cryptophycin (BioDeep_00000171820)

   

human metabolite blood metabolite


代谢物信息卡片


10-[(3-chloro-4-methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[1-(3-phenyloxiran-2-yl)ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone

化学式: C35H43ClN2O8 (654.2708)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 96.27%

分子结构信息

SMILES: COC1=CC=C(CC2NC(=O)C=CCC(OC(=O)C(CC(C)C)OC(=O)C(C)CNC2=O)C(C)C2OC2C2=CC=CC=C2)C=C1Cl
InChI: InChI=1S/C35H43ClN2O8/c1-20(2)16-29-35(42)44-27(22(4)31-32(46-31)24-10-7-6-8-11-24)12-9-13-30(39)38-26(33(40)37-19-21(3)34(41)45-29)18-23-14-15-28(43-5)25(36)17-23/h6-11,13-15,17,20-22,26-27,29,31-32H,12,16,18-19H2,1-5H3,(H,37,40)(H,38,39)



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ABCB1, ALB, BCL2, CASP3, DMPK, FNTA, NRP1, PGP, TUBB4B, VIM
Peripheral membrane protein 2 CTSB, CYP1B1
Endoplasmic reticulum membrane 4 BCL2, CALU, CYP1B1, DMPK
Mitochondrion membrane 1 NRP1
Nucleus 6 ALB, BCL2, BRD3, CA9, CASP3, TUBB4B
cytosol 10 ALB, BCL2, CASP3, DMPK, FNTA, NRP1, SST, SSTR2, TUBB4B, VIM
mitochondrial membrane 1 NRP1
phagocytic vesicle 1 VIM
centrosome 1 ALB
nucleoplasm 1 CASP3
Cell membrane 7 ABCB1, CA9, DMPK, GPRC5A, ITGAM, NRP1, VIM
Cytoplasmic side 1 DMPK
Multi-pass membrane protein 2 ABCB1, GPRC5A
cell surface 2 ABCB1, ITGAM
glutamatergic synapse 2 CASP3, NRP1
Golgi apparatus 2 ALB, CALU
neuronal cell body 2 CASP3, SST
Cytoplasm, cytosol 1 DMPK
Lysosome 1 CTSB
plasma membrane 9 ABCB1, CA9, DMPK, FNTA, GPRC5A, ITGAM, NRP1, SSTR2, VIM
Membrane 7 ABCB1, BCL2, CA9, CALU, CYP1B1, ITGAM, NRP1
apical plasma membrane 2 ABCB1, CTSB
axon 2 NRP1, VIM
basolateral plasma membrane 1 CA9
extracellular exosome 8 ABCB1, ALB, CTSB, GPRC5A, ITGAM, TUBB4B, VIM, VTN
endoplasmic reticulum 4 ALB, BCL2, CALU, VTN
extracellular space 6 ALB, CTSB, ITGAM, NRP1, SST, VTN
perinuclear region of cytoplasm 2 CTSB, NRP1
mitochondrion 2 BCL2, CYP1B1
protein-containing complex 2 ALB, BCL2
intracellular membrane-bounded organelle 3 CYP1B1, GPRC5A, VTN
Microsome membrane 1 CYP1B1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 3 CA9, ITGAM, NRP1
Secreted 5 ALB, CALU, NRP1, SST, VTN
extracellular region 6 ALB, CALU, CTSB, SST, TUBB4B, VTN
Mitochondrion outer membrane 2 BCL2, DMPK
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, DMPK
[Isoform 2]: Secreted 1 NRP1
Extracellular side 1 CTSB
anchoring junction 1 ALB
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, DMPK
external side of plasma membrane 2 CTSB, ITGAM
Extracellular vesicle 1 TUBB4B
cytoplasmic vesicle 1 NRP1
microtubule cytoskeleton 1 TUBB4B
nucleolus 2 CA9, GPRC5A
Early endosome 1 NRP1
vesicle 1 GPRC5A
postsynaptic membrane 1 NRP1
Apical cell membrane 2 ABCB1, CTSB
Membrane raft 1 ITGAM
pore complex 1 BCL2
Cytoplasm, cytoskeleton 2 TUBB4B, VIM
focal adhesion 2 NRP1, VIM
microtubule 1 TUBB4B
GABA-ergic synapse 1 SST
Peroxisome 1 VIM
basement membrane 1 VTN
collagen-containing extracellular matrix 2 CTSB, VTN
intermediate filament 1 VIM
Nucleus outer membrane 1 DMPK
nuclear outer membrane 1 DMPK
receptor complex 2 GPRC5A, NRP1
neuron projection 3 NRP1, SSTR2, VIM
ciliary basal body 1 ALB
chromatin 1 BRD3
cell leading edge 1 VIM
microtubule associated complex 1 FNTA
mitotic spindle 1 TUBB4B
Chromosome 1 BRD3
cytoskeleton 2 TUBB4B, VIM
centriole 1 ALB
Secreted, extracellular space 2 CTSB, VTN
Nucleus, nucleolus 1 CA9
spindle pole 1 ALB
blood microparticle 2 ALB, VTN
Cell projection, microvillus membrane 1 CA9
microvillus membrane 1 CA9
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
nuclear envelope 1 NRP1
Nucleus envelope 1 NRP1
sorting endosome 1 NRP1
axonemal microtubule 1 TUBB4B
microtubule organizing center 1 VIM
Cytoplasmic vesicle membrane 1 GPRC5A
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
Melanosome 2 CALU, CTSB
myelin sheath 1 BCL2
intermediate filament cytoskeleton 1 VIM
plasma membrane raft 1 ITGAM
ficolin-1-rich granule lumen 1 CTSB
Golgi lumen 1 VTN
endoplasmic reticulum lumen 2 ALB, CALU
nuclear matrix 1 VIM
platelet alpha granule lumen 1 ALB
azurophil granule lumen 1 TUBB4B
Sarcoplasmic reticulum membrane 1 DMPK
neuronal dense core vesicle 1 SST
Single-pass type IV membrane protein 1 DMPK
Nucleus matrix 1 VIM
neurofilament 1 NRP1
semaphorin receptor complex 1 NRP1
Sarcoplasmic reticulum lumen 1 CALU
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
integrin complex 1 ITGAM
protein complex involved in cell-matrix adhesion 1 VTN
peptidase inhibitor complex 2 CTSB, VTN
Parasitophorous vacuole 1 VTN
alphav-beta3 integrin-vitronectin complex 1 VTN
rough endoplasmic reticulum lumen 1 VTN
integrin alphaM-beta2 complex 1 ITGAM
endolysosome lumen 1 CTSB
BAD-BCL-2 complex 1 BCL2
CAAX-protein geranylgeranyltransferase complex 1 FNTA
protein farnesyltransferase complex 1 FNTA
ciliary transition fiber 1 ALB


文献列表

  • James P Stevenson, Weijing Sun, Maryann Gallagher, Robert Johnson, David Vaughn, Lynn Schuchter, Kenneth Algazy, Stephen Hahn, Nathan Enas, Diane Ellis, Donald Thornton, Peter J O'Dwyer. Phase I trial of the cryptophycin analogue LY355703 administered as an intravenous infusion on a day 1 and 8 schedule every 21 days. Clinical cancer research : an official journal of the American Association for Cancer Research. 2002 Aug; 8(8):2524-9. doi: . [PMID: 12171879]
  • M M Lieberman, G M Patterson, R E Moore. In vitro bioassays for anticancer drug screening: effects of cell concentration and other assay parameters on growth inhibitory activity. Cancer letters. 2001 Nov; 173(1):21-9. doi: 10.1016/s0304-3835(01)00681-4. [PMID: 11578805]
  • M Berna, R Shugert, J Mullen. Determination of LY355703 in dog and mouse plasma by positive ion liquid chromatography/tandem mass spectrometry with atmospheric pressure chemical ionization. Journal of mass spectrometry : JMS. 1998 Feb; 33(2):138-43. doi: 10.1002/(sici)1096-9888(199802)33:2<138::aid-jms617>3.0.co;2-7. [PMID: 9487688]