N-Acetyl-L-aspartic acid (BioDeep_00000001686)
Secondary id: BioDeep_00000265248, BioDeep_00000399929, BioDeep_00000400346, BioDeep_00000412715
natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite
代谢物信息卡片
化学式: C6H9NO5 (175.0480704)
中文名称: N-乙酰-L-天门冬氨酸, N-乙酰-DL-天冬氨酸, N-乙酰-DL-天冬氨酸, N-乙酰-天冬氨酸, N-乙酰基-L-天冬氨酸
谱图信息:
最多检出来源 Homo sapiens(blood) 0.47%
分子结构信息
SMILES: CC(=O)NC(CC(=O)O)C(=O)O
InChI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)
描述信息
N-Acetyl-L-Aspartic acid (NAA) or N-Acetylaspartic acid, belongs to the class of organic compounds known as N-acyl-alpha amino acids. N-acyl-alpha amino acids are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. N-alpha-Acetyl-L-aspartic acid can also be classified as an alpha amino acid or a derivatized alpha amino acid. Technically, N-Acetyl-L-aspartic acid is a biologically available N-terminal capped form of the proteinogenic alpha amino acid L-aspartic acid. N-acetyl amino acids can be produced either via direct synthesis of specific N-acetyltransferases or via the proteolytic degradation of N-acetylated proteins by specific hydrolases. N-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins (PMID: 16465618). About 85\\\% of all human proteins and 68\\\% of all yeast proteins are acetylated at their N-terminus (PMID: 21750686). Several proteins from prokaryotes and archaea are also modified by N-terminal acetylation. The majority of eukaryotic N-terminal-acetylation reactions occur through N-acetyltransferase enzymes or NAT’s (PMID: 30054468). These enzymes consist of three main oligomeric complexes NatA, NatB, and NatC, which are composed of at least a unique catalytic subunit and one unique ribosomal anchor. The substrate specificities of different NAT enzymes are mainly determined by the identities of the first two N-terminal residues of the target protein. The human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G) (PMID: 30054468). NatA also exists in a monomeric state and can post-translationally acetylate acidic N-termini residues (D-, E-). NatB and NatC acetylate N-terminal methionine with further specificity determined by the identity of the second amino acid. N-acetylated amino acids, such as N-acetylaspartate can be released by an N-acylpeptide hydrolase from peptides generated by proteolytic degradation (PMID: 16465618). In addition to the NAT enzymes and protein-based acetylation, N-acetylation of free aspartic acid can also occur. In particular, N-Acetyl-L-aspartic acid can be synthesized in neurons from the amino acid aspartate and acetyl coenzyme A (acetyl CoA). Specifically, the enzyme known as aspartate N-acetyltransferase (EC 2.3.1.17) catalyzes the transfer of the acetyl group of acetyl CoA to the amino group of aspartate. N-Acetyl-L-aspartic acid is the second most concentrated molecule in the brain after the amino acid glutamate. The various functions served by N-acetylaspartic acid are still under investigation, but the primary proposed functions include (1) acting as a neuronal osmolyte that is involved in fluid balance in the brain, (2) serving as a source of acetate for lipid and myelin synthesis in oligodendrocytes (the glial cells that myelinate neuronal axons), (3) serving as a precursor for the synthesis of the important dipeptide neurotransmitter N-acetylaspartylglutamate (NAAG), and (4) playing a potential role in energy production from the amino acid glutamate in neuronal mitochondria. High neurotransmitter (i.e. N-acetylaspartic acid) levels can lead to abnormal neural signaling, delayed or arrested intellectual development, and difficulties with general motor skills. When present in sufficiently high levels, N-acetylaspartic acid can be a neurotoxin, an acidogen, and a metabotoxin. A neurotoxin is a compound that disrupts or attacks neural tissue. An acidogen is an acidic compound that induces acidosis, which has multiple adverse effects on many organ systems. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of N-acetylaspartic acid are associated with Canavan disease. Because N-acetylaspartic acid functions as an organic acid and high levels of organic acids can lead to a condition known...
N-Acetylaspartic acid is a derivative of aspartic acid. It is the second most concentrated molecule in the brain after the amino acid glutamate. It is synthesized in neurons from the amino acid aspartate and acetyl coenzyme A. The various functions served by N-acetylaspartic acid are still under investigation, but the primary proposed functions include:
Acquisition and generation of the data is financially supported in part by CREST/JST.
D018377 - Neurotransmitter Agents > D018846 - Excitatory Amino Acids
KEIO_ID A142
N-Acetyl-L-aspartic acid is a derivative of aspartic acid.
同义名列表
25 个代谢物同义名
N-Acetylaspartate, monopotassium salt; (S)-2-(Acetylamino)butanedioic acid; (S)-2-(Acetylamino)succinic acid; (2S)-2-Acetamidobutanedioic acid; (S)-2-(Acetylamino)butanedioate; (S)-2-(Acetylamino)succinate; (2S)-2-Acetamidobutanedioate; N-Acetyl-DL-aspartic acid; N-Acetyl-S-aspartic acid; N-acetyl-L-aspartic acid; L-N-Acetylaspartic acid; Acetyl-L-aspartic acid; N-Acetylaspartic acid; Acetyl aspartic acid; N-Acetyl-L-aspartate; N-Acetyl-S-aspartate; Acetylaspartic acid; L-N-Acetylaspartate; Acetyl-L-aspartate; N-Acetyl aspartate; N-Acetylaspartate; Acetylaspartate; Ac-Asp; NAA; N-Acetylaspartic acid
数据库引用编号
33 个数据库交叉引用编号
- ChEBI: CHEBI:177033
- ChEBI: CHEBI:21547
- KEGG: C01042
- KEGGdrug: D70679
- PubChem: 97508
- PubChem: 65065
- HMDB: HMDB0000812
- Metlin: METLIN3769
- ChEMBL: CHEMBL1162493
- ChEMBL: CHEMBL1162494
- Wikipedia: N-acetylaspartic_acid
- MetaCyc: CPD-420
- foodb: FDB022260
- chemspider: 58576
- CAS: 2545-40-6
- CAS: 997-55-7
- MoNA: PS099707
- MoNA: PR100395
- MoNA: PS099701
- MoNA: KO000237
- MoNA: KO000236
- MoNA: KO000235
- MoNA: PR100851
- MoNA: KO000233
- MoNA: PS099702
- MoNA: KO000234
- PMhub: MS000000984
- ChEBI: CHEBI:16953
- PubChem: 4284
- PDB-CCD: KKD
- 3DMET: B00227
- NIKKAJI: J62.824G
- medchemexpress: HY-113524
分类词条
相关代谢途径
Reactome(5)
BioCyc(0)
PlantCyc(0)
代谢反应
70 个相关的代谢反应过程信息。
Reactome(56)
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp
- Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid synthesis and interconversion (transamination):
ATP + H2O + L-Asp + L-Gln ⟶ AMP + L-Asn + L-Glu + PPi
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid synthesis and interconversion (transamination):
ATP + H2O + L-Asp + L-Gln ⟶ AMP + L-Asn + L-Glu + PPi
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp
- Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid synthesis and interconversion (transamination):
H2O + NAA ⟶ CH3COO- + L-Asp
- Aspartate and asparagine metabolism:
H2O + NAA ⟶ CH3COO- + L-Asp
- Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala
- Aspartate and asparagine metabolism:
H2O + NAA ⟶ CH3COO- + L-Asp
- Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala
- Aspartate and asparagine metabolism:
H2O + L-Asn ⟶ L-Asp + ammonia
- Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala
- Aspartate and asparagine metabolism:
H2O + NAA ⟶ CH3COO- + L-Asp
- Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala
- Aspartate and asparagine metabolism:
H2O + NAA ⟶ CH3COO- + L-Asp
- Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala
- Aspartate and asparagine metabolism:
H2O + NAA ⟶ CH3COO- + L-Asp
- Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala
- Aspartate and asparagine metabolism:
H2O + NAA ⟶ CH3COO- + L-Asp
- Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala
- Aspartate and asparagine metabolism:
L-Asp + L-Glu ⟶ Glu + L-Asp
- Aspartate and asparagine metabolism:
H2O + NAA ⟶ CH3COO- + L-Asp
- Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala
- Aspartate and asparagine metabolism:
H2O + NAA ⟶ CH3COO- + L-Asp
- Glutamate and glutamine metabolism:
L-Gln + PYR ⟶ 2OGA + L-Ala
- Aspartate and asparagine metabolism:
2OG + L-Asp ⟶ Glu + OAA
BioCyc(0)
WikiPathways(1)
- Cerebral organic acidurias, including diseases:
L-2-Aminoadipic acid ⟶ 2-Oxoadipic acid
Plant Reactome(0)
INOH(1)
- Alanine,Aspartic acid and Asparagine metabolism ( Alanine,Aspartic acid and Asparagine metabolism ):
H2O + N-Acetyl-L-aspartic acid ⟶ Acetic acid + L-Aspartic acid
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(12)
- Aspartate Metabolism:
N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
- Canavan Disease:
N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
- Hypoacetylaspartia:
N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
- Aspartate Metabolism:
N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
- Canavan Disease:
N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
- Hypoacetylaspartia:
N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
- Aspartate Metabolism:
N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
- Aspartate Metabolism:
N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
- Aspartate Metabolism:
N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
- Aspartate Metabolism:
N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
- Canavan Disease:
N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
- Hypoacetylaspartia:
N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
PharmGKB(0)
4 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Anoushka Lotun, Danning Li, Hongxia Xu, Qin Su, Serafettin Tuncer, Julio Sanmiguel, Morgan Mooney, Christina E Baer, Russell Ulbrich, Stephen J Eyles, Lara Strittmatter, Lawrence J Hayward, Dominic J Gessler, Guangping Gao. Renewal of Oligodendrocyte Lineage Reverses Dysmyelination and CNS Neurodegeneration Through Corrected N-acetylaspartate Metabolism.
Progress in neurobiology.
2023 May; ?(?):102460. doi:
10.1016/j.pneurobio.2023.102460
. [PMID: 37149081] - Eleni Rebelos, Giuseppe Daniele, Beatrice Campi, Alessandro Saba, Kalle Koskensalo, Jukka Ihalainen, Ekaterina Saukko, Pirjo Nuutila, Walter H Backes, Jacobus F A Jansen, Pieter C Dagnelie, Sebastian Köhler, Bastiaan E de Galan, Thomas T van Sloten, Coen D A Stehouwer, Ele Ferrannini. Circulating N-Acetylaspartate does not track brain NAA concentrations, cognitive function or features of small vessel disease in humans.
Scientific reports.
2022 Jul; 12(1):11530. doi:
10.1038/s41598-022-15670-0
. [PMID: 35798828] - Thaysa Mara Gazzotto Neves, Estefania Simoes, Maria Concepcíon García Otaduy, Elie Leal de Barros Calfat, Pâmela Bertolazzi, Naomi Antunes da Costa, Fábio Luís de Souza Duran, Joanna Correia-Lima, Maria da Graça Morais Martin, Marília Cerqueira Leite Seelander, Victor Henrique Oyamada Otani, Thais Zélia Dos Santos Otani, Daniel Augusto Corrêa Vasques, Geraldo Busatto Filho, Cristiane Kochi, Ricardo Riyoiti Uchida. Inverse Association Between Hypothalamic N-Acetyl Aspartate/Creatine Ratio and Indices of Body Mass in Adolescents with Obesity.
The Journal of nutrition.
2022 03; 152(3):663-670. doi:
10.1093/jn/nxab415
. [PMID: 34888674] - Kimberly A Lewis, Nico Osier, Ruy Carrasco, Jennifer Chiou, Patricia Carter, Alexandra Garcia, Elena Flowers, Efstathios D Gennatas, Christina Nguyen, Ambreen Rana, Sharon A Brown, Stefano Tiziani. Serine, N-acetylaspartate differentiate adolescents with juvenile idiopathic arthritis compared with healthy controls: a metabolomics cross-sectional study.
Pediatric rheumatology online journal.
2022 Feb; 20(1):12. doi:
10.1186/s12969-022-00672-z
. [PMID: 35144633] - Laura L Gramegna, Stefania Evangelisti, Lidia Di Vito, Chiara La Morgia, Alessandra Maresca, Leonardo Caporali, Giulia Amore, Lia Talozzi, Claudio Bianchini, Claudia Testa, David N Manners, Irene Cortesi, Maria L Valentino, Rocco Liguori, Valerio Carelli, Caterina Tonon, Raffaele Lodi. Brain MRS correlates with mitochondrial dysfunction biomarkers in MELAS-associated mtDNA mutations.
Annals of clinical and translational neurology.
2021 06; 8(6):1200-1211. doi:
10.1002/acn3.51329
. [PMID: 33951347] - Umit Haluk Yesilkaya, Meltem Sen, Yasin Hasan Balcioglu. COVID-19-related cognitive dysfunction may be associated with transient disruption in the DLPFC glutamatergic pathway.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.
2021 May; 87(?):153-155. doi:
10.1016/j.jocn.2021.03.007
. [PMID: 33863524] - Beatrice Campi, Simone Codini, Giuseppe Daniele, Antonella Marvelli, Giovanni Ceccarini, Ferruccio Santini, Riccardo Zucchi, Ele Ferrannini, Alessandro Saba. Plasma N-acetylaspartate: Development and validation of a quantitative assay based on HPLC-MS-MS and sample derivatization.
Clinica chimica acta; international journal of clinical chemistry.
2020 Sep; 508(?):146-153. doi:
10.1016/j.cca.2020.05.020
. [PMID: 32417212] - Zhifu Wang, Sheng Huang, Xiangmei Yu, Long Li, Minguang Yang, Shengxiang Liang, Weilin Liu, Jing Tao. Altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic pain.
Biological research.
2020 Aug; 53(1):36. doi:
10.1186/s40659-020-00303-5
. [PMID: 32843088] - Jiachen Wang, Tong Zhou, Jihua Liu, Jingjun Shangguan, Xuejun Liu, Zhiming Li, Xiaoming Zhou, Yande Ren, Chengjian Wang. Application of 1H-MRS in end-stage renal disease with depression.
BMC nephrology.
2020 06; 21(1):225. doi:
10.1186/s12882-020-01863-0
. [PMID: 32539705] - Emrah Güleş, Dan Vlad Iosifescu, Ümit Tural. Plasma Neuronal and Glial Markers and Anterior Cingulate Metabolite Levels in Major Depressive Disorder: A Pilot Study.
Neuropsychobiology.
2020; 79(3):214-221. doi:
10.1159/000505782
. [PMID: 32045918] - Giuseppe Daniele, Beatrice Campi, Alessandro Saba, Simone Codini, Annamaria Ciccarone, Laura Giusti, Stefano Del Prato, Russel L Esterline, Ele Ferrannini. Plasma N-Acetylaspartate Is Related to Age, Obesity, and Glucose Metabolism: Effects of Antidiabetic Treatment and Bariatric Surgery.
Frontiers in endocrinology.
2020; 11(?):216. doi:
10.3389/fendo.2020.00216
. [PMID: 32362872] - Joshua Chiappelli, Laura M Rowland, S Andrea Wijtenburg, Hongji Chen, Andrew A Maudsley, Sulaiman Sheriff, Shuo Chen, Anya Savransky, Wyatt Marshall, Meghann C Ryan, Heather A Bruce, Alan R Shuldiner, Braxton D Mitchell, Peter Kochunov, L Elliot Hong. Cardiovascular risks impact human brain N-acetylaspartate in regionally specific patterns.
Proceedings of the National Academy of Sciences of the United States of America.
2019 12; 116(50):25243-25249. doi:
10.1073/pnas.1907730116
. [PMID: 31754041] - Dina C Hofer, Gabriel Zirkovits, Helmut J Pelzmann, Katharina Huber, Ariane R Pessentheiner, Wenmin Xia, Kyosuke Uno, Toh Miyazaki, Kanta Kon, Hiroshi Tsuneki, Tobias Pendl, Wael Al Zoughbi, Corina T Madreiter-Sokolowski, Gert Trausinger, Mahmoud Abdellatif, Gabriele Schoiswohl, Renate Schreiber, Tobias Eisenberg, Christoph Magnes, Simon Sedej, Matthias Eckhardt, Masakiyo Sasahara, Toshiyasu Sasaoka, Atsumi Nitta, Gerald Hoefler, Wolfgang F Graier, Dagmar Kratky, Johan Auwerx, Juliane G Bogner-Strauss. N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 12; 33(12):13808-13824. doi:
10.1096/fj.201801323r
. [PMID: 31638418] - Min-Zhi Peng, Yan-Na Cai, Yong-Xian Shao, Lu Zhao, Min-Yan Jiang, Yun-Ting Lin, Xi Yin, Hui-Ying Sheng, Li Liu. Simultaneous quantification of 48 plasma amino acids by liquid chromatography-tandem mass spectrometry to investigate urea cycle disorders.
Clinica chimica acta; international journal of clinical chemistry.
2019 Aug; 495(?):406-416. doi:
10.1016/j.cca.2019.05.011
. [PMID: 31095934] - Jameen Arm, Oun Al-Iedani, Rod Lea, Jeannette Lechner-Scott, Saadallah Ramadan. Diurnal variability of cerebral metabolites in healthy human brain with 2D localized correlation spectroscopy (2D L-COSY).
Journal of magnetic resonance imaging : JMRI.
2019 08; 50(2):592-601. doi:
10.1002/jmri.26642
. [PMID: 30629765] - Barbora Vorlova, Tomas Knedlik, Jan Tykvart, Jan Konvalinka. GCPII and its close homolog GCPIII: from a neuropeptidase to a cancer marker and beyond.
Frontiers in bioscience (Landmark edition).
2019 03; 24(4):648-687. doi:
10.2741/4742
. [PMID: 30844704] - Katharina Huber, Dina C Hofer, Sophie Trefely, Helmut J Pelzmann, Corina Madreiter-Sokolowski, Madalina Duta-Mare, Stefanie Schlager, Gert Trausinger, Sarah Stryeck, Wolfgang F Graier, Dagmar Kolb, Christoph Magnes, Nathaniel W Snyder, Andreas Prokesch, Dagmar Kratky, Tobias Madl, Kathryn E Wellen, Juliane G Bogner-Strauss. N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes.
Biochimica et biophysica acta. Molecular cell research.
2019 03; 1866(3):337-348. doi:
10.1016/j.bbamcr.2018.08.017
. [PMID: 30595160] - Joseph P Dewulf, Elsa Wiame, Imen Dorboz, Monique Elmaleh-Bergès, Apolline Imbard, Dana Dumitriu, Malgorzata Rak, Agnès Bourillon, Raphaël Helaers, Alisha Malla, Florence Renaldo, Odile Boespflug-Tanguy, Marie-Françoise Vincent, Jean-François Benoist, Ron A Wevers, Avner Schlessinger, Emile Van Schaftingen, Marie-Cécile Nassogne, Manuel Schiff. SLC13A3 variants cause acute reversible leukoencephalopathy and α-ketoglutarate accumulation.
Annals of neurology.
2019 03; 85(3):385-395. doi:
10.1002/ana.25412
. [PMID: 30635937] - Omkar B Ijare, David S Baskin, Kumar Pichumani. Ex Vivo 1H NMR study of pituitary adenomas to differentiate various immunohistochemical subtypes.
Scientific reports.
2019 02; 9(1):3007. doi:
10.1038/s41598-019-38542-6
. [PMID: 30816132] - Aljoharah Alakkas, Ronald J Ellis, Caitlin Wei-Ming Watson, Anya Umlauf, Robert K Heaton, Scott Letendre, Ann Collier, Christina Marra, David B Clifford, Benjamin Gelman, Ned Sacktor, Susan Morgello, David Simpson, J Allen McCutchan, Asha Kallianpur, Sara Gianella, Thomas Marcotte, Igor Grant, Christine Fennema-Notestine. White matter damage, neuroinflammation, and neuronal integrity in HAND.
Journal of neurovirology.
2019 02; 25(1):32-41. doi:
10.1007/s13365-018-0682-9
. [PMID: 30291567] - I I Miroshnichenko, O B Yakovleva, T P Safarova, E S Shipilova, N V Baymeeva. [The content of N-acetylaspartate in depressed elderly patients during therapy with antidepressants and actovegin].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2019; 119(4):38-42. doi:
10.17116/jnevro201911904138
. [PMID: 31156220] - Sahar Nassirpour, Paul Chang, Anke Henning. MultiNet PyGRAPPA: Multiple neural networks for reconstructing variable density GRAPPA (a 1H FID MRSI study).
NeuroImage.
2018 12; 183(?):336-345. doi:
10.1016/j.neuroimage.2018.08.032
. [PMID: 30125713] - Talitha C Ford, Luke A Downey, Tamara Simpson, Grace McPhee, Chris Oliver, Con Stough. The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial.
Nutrients.
2018 Dec; 10(12):. doi:
10.3390/nu10121860
. [PMID: 30513795] - Xueying Ma, Yan Zhang, Shaohui Ma, Peng Li, Dun Ding, Hua Liu, Jixin Liu, Ming Zhang. Association between abnormal thalamic metabolites and sleep disturbance in patients with end-stage renal disease.
Metabolic brain disease.
2018 10; 33(5):1641-1648. doi:
10.1007/s11011-018-0272-9
. [PMID: 29974312] - Paul Chang, Sahar Nassirpour, Nikolai Avdievitch, Anke Henning. Non-water-suppressed 1 H FID-MRSI at 3T and 9.4T.
Magnetic resonance in medicine.
2018 08; 80(2):442-451. doi:
10.1002/mrm.27049
. [PMID: 29285781] - Ruhui Lin, Long Li, Yingzheng Zhang, Sheng Huang, Shangjie Chen, Jiao Shi, Peiyuan Zhuo, Hao Jin, Zuanfang Li, Weilin Liu, Zhifu Wang, Lidian Chen, Jing Tao. Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice.
Biological research.
2018 Jul; 51(1):21. doi:
10.1186/s40659-018-0166-7
. [PMID: 29980225] - Monika Karczewska-Kupczewska, Agnieszka Nikolajuk, Remigiusz Filarski, Radoslaw Majewski, Eugeniusz Tarasów. Intralipid/Heparin Infusion Alters Brain Metabolites Assessed With 1H-MRS Spectroscopy in Young Healthy Men.
The Journal of clinical endocrinology and metabolism.
2018 07; 103(7):2563-2570. doi:
10.1210/jc.2018-00107
. [PMID: 29860500] - Ye-Ha Jung, Hyeonjin Kim, So Yeon Jeon, Jeong Min Kwon, Dasom Lee, Soo-Hee Choi, Do-Hyung Kang. Aberrant interactions of peripheral measures and neurometabolites with lipids in complex regional pain syndrome using magnetic resonance spectroscopy: A pilot study.
Molecular pain.
2018 Jan; 14(?):1744806917751323. doi:
10.1177/1744806917751323
. [PMID: 29336203] - Emin Fidan, Lesley M Foley, Lee Ann New, Henry Alexander, Patrick M Kochanek, T Kevin Hitchens, Hülya Bayır. Metabolic and Structural Imaging at 7 Tesla After Repetitive Mild Traumatic Brain Injury in Immature Rats.
ASN neuro.
2018 Jan; 10(?):1759091418770543. doi:
10.1177/1759091418770543
. [PMID: 29741097] - Claire J Scavuzzo, Christopher J Moulton, Ryan J Larsen. The use of magnetic resonance spectroscopy for assessing the effect of diet on cognition.
Nutritional neuroscience.
2018 Jan; 21(1):1-15. doi:
10.1080/1028415x.2016.1218191
. [PMID: 27571302] - Kazuyuki Sumi, Kyosuke Uno, Hiroshi Noike, Takenori Tomohiro, Yasumaru Hatanaka, Yoko Furukawa-Hibi, Toshitaka Nabeshima, Yoshiaki Miyamoto, Atsumi Nitta. Behavioral impairment in SHATI/NAT8L knockout mice via dysfunction of myelination development.
Scientific reports.
2017 12; 7(1):16872. doi:
10.1038/s41598-017-17151-1
. [PMID: 29203794] - Austin T Mudd, Kirsten Berding, Mei Wang, Sharon M Donovan, Ryan N Dilger. Serum cortisol mediates the relationship between fecal Ruminococcus and brain N-acetylaspartate in the young pig.
Gut microbes.
2017 11; 8(6):589-600. doi:
10.1080/19490976.2017.1353849
. [PMID: 28703640] - Gaetano Barbagallo, Gennarina Arabia, Maurizio Morelli, Rita Nisticò, Fabiana Novellino, Maria Salsone, Federico Rocca, Andrea Quattrone, Manuela Caracciolo, Umberto Sabatini, Andrea Cherubini, Aldo Quattrone. Thalamic neurometabolic alterations in tremulous Parkinson's disease: A preliminary proton MR spectroscopy study.
Parkinsonism & related disorders.
2017 Oct; 43(?):78-84. doi:
10.1016/j.parkreldis.2017.07.028
. [PMID: 28774469] - Nina Kemala Sari, Siti Setiati, Akmal Taher, Martina Wiwie, Samsuridjal Djauzi, Jacub Pandelaki, Jan Sudir Purba, Mohamad Sadikin. The role of autosuggestion in geriatric patients' quality of life: a study on psycho-neuro-endocrine-immunology pathway.
Social neuroscience.
2017 10; 12(5):551-559. doi:
10.1080/17470919.2016.1196243
. [PMID: 27376875] - Frederic Sampedro, Mario de la Fuente Revenga, Marta Valle, Natalia Roberto, Elisabet Domínguez-Clavé, Matilde Elices, Luís Eduardo Luna, José Alexandre S Crippa, Jaime E C Hallak, Draulio B de Araujo, Pablo Friedlander, Steven A Barker, Enrique Álvarez, Joaquim Soler, Juan C Pascual, Amanda Feilding, Jordi Riba. Assessing the Psychedelic 'After-Glow' in Ayahuasca Users: Post-Acute Neurometabolic and Functional Connectivity Changes Are Associated with Enhanced Mindfulness Capacities.
The international journal of neuropsychopharmacology.
2017 09; 20(9):698-711. doi:
10.1093/ijnp/pyx036
. [PMID: 28525587] - Shin-Eui Park, Nam-Gil Choi, Gwang-Woo Jeong. Metabolic abnormality in the right dorsolateral prefrontal cortex in patients with obsessive-compulsive disorder: proton magnetic resonance spectroscopy.
Acta neuropsychiatrica.
2017 Jun; 29(3):164-169. doi:
10.1017/neu.2016.48
. [PMID: 27748207] - S-Y Wang, M Wang, X-X Wang, W Chen, C Sheng, Z-K Gong. Study on the clinical application of the MRS in the cognitive assessment after stroke.
European review for medical and pharmacological sciences.
2017 05; 21(10):2437-2442. doi:
"
. [PMID: 28617543] - Elham Rahimy, Fang-Yong Li, Lars Hagberg, Dietmar Fuchs, Kevin Robertson, Dieter J Meyerhoff, Henrik Zetterberg, Richard W Price, Magnus Gisslén, Serena Spudich. Blood-Brain Barrier Disruption Is Initiated During Primary HIV Infection and Not Rapidly Altered by Antiretroviral Therapy.
The Journal of infectious diseases.
2017 04; 215(7):1132-1140. doi:
10.1093/infdis/jix013
. [PMID: 28368497] - Moran Artzi, Gilad Liberman, Nachum Vaisman, Felix Bokstein, Faina Vitinshtein, Orna Aizenstein, Dafna Ben Bashat. Changes in cerebral metabolism during ketogenic diet in patients with primary brain tumors: 1H-MRS study.
Journal of neuro-oncology.
2017 04; 132(2):267-275. doi:
10.1007/s11060-016-2364-x
. [PMID: 28074323] - L J Peng, H R Qian, L L Mao, D Y Xia, X K Qi. [A clinical analysis of 5 patients with infratentorial primary angiitis of central nervous system].
Zhonghua nei ke za zhi.
2017 Apr; 56(4):284-289. doi:
10.3760/cma.j.issn.0578-1426.2017.04.009
. [PMID: 28355722] - Ana I Amaral, Mussie Ghezu Hadera, Mark Kotter, Ursula Sonnewald. Oligodendrocytes Do Not Export NAA-Derived Aspartate In Vitro.
Neurochemical research.
2017 Mar; 42(3):827-837. doi:
10.1007/s11064-016-1985-y
. [PMID: 27394419] - Sergej M Ostojic, Jelena Ostojic, Patrik Drid, Milan Vranes, Pavle Jovanov. Dietary guanidinoacetic acid increases brain creatine levels in healthy men.
Nutrition (Burbank, Los Angeles County, Calif.).
2017 Jan; 33(?):149-156. doi:
10.1016/j.nut.2016.06.001
. [PMID: 27497517] - Ruth Schneider, Barbara Bellenberg, Robert Hoepner, Eva-Maria Kolb, Gisa Ellrichmann, Aiden Haghikia, Ralf Gold, Carsten Lukas. Metabolic profiles by 1H-magnetic resonance spectroscopy in natalizumab-associated post-PML lesions of multiple sclerosis patients who survived progressive multifocal leukoencephalopathy (PML).
PloS one.
2017; 12(4):e0176415. doi:
10.1371/journal.pone.0176415
. [PMID: 28445498] - N K Singhal, H Huang, S Li, R Clements, J Gadd, A Daniels, E E Kooijman, P Bannerman, T Burns, F Guo, D Pleasure, E Freeman, L Shriver, J McDonough. The neuronal metabolite NAA regulates histone H3 methylation in oligodendrocytes and myelin lipid composition.
Experimental brain research.
2017 01; 235(1):279-292. doi:
10.1007/s00221-016-4789-z
. [PMID: 27709268] - H Rosewich, P Dechent, C Krause, A Ohlenbusch, K Brockmann, J Gärtner. Diagnostic and prognostic value of in vivo proton MR spectroscopy for Zellweger syndrome spectrum patients.
Journal of inherited metabolic disease.
2016 11; 39(6):869-876. doi:
10.1007/s10545-016-9965-6
. [PMID: 27488561] - Sarah J Nelson, Yan Li, Janine M Lupo, Marram Olson, Jason C Crane, Annette Molinaro, Ritu Roy, Jennifer Clarke, Nicholas Butowski, Michael Prados, Soonmee Cha, Susan M Chang. Serial analysis of 3D H-1 MRSI for patients with newly diagnosed GBM treated with combination therapy that includes bevacizumab.
Journal of neuro-oncology.
2016 10; 130(1):171-179. doi:
10.1007/s11060-016-2229-3
. [PMID: 27535746] - Monika Cichocka, Justyna Kozub, Paulina Karcz, Andrzej Urbanik. Differences in Metabolite Concentrations Between the Hemispheres of the Brain in Healthy Children: A Proton Magnetic Resonance Spectroscopy Study (1HMRS).
Journal of child neurology.
2016 10; 31(11):1296-301. doi:
10.1177/0883073816653784
. [PMID: 27364739] - Abas Abdoli, Andrew A Maudsley. Phased-array combination for MR spectroscopic imaging using a water reference.
Magnetic resonance in medicine.
2016 09; 76(3):733-41. doi:
10.1002/mrm.25992
. [PMID: 26413752] - Ai Nishitani, Miyuu Tanaka, Saki Shimizu, Naofumi Kunisawa, Mayuko Yokoe, Yusaku Yoshida, Toshiro Suzuki, Tetsushi Sakuma, Takashi Yamamoto, Mitsuru Kuwamura, Shigeo Takenaka, Yukihiro Ohno, Takashi Kuramoto. Involvement of aspartoacylase in tremor expression in rats.
Experimental animals.
2016 Jul; 65(3):293-301. doi:
10.1538/expanim.16-0007
. [PMID: 27026062] - Devender Bairwa, Virendra Kumar, Surabhi Vyas, Bimal Kumar Das, Achal Kumar Srivastava, Ravinder M Pandey, Surendra K Sharma, Naranamangalam R Jagannathan, Sanjeev Sinha. Case control study: magnetic resonance spectroscopy of brain in HIV infected patients.
BMC neurology.
2016 Jul; 16(?):99. doi:
10.1186/s12883-016-0628-x
. [PMID: 27405321] - Catherine Sarret, Odile Boespflug-Tanguy, Diana Rodriguez. Atypical clinical and radiological course of a patient with Canavan disease.
Metabolic brain disease.
2016 Apr; 31(2):475-9. doi:
10.1007/s11011-015-9767-9
. [PMID: 26586007] - A N Inci Kenar, G A Ünal, H Güler, B Albuz, Y Kıroğlu, M E Erdal, H Herken. Relationship between the DAT1 gene and the effects of methylphenidate administration in adult attention deficit hyperactivity disorder: a magnetic resonance spectroscopy study.
European review for medical and pharmacological sciences.
2016 Apr; 20(7):1373-8. doi:
. [PMID: 27097961]
- F Jiru, A Skoch, D Wagnerova, M Dezortova, J Viskova, O Profant, J Syka, M Hajek. The age dependence of T2 relaxation times of N-acetyl aspartate, creatine and choline in the human brain at 3 and 4T.
NMR in biomedicine.
2016 Mar; 29(3):284-92. doi:
10.1002/nbm.3456
. [PMID: 26752593] - Ramandeep Garg, Lorraine Brennan, Ruth K Price, Julie M W Wallace, J J Strain, Mike J Gibney, Peter R Shewry, Jane L Ward, Lalit Garg, Robert W Welch. Using NMR-Based Metabolomics to Evaluate Postprandial Urinary Responses Following Consumption of Minimally Processed Wheat Bran or Wheat Aleurone by Men and Women.
Nutrients.
2016 Feb; 8(2):96. doi:
10.3390/nu8020096
. [PMID: 26901221] - Alan K Jarmusch, Valentina Pirro, Zane Baird, Eyas M Hattab, Aaron A Cohen-Gadol, R Graham Cooks. Lipid and metabolite profiles of human brain tumors by desorption electrospray ionization-MS.
Proceedings of the National Academy of Sciences of the United States of America.
2016 Feb; 113(6):1486-91. doi:
10.1073/pnas.1523306113
. [PMID: 26787885] - Napapon Sailasuta, Jintanat Ananworanich, Sukalaya Lerdlum, Pasiri Sithinamsuwan, James L K Fletcher, Somporn Tipsuk, Mantana Pothisri, Tanate Jadwattanakul, Supunnee Jirajariyavej, Thep Chalermchai, Stephanie Catella, Edgar Busovaca, Akash Desai, Robert Paul, Victor Valcour. Neuronal-Glia Markers by Magnetic Resonance Spectroscopy in HIV Before and After Combination Antiretroviral Therapy.
Journal of acquired immune deficiency syndromes (1999).
2016 Jan; 71(1):24-30. doi:
10.1097/qai.0000000000000779
. [PMID: 26258565] - Helena Maier, Lihua Wang-Eckhardt, Dieter Hartmann, Volkmar Gieselmann, Matthias Eckhardt. N-Acetylaspartate Synthase Deficiency Corrects the Myelin Phenotype in a Canavan Disease Mouse Model But Does Not Affect Survival Time.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015 Oct; 35(43):14501-16. doi:
10.1523/jneurosci.1056-15.2015
. [PMID: 26511242] - Dominik Strzelecki, Michał Podgórski, Olga Kałużyńska, Oliwia Gawlik-Kotelnicka, Ludomir Stefańczyk, Magdalena Kotlicka-Antczak, Agnieszka Gmitrowicz, Piotr Grzelak. Supplementation of antipsychotic treatment with sarcosine – GlyT1 inhibitor – causes changes of glutamatergic (1)NMR spectroscopy parameters in the left hippocampus in patients with stable schizophrenia.
Neuroscience letters.
2015 Oct; 606(?):7-12. doi:
10.1016/j.neulet.2015.08.039
. [PMID: 26306650] - Stefan Smesny, Alexander Gussew, Natalie Joan Biesel, Stephan Schack, Mario Walther, Reinhard Rzanny, Berko Milleit, Christian Gaser, Thomas Sobanski, Carl Christoph Schultz, Paul Amminger, Uta-Christina Hipler, Heinrich Sauer, Jürgen R Reichenbach. Glutamatergic dysfunction linked to energy and membrane lipid metabolism in frontal and anterior cingulate cortices of never treated first-episode schizophrenia patients.
Schizophrenia research.
2015 Oct; 168(1-2):322-9. doi:
10.1016/j.schres.2015.07.013
. [PMID: 26255566] - Anne Drenckhahn, Markus Schuelke, Ellen Knierim. Leukodystrophy with multiple beaded periventricular cysts: unusual cranial MRI results in Canavan disease.
Journal of inherited metabolic disease.
2015 Sep; 38(5):983-4. doi:
10.1007/s10545-015-9812-1
. [PMID: 25647544] - Giuseppe De Bernardo, Maurizio Giordano, Desiree Sordino, Salvatore Buono. Early diagnosis of Canavan syndrome: how can we get there?.
BMJ case reports.
2015 Aug; 2015(?):. doi:
10.1136/bcr-2014-208755
. [PMID: 26245283] - Sarah A Moore, Kate Hallsworth, Djordje G Jakovljevic, Andrew M Blamire, Jiabao He, Gary A Ford, Lynn Rochester, Michael I Trenell. Effects of Community Exercise Therapy on Metabolic, Brain, Physical, and Cognitive Function Following Stroke: A Randomized Controlled Pilot Trial.
Neurorehabilitation and neural repair.
2015 Aug; 29(7):623-35. doi:
10.1177/1545968314562116
. [PMID: 25538152] - Yi Zhang, Jinyuan Zhou, Paul A Bottomley. Minimizing lipid signal bleed in brain (1) H chemical shift imaging by post-acquisition grid shifting.
Magnetic resonance in medicine.
2015 Aug; 74(2):320-9. doi:
10.1002/mrm.25438
. [PMID: 25168657] - Lai Wei, Rong Xue, Panpan Zhang, Yijie Wu, Xiaojing Li, Fengkui Pei. (1)H NMR-Based Metabolomics and Neurotoxicity Study of Cerebrum and Cerebellum in Rats Treated with Cinnabar, a Traditional Chinese Medicine.
Omics : a journal of integrative biology.
2015 Aug; 19(8):490-8. doi:
10.1089/omi.2015.0042
. [PMID: 26110755] - Yanbin Jia, Shuming Zhong, Ying Wang, Tao Liu, Xiaoxiao Liao, Li Huang. The correlation between biochemical abnormalities in frontal white matter, hippocampus and serum thyroid hormone levels in first-episode patients with major depressive disorder.
Journal of affective disorders.
2015 Jul; 180(?):162-9. doi:
10.1016/j.jad.2015.04.005
. [PMID: 25913802] - Li Zhou, Yongping Fan. Randomized trial of erhuangfang for relapsing multiple sclerosis.
Neurological research.
2015 Jul; 37(7):633-7. doi:
10.1179/1743132815y.0000000011
. [PMID: 25668581] - Antonio Bravo-Oro, Danae Acosta-Yebra, Ilse P Grimaldo-Zapata, Guillermo Reyes-Vaca. [Reversible cortical atrophy secondary to anti-NMDA receptor antibody encephalitis].
Revista de neurologia.
2015 May; 60(10):447-52. doi:
NULL
. [PMID: 25952599] - Radka Tušková, Boris Lipták, Pavol Szomolányi, Oľga Vančová, Oľga Uličná, Zuzana Sumbalová, Jarmila Kucharská, Michal Dubovický, Siegfried Trattnig, Tibor Liptaj, Svatava Kašparová. Neuronal marker recovery after Simvastatin treatment in dementia in the rat brain: in vivo magnetic resonance study.
Behavioural brain research.
2015 May; 284(?):257-64. doi:
10.1016/j.bbr.2015.02.016
. [PMID: 25698600] - Bharath Wootla, Aleksandar Denic, Jens O Watzlawik, Arthur E Warrington, Moses Rodriguez. A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis.
Journal of neuroinflammation.
2015 Apr; 12(?):83. doi:
10.1186/s12974-015-0303-y
. [PMID: 25924771] - Kaja Nordengen, Christoph Heuser, Johanne Egge Rinholm, Reuben Matalon, Vidar Gundersen. Localisation of N-acetylaspartate in oligodendrocytes/myelin.
Brain structure & function.
2015 Mar; 220(2):899-917. doi:
10.1007/s00429-013-0691-7
. [PMID: 24379086] - Xiao-Qi Ding, Andrew A Maudsley, Mohammad Sabati, Sulaiman Sheriff, Paulo R Dellani, Heinrich Lanfermann. Reproducibility and reliability of short-TE whole-brain MR spectroscopic imaging of human brain at 3T.
Magnetic resonance in medicine.
2015 Mar; 73(3):921-8. doi:
10.1002/mrm.25208
. [PMID: 24677384] - Alan Winston, Rebekah Puls, Stephen J Kerr, Chris Duncombe, Patrick Li, John M Gill, Reshmie Ramautarsing, Simon D Taylor-Robinson, Sean Emery, David A Cooper. Differences in the direction of change of cerebral function parameters are evident over three years in HIV-infected individuals electively commencing initial cART.
PloS one.
2015; 10(2):e0118608. doi:
10.1371/journal.pone.0118608
. [PMID: 25723494] - Suzanna Maria Zick, Heather Zwickey, Lisa Wood, Bradley Foerster, Tohfa Khabir, Benjamin Wright, Eric Ichesco, Ananda Sen, Richard Edmund Harris. Preliminary differences in peripheral immune markers and brain metabolites between fatigued and non-fatigued breast cancer survivors: a pilot study.
Brain imaging and behavior.
2014 Dec; 8(4):506-16. doi:
10.1007/s11682-013-9270-z
. [PMID: 24222427] - Marcos Hortes N Chagas, Antonio W Zuardi, Vitor Tumas, Márcio Alexandre Pena-Pereira, Emmanuelle T Sobreira, Mateus M Bergamaschi, Antonio Carlos dos Santos, Antonio Lucio Teixeira, Jaime E C Hallak, José Alexandre S Crippa. Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trial.
Journal of psychopharmacology (Oxford, England).
2014 Nov; 28(11):1088-98. doi:
10.1177/0269881114550355
. [PMID: 25237116] - Ioannis Markakis, Harry Alexopoulos, Cornelia Poulopoulou, Sofia Akrivou, Athanasios Papathanasiou, Vassiliki Katsiva, Georgios Lyrakos, Georgios Gekas, Marinos C Dalakas. Immunotherapy-responsive limbic encephalitis with antibodies to glutamic acid decarboxylase.
Journal of the neurological sciences.
2014 Aug; 343(1-2):192-4. doi:
10.1016/j.jns.2014.05.032
. [PMID: 24950904] - Yoon J Choi, Patrik Gabikian, Fang Zhu, Daniel E Appelbaum, Robert Wollmann, Rimas V Lukas. Advanced neuroimaging studies in a patient with brain metastases from transitional cell carcinoma of the bladder.
Journal of neuroimaging : official journal of the American Society of Neuroimaging.
2014 Jul; 24(4):429-31. doi:
10.1111/jon.12024
. [PMID: 23551927] - A Rhodin, M von Ehren, B Skottheim, A Grönbladh, F Ortiz-Nieto, R Raininko, T Gordh, F Nyberg. Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids.
Acta anaesthesiologica Scandinavica.
2014 Jul; 58(6):759-65. doi:
10.1111/aas.12309
. [PMID: 24712862] - Ye-Ming Guan, Yao Zhu, Xue-Chun Liu, Hai-Li Huang, Zhi-Wei Wang, Bo Liu, You-Zi Zhu, Qing-Song Wang. Effect of human umbilical cord blood mesenchymal stem cell transplantation on neuronal metabolites in ischemic rabbits.
BMC neuroscience.
2014 Mar; 15(?):41. doi:
10.1186/1471-2202-15-41
. [PMID: 24635873] - Takeshi Sato, Koji Muroya, Junko Hanakawa, Yumi Asakura, Noriko Aida, Moyoko Tomiyasu, Go Tajima, Tomonobu Hasegawa, Masanori Adachi. Neonatal case of classic maple syrup urine disease: usefulness of (1) H-MRS in early diagnosis.
Pediatrics international : official journal of the Japan Pediatric Society.
2014 Feb; 56(1):112-5. doi:
10.1111/ped.12211
. [PMID: 24548198] - S-S Lu, S J Kim, H S Kim, C G Choi, Y-M Lim, E J Kim, D Y Kim, S H Cho. Utility of proton MR spectroscopy for differentiating typical and atypical primary central nervous system lymphomas from tumefactive demyelinating lesions.
AJNR. American journal of neuroradiology.
2014 Feb; 35(2):270-7. doi:
10.3174/ajnr.a3677
. [PMID: 23928144] - Cedric Annweiler, Olivier Beauchet, Robert Bartha, Vladimir Hachinski, Manuel Montero-Odasso. Vitamin D and caudal primary motor cortex: a magnetic resonance spectroscopy study.
PloS one.
2014; 9(1):e87314. doi:
10.1371/journal.pone.0087314
. [PMID: 24498072] - Beata R Godlewska, Sarah W Yip, Jamie Near, Guy M Goodwin, Philip J Cowen. Cortical glutathione levels in young people with bipolar disorder: a pilot study using magnetic resonance spectroscopy.
Psychopharmacology.
2014 Jan; 231(2):327-32. doi:
10.1007/s00213-013-3244-0
. [PMID: 23955702] - Valentina Di Pietro, Ugo Cavallari, Angela M Amorini, Giacomo Lazzarino, Salvatore Longo, Carlo Poggiani, Pietro Cavalli, Barbara Tavazzi. New T530C mutation in the aspartoacylase gene caused Canavan disease with no correlation between severity and N-acetylaspartate excretion.
Clinical biochemistry.
2013 Dec; 46(18):1902-4. doi:
10.1016/j.clinbiochem.2013.09.004
. [PMID: 24036223] - Ahmed Abdel Khalek Abdel Razek, Ahmed Abdalla, Nahed Abdel Gaber, Abeer Fathy, Ahmed Megahed, Tarek Barakat, Mona Abdel Latif Alsayed. Proton MR Spectroscopy of the brain in children with neuronopathic Gaucher's disease.
European radiology.
2013 Nov; 23(11):3005-11. doi:
10.1007/s00330-013-2924-9
. [PMID: 23783781] - Hyungseok Seo, Keun Ho Lim, Jae-Hyung Choi, Sung-Moon Jeong. Similar neuroprotective effects of ischemic and hypoxic preconditioning on hypoxia-ischemia in the neonatal rat: a proton MRS study.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2013 Nov; 31(7):616-23. doi:
10.1016/j.ijdevneu.2013.08.001
. [PMID: 23958850] - Andreana P Haley, Mitzi M Gonzales, Takashi Tarumi, Hirofumi Tanaka. Dyslipidemia links obesity to early cerebral neurochemical alterations.
Obesity (Silver Spring, Md.).
2013 Oct; 21(10):2007-13. doi:
10.1002/oby.20332
. [PMID: 23512296] - Xia Ge, Xiao-yun Xu, Chun-hua Feng, Yue Wang, Yuan-ling Li, Bo Feng. Relationships among serum C-reactive protein, receptor for advanced glycation products, metabolic dysfunction, and cognitive impairments.
BMC neurology.
2013 Aug; 13(?):110. doi:
10.1186/1471-2377-13-110
. [PMID: 23978069] - R Caivano, A Lotumolo, P Rabasco, A Zandolino, F D'Antuono, A Villonio, M I Lancellotti, L Macarini, A Cammarota. 3 Tesla magnetic resonance spectroscopy: cerebral gliomas vs. metastatic brain tumors. Our experience and review of the literature.
The International journal of neuroscience.
2013 Aug; 123(8):537-43. doi:
10.3109/00207454.2013.774395
. [PMID: 23390934] - Demet Terek, Ozge Koroglu, Mehmet Yalaz, Sarenur Gokben, Cem Calli, Mahmut Coker, Nilgun Kultursay. Diagnostic tools of early brain disturbances in an asymptomatic neonate with maple syrup urine disease.
Neuropediatrics.
2013 Aug; 44(4):208-12. doi:
10.1055/s-0032-1332741
. [PMID: 23341096] - Débora Coimbra Costa, Norma Alva, Laia Trigueros, Antonio Gamez, Teresa Carbonell, Ramón Rama. Intermittent hypobaric hypoxia induces neuroprotection in kainate-induced oxidative stress in rats.
Journal of molecular neuroscience : MN.
2013 Jul; 50(3):402-10. doi:
10.1007/s12031-012-9945-8
. [PMID: 23288703] - Assawin Gongvatana, Jaroslaw Harezlak, Steven Buchthal, Eric Daar, Giovanni Schifitto, Thomas Campbell, Michael Taylor, Elyse Singer, Jeffrey Algers, Jianhui Zhong, Mark Brown, Deborah McMahon, Yuen T So, Deming Mi, Robert Heaton, Kevin Robertson, Constantin Yiannoutsos, Ronald A Cohen, Bradford Navia. Progressive cerebral injury in the setting of chronic HIV infection and antiretroviral therapy.
Journal of neurovirology.
2013 Jun; 19(3):209-18. doi:
10.1007/s13365-013-0162-1
. [PMID: 23613008] - Silvia Mangia, Anjali F Kumar, Amir A Moheet, Rachel J Roberts, Lynn E Eberly, Elizabeth R Seaquist, Ivan Tkáč. Neurochemical profile of patients with type 1 diabetes measured by ¹H-MRS at 4 T.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2013 May; 33(5):754-9. doi:
10.1038/jcbfm.2013.13
. [PMID: 23403373] - Wang Qingsong, Guan Yeming, Liu Xuechun, Liu Hongjuan, Wang Jing. The free radical scavenger, edaravone, ameliorates delayed neuropsychological sequelae after acute carbon monoxide poisoning in rabbits.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc.
2013 May; 40(3):223-9. doi:
. [PMID: 23789557]
- Tae-Hoon Kim, Heoung-Keun Kang, Gwang-Woo Jeong. Assessment of brain metabolites change during visual sexual stimulation in healthy women using functional MR spectroscopy.
The journal of sexual medicine.
2013 Apr; 10(4):1001-11. doi:
10.1111/jsm.12057
. [PMID: 23347356] - Emilie R Muelly, Gregory J Moore, Scott C Bunce, Julie Mack, Don C Bigler, D Holmes Morton, Kevin A Strauss. Biochemical correlates of neuropsychiatric illness in maple syrup urine disease.
The Journal of clinical investigation.
2013 Apr; 123(4):1809-20. doi:
10.1172/jci67217
. [PMID: 23478409] - Martin Bulik, Radim Jancalek, Jiri Vanicek, Antonin Skoch, Marek Mechl. Potential of MR spectroscopy for assessment of glioma grading.
Clinical neurology and neurosurgery.
2013 Feb; 115(2):146-53. doi:
10.1016/j.clineuro.2012.11.002
. [PMID: 23237636] - Joseph J Gallagher, Xiaowei Zhang, F Scott Hall, George R Uhl, Elaine L Bearer, Russell E Jacobs. Altered reward circuitry in the norepinephrine transporter knockout mouse.
PloS one.
2013; 8(3):e57597. doi:
10.1371/journal.pone.0057597
. [PMID: 23469209] - Alan Winston, Chris Duncombe, Patrick C K Li, John M Gill, Stephen J Kerr, Rebekah L Puls, Simon D Taylor-Robinson, Sean Emery, David A Cooper. Two patterns of cerebral metabolite abnormalities are detected on proton magnetic resonance spectroscopy in HIV-infected subjects commencing antiretroviral therapy.
Neuroradiology.
2012 Dec; 54(12):1331-9. doi:
10.1007/s00234-012-1061-5
. [PMID: 22772471] - Emilie A Steffen-Smith, David J Venzon, Robyn S Bent, Sean J Hipp, Katherine E Warren. Single- and multivoxel proton spectroscopy in pediatric patients with diffuse intrinsic pontine glioma.
International journal of radiation oncology, biology, physics.
2012 Nov; 84(3):774-9. doi:
10.1016/j.ijrobp.2012.01.032
. [PMID: 22445531]