-Hui Xu, Ming Li, Jia-Yuan Zhang, Jie Cheng, Cheng-Fu Li, Li-Tao Yi. Yamogenin Exhibits Antidepressant-like Effects via Inhibition of ER Stress and Microglial Activation in LPS-Induced Mice. ACS chemical neuroscience. 2023 Aug; ?(?):. doi: 10.1021/acschemneuro.3c00306. [PMID: 37579249]
  • Yi Xiao, Fang Liu, Qinyi Wu, Xinting Zhu, Changyan Yu, Nian Jiang, Sanhua Li, Yun Liu. Dioscin activates endoplasmic reticulum UPR for defense against pathogen bacteria in Caenorhabditis elegans via IRE-1/XBP-1 pathway. The Journal of infectious diseases. 2023 Jul; ?(?):. doi: 10.1093/infdis/jiad294. [PMID: 37499184]
  • Min He, Si-Yuan Guo, Yan Yin, Chi Zhang, Xia-Nan Zhang. [Gene clone and functional identification of sterol glycosyltransferases from Paris polyphylla var. yunnanensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Jul; 48(14):3774-3785. doi: 10.19540/j.cnki.cjcmm.20230413.101. [PMID: 37475069]
  • Weiyi Shen, Wentao Shao, Qihan Wang, Bo Wang, Gang Zhao, Aihua Gu, Zhaoyan Jiang, Hai Hu. Dietary diosgenin transcriptionally down-regulated intestinal NPC1L1 expression to prevent cholesterol gallstone formation in mice. Journal of biomedical science. 2023 Jun; 30(1):44. doi: 10.1186/s12929-023-00933-3. [PMID: 37370162]
  • Michael Yu-Chih Chen, Bruce Chi-Kang Tsai, Wei-Wen Kuo, Chia-Hua Kuo, Yueh-Min Lin, Dennis Jine-Yuan Hsieh, Pei-Ying Pai, Shih-Chieh Liao, Shang-En Huang, Shin-Da Lee, Chih-Yang Huang. Diosgenin Attenuates Myocardial Cell Apoptosis Triggered by Oxidative Stress through Estrogen Receptor to Activate the PI3K/Akt and ERK Axes. The American journal of Chinese medicine. 2023 Jun; ?(?):1-22. doi: 10.1142/s0192415x23500556. [PMID: 37335210]
  • Suwen Chen, Shangwen Sun, Yanan Feng, Xiu Li, Guoliang Yin, Pengpeng Liang, Wenfei Yu, Decheng Meng, Xin Zhang, Hongshuai Liu, Fengxia Zhang. Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic FXR-SHP-SREBP1C/PPARα/CD36 pathway. European journal of pharmacology. 2023 May; ?(?):175808. doi: 10.1016/j.ejphar.2023.175808. [PMID: 37263401]
  • Weipeng Wang, Lixiu Hou, Song Li, Jiaru Li. The Functional Characterization of DzCYP72A12-4 Related to Diosgenin Biosynthesis and Drought Adaptability in Dioscorea zingiberensis. International journal of molecular sciences. 2023 May; 24(9):. doi: 10.3390/ijms24098430. [PMID: 37176134]
  • Shahla Sheikhi, Amin Ebrahimi, Parviz Heidari, Mohamad Reza Amerian, Sajad Rashidi-Monfared, Hadi Alipour. Exogenous 24-epibrassinolide ameliorates tolerance to high-temperature by adjusting the biosynthesis of pigments, enzymatic, non-enzymatic antioxidants, and diosgenin content in fenugreek. Scientific reports. 2023 Apr; 13(1):6661. doi: 10.1038/s41598-023-33913-6. [PMID: 37095206]
  • Xinxin Zhang, Yu Zhang, Yuting Guo, Peiyun Xue, Zhaowei Xue, Yan Zhang, Hong Zhang, Yoichiro Ito, Jianwei Dou, Zengjun Guo. Research progress of diosgenin extraction from Dioscorea zingiberensis C. H. Wright: Inspiration of novel method with environmental protection and efficient characteristics. Steroids. 2023 04; 192(?):109181. doi: 10.1016/j.steroids.2023.109181. [PMID: 36642106]
  • Yanjie Li, Chengyu Zhang, Kexin Kong, Xiaohui Yan. Characterization and Biological Activities of Four Biotransformation Products of Diosgenin from Rhodococcus erythropolis. Molecules (Basel, Switzerland). 2023 Mar; 28(7):. doi: 10.3390/molecules28073093. [PMID: 37049855]
  • Joan Candice Ondevilla, Shinya Hanashima, Akane Mukogawa, Darcy Garza Miyazato, Yuichi Umegawa, Michio Murata. Effect of the number of sugar units on the interaction between diosgenyl saponin and membrane lipids. Biochimica et biophysica acta. Biomembranes. 2023 Mar; 1865(5):184145. doi: 10.1016/j.bbamem.2023.184145. [PMID: 36914020]
  • Lubomir Petrov, Olya Stoilova, Georgi Pramatarov, Hristiyana Kanzova, Elina Tsvetanova, Madlena Andreeva, Almira Georgieva, Dimitrinka Atanasova, Stanislav Philipov, Albena Alexandrova. Effect of Chitosan-Diosgenin Combination on Wound Healing. International journal of molecular sciences. 2023 Mar; 24(5):. doi: 10.3390/ijms24055049. [PMID: 36902475]
  • Kexin Nie, Yang Gao, Shen Chen, Zhi Wang, Hongzhan Wang, Yueheng Tang, Hao Su, Fuer Lu, Hui Dong, Ke Fang. Diosgenin attenuates non-alcoholic fatty liver disease in type 2 diabetes through regulating SIRT6-related fatty acid uptake. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 111(?):154661. doi: 10.1016/j.phymed.2023.154661. [PMID: 36682299]
  • Wen-Ling Liao, Chun-Ping Huang, Hao-Pei Wang, Yu-Jie Lei, Hui-Ju Lin, Yu-Chuen Huang. Diosgenin, a Natural Steroidal Sapogenin, Alleviates the Progression of Diabetic Retinopathy in Diabetic Mice. In vivo (Athens, Greece). 2023 Mar; 37(2):661-666. doi: 10.21873/invivo.13126. [PMID: 36881067]
  • Xue Yin, Jia Liu, Chengxi Kou, Jiaojiao Lu, He Zhang, Wei Song, Yuhua Li, Zheyong Xue, Xin Hua. Deciphering the network of cholesterol biosynthesis in Paris polyphylla laid a base for efficient diosgenin production in plant chassis. Metabolic engineering. 2023 Feb; 76(?):232-246. doi: 10.1016/j.ymben.2023.02.009. [PMID: 36849090]
  • Jun-Ji Cui, Ze-Yun Huang, Yi-Hang Xie, Jun-Bin Wu, Guang-Hui Xu, Cheng-Fu Li, Man-Man Zhang, Li-Tao Yi. Gut microbiota mediated inflammation, neuroendocrine and neurotrophic functions involved in the antidepressant-like effects of diosgenin in chronic restraint stress. Journal of affective disorders. 2023 01; 321(?):242-252. doi: 10.1016/j.jad.2022.10.045. [PMID: 36349650]
  • Bharathi Nathan, Archana Prabahar, M M Sudheer Mohammed. Network analysis of anti-inflammatory phytochemicals and omics data for Rheumatoid arthritis. Current computer-aided drug design. 2023 Jan; ?(?):. doi: 10.2174/1573409919666230106125058. [PMID: 36617711]
  • Shi-Zhao Zhang, Peng-Peng Liang, Ya-Nan Feng, Guo-Liang Yin, Feng-Cui Sun, Chao-Qun Ma, Feng-Xia Zhang. Therapeutic potential and research progress of diosgenin for lipid metabolism diseases. Drug development research. 2022 12; 83(8):1725-1738. doi: 10.1002/ddr.21991. [PMID: 36126194]
  • Olga Michalak, Piotr Krzeczyński, Anna Jaromin, Piotr Cmoch, Marcin Cybulski, Kinga Trzcińska, Przemysław Miszta, Pakhuri Mehta, Jerzy Gubernator, Sławomir Filipek. Antioxidant activity of novel diosgenin derivatives: Synthesis, biological evaluation, and in silico ADME prediction. Steroids. 2022 12; 188(?):109115. doi: 10.1016/j.steroids.2022.109115. [PMID: 36154831]
  • Jinling Zhang, Wenbao Wang, Yanzhao Tian, Liwei Ma, Lin Zhou, Hao Sun, Yukun Ma, Huiling Hou, Xiaoli Wang, Jin Ye, Xiaobo Wang. Design, synthesis and biological evaluation of novel diosgenin-benzoic acid mustard hybrids with potential anti-proliferative activities in human hepatoma HepG2 cells. Journal of enzyme inhibition and medicinal chemistry. 2022 Dec; 37(1):1299-1314. doi: 10.1080/14756366.2022.2070161. [PMID: 35652316]
  • Yujie Zhong, Zhiman Li, Ruyi Jin, Yanpeng Yao, Silan He, Min Lei, Xin Wang, Chao Shi, Li Gao, Xiaoli Peng. Diosgenin Ameliorated Type II Diabetes-Associated Nonalcoholic Fatty Liver Disease through Inhibiting De Novo Lipogenesis and Improving Fatty Acid Oxidation and Mitochondrial Function in Rats. Nutrients. 2022 Nov; 14(23):. doi: 10.3390/nu14234994. [PMID: 36501024]
  • Soledad García-Morales, Ilenia Janeth Corzo-Jiménez, Natalina Frine Silva-Córdova, Andrés Michelle Soto-Cordero, Diego Iván Rodríguez-Mejía, Joaliné Pardo-Núñez, Janet María León-Morales. Comparative study of steroidal sapogenins content in leaves of five Agave species. Journal of the science of food and agriculture. 2022 Oct; 102(13):5653-5659. doi: 10.1002/jsfa.11912. [PMID: 35368099]
  • Ahmad Nasiri, Sajad Rashidi-Monfared, Amin Ebrahimi, Nargues Falahi Charkhabi, Ahmad Moieni. Metabolic engineering of the diosgenin biosynthesis pathway in Trigonella foenum-graceum hairy root cultures. Plant science : an international journal of experimental plant biology. 2022 Oct; 323(?):111410. doi: 10.1016/j.plantsci.2022.111410. [PMID: 35944746]
  • Zhi Wang, Qiao Wu, Hongzhan Wang, Yang Gao, Kexin Nie, Yueheng Tang, Hao Su, Meilin Hu, Jing Gong, Ke Fang, Hui Dong. Diosgenin protects against podocyte injury in early phase of diabetic nephropathy through regulating SIRT6. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Sep; 104(?):154276. doi: 10.1016/j.phymed.2022.154276. [PMID: 35728388]
  • Shofiul Azam, Yon-Suk Kim, Md Jakaria, Ye-Ji Yu, Jae-Yong Ahn, In-Su Kim, Dong-Kug Choi. Dioscorea nipponica Makino Rhizome Extract and Its Active Compound Dioscin Protect against Neuroinflammation and Scopolamine-Induced Memory Deficits. International journal of molecular sciences. 2022 Sep; 23(17):. doi: 10.3390/ijms23179923. [PMID: 36077321]
  • Lixiu Hou, Song Li, Furui Zhang, Yongbin Gu, Jiaru Li. Effect of exogenous jasmonic acid on physiology and steroidal saponin accumulation in Dioscorea zingiberensis. Plant physiology and biochemistry : PPB. 2022 Sep; 186(?):1-10. doi: 10.1016/j.plaphy.2022.06.025. [PMID: 35792454]
  • Nguyen Thi Duyen, Le Ba Vinh, Nguyen Viet Phong, Nguyen Minh Khoi, Do Thi Ha, Pham Quoc Long, Le Viet Dung, Tran Thi Hien, Nguyen Tien Dat, Ki Yong Lee. Steroid glycosides isolated from Paris polyphylla var. chinensis aerial parts and paris saponin II induces G1/S-phase MCF-7 cell cycle arrest. Carbohydrate research. 2022 Sep; 519(?):108613. doi: 10.1016/j.carres.2022.108613. [PMID: 35752103]
  • Mahantesha B N Naika, Nitish Sathyanarayanan, Radha Sivarajan Sajeevan, Teerna Bhattacharyya, Pritha Ghosh, Meenakshi S Iyer, Mahita Jarjapu, Adwait G Joshi, K Harini, K Mohamed Shafi, Neha Kalmankar, Snehal D Karpe, Bhavika Mam, Shaik Naseer Pasha, Ramanathan Sowdhamini. Exploring the medicinally important secondary metabolites landscape through the lens of transcriptome data in fenugreek (Trigonella foenum graecum L.). Scientific reports. 2022 08; 12(1):13534. doi: 10.1038/s41598-022-17779-8. [PMID: 35941189]
  • Linshu Guan, Zhang Mao, Sen Yang, Guanlin Wu, Yurong Chen, Lianhong Yin, Yan Qi, Lan Han, Lina Xu. Dioscin alleviates Alzheimer's disease through regulating RAGE/NOX4 mediated oxidative stress and inflammation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Aug; 152(?):113248. doi: 10.1016/j.biopha.2022.113248. [PMID: 35691153]
  • Zhe Zhang, Xuerong Zhao, Meng Gao, Lina Xu, Yan Qi, Jinhong Wang, Lianhong Yin. Dioscin alleviates myocardial infarction injury via regulating BMP4/NOX1-mediated oxidative stress and inflammation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Aug; 103(?):154222. doi: 10.1016/j.phymed.2022.154222. [PMID: 35675750]
  • Jude E Okokon, Idongesit C Etuk, Paul S Thomas, Falko P Drijfhout, Tim D W Claridge, Wen-Wu Li. In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jul; 151(?):113153. doi: 10.1016/j.biopha.2022.113153. [PMID: 35598372]
  • Ruixia Bao, Wei Wang, Beibei Chen, Jujie Pan, Qian Chen, Mengyang Liu, Dan Wang, Yuzheng Wu, Haiyang Yu, Lifeng Han, Yi Zhang, Tao Wang. Dioscin Ameliorates Hyperuricemia-Induced Atherosclerosis by Modulating of Cholesterol Metabolism through FXR-Signaling Pathway. Nutrients. 2022 May; 14(9):. doi: 10.3390/nu14091983. [PMID: 35565954]
  • Monisha Prasad, Selvaraj Jayaraman, Ponnulakshmi Rajagopal, Vishnu Priya Veeraraghavan, Praveen Kumar Kumar, Shanmughavel Piramanayagam, Leelavinothan Pari. Diosgenin inhibits ER stress-induced inflammation in aorta via iRhom2/TACE mediated signaling in experimental diabetic rats: An in vivo and in silico approach. Chemico-biological interactions. 2022 May; 358(?):109885. doi: 10.1016/j.cbi.2022.109885. [PMID: 35305976]
  • Ruolan Fan, Weishen He, Yong Fan, Wen Xu, Wei Xu, Guohong Yan, Shaohua Xu. Recent advances in chemical synthesis, biocatalysis, and biological evaluation of diosgenin derivatives - A review. Steroids. 2022 04; 180(?):108991. doi: 10.1016/j.steroids.2022.108991. [PMID: 35217033]
  • Lili Song, Congjun Li, Fei Wu, Shicui Zhang. Dietary intake of diosgenin delays aging of male fish Nothobranchius guentheri through modulation of multiple pathways that play prominent roles in ROS production. Biogerontology. 2022 04; 23(2):201-213. doi: 10.1007/s10522-022-09955-0. [PMID: 35102470]
  • Yujie Zhong, Jiayu Liu, Dianjun Sun, Tianmin Guo, Yanpeng Yao, Xiaodong Xia, Chao Shi, Xiaoli Peng. Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis, and improving mitochondrial quality and quantity control. Food & function. 2022 Mar; 13(6):3660-3673. doi: 10.1039/d1fo02733f. [PMID: 35262539]
  • Xu-Bo Wu, Chin-Hu Lai, Ying-Jui Ho, Chia-Hua Kuo, Pei-Fang Lai, Ching-Yi Tasi, Guohua Jin, Minqian Wei, Marthandam Asokan Shibu, Chih-Yang Huang, Shin-Da Lee. Anti-apoptotic effects of diosgenin on ovariectomized hearts. Steroids. 2022 03; 179(?):108980. doi: 10.1016/j.steroids.2022.108980. [PMID: 35157911]
  • Yujie Zhong, Dianjun Sun, Yanpeng Yao, Qi Liu, Tianmin Guo, Xin Wang, Xiaoli Peng. Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury. Chemico-biological interactions. 2022 Mar; 355(?):109850. doi: 10.1016/j.cbi.2022.109850. [PMID: 35149085]
  • Yaoyao Cai, Fengfeng Xie, Haiou Wang, Qi Zhai, Feng Lin, Shishi Pan. Polyphyllin I alleviates inflammatory injury in mice with gestational diabetes through AMPK pathway. General physiology and biophysics. 2022 Mar; 41(2):159-164. doi: 10.4149/gpb_2022006. [PMID: 35416179]
  • Liping Xu, Dong Wang, Jing Chen, Bo Li, Qingyan Li, Pingping Liu, Ying Qin, Zhubo Dai, Feiyu Fan, Xueli Zhang. Metabolic engineering of Saccharomyces cerevisiae for gram-scale diosgenin production. Metabolic engineering. 2022 03; 70(?):115-128. doi: 10.1016/j.ymben.2022.01.013. [PMID: 35085779]
  • Geetika Wadhwa, Kowthavarapu Venkata Krishna, Rajeev Taliyan, Neeraj Tandon, Satyapal Singh Yadav, Dipankar Banerjee, Avinash Narwaria, Chandrakant Katiyar, Sunil Kumar Dubey. A novel UPLC-MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats. Biomedical chromatography : BMC. 2022 Feb; 36(2):e5275. doi: 10.1002/bmc.5275. [PMID: 34738247]
  • Chen Zhou, Yuhui Yang, Jingyi Tian, Yihan Wu, Faliang An, Changfu Li, Yansheng Zhang. 22R- but not 22S-hydroxycholesterol is recruited for diosgenin biosynthesis. The Plant journal : for cell and molecular biology. 2022 02; 109(4):940-951. doi: 10.1111/tpj.15604. [PMID: 34816537]
  • Wenbao Wang, Chuan Li, Zhe Chen, Jinling Zhang, Liwei Ma, Yanzhao Tian, Yukun Ma, Lina Guo, Xiaoli Wang, Jin Ye, Xiaobo Wang. Novel diosgenin-amino acid-benzoic acid mustard trihybrids exert antitumor effects via cell cycle arrest and apoptosis. The Journal of steroid biochemistry and molecular biology. 2022 02; 216(?):106038. doi: 10.1016/j.jsbmb.2021.106038. [PMID: 34861390]
  • Yanni Zhang, Le Liu, Na Li, Yihua Wang, Xuanfeng Yue. 3D scaffold fabricated with composite material for cell culture and its derived platform for safety evaluation of drugs. Toxicology. 2022 01; 466(?):153066. doi: 10.1016/j.tox.2021.153066. [PMID: 34919984]
  • Dan Wang, Xiaolong Wang. Diosgenin and Its Analogs: Potential Protective Agents Against Atherosclerosis. Drug design, development and therapy. 2022; 16(?):2305-2323. doi: 10.2147/dddt.s368836. [PMID: 35875677]
  • Zonglang Lai, Huaibi Wang, Xiaohui Tang, Liufan Zhang, Tiantian Wang, Jun Cheng. Study on the Mechanism of Diosgenin Targeting STAT3 to Inhibit Colon Cancer Proliferation and Migration. Disease markers. 2022; 2022(?):7494887. doi: 10.1155/2022/7494887. [PMID: 35698571]
  • Shinjini Bandopadhyay, Uttpal Anand, Vijaykumar Shivaji Gadekar, Niraj Kumar Jha, Piyush Kumar Gupta, Tapan Behl, Manoj Kumar, Radha, Mahipal S Shekhawat, Abhijit Dey. Dioscin: A review on pharmacological properties and therapeutic values. BioFactors (Oxford, England). 2022 Jan; 48(1):22-55. doi: 10.1002/biof.1815. [PMID: 34919768]
  • Le Zhang, Runfeng Ni, Jiani Li, Liwei Fan, Yanqi Song, Haijin Wang, Aidi Wang, Baoshan Liu. Dioscin Regulating Bone Marrow Apoptosis in Aplastic Anemia. Drug design, development and therapy. 2022; 16(?):3041-3053. doi: 10.2147/dddt.s370506. [PMID: 36105320]
  • Prabhakar Semwal, Sakshi Painuli, Tareq Abu-Izneid, Abdur Rauf, Anshu Sharma, Sevgi Durna Daştan, Manoj Kumar, Mohammed M Alshehri, Yasaman Taheri, Rajib Das, Saikat Mitra, Talha Bin Emran, Javad Sharifi-Rad, Daniela Calina, William C Cho. Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives. Oxidative medicine and cellular longevity. 2022; 2022(?):1035441. doi: 10.1155/2022/1035441. [PMID: 35677108]
  • Fangli Mao, Aiping Wu. Polyphyllin I alleviates lipopolysaccharide-induced inflammation reduces pyroptosis in BEAS-2B and HPAEC cells by inhibiting NF-κB signaling. Allergologia et immunopathologia. 2022; 50(4):23-30. doi: 10.15586/aei.v50i4.591. [PMID: 35789400]
  • Shuxian Yu, Wenhui Gao, Puhua Zeng, Chenglong Chen, Zhuo Liu, Zhen Zhang, Jiyong Liu. Exploring the Effect of Polyphyllin I on Hepatitis B Virus-related Liver Cancer through Network Pharmacology and in vitro Experiments. Combinatorial chemistry & high throughput screening. 2022; 25(5):934-944. doi: 10.2174/1386207324666210816141436. [PMID: 34397325]
  • Muhammad Nabeel Ghayur, Mohnad Abdalla, Asaad Khalid, Saeed Ahmad, Anwarul Hassan Gilani. Trigonella foenum-graecum Methanolic Extract on Isolated Smooth Muscles and Acetylcholinesterase Enzyme: An In Vitro and Mechanistic In Silico Investigation. BioMed research international. 2022; 2022(?):4849464. doi: 10.1155/2022/4849464. [PMID: 35425837]
  • Zhengchao Shen, Jian Wang, Kunbin Ke, Rong Chen, Aixue Zuo, Rongping Zhang, Weiping Wan, Xingxing Xie, Xuhua Li, Na Song, Hao Fu, Zhiwei Zhang, Enli Cai, Jihong Shen, Qingyu Zhang, Xinan Shi. Polyphyllin I, a lethal partner of Palbociclib, suppresses non-small cell lung cancer through activation of p21/CDK2/Rb pathway in vitro and in vivo. Cell cycle (Georgetown, Tex.). 2021 12; 20(23):2494-2506. doi: 10.1080/15384101.2021.1991121. [PMID: 34658297]
  • Xiao Liu, Qian Zhou, Jia-He Zhang, Ke-Yong Wang, Takashi Saito, Takaomi C Saido, Xiaoying Wang, Xiumei Gao, Kagaku Azuma. Microglia-Based Sex-Biased Neuropathology in Early-Stage Alzheimer's Disease Model Mice and the Potential Pharmacologic Efficacy of Dioscin. Cells. 2021 11; 10(11):. doi: 10.3390/cells10113261. [PMID: 34831483]
  • Lixiu Hou, Xincheng Yuan, Song Li, Yi Li, Zihao Li, Jiaru Li. Genome-Wide Identification of CYP72A Gene Family and Expression Patterns Related to Jasmonic Acid Treatment and Steroidal Saponin Accumulation in Dioscorea zingiberensis. International journal of molecular sciences. 2021 Oct; 22(20):. doi: 10.3390/ijms222010953. [PMID: 34681613]
  • Hossein Zeinali, Tourandokht Baluchnejadmojarad, Mehrdad Roghani. Diosgenin ameliorates cellular and molecular changes in multiple sclerosis in C57BL/6 mice. Multiple sclerosis and related disorders. 2021 Oct; 55(?):103211. doi: 10.1016/j.msard.2021.103211. [PMID: 34425463]
  • Paulo Vinicius Moreira da Costa Menezes, Adriano Antonio Silva, Márcio Shigueaki Mito, Gislaine Cristiane Mantovanelli, Gabriel Felipe Stulp, Ana Luiza Wagner, Rodrigo Polimeni Constantin, Débora Cristina Baldoqui, Raísa Gonçales Silva, Amanda Aparecida Oliveira do Carmo, Luíz Antonio de Souza, Rubem Silvério de Oliveira Junior, Fabrizio Araniti, Maria Rosa Abenavoli, Emy Luiza Ishii-Iwamoto. Morphogenic responses and biochemical alterations induced by the cover crop Urochloa ruziziensis and its component protodioscin in weed species. Plant physiology and biochemistry : PPB. 2021 Sep; 166(?):857-873. doi: 10.1016/j.plaphy.2021.06.040. [PMID: 34237604]
  • Yujie Zhong, Chengni Jin, Jiahui Han, Jiachang Zhu, Qi Liu, Dianjun Sun, Xiaodong Xia, Yu Zhang, Xiaoli Peng. Diosgenin Protects Against Kidney Injury and Mitochondrial Apoptosis Induced by 3-MCPD Through the Regulation of ER Stress, Ca2+ Homeostasis, and Bcl2 Expression. Molecular nutrition & food research. 2021 08; 65(15):e2001202. doi: 10.1002/mnfr.202001202. [PMID: 34075698]
  • Yun Zhang, Yuangen Li, Changda Lin, Jiequn Zhang, Hanyuan Gao, Jinhai Chen. Dioscin-loaded zein nanoparticles alleviate lipopolysaccharide-induced acute kidney injury via the microRNA-let 7i signalling pathways. IET nanobiotechnology. 2021 Jul; 15(5):465-472. doi: 10.1049/nbt2.12051. [PMID: 34694758]
  • Li-Jiao You, Huan Geng, Xiao-Fang Yang, Gui-Lin Wei, Ya-Di Zhu, Guang-Bo Ge, Ming Lei, Dan-Dan Wang. The comparison analysis of polyphyllin I and its analogues induced apoptosis of colon and lung cancer cells via mitochondrial dysfunction. Basic & clinical pharmacology & toxicology. 2021 Jul; 129(1):15-25. doi: 10.1111/bcpt.13596. [PMID: 33915023]
  • Xiaofen Li, Sili Liu, Liping Qu, Yang Chen, Chuqiao Yuan, Anquan Qin, Jiyi Liang, Qianqian Huang, Miao Jiang, Wenjun Zou. Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases. Journal of ethnopharmacology. 2021 Jun; 274(?):114018. doi: 10.1016/j.jep.2021.114018. [PMID: 33716083]
  • Poonam Rawat, Manish Kumar, Akanksha Srivastava, Bhanu Kumar, Ankita Misra, Satyendra Pratap Singh, Sharad Srivastava. Influence of Soil Variation on Diosgenin Content Profile in Costus speciosus from Indo-Gangetic Plains. Chemistry & biodiversity. 2021 Jun; 18(6):e2000977. doi: 10.1002/cbdv.202000977. [PMID: 33837994]
  • Roujun Wang, Yumeng Sun, Xiaowen Jin, Weibo Wen, Yongjun Cao. Diosgenin Inhibits Excessive Proliferation and Inflammatory Response of Synovial Fibroblasts in Rheumatoid Arthritis by Targeting PDE3B. Inflammation. 2021 Jun; 44(3):946-955. doi: 10.1007/s10753-020-01389-5. [PMID: 33237390]
  • Y Li, M Gao, L-H Yin, L-N Xu, Y Qi, Pengyuan Sun, J-Y Peng. Dioscin ameliorates methotrexate-induced liver and kidney damages via adjusting miRNA-145-5p-mediated oxidative stress. Free radical biology & medicine. 2021 06; 169(?):99-109. doi: 10.1016/j.freeradbiomed.2021.03.035. [PMID: 33836263]
  • Hui Tian, Xiyan Chen, Yafei Zhang, Ying Wang, Xucheng Fu, Weiting Gu, Yong Wen. Dioscin inhibits SCC15 cell proliferation via the RASSF1A/MST2/YAP axis. Molecular medicine reports. 2021 06; 23(6):. doi: 10.3892/mmr.2021.12053. [PMID: 33786612]
  • Neda Mohamadi, Fariba Sharififar, Mehdi Ansari, Mostafa Pournamdari, Mahdieh Rezaei, Navid Hassanabadi. Pharmacokinetic profile of diosgenin and trigonelline following intravenous and oral administration of fenugreek seed extract and pure compound in rabbit. Journal of Asian natural products research. 2021 May; 23(5):466-477. doi: 10.1080/10286020.2020.1769609. [PMID: 32447972]
  • Zhongyi Sun, Peng Zhao, Xizhen Ge, Pingfang Tian. [Pathway design and key enzyme analysis of diosgenin biosynthesis]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2021 Apr; 37(4):1178-1188. doi: 10.13345/j.cjb.200389. [PMID: 33973434]
  • Debmalya Das Gupta, Shruti Mishra, Sumit Singh Verma, Anusmita Shekher, Vipin Rai, Nikee Awasthee, Tridip J Das, Dipayan Paul, Sanjib K Das, Hui Tag, Subash Chandra Gupta, Pallabi K Hui. Evaluation of antioxidant, anti-inflammatory and anticancer activities of diosgenin enriched Paris polyphylla rhizome extract of Indian Himalayan landraces. Journal of ethnopharmacology. 2021 Apr; 270(?):113842. doi: 10.1016/j.jep.2021.113842. [PMID: 33460752]
  • Ali Ghanbari, Nasim Akhshi, Seyed Ershad Nedaei, Adriano Mollica, Ina Yosifova Aneva, Yaping Qi, Pan Liao, Sara Darakhshan, Mohammad Hosein Farzaei, Jianbo Xiao, Javier Echeverría. Tribulus terrestris and female reproductive system health: A comprehensive review. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Apr; 84(?):153462. doi: 10.1016/j.phymed.2021.153462. [PMID: 33602600]
  • Ming-Ming Liu, Miao-Lin Zhu, Rui-Fang Dong, Chao Zhang, Hao Zhang, Lei Yang, Ling-Yi Kong, Yuan-Zheng Xia. Polyphyllin I promotes cell death via suppressing UPR-mediated CHOP ubiquitination and degradation in non-small cell lung cancer. Chinese journal of natural medicines. 2021 Apr; 19(4):255-266. doi: 10.1016/s1875-5364(21)60027-4. [PMID: 33875166]
  • Chengfei Zhang, Lingling Qin, Boju Sun, You Wu, Fengying Zhong, Lili Wu, Tonghua Liu. Transcriptome analysis of the effect of diosgenin on autoimmune thyroiditis in a rat model. Scientific reports. 2021 03; 11(1):6401. doi: 10.1038/s41598-021-85822-1. [PMID: 33737640]
  • Joan Candice Ondevilla, Shinya Hanashima, Akane Mukogawa, Yuichi Umegawa, Michio Murata. Diosgenin-induced physicochemical effects on phospholipid bilayers in comparison with cholesterol. Bioorganic & medicinal chemistry letters. 2021 03; 36(?):127816. doi: 10.1016/j.bmcl.2021.127816. [PMID: 33516912]
  • Lu Yu, Haifei Lu, Xiufen Yang, Ruoqi Li, Jingjing Shi, Yantong Yu, Chaoqun Ma, Fengcui Sun, Shizhao Zhang, Fengxia Zhang. Diosgenin alleviates hypercholesterolemia via SRB1/CES-1/CYP7A1/FXR pathway in high-fat diet-fed rats. Toxicology and applied pharmacology. 2021 02; 412(?):115388. doi: 10.1016/j.taap.2020.115388. [PMID: 33383043]
  • Cao Yongjun, Qiao Nan, Sun Yumeng, Jin Xiaowen, Wen Weibo. Dioscin alleviates hashimoto's thyroiditis by regulating the SUMOylation of IRF4 to promote CD4+CD25+Foxp3+ treg cell differentiation. Autoimmunity. 2021 02; 54(1):51-59. doi: 10.1080/08916934.2020.1855428. [PMID: 33274645]
  • Ai-Mei Liao, Bangrong Cai, Ji-Hong Huang, Ming Hui, Kyung-Ku Lee, Kwang Youl Lee, ChangJu Chun. Synthesis, anticancer activity and potential application of diosgenin modified cancer chemotherapeutic agent cytarabine. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Feb; 148(?):111920. doi: 10.1016/j.fct.2020.111920. [PMID: 33346046]
  • Alexander V Sirotkin, Richard Alexa, Aneta Stochmalova, Sona Scsukova. Plant isoflavones can affect accumulation and impact of silver and titania nanoparticles on ovarian cells. Endocrine regulations. 2021 Jan; 55(1):52-60. doi: 10.2478/enr-2021-0007. [PMID: 33600664]
  • Jian Cheng, Jing Chen, Xiaonan Liu, Xiangchen Li, Weixiong Zhang, Zhubo Dai, Lina Lu, Xiang Zhou, Jing Cai, Xueli Zhang, Huifeng Jiang, Yanhe Ma. The origin and evolution of the diosgenin biosynthetic pathway in yam. Plant communications. 2021 01; 2(1):100079. doi: 10.1016/j.xplc.2020.100079. [PMID: 33511341]
  • Romaan Nazir, Vijay Kumar, Suphala Gupta, Padmanabh Dwivedi, Devendra Kumar Pandey, Abhijit Dey. Biotechnological strategies for the sustainable production of diosgenin from Dioscorea spp. Applied microbiology and biotechnology. 2021 Jan; 105(2):569-585. doi: 10.1007/s00253-020-11055-3. [PMID: 33404834]
  • Romaan Nazir, Devendra Kumar Pandey, Babita Pandey, Vijay Kumar, Padmanabh Dwivedi, Aditya Khampariya, Abhijit Dey, Tabarak Malik. Optimization of diosgenin extraction from Dioscorea deltoidea tubers using response surface methodology and artificial neural network modelling. PloS one. 2021; 16(7):e0253617. doi: 10.1371/journal.pone.0253617. [PMID: 34288904]
  • Yao Tan, Liming Wang, Jian Gao, Junhong Ma, Haiyang Yu, Yi Zhang, Tao Wang, Lifeng Han. Multiomics Integrative Analysis for Discovering the Potential Mechanism of Dioscin against Hyperuricemia Mice. Journal of proteome research. 2021 01; 20(1):645-660. doi: 10.1021/acs.jproteome.0c00584. [PMID: 33107303]