Tetrachlorvinphos (BioDeep_00000001589)

   


代谢物信息卡片


2-Chloro-1-(2,4,5-trichlorophenyl)vinyl dimethyl phosphate

化学式: C10H9Cl4O4P (363.8993)
中文名称: 杀虫畏, 杀虫威
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COP(=O)(OC)O/C(=C\Cl)/c1cc(c(cc1Cl)Cl)Cl
InChI: InChI=1S/C10H9Cl4O4P/c1-16-19(15,17-2)18-10(5-11)6-3-8(13)9(14)4-7(6)12/h3-5H,1-2H3/b10-5-

描述信息

D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
D010575 - Pesticides > D007306 - Insecticides
D004791 - Enzyme Inhibitors
D016573 - Agrochemicals
CONFIDENCE standard compound; INTERNAL_ID 497; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9564; ORIGINAL_PRECURSOR_SCAN_NO 9561
ORIGINAL_PRECURSOR_SCAN_NO 9569; CONFIDENCE standard compound; INTERNAL_ID 497; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9571
CONFIDENCE standard compound; INTERNAL_ID 497; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9637; ORIGINAL_PRECURSOR_SCAN_NO 9633
CONFIDENCE standard compound; INTERNAL_ID 497; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9615; ORIGINAL_PRECURSOR_SCAN_NO 9613
CONFIDENCE standard compound; INTERNAL_ID 497; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9571; ORIGINAL_PRECURSOR_SCAN_NO 9569
CONFIDENCE standard compound; INTERNAL_ID 497; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9608; ORIGINAL_PRECURSOR_SCAN_NO 9606
CONFIDENCE standard compound; INTERNAL_ID 497; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9523; ORIGINAL_PRECURSOR_SCAN_NO 9519

同义名列表

4 个代谢物同义名

Tetrachlorvinphos; 2-Chloro-1-(2,4,5-trichlorophenyl)vinyl dimethyl phosphate; Z-Tetrachlorvinphos; Tetrachlorvinphos



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AXIN2, CYP1A1, DNMT3A, ESR1, G6PD, HPGDS, PTGS2
Peripheral membrane protein 6 ACHE, AP2S1, CYP1A1, ESR1, G6PD, PTGS2
Endoplasmic reticulum membrane 3 CYP1A1, CYP1A2, PTGS2
Nucleus 8 ACHE, AXIN2, DFFA, DNMT3A, DNMT3B, ESR1, KDR, TRIM33
cytosol 9 AP2S1, ATP12A, AXIN2, DFFA, ESR1, G6PD, GLS, HPGDS, PRF1
centrosome 1 AXIN2
nucleoplasm 7 ATP2B1, DFFA, DNMT3A, DNMT3B, ESR1, HPGDS, TRIM33
Cell membrane 6 ACHE, AP2S1, ATP2B1, ESR1, KDR, PRF1
Cytoplasmic side 2 AP2S1, ESR1
Multi-pass membrane protein 3 ATP12A, ATP2B1, PRF1
Synapse 3 ACHE, ATP2B1, GLS
cell junction 1 KDR
cell surface 1 ACHE
glutamatergic synapse 1 ATP2B1
Golgi apparatus 3 ACHE, ESR1, KDR
mitochondrial inner membrane 1 CYP1A1
neuromuscular junction 1 ACHE
postsynapse 1 AP2S1
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 2 G6PD, GLS
Presynapse 1 AP2S1
endosome 1 KDR
plasma membrane 10 ACHE, AP2S1, ATP12A, ATP2B1, AXIN2, BCHE, DFFA, ESR1, KDR, PRF1
synaptic vesicle membrane 1 ATP2B1
Membrane 5 ACHE, ATP2B1, ESR1, G6PD, PRF1
apical plasma membrane 1 ATP12A
basolateral plasma membrane 2 ATP12A, ATP2B1
caveola 1 PTGS2
extracellular exosome 2 ATP2B1, G6PD
endoplasmic reticulum 2 KDR, PTGS2
extracellular space 2 ACHE, BCHE
perinuclear region of cytoplasm 1 ACHE
mitochondrion 2 CYP1A1, GLS
protein-containing complex 3 DFFA, ESR1, PTGS2
intracellular membrane-bounded organelle 6 AP2S1, ATP2B1, CYP1A1, CYP1A2, G6PD, HPGDS
Microsome membrane 3 CYP1A1, CYP1A2, PTGS2
Secreted 3 ACHE, BCHE, PRF1
extracellular region 4 ACHE, BCHE, KDR, PRF1
cytoplasmic side of plasma membrane 2 AP2S1, G6PD
[Isoform 2]: Secreted 1 KDR
mitochondrial matrix 1 GLS
Extracellular side 1 ACHE
anchoring junction 1 KDR
transcription regulator complex 1 ESR1
centriolar satellite 1 G6PD
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 KDR
actin cytoskeleton 1 ATP12A
beta-catenin destruction complex 1 AXIN2
Early endosome 1 KDR
Apical cell membrane 1 ATP12A
Mitochondrion inner membrane 1 CYP1A1
heterochromatin 1 DNMT3A
Membrane raft 1 KDR
cis-Golgi network 1 GOLGA6A
basement membrane 1 ACHE
lateral plasma membrane 1 ATP2B1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 KDR
neuron projection 1 PTGS2
chromatin 3 DFFA, ESR1, TRIM33
cell projection 1 ATP2B1
cell periphery 1 AP2S1
Chromosome 1 DNMT3A
[Isoform 1]: Mitochondrion 1 GLS
blood microparticle 1 BCHE
Basolateral cell membrane 1 ATP2B1
Lipid-anchor, GPI-anchor 1 ACHE
endosome lumen 1 PRF1
sorting endosome 1 KDR
Golgi cisterna membrane 1 GOLGA6A
euchromatin 2 DNMT3A, ESR1
Presynaptic cell membrane 1 ATP2B1
side of membrane 1 ACHE
endoplasmic reticulum lumen 2 BCHE, PTGS2
nuclear matrix 1 DNMT3A
endocytic vesicle membrane 1 AP2S1
XY body 1 DNMT3A
immunological synapse 2 ATP2B1, PRF1
clathrin-coated endocytic vesicle 1 AP2S1
nuclear envelope lumen 1 BCHE
chromosome, centromeric region 1 DNMT3A
clathrin-coated endocytic vesicle membrane 1 AP2S1
[Isoform 1]: Nucleus 1 ESR1
synaptic cleft 1 ACHE
endolysosome membrane 1 AP2S1
membrane coat 1 AP2S1
[Isoform 3]: Mitochondrion 1 GLS
Membrane, coated pit 1 AP2S1
[Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix 1 GLS
[Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix 1 GLS
AP-2 adaptor complex 1 AP2S1
catalytic complex 2 DNMT3A, DNMT3B
Cytolytic granule 1 PRF1
cytolytic granule lumen 1 PRF1
photoreceptor ribbon synapse 1 ATP2B1
potassium:proton exchanging ATPase complex 1 ATP12A
[Isoform H]: Cell membrane 1 ACHE
Golgi cis cisterna 1 GOLGA6A


文献列表

  • Hacer Ergun, Akin Cayir. Exposure to glyphosate and tetrachlorvinphos induces cytotoxicity and global DNA methylation in human cells. Toxicology and industrial health. 2021 Oct; 37(10):610-618. doi: 10.1177/07482337211033149. [PMID: 34542374]
  • Alison L Clune, P Barry Ryan, Dana Boyd Barr. Have regulatory efforts to reduce organophosphorus insecticide exposures been effective?. Environmental health perspectives. 2012 Apr; 120(4):521-5. doi: 10.1289/ehp.1104323. [PMID: 22251442]
  • Hiroyuki Kojima, Fumihiro Sata, Shinji Takeuchi, Tatsuya Sueyoshi, Tadanori Nagai. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb; 280(3):77-87. doi: 10.1016/j.tox.2010.11.008. [PMID: 21115097]
  • M Keith Davis, J Scott Boone, John E Moran, John W Tyler, Janice E Chambers. Assessing intermittent pesticide exposure from flea control collars containing the organophosphorus insecticide tetrachlorvinphos. Journal of exposure science & environmental epidemiology. 2008 Nov; 18(6):564-70. doi: 10.1038/sj.jes.7500647. [PMID: 18167506]
  • Subramanya Karanth, Todd Holbrook, Charles MacAllister, Carey N Pope. Selective inhibition of butyrylcholinesterase in vivo in horses by the feed-through larvacide Equitrol. Regulatory toxicology and pharmacology : RTP. 2008 Mar; 50(2):200-5. doi: 10.1016/j.yrtph.2007.11.006. [PMID: 18166255]
  • Subramanya Karanth, Carey Pope. In vitro inhibition of blood cholinesterase activities from horse, cow, and rat by tetrachlorvinphos. International journal of toxicology. 2003 Nov; 22(6):429-33. doi: 10.1177/109158180302200604. [PMID: 14680990]
  • Y Ogawa, S Suzuki, K Takada, K Sai, E Kamata, T Umemura, T Kaneko, Y Kurokawa. [Twenty-eight-day repeated dose toxicity test for tetrachlorvinphos in Wistar rat]. Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences. 1990; ?(108):45-51. doi: . [PMID: 1364360]
  • C M Parker, G A Van Gelder, E Y Chai, J B Gellatly, D G Serota, R W Voelker, S D Vesselinovitch. Oncogenic evaluation of tetrachlorvinphos in the B6C3F1 mouse. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1985 Oct; 5(5):840-54. doi: 10.1016/0272-0590(85)90167-8. [PMID: 4065460]
  • S Haider, N Upadhyaya. Effect of commercial formulation of four organophosphorus insecticides on the ovaries of a freshwater teleost, Mystus vittatus (bloch)--a histological and histochemical study. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 1985 Jun; 20(3):321-40. doi: 10.1080/03601238509372482. [PMID: 3861690]
  • S M Zayed, I Y Mostafa, B Hegazi. Alkylation of urinary guanine in mice by the organophosphorus insecticide tetrachlorvinphos. Ecotoxicology and environmental safety. 1984 Jun; 8(3):205-7. doi: 10.1016/0147-6513(84)90022-8. [PMID: 6734497]
  • S M Amer, E Mikhael. Cytological effects of the insecticide tetrachlorvinphos. Toxicology letters. 1983 Sep; 18(3):231-4. doi: 10.1016/0378-4274(83)90098-x. [PMID: 6665795]
  • J L Riner, R L Byford, J A Hair. Sustained-release Rabon bolus for face fly control in cattle feces. Journal of economic entomology. 1981 Jun; 74(3):359-62. doi: 10.1093/jee/74.3.359. [PMID: 7276364]
  • M H Akhtar, T S Foster. Metabolism and excretion of tetrachlorvinphos in dairy cows. Journal of agricultural and food chemistry. 1980 Jul; 28(4):698-704. doi: 10.1021/jf60230a009. [PMID: 7462487]
  • R Benigni, M Bignami, I Camoni, A Carere, G Conti, R Iachetta, G Morpurgo, V A Ortali. A new in vitro method for testing plant metabolism in mutagenicity studies. Journal of toxicology and environmental health. 1979 Sep; 5(5):809-19. doi: 10.1080/15287397909529791. [PMID: 513148]
  • G P Noblet. Tetrachlorvinphos as an ineffective feed additive in control of gastrointestinal nematodes of beef cattle. American journal of veterinary research. 1978 Jun; 39(6):1033-6. doi: NULL. [PMID: 666078]
  • A H El-Sebae, N S Ahmed, S A Soliman. Effect of pre-exposure on acute toxicity of organophosphorus insecticides to white mice. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 1978; 13(1):11-24. doi: 10.1080/03601237809372074. [PMID: 75904]
  • G K Sukhomlinova. [Detection of gardona in the blood, organs and droppings of chickens]. Veterinariia. 1977 Jul; ?(7):95-6. doi: NULL. [PMID: 888345]
  • J E Wright. Insect growth regulators: development of house flies in feces of bovines fed TH 6040 in mineral blocks and reduction in field populations by surface treatments with TH 6040 or a mixture of stirofos and dichlorvoa at larval breeding areas. Journal of economic entomology. 1975 Jun; 68(3):322-4. doi: 10.1093/jee/68.3.322. [PMID: 1141488]
  • R W Miller, C H Gordon. Technical Rabon for larval house fly control in cow manure. Journal of economic entomology. 1972 Aug; 65(4):1064-6. doi: 10.1093/jee/65.4.1064. [PMID: 5053475]
  • W H Gutenmann, D J Lisk, L E St John. Metabolic studies with Gardona insecticide in the dairy cow. Journal of agricultural and food chemistry. 1971 Nov; 19(6):1259-60. doi: 10.1021/jf60178a037. [PMID: 5132658]