Protoporphyrin IX (BioDeep_00000001680)

 

Secondary id: BioDeep_00000399613, BioDeep_00001868018

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


3-[20-(2-carboxyethyl)-9,14-diethenyl-5,10,15,19-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1^{3,6}.1^{8,11}.1^{13,16}]tetracosa-1(21),2,4,6,8(23),9,11,13,15,17,19-undecaen-4-yl]propanoic acid

化学式: C34H34N4O4 (562.2579924)
中文名称: 原卟啉, 原卟啉IX
谱图信息: 最多检出来源 Homo sapiens(blood) 0.05%

分子结构信息

SMILES: C=CC1=C(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5CCC(=O)O)C(CCC(=O)O)=C4C)c(C)c3C=C
InChI: InChI=1S/C34H34N4O4/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25/h7-8,13-16,35,38H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42)/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-

描述信息

Protoporphyrins are tetrapyrroles containing 4 methyl, 2 propionic, and 2 vinyl side chains. Protoporphyrin is produced by oxidation of the methylene bridge of protoporphyrinogen. Protoporphyrin IX is the only naturally occurring isomer; it is an intermediate in heme biosynthesis, combining with ferrous iron to form protoheme IX, the heme prosthetic group of hemoglobin. Protoporphyrin IX is created by the enzyme protoporphyrinogen oxidase. The enzyme ferrochelatase converts it into heme. Protoporphyrin IX naturally occurs in small amounts in feces. Protoporphyrin IX is also responsible for the brown pigment (ooporphyrin) of birds eggs. Protoporphyrin IX is used as a branch point in the biosynthetic pathway leading to heme (by insertion of iron) and chlorophylls (by insertion of Mg and further side-chain transformation). Protoporphyrin IX can be used to treat liver disorders, mainly as the sodium salt. Under certain conditions, protoporphyrin IX can act as a neurotoxin, a phototoxin, and a metabotoxin. A neurotoxin causes damage to nerve cells and nerve tissues. A phototoxin causes cell damage upon exposure to light. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of porphyrins are associated with porphyrias such as porphyria variegate, acute intermittent porphyria, and hereditary coproporphyria (HCP). In particular, it is accumulated and excreted excessively in the feces in acute intermittent porphyria, protoporphyria, and variegate porphyria. There are several types of porphyrias (most are inherited). Hepatic porphyrias are characterized by acute neurological attacks (seizures, psychosis, extreme back and abdominal pain, and an acute polyneuropathy), while the erythropoietic forms present with skin problems (usually a light-sensitive blistering rash and increased hair growth). The neurotoxicity of porphyrins may be due to their selective interactions with tubulin, which disrupt microtubule formation and cause neural malformations (PMID: 3441503).
obtained by demetallation of Haemin, occurs in small amounts in faeces. Brown pigment (Ooporphyrin) of birds eggs. Isolated from Atolla wyvillei (CCD). Protoporphyrin is found in red beetroot.
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents
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C1420 - Photosensitizing Agent
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Protoporphyrin IX is the final intermediate in the heme biosynthetic pathway.
Protoporphyrin IX is the final intermediate in the heme biosynthetic pathway.

同义名列表

17 个代谢物同义名

3-[20-(2-carboxyethyl)-9,14-diethenyl-5,10,15,19-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1^{3,6}.1^{8,11}.1^{13,16}]tetracosa-1(21),2,4,6,8(23),9,11,13,15,17,19-undecaen-4-yl]propanoic acid; 3,3-(3,7,12,17-Tetramethyl-8,13-divinyl-21H,23H-porphine-2,18-diyl)-bis-propionic acid; 3,3-(3,7,12,17-Tetramethyl-8,13-divinyl-21H,23H-porphine-2,18-diyl)-bis-propionate; 3,7,12,17-Tetramethyl-8,13-divinylporphyrin-2,18-dipropanoic acid; 3,7,12,17-Tetramethyl-8,13-divinylporphyrin-2,18-dipropanoate; 3,3-(3,7,12,17-Tetramethyl-8,13-divinylporphine-2,18-diyl)di; Protoporphyrin-"ix"; Kammerers prophyrin; Protoporphyrin-IX; protoporphyrin IX; Porphyrinogen IX; Protoporphyrin; Ooporphyrin; H2PpIX; PpIX; Protoporphyrin; Protoporphyrin



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(1)

PlantCyc(0)

代谢反应

62 个相关的代谢反应过程信息。

Reactome(57)

BioCyc(3)

WikiPathways(0)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Peiyu Xu, Jing Liu, Ying Yi, Zhi Cai, Yihua Yin, Weiquan Cai, Jingli Zhang, Zhixia Gong, Yaqi Xiao. A dew-responsive pectin-based herbicide for enhanced photodynamic inactivation. Carbohydrate polymers. 2024 Jul; 336(?):122114. doi: 10.1016/j.carbpol.2024.122114. [PMID: 38670775]
  • Rajendra P Giri, Subhadip Chowdhury, Mrinmay K Mukhopadhyay, Abhijit Chakrabarti, Milan K Sanyal. Ganglioside GM1 Drives Hemin and Protoporphyrin Adsorption in Phospholipid Membranes: A Structural Study. The journal of physical chemistry. B. 2024 Mar; 128(11):2745-2754. doi: 10.1021/acs.jpcb.3c08239. [PMID: 38447189]
  • Giovanni Genovese, Carlo Alberto Maronese, Chiara Moltrasio, Roberta Piccinno, Dario Antonio Marletta, Giacomo De Luca, Giovanna Graziadei, Francesca Granata, Elena Di Pierro, Maria Domenica Cappellini, Angelo Valerio Marzano. Ultraviolet A phototest positivity is associated with higher free erythrocyte protoporphyrin IX concentration and lower transferrin saturation values in erythropoietic protoporphyria. Photodermatology, photoimmunology & photomedicine. 2022 Mar; 38(2):141-149. doi: 10.1111/phpp.12727. [PMID: 34420239]
  • Liyun Zeng, Qiongyan Zou, Peng Huang, Li Xiong, Yan Cheng, Qitong Chen, Yitong Li, Hongye He, Wenjun Yi, Wu Wei. Inhibition of autophagy with Chloroquine enhanced apoptosis induced by 5-aminolevulinic acid-photodynamic therapy in secondary hyperparathyroidism primary cells and organoids. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):111994. doi: 10.1016/j.biopha.2021.111994. [PMID: 34411921]
  • Natalia Sh Lebedeva, Yury A Gubarev, Galina M Mamardashvili, Svetlana V Zaitceva, Sergey A Zdanovich, Alena S Malyasova, Julia V Romanenko, Mikhail O Koifman, Oskar I Koifman. Theoretical and experimental study of interaction of macroheterocyclic compounds with ORF3a of SARS-CoV-2. Scientific reports. 2021 09; 11(1):19481. doi: 10.1038/s41598-021-99072-8. [PMID: 34593970]
  • Anna Walke, Simone König. Protoporphyrin IX purification from blood and serum for mass analysis - Considerations with respect to neurosurgery. Rapid communications in mass spectrometry : RCM. 2021 09; 35(17):e9138. doi: 10.1002/rcm.9138. [PMID: 34089543]
  • Guilherme C Lechuga, Franklin Souza-Silva, Carolina Q Sacramento, Monique R O Trugilho, Richard H Valente, Paloma Napoleão-Pêgo, Suelen S G Dias, Natalia Fintelman-Rodrigues, Jairo R Temerozo, Nicolas Carels, Carlos R Alves, Mirian C S Pereira, David W Provance, Thiago M L Souza, Salvatore G De-Simone. SARS-CoV-2 Proteins Bind to Hemoglobin and Its Metabolites. International journal of molecular sciences. 2021 Aug; 22(16):. doi: 10.3390/ijms22169035. [PMID: 34445741]
  • François Halloy, Pavithra S Iyer, Alice Ghidini, Veronika Lysenko, Jasmin Barman-Aksözen, Chia-Pei Grubenmann, Jessica Jucker, Nicole Wildner-Verhey van Wijk, Marc-David Ruepp, Elisabeth I Minder, Anna-Elisabeth Minder, Xiaoye Schneider-Yin, Alexandre P A Theocharides, Daniel Schümperli, Jonathan Hall. Repurposing of glycine transport inhibitors for the treatment of erythropoietic protoporphyria. Cell chemical biology. 2021 08; 28(8):1221-1234.e6. doi: 10.1016/j.chembiol.2021.02.021. [PMID: 33756123]
  • Xuerong Dong, Xiang Zhang, Manyuan Wang, Liwei Gu, Jing Li, Muxin Gong. Heparin-decorated nanostructured lipid carriers of artemether-protoporphyrin IX-transferrin combination for therapy of malaria. International journal of pharmaceutics. 2021 Aug; 605(?):120813. doi: 10.1016/j.ijpharm.2021.120813. [PMID: 34144137]
  • Taiga Yamada, Teruyuki Komatsu. Methemoglobin-Albumin Cluster Incorporating Protoporphyrin IX: Dual Functional Protein Drug for Photodynamic Therapy. Chembiochem : a European journal of chemical biology. 2021 08; 22(15):2526-2529. doi: 10.1002/cbic.202100213. [PMID: 34156148]
  • Thibaud Lefebvre, Muriel Coupaye, Marina Esposito-Farèse, Nathalie Gault, Neila Talbi, Caroline Quintin, Caroline Schmitt, Soumeya Bekri, André Bado, Hervé Puy, Simon Msika, Carole Brasse-Lagnel, Zoubida Karim. Hepcidin and Iron Deficiency in Women One Year after Sleeve Gastrectomy: A Prospective Cohort Study. Nutrients. 2021 Jul; 13(8):. doi: 10.3390/nu13082516. [PMID: 34444676]
  • Dhiman Maitra, Benjamin M Pinsky, Amenah Soherawardy, Haiyan Zheng, Ruma Banerjee, M Bishr Omary. Protein-aggregating ability of different protoporphyrin-IX nanostructures is dependent on their oxidation and protein-binding capacity. The Journal of biological chemistry. 2021 07; 297(1):100778. doi: 10.1016/j.jbc.2021.100778. [PMID: 34023387]
  • Lilia Coronato Courrol, Flávia Rodrigues de Oliveira Silva, Valdivel Masilamani. SARS-CoV-2, hemoglobin and protoporphyrin IX: Interactions and perspectives. Photodiagnosis and photodynamic therapy. 2021 Jun; 34(?):102324. doi: 10.1016/j.pdpdt.2021.102324. [PMID: 33965601]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Kit Man Chan, Jonathan Gleadle, Jordan Li, Thomas Danny Michl, Krasimir Vasilev, Melanie MacGregor. Improving hexaminolevulinate enabled cancer cell detection in liquid biopsy immunosensors. Scientific reports. 2021 03; 11(1):7283. doi: 10.1038/s41598-021-86649-6. [PMID: 33790357]
  • Shengsheng Lu, Xiaoyan Pan, Daiwei Chen, Xi Xie, Yan Wu, Weijuan Shang, Xiaming Jiang, Yuan Sun, Sheng Fan, Jian He. Broad-spectrum antivirals of protoporphyrins inhibit the entry of highly pathogenic emerging viruses. Bioorganic chemistry. 2021 02; 107(?):104619. doi: 10.1016/j.bioorg.2020.104619. [PMID: 33450541]
  • Kulwinder Sagoo, Nathan Cumberbatch, Adam Holland, Graham Hungerford. Rapid (FLASH-FLIM) imaging of protoporphyrin IX in a lipid mixture using a CMOS based widefield fluorescence lifetime imaging camera in real time for margin demarcation applications. Methods and applications in fluorescence. 2021 Jan; 9(1):. doi: 10.1088/2050-6120/abbcc6. [PMID: 32992309]
  • Yuan-Yuan Li, Min Han, Rui-Hua Wang, Ming-Gang Gao. Comparative transcriptome analysis identifies genes associated with chlorophyll levels and reveals photosynthesis in green flesh of radish taproot. PloS one. 2021; 16(5):e0252031. doi: 10.1371/journal.pone.0252031. [PMID: 34043661]
  • Richard Howley, Matthew Mansi, Janhavi Shinde, Juliana Restrepo, Bin Chen. Evaluation of aminolevulinic acid-mediated protoporphyrin IX fluorescence and enhancement by ABCG2 inhibitors in renal cell carcinoma cells. Journal of photochemistry and photobiology. B, Biology. 2020 Oct; 211(?):112017. doi: 10.1016/j.jphotobiol.2020.112017. [PMID: 32919173]
  • R D R Tiveron, D A Costa, M D I Leite, C B S Vaz, M Sousa, S M C F Carlos, C J F Oliveira, R R Machado, T P Paulino. Evaluation of cell damage and modulation of cytokines TNF-α, IL-6 and IL-10 in macrophages exposed to PpIX-mediated photodynamic therapy. Brazilian journal of biology = Revista brasleira de biologia. 2020 Sep; 80(3):497-505. doi: 10.1590/1519-6984.193748. [PMID: 31576928]
  • Atefeh Vejdani Noghreiyan, Armin Imanparast, Elham Shayesteh Ara, Samaneh Soudmand, Vajiheh Vejdani Noghreiyan, Ameneh Sazgarnia. In-vitro investigation of cold atmospheric plasma induced photodynamic effect by Indocyanine green and Protoporphyrin IX. Photodiagnosis and photodynamic therapy. 2020 Sep; 31(?):101822. doi: 10.1016/j.pdpdt.2020.101822. [PMID: 32428573]
  • Ya-Xuan Zhu, Hao-Ran Jia, Qiu-Yi Duan, Xiaoyang Liu, Jing Yang, Yi Liu, Fu-Gen Wu. Photosensitizer-Doped and Plasma Membrane-Responsive Liposomes for Nuclear Drug Delivery and Multidrug Resistance Reversal. ACS applied materials & interfaces. 2020 Aug; 12(33):36882-36894. doi: 10.1021/acsami.0c09110. [PMID: 32666795]
  • Takahiro Nishimura, Keisuke Hara, Norihiro Honda, Shigetoshi Okazaki, Hisanao Hazama, Kunio Awazu. Determination and analysis of singlet oxygen quantum yields of talaporfin sodium, protoporphyrin IX, and lipidated protoporphyrin IX using near-infrared luminescence spectroscopy. Lasers in medical science. 2020 Aug; 35(6):1289-1297. doi: 10.1007/s10103-019-02907-0. [PMID: 31853809]
  • Hana Manceau, Sophie D Lefevre, Arienne Mirmiran, Claude Hattab, Hugo R Sugier, Caroline Schmitt, Katell Peoc'h, Hervé Puy, Mariano A Ostuni, Laurent Gouya, Jean-Jacques Lacapere. TSPO2 translocates 5-aminolevulinic acid into human erythroleukemia cells. Biology of the cell. 2020 Apr; 112(4):113-126. doi: 10.1111/boc.201900098. [PMID: 31989647]
  • Irena Maliszewska, Dominika Wawrzyńczyk, Ewelina Wanarska. The effect of glucose and human serum on 5-aminolevulinic acid mediated photodynamic inactivation of Candida albicans. Photodiagnosis and photodynamic therapy. 2020 Mar; 29(?):101623. doi: 10.1016/j.pdpdt.2019.101623. [PMID: 31904553]
  • Tiago N Figueira, Marco M Domingues, Françoise Illien, Iris Cadima-Couto, Toni Todorovski, David Andreu, Sandrine Sagan, Miguel A R B Castanho, Astrid Walrant, Ana Salomé Veiga. Enfuvirtide-Protoporphyrin IX Dual-Loaded Liposomes: In Vitro Evidence of Synergy against HIV-1 Entry into Cells. ACS infectious diseases. 2020 02; 6(2):224-236. doi: 10.1021/acsinfecdis.9b00285. [PMID: 31855415]
  • Deborah Piffaretti, Floriana Burgio, Marcus Thelen, Alain Kaelin-Lang, Paolo Paganetti, Michael Reinert, Maria Luisa D'Angelo. Protoporphyrin IX tracer fluorescence modulation for improved brain tumor cell lines visualization. Journal of photochemistry and photobiology. B, Biology. 2019 Dec; 201(?):111640. doi: 10.1016/j.jphotobiol.2019.111640. [PMID: 31734545]
  • Kit Man Chan, Krasimir Vasilev, Hanieh Safizadeh Shirazi, Kym McNicholas, Jordan Li, Jonathan Gleadle, Melanie MacGregor. Biosensor device for the photo-specific detection of immuno-captured bladder cancer cells using hexaminolevulinate: An ex-vivo study. Photodiagnosis and photodynamic therapy. 2019 Dec; 28(?):238-247. doi: 10.1016/j.pdpdt.2019.08.001. [PMID: 31394301]
  • Hong Cheng, Gui-Ling Fan, Jing-Hao Fan, Ping Yuan, Fu-An Deng, Xiao-Zhong Qiu, Xi-Yong Yu, Shi-Ying Li. Epigenetics-inspired photosensitizer modification for plasma membrane-targeted photodynamic tumor therapy. Biomaterials. 2019 12; 224(?):119497. doi: 10.1016/j.biomaterials.2019.119497. [PMID: 31541935]
  • Tao-Cheng Wu, Jia-Shiong Chen, Chao-Hung Wang, Po-Hsun Huang, Feng-Yen Lin, Liang-Yu Lin, Shing-Jong Lin, Jaw-Wen Chen. Activation of heme oxygenase-1 by Ginkgo biloba extract differentially modulates endothelial and smooth muscle-like progenitor cells for vascular repair. Scientific reports. 2019 11; 9(1):17316. doi: 10.1038/s41598-019-53818-7. [PMID: 31754254]
  • John Phillips, Collin Farrell, Yongming Wang, Ashwani K Singal, Karl Anderson, Manisha Balwani, Montgomery Bissell, Herbert Bonkovsky, Toni Seay, Barry Paw, Robert Desnick, Joseph Bloomer. Strong correlation of ferrochelatase enzymatic activity with Mitoferrin-1 mRNA in lymphoblasts of patients with protoporphyria. Molecular genetics and metabolism. 2019 11; 128(3):391-395. doi: 10.1016/j.ymgme.2018.10.005. [PMID: 30391163]
  • Lizette Mares, Felipe Vilchis, Bertha Chávez, Luis Ramos. Expression and regulation of ABCG2/BCRP1 by sex steroids in the Harderian gland of the Syrian hamster (Mesocricetus auratus). Comptes rendus biologies. 2019 Nov; 342(9-10):279-289. doi: 10.1016/j.crvi.2019.11.003. [PMID: 31780416]
  • Charles J Parker, Robert J Desnick, Montgomery D Bissel, Joseph R Bloomer, Ashwani Singal, Laurent Gouya, Herve Puy, Karl E Anderson, Manisha Balwani, John D Phillips. Results of a pilot study of isoniazid in patients with erythropoietic protoporphyria. Molecular genetics and metabolism. 2019 11; 128(3):309-313. doi: 10.1016/j.ymgme.2019.07.017. [PMID: 31395332]
  • Jasmin Barman-Aksözen, Francois Halloy, Pavithra S Iyer, Daniel Schümperli, Anna Elisabeth Minder, Jonathan Hall, Elisabeth I Minder, Xiaoye Schneider-Yin. Delta-aminolevulinic acid synthase 2 expression in combination with iron as modifiers of disease severity in erythropoietic protoporphyria. Molecular genetics and metabolism. 2019 11; 128(3):304-308. doi: 10.1016/j.ymgme.2019.04.013. [PMID: 31076252]
  • Pamela S Jones, Anudeep Yekula, Elizabeth Lansbury, Julia L Small, Caroline Ayinon, Scott Mordecai, Fred H Hochberg, John Tigges, Bethany Delcuze, Alain Charest, Ionita Ghiran, Leonora Balaj, Bob S Carter. Characterization of plasma-derived protoporphyrin-IX-positive extracellular vesicles following 5-ALA use in patients with malignant glioma. EBioMedicine. 2019 Oct; 48(?):23-35. doi: 10.1016/j.ebiom.2019.09.025. [PMID: 31628025]
  • Keita Iwaki, Tohru Fujiwara, Takako Ito, Chie Suzuki, Katsuyuki Sasaki, Koya Ono, Kei Saito, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Shinichi Fujimaki, Tohru Tanaka, Hideto Tamura, Minami Fujiwara, Hideo Harigae. Flow Cytometry-Based Photodynamic Diagnosis with 5-Aminolevulinic Acid for the Detection of Minimal Residual Disease in Multiple Myeloma. The Tohoku journal of experimental medicine. 2019 09; 249(1):19-28. doi: 10.1620/tjem.249.19. [PMID: 31511451]
  • Jingcheng Dai, Yaqi Liu, Shuangyuan Liu, Shuyang Li, Na Gao, Jing Wang, Jizhong Zhou, Dongru Qiu. Differential gene content and gene expression for bacterial evolution and speciation of Shewanella in terms of biosynthesis of heme and heme-requiring proteins. BMC microbiology. 2019 07; 19(1):173. doi: 10.1186/s12866-019-1549-9. [PMID: 31362704]
  • Pei Liu, Jinghua Ren, Yuxuan Xiong, Zhe Yang, Wei Zhu, Qianyuan He, Zushun Xu, Wenshan He, Jing Wang. Enhancing magnetic resonance/photoluminescence imaging-guided photodynamic therapy by multiple pathways. Biomaterials. 2019 04; 199(?):52-62. doi: 10.1016/j.biomaterials.2019.01.044. [PMID: 30738335]
  • Marta Mascaraque, Pablo Delgado-Wicke, Alejandra Damian, Silvia Rocío Lucena, Elisa Carrasco, Ángeles Juarranz. Mitotic Catastrophe Induced in HeLa Tumor Cells by Photodynamic Therapy with Methyl-aminolevulinate. International journal of molecular sciences. 2019 Mar; 20(5):. doi: 10.3390/ijms20051229. [PMID: 30862116]
  • Christopher Trent Brewer, Lei Yang, Anne Edwards, Yan Lu, Jonathan Low, Jing Wu, Richard E Lee, Taosheng Chen. The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis. Toxicological sciences : an official journal of the Society of Toxicology. 2019 03; 168(1):209-224. doi: 10.1093/toxsci/kfy294. [PMID: 30517741]
  • Ai-Nv Zhang, Wei Wu, Chi Zhang, Qiu-Yang Wang, Ze-Nan Zhuang, Han Cheng, Xian-Zheng Zhang. A versatile bacterial membrane-binding chimeric peptide with enhanced photodynamic antimicrobial activity. Journal of materials chemistry. B. 2019 02; 7(7):1087-1095. doi: 10.1039/c8tb03094d. [PMID: 32254776]
  • Zhengyu Cao, Tianyi Zhang, Xin Sun, Mingyu Liu, Zhaoqian Shen, Bicheng Li, Xuezhu Zhao, Hong Jin, Zhiguo Zhang, Ye Tian. Membrane-permeabilized sonodynamic therapy enhances drug delivery into macrophages. PloS one. 2019; 14(6):e0217511. doi: 10.1371/journal.pone.0217511. [PMID: 31181129]
  • Pawel Brzezowski, Brigitte Ksas, Michel Havaux, Bernhard Grimm, Marie Chazaux, Gilles Peltier, Xenie Johnson, Jean Alric. The function of PROTOPORPHYRINOGEN IX OXIDASE in chlorophyll biosynthesis requires oxidised plastoquinone in Chlamydomonas reinhardtii. Communications biology. 2019; 2(?):159. doi: 10.1038/s42003-019-0395-5. [PMID: 31069268]
  • Hong Cheng, Rong-Rong Zheng, Gui-Ling Fan, Jing-Hao Fan, Lin-Ping Zhao, Xue-Yan Jiang, Bin Yang, Xi-Yong Yu, Shi-Ying Li, Xian-Zheng Zhang. Mitochondria and plasma membrane dual-targeted chimeric peptide for single-agent synergistic photodynamic therapy. Biomaterials. 2019 01; 188(?):1-11. doi: 10.1016/j.biomaterials.2018.10.005. [PMID: 30312907]
  • Alejandro M Armas, Manuel Balparda, Agustina Terenzi, Maria V Busi, Maria A Pagani, Diego F Gomez-Casati. Ferrochelatase activity of plant frataxin. Biochimie. 2019 Jan; 156(?):118-122. doi: 10.1016/j.biochi.2018.10.009. [PMID: 30342111]
  • Gihan Mahmoud, Jarmila Jedelská, Samia Mohamed Omar, Boris Strehlow, Marc Schneider, Udo Bakowsky. Stabilized tetraether lipids based particles guided prophyrins photodynamic therapy. Drug delivery. 2018 Nov; 25(1):1526-1536. doi: 10.1080/10717544.2018.1482970. [PMID: 29996694]
  • Sabrina Kröger, Ann-Christin Niehoff, Astrid Jeibmann, Michael Sperling, Werner Paulus, Walter Stummer, Uwe Karst. Complementary Molecular and Elemental Mass-Spectrometric Imaging of Human Brain Tumors Resected by Fluorescence-Guided Surgery. Analytical chemistry. 2018 10; 90(20):12253-12260. doi: 10.1021/acs.analchem.8b03516. [PMID: 30215510]
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