Mevalonic acid (BioDeep_00000015779)

Main id: BioDeep_00000001671

Secondary id: BioDeep_00001870195

BioNovoGene_Lab2019 natural product


代谢物信息卡片


3R-methyl-3,5-dihydroxy-pentanoic acid

化学式: C6H12O4 (148.0736)
中文名称: 3,5-二羟基-3-甲基戊酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C[C@](C)(O)CCO)(=O)O
InChI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)

描述信息

A dihydroxy monocarboxylic acid comprising valeric acid having two hydroxy groups at the 3- and 5-positions together with a methyl group at the 3-position.

同义名列表

9 个代谢物同义名

Mevalonic acid; 3R-methyl-3,5-dihydroxy-pentanoic acid; 3,5-Dihydroxy-3-methylvaleric acid; FA 6:0;O2; 3,5-dihydroxy-3-methylpentanoic acid; (S)-Mevalonic acid; (S)-Mevalonate; (R)-Mevalonate; Mevalonic acid



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

28 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 BCL2, CASP3, CCND1, CDKN1A, FDPS, FNTA, MAPK14, MVD, MVK, PIK3CA, RAC1, VEGFA
Endosome membrane 1 LDLR
Endoplasmic reticulum membrane 4 ACAT1, BCL2, HSP90B1, RAC1
Nucleus 8 BCL2, CASP3, CCND1, CDKN1A, HSP90B1, MAPK14, RAC1, VEGFA
cytosol 13 BCL2, CASP3, CCND1, CDKN1A, FDPS, FNTA, HSP90B1, MAPK14, MVD, MVK, PIK3CA, PMVK, RAC1
dendrite 1 RAC1
nuclear body 1 CDKN1A
trans-Golgi network 1 RAC1
centrosome 1 CCND1
nucleoplasm 5 CASP3, CCND1, CDKN1A, FDPS, MAPK14
Cell membrane 3 LDLR, RAC1, TNF
Lipid-anchor 1 RAC1
Cytoplasmic side 1 RAC1
lamellipodium 2 PIK3CA, RAC1
ruffle membrane 1 RAC1
Multi-pass membrane protein 1 ACAT1
Synapse 1 RAC1
cell cortex 1 RAC1
cell surface 3 LDLR, TNF, VEGFA
glutamatergic synapse 3 CASP3, MAPK14, RAC1
Golgi apparatus 2 LDLR, VEGFA
Golgi membrane 1 INS
lysosomal membrane 1 EGF
neuronal cell body 2 CASP3, TNF
postsynapse 1 RAC1
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 PMVK
Lysosome 1 LDLR
plasma membrane 7 EGF, FNTA, IFNLR1, LDLR, PIK3CA, RAC1, TNF
Membrane 10 ACAT1, BCL2, EGF, FDPS, HSP90B1, IFNLR1, LDLR, PMVK, RAC1, VEGFA
basolateral plasma membrane 1 LDLR
extracellular exosome 5 ACAT1, EGF, HSP90B1, PMVK, RAC1
endoplasmic reticulum 4 ACAT1, BCL2, HSP90B1, VEGFA
extracellular space 4 EGF, INS, TNF, VEGFA
perinuclear region of cytoplasm 3 CDKN1A, HSP90B1, PIK3CA
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 3 ACAT1, BCL2, MAPK14
protein-containing complex 3 BCL2, CDKN1A, HSP90B1
intracellular membrane-bounded organelle 1 MVK
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 IFNLR1, LDLR
Secreted 3 INS, RAC1, VEGFA
extracellular region 7 EGF, HSP90B1, INS, MAPK14, RAC1, TNF, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, LDLR
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 2 ACAT1, FDPS
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 2 LDLR, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
low-density lipoprotein particle 1 LDLR
dendritic spine 1 RAC1
cytoplasmic vesicle 1 RAC1
nucleolus 1 CDKN1A
midbody 1 HSP90B1
Early endosome 1 LDLR
Membrane, clathrin-coated pit 1 LDLR
apical part of cell 1 LDLR
clathrin-coated pit 1 LDLR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cell projection, lamellipodium 1 RAC1
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 2 HSP90B1, RAC1
extracellular matrix 1 VEGFA
Peroxisome 3 FDPS, MVK, PMVK
collagen-containing extracellular matrix 1 HSP90B1
secretory granule 1 VEGFA
nuclear speck 1 MAPK14
Late endosome 1 LDLR
receptor complex 1 LDLR
microtubule associated complex 1 FNTA
phagocytic cup 1 TNF
cytoskeleton 1 RAC1
cytoplasmic ribonucleoprotein granule 1 RAC1
spindle pole 1 MAPK14
Recycling endosome membrane 1 RAC1
Endomembrane system 1 LDLR
endosome lumen 1 INS
sorting endosome 1 LDLR
Cell projection, dendrite 1 RAC1
Melanosome 2 HSP90B1, RAC1
myelin sheath 1 BCL2
sperm plasma membrane 1 HSP90B1
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
secretory granule membrane 1 RAC1
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 HSP90B1, INS
transcription repressor complex 1 CCND1
platelet alpha granule lumen 2 EGF, VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 2 EGF, LDLR
Sarcoplasmic reticulum lumen 1 HSP90B1
ficolin-1-rich granule membrane 1 RAC1
endolysosome membrane 1 LDLR
death-inducing signaling complex 1 CASP3
somatodendritic compartment 1 LDLR
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, CDKN1A
endocytic vesicle lumen 1 HSP90B1
PCSK9-LDLR complex 1 LDLR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
NADPH oxidase complex 1 RAC1
endoplasmic reticulum chaperone complex 1 HSP90B1
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
PCNA-p21 complex 1 CDKN1A
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
CAAX-protein geranylgeranyltransferase complex 1 FNTA
protein farnesyltransferase complex 1 FNTA
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Man Xu, Nan Yang, Jiang Pan, Qiang Hua, Chun-Xiu Li, Jian-He Xu. Remodeling the Homologous Recombination Mechanism of Yarrowia lipolytica for High-Level Biosynthesis of Squalene. Journal of agricultural and food chemistry. 2024 May; 72(17):9984-9993. doi: 10.1021/acs.jafc.4c01779. [PMID: 38635942]
  • Patricia Guerrero-Ochoa, Sergio Rodríguez-Zapater, Alberto Anel, Luis Mariano Esteban, Alejandro Camón-Fernández, Raquel Espilez-Ortiz, María Jesús Gil-Sanz, Ángel Borque-Fernando. Prostate Cancer and the Mevalonate Pathway. International journal of molecular sciences. 2024 Feb; 25(4):. doi: 10.3390/ijms25042152. [PMID: 38396837]
  • Bridget A Luckie, Meera Kashyap, Allison N Pearson, Yan Chen, Yuzhong Liu, Luis E Valencia, Alexander Carrillo Romero, Graham A Hudson, Xavier B Tao, Bryan Wu, Christopher J Petzold, Jay D Keasling. Development of Corynebacterium glutamicum as a monoterpene production platform. Metabolic engineering. 2024 Jan; 81(?):110-122. doi: 10.1016/j.ymben.2023.11.009. [PMID: 38056688]
  • Giorgia Centonze, Dora Natalini, Silvia Grasso, Alessandro Morellato, Vincenzo Salemme, Alessio Piccolantonio, Giacomo D'Attanasio, Aurora Savino, Olga Teresa Bianciotto, Matteo Fragomeni, Andrea Scavuzzo, Matteo Poncina, Francesca Nigrelli, Mario De Gregorio, Valeria Poli, Pietro Arina, Daniela Taverna, Joanna Kopecka, Sirio Dupont, Emilia Turco, Chiara Riganti, Paola Defilippi. p140Cap modulates the mevalonate pathway decreasing cell migration and enhancing drug sensitivity in breast cancer cells. Cell death & disease. 2023 12; 14(12):849. doi: 10.1038/s41419-023-06357-z. [PMID: 38123597]
  • Xiaoteng Cui, Jixing Zhao, Guanzhang Li, Chao Yang, Shixue Yang, Qi Zhan, Junhu Zhou, Yunfei Wang, Menglin Xiao, Biao Hong, Kaikai Yi, Fei Tong, Yanli Tan, Hu Wang, Qixue Wang, Tao Jiang, Chuan Fang, Chunsheng Kang. Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma. Cancer communications (London, England). 2023 Nov; ?(?):. doi: 10.1002/cac2.12502. [PMID: 37920878]
  • Man-Yu Xiao, Fang-Fang Li, Peng Xie, Yan-Shuang Qi, Jin-Bo Xie, Wen-Jing Pei, Hao-Tian Luo, Mei Guo, Yu-Long Gu, Xiang-Lan Piao. Gypenosides suppress hepatocellular carcinoma cells by blocking cholesterol biosynthesis through inhibition of MVA pathway enzyme HMGCS1. Chemico-biological interactions. 2023 Aug; 383(?):110674. doi: 10.1016/j.cbi.2023.110674. [PMID: 37604220]
  • Kelly T Kennewick, Steven J Bensinger. Decoding the crosstalk between mevalonate metabolism and T cell function. Immunological reviews. 2023 08; 317(1):71-94. doi: 10.1111/imr.13200. [PMID: 36999733]
  • Yuan-Chii Gladys Lee, Fang-Ning Chou, Szu-Yu Tung, Hsiu-Chu Chou, Tsui-Ling Ko, Yang C Fann, Shu-Hui Juan. Tumoricidal Activity of Simvastatin in Synergy with RhoA Inactivation in Antimigration of Clear Cell Renal Cell Carcinoma Cells. International journal of molecular sciences. 2023 Jun; 24(11):. doi: 10.3390/ijms24119738. [PMID: 37298689]
  • Kensuke Kitsugi, Hidenao Noritake, Moe Matsumoto, Tomohiko Hanaoka, Masahiro Umemura, Maho Yamashita, Shingo Takatori, Jun Ito, Kazuyoshi Ohta, Takeshi Chida, Takafumi Suda, Kazuhito Kawata. Simvastatin inhibits hepatic stellate cells activation by regulating the ferroptosis signaling pathway. Biochimica et biophysica acta. Molecular basis of disease. 2023 May; ?(?):166750. doi: 10.1016/j.bbadis.2023.166750. [PMID: 37268254]
  • Yoshihiro Shidoji. Geranylgeranoic acid, a bioactive and endogenous fatty acid in mammals: a review. Journal of lipid research. 2023 May; ?(?):100396. doi: 10.1016/j.jlr.2023.100396. [PMID: 37247782]
  • Xiongjie Zheng, Yasha Zhang, Aparna Balakrishna, Kit Xi Liew, Hendrik N J Kuijer, Ting Ting Xiao, Ikram Blilou, Salim Al-Babili. Installing the Neurospora carotenoid pathway in plants enables cytosolic formation of provitamin A and its sequestration in lipid droplets. Molecular plant. 2023 May; ?(?):. doi: 10.1016/j.molp.2023.05.003. [PMID: 37198885]
  • Corentin Conart, Dikki Pedenla Bomzan, Xing-Qi Huang, Jean-Etienne Bassard, Saretta N Paramita, Denis Saint-Marcoux, Aurélie Rius-Bony, Gal Hivert, Anthony Anchisi, Hubert Schaller, Latifa Hamama, Jean-Louis Magnard, Agata Lipko, Ewa Swiezewska, Patrick Jame, Geneviève Riveill, Laurence Hibrand-Saint Oyant, Michel Rohmer, Efraim Lewinsohn, Natalia Dudareva, Sylvie Baudino, Jean-Claude Caissard, Benoît Boachon. A cytosolic bifunctional geranyl/farnesyl diphosphate synthase provides MVA-derived GPP for geraniol biosynthesis in rose flowers. Proceedings of the National Academy of Sciences of the United States of America. 2023 May; 120(19):e2221440120. doi: 10.1073/pnas.2221440120. [PMID: 37126706]
  • Agata Lipko, Cezary Pączkowski, Laura Perez-Fons, Paul David Fraser, Magdalena Kania, Marta Hoffman-Sommer, Witold Danikiewicz, Michel Rohmer, Jarosław Poznański, Ewa Swiezewska. Divergent contribution of the MVA and MEP pathways to the formation of polyprenols and dolichols in Arabidopsis. The Biochemical journal. 2023 Apr; ?(?):. doi: 10.1042/bcj20220578. [PMID: 37022297]
  • Evelyn Andrades, Agustí Toll, Gustavo Deza, Sonia Segura, Ramón Gimeno, Guadalupe Espadas, Eduard Sabidó, Noemí Haro, Óscar J Pozo, Marta Bódalo, Paloma Torres, Ramon M Pujol, Inmaculada Hernández-Muñoz. Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathway. Life science alliance. 2023 Apr; 6(4):. doi: 10.26508/lsa.202201692. [PMID: 36732018]
  • Fengjiao He, Qiong Liu, Huan Liu, Qian Pei, Hong Zhu. Circular RNA ACACA negatively regulated p53-modulated mevalonate pathway to promote colorectal tumorigenesis via regulating miR-193a/b-3p/HDAC3 axis. Molecular carcinogenesis. 2023 Mar; ?(?):. doi: 10.1002/mc.23522. [PMID: 36920044]
  • Shuai Wang, Yumei Feng, Yin Lou, Jingping Niu, Congcong Yin, Jinzhong Zhao, Weijun Du, Aiqin Yue. 3-Hydroxy-3-methylglutaryl coenzyme A reductase genes from Glycine max regulate plant growth and isoprenoid biosynthesis. Scientific reports. 2023 03; 13(1):3902. doi: 10.1038/s41598-023-30797-4. [PMID: 36890158]
  • Garima Pathak, Shivanand S Dudhagi, Saumya Raizada, Rajesh K Singh, A P Sane, Vidhu A Sane. Phosphomevalonate kinase regulates the MVA/MEP pathway in mango during ripening. Plant physiology and biochemistry : PPB. 2023 Jan; 196(?):174-185. doi: 10.1016/j.plaphy.2023.01.030. [PMID: 36724702]
  • Si-Jia Sun, Ying-Jie Ai, Kun-Long Duan, Jin-Ye Zhang, Cheng Zhang, Yi-Ping Sun, Yue Xiong, Kun-Liang Guan, Hai-Xin Yuan. TET2 deficiency sensitizes tumor cells to statins by reducing HMGCS1 expression. Oncogene. 2022 Dec; 41(50):5385-5396. doi: 10.1038/s41388-022-02531-3. [PMID: 36348011]
  • Alessandra Pinzon Grimaldos, Ilenia Pacella, Simone Bini, Gloria Tucci, Ilenia Cammarata, Alessia Di Costanzo, Ilenia Minicocci, Laura D'Erasmo, Marcello Arca, Silvia Piconese. ANGPTL3 deficiency associates with the expansion of regulatory T cells with reduced lipid content. Atherosclerosis. 2022 12; 362(?):38-46. doi: 10.1016/j.atherosclerosis.2022.09.014. [PMID: 36253169]
  • Bin Chen, Nan Lu, KeeSuh Lee, Lei Ye, Chiho Hasegawa, Kazuhisa Maeda. Application of mevalonolactone prevents deterioration of epidermal barrier function by accelerating the lamellar granule lipid transport system. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2022 Nov; 28(6):804-814. doi: 10.1111/srt.13202. [PMID: 36148627]
  • Muhammad Ahmad, Alicia Varela Alonso, Antigoni E Koletti, Nebojša Rodić, Michael Reichelt, Philipp Rödel, Andreana N Assimopoulou, Ovidiu Paun, Stéphane Declerck, Carolin Schneider, Eva M Molin. Dynamics of alkannin/shikonin biosynthesis in response to jasmonate and salicylic acid in Lithospermum officinale. Scientific reports. 2022 10; 12(1):17093. doi: 10.1038/s41598-022-21322-0. [PMID: 36224205]
  • Samantha Louise Saunders, Nathan Scott McOrist, Kanika Chaudhri, Sonali R Gnanenthiran, Grant Shalaby. Do bisphosphonates and RANKL inhibitors alter the progression of coronary artery calcification? A systematic review and meta-analysis protocol. BMJ open. 2022 10; 12(10):e066255. doi: 10.1136/bmjopen-2022-066255. [PMID: 36207048]
  • Joel Haywood, Karen J Breese, Jingjing Zhang, Mark T Waters, Charles S Bond, Keith A Stubbs, Joshua S Mylne. A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action. Nature communications. 2022 09; 13(1):5563. doi: 10.1038/s41467-022-33185-0. [PMID: 36137996]
  • Akhil Rautela, Sanjay Kumar. Engineering plant family TPS into cyanobacterial host for terpenoids production. Plant cell reports. 2022 Sep; 41(9):1791-1803. doi: 10.1007/s00299-022-02892-9. [PMID: 35789422]
  • Ye Cao, Wen-Jin Zhang, Li-Kun Chang, Chuan-Zhi Kang, Yue-Feng Wang, Dong-Mei Xie, Sheng Wang, Lan-Ping Guo. [Comparison of transcriptome of Atractylodes lancea rhizome and exploration of genes for sesquiterpenoid biosynthesis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(18):4895-4907. doi: 10.19540/j.cnki.cjcmm.20220615.101. [PMID: 36164899]
  • Yuxi Jin, Xiaoya Yuan, Jianfeng Liu, Jie Wen, Huanxian Cui, Guiping Zhao. Inhibition of cholesterol biosynthesis promotes the production of 1-octen-3-ol through mevalonic acid. Food research international (Ottawa, Ont.). 2022 08; 158(?):111392. doi: 10.1016/j.foodres.2022.111392. [PMID: 35840187]
  • Trang Thi Nguyen, Heejin Kim, Tran Xuan Ngoc Huy, Wongi Min, Hujang Lee, Alisha Wehdnesday Bernardo Reyes, Johnhwa Lee, Suk Kim. Simvastatin Inhibits Brucella abortus Invasion into RAW 264.7 Cells through Suppression of the Mevalonate Pathway and Promotes Host Immunity during Infection in a Mouse Model. International journal of molecular sciences. 2022 Jul; 23(15):. doi: 10.3390/ijms23158337. [PMID: 35955474]
  • Liselot Dewachter, Julien Dénéréaz, Xue Liu, Vincent de Bakker, Charlotte Costa, Mara Baldry, Jean-Claude Sirard, Jan-Willem Veening. Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq. eLife. 2022 06; 11(?):. doi: 10.7554/elife.75607. [PMID: 35748540]
  • Alessandra Pinzon Grimaldos, Simone Bini, Ilenia Pacella, Alessandra Rossi, Alessia Di Costanzo, Ilenia Minicocci, Laura D'Erasmo, Marcello Arca, Silvia Piconese. The role of lipid metabolism in shaping the expansion and the function of regulatory T cells. Clinical and experimental immunology. 2022 06; 208(2):181-192. doi: 10.1093/cei/uxab033. [PMID: 35020862]
  • Shama Afroz, Zafar Iqbal Warsi, Kahkashan Khatoon, Neelam S Sangwan, Feroz Khan, Laiq Ur Rahman. Molecular cloning and characterization of Triterpenoid Biosynthetic Pathway Gene HMGS in Centella asiatica (Linn.). Molecular biology reports. 2022 Jun; 49(6):4555-4563. doi: 10.1007/s11033-022-07300-9. [PMID: 35526254]
  • Alec G Trub, Gregory R Wagner, Kristin A Anderson, Scott B Crown, Guo-Fang Zhang, J Will Thompson, Olga R Ilkayeva, Robert D Stevens, Paul A Grimsrud, Rhushikesh A Kulkarni, Donald S Backos, Jordan L Meier, Matthew D Hirschey. Statin therapy inhibits fatty acid synthase via dynamic protein modifications. Nature communications. 2022 05; 13(1):2542. doi: 10.1038/s41467-022-30060-w. [PMID: 35538051]
  • Xiao-Li Zhang, Er-Kun Chao, Meng-Chu Sun, Hong-Fei Zhao, Cai-Xia Wang, Bo-Lin Zhang. [Effects of tHMGR from three different plant sources on mevalonate (MVA) pathway flux in Saccharomyces cerevisiae]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 May; 47(10):2614-2622. doi: 10.19540/j.cnki.cjcmm.20220116.102. [PMID: 35718479]
  • Jonathan Asmund Arnesen, Irene Hjorth Jacobsen, Jane Dannow Dyekjær, Daniela Rago, Mette Kristensen, Andreas Koedfoed Klitgaard, Milica Randelovic, José Luis Martinez, Irina Borodina. Production of abscisic acid in the oleaginous yeast Yarrowia lipolytica. FEMS yeast research. 2022 04; 22(1):. doi: 10.1093/femsyr/foac015. [PMID: 35274684]
  • Lucía Pérez, Rui Alves, Laura Perez-Fons, Alfonso Albacete, Gemma Farré, Erika Soto, Ester Vilaprinyó, Cristina Martínez-Andújar, Oriol Basallo, Paul D Fraser, Vicente Medina, Changfu Zhu, Teresa Capell, Paul Christou. Multilevel interactions between native and ectopic isoprenoid pathways affect global metabolism in rice. Transgenic research. 2022 04; 31(2):249-268. doi: 10.1007/s11248-022-00299-6. [PMID: 35201538]
  • Joshua Zechner, Susan M Britza, Rachael Farrington, Roger W Byard, Ian F Musgrave. Flavonoid-statin interactions causing myopathy and the possible significance of OATP transport, CYP450 metabolism and mevalonate synthesis. Life sciences. 2022 Feb; 291(?):119975. doi: 10.1016/j.lfs.2021.119975. [PMID: 34560084]
  • Miguel A Lasunción, Javier Martínez-Botas, Covadonga Martín-Sánchez, Rebeca Busto, Diego Gómez-Coronado. Cell cycle dependence on the mevalonate pathway: Role of cholesterol and non-sterol isoprenoids. Biochemical pharmacology. 2022 02; 196(?):114623. doi: 10.1016/j.bcp.2021.114623. [PMID: 34052188]
  • Sung-Hwan Cho, Katalin Tóth, Daewon Kim, Phuc H Vo, Chung-Ho Lin, Pubudu P Handakumbura, Albert Rivas Ubach, Sterling Evans, Ljiljana Paša-Tolić, Gary Stacey. Activation of the plant mevalonate pathway by extracellular ATP. Nature communications. 2022 01; 13(1):450. doi: 10.1038/s41467-022-28150-w. [PMID: 35064110]
  • Yujie Jiang, Dekai Wang, Kangjing Wu, Feifeng Wang, Qingwen Yang, Ruilian Han, Zongsuo Liang, Qiaojun Jia. Cloning and Characterization of the Gene Encoding HMGS Synthase in Polygonatum sibiricum. BioMed research international. 2022; 2022(?):7441296. doi: 10.1155/2022/7441296. [PMID: 36246988]
  • Efosa Amadasu, Richard Kang, Ahsan Usmani, Cesario V Borlongan. Effects of Lovastatin on Brain Cancer Cells. Cell transplantation. 2022 Jan; 31(?):9636897221102903. doi: 10.1177/09636897221102903. [PMID: 35670207]
  • Claudia Tonini, Sara Schiavi, Fabrizio Macca, Marco Segatto, Viviana Trezza, Valentina Pallottini. Long-lasting impact of perinatal dietary supplementation of omega 3 fatty acids on mevalonate pathway: potential role on neuron trophism in male offspring hippocampal formation. Nutritional neuroscience. 2022 Jan; 25(1):110-121. doi: 10.1080/1028415x.2020.1724452. [PMID: 32037984]
  • Valeryia Mikalayeva, Monika Pankevičiūtė, Vaidotas Žvikas, V Arvydas Skeberdis, Sergio Bordel. Contribution of branched chain amino acids to energy production and mevalonate synthesis in cancer cells. Biochemical and biophysical research communications. 2021 12; 585(?):61-67. doi: 10.1016/j.bbrc.2021.11.034. [PMID: 34794035]
  • Mei-Ling Cheng, Hsiang-Yu Tang, Pei-Ting Wu, Cheng-Hung Yang, Chi-Jen Lo, Jui-Fen Lin, Hung-Yao Ho. 7-Ketocholesterol Induces Lipid Metabolic Reprogramming and Enhances Cholesterol Ester Accumulation in Cardiac Cells. Cells. 2021 12; 10(12):. doi: 10.3390/cells10123597. [PMID: 34944104]
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