Salicyluric acid (BioDeep_00000001399)

 

Secondary id: BioDeep_00000229649, BioDeep_00000265249, BioDeep_00000405379

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


2-[(2-hydroxyphenyl)formamido]acetic acid

化学式: C9H9NO4 (195.0532)
中文名称: 2-羟基马尿酸, 水杨尿酸
谱图信息: 最多检出来源 Homo sapiens(urine) 29.7%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Salicyluric acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/salicyluric_acid (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001399). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1=CC=C(C(=C1)C(=O)NCC(=O)O)O
InChI: InChI=1S/C9H9NO4/c11-7-4-2-1-3-6(7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)

描述信息

Salicyluric acid is an aryl glycine conjugate formed by the body to eliminate excess salicylates, including aspirin. Aspirin is rapidly hydrolysed to salicylic acid which is further metabolized to various compounds, including salicyluric acid (SU) as well as various acyl and phenolic glucuronides, and hydroxylated metabolites. SU is the major metabolite of SA excreted in urine and it is present in the urine of people who have not taken salicylate drugs, although it has no anti-inflammatory effects in humans or in animals. More salicyluric acid (SU) is excreted in the urine of vegetarians than in non-vegetarians, primarily because fruits and vegetables are important sources of dietary salicylates. However, significantly less (10-15X) SU is excreted by vegetarians than individuals taking low-dose aspirin (PMID: 12944546). The induction of the salicyluric acid formation is one of the saturable pathways of salicylate elimination. The formation of the methyl ester of salicyluric acid is observed during the quantitation of salicyluric acid and other salicylate metabolites in urine by high-pressure liquid chromatography. This methyl ester formation causes artificially low values for salicyluric acid and high values for salicylic acid. (PMID: 6101164, 6857178). Salicyluric acid has been found to be a microbial metabolite.
Constituent of milk
KEIO_ID H028
Salicyluric acid is an endogenous metabolite.

同义名列表

35 个代谢物同义名

2-[(2-hydroxyphenyl)formamido]acetic acid; 2-[(2-Hydroxybenzoyl)amino]acetic acid; ((2-Hydroxybenzoyl)amino)acetic acid; [(2-Hydroxybenzoyl)amino]acetic acid; 2-Hydroxybenzoylaminoacetic acid; [(2-Hydroxybenzoyl)amino]acetate; Salicylurate, monosodium salt; Glycine,N-(2-hydroxybenzoyl)-; N-(2-Hydroxybenzoyl)-glycine; 2-Hydroxybenzoylaminoacetate; N-(O-Hydroxybenzoyl)glycine; N-(2-Hydroxybenzoyl)glycine; Ortho-hydroxyhippuric acid; N-O-Hydroxybenzoylglycine; (2-Hydroxybenzoyl)glycine; O-Hydroxy-hippuric acid; 2-Hydroxybenzoylglycine; 2-Hydroxyhippuric acid; o-Hydroxyhippuric acid; Ortho-hydroxyhippurate; O-Hydroxyhippic acid; O-Hydroxy-hippurate; N-Salicyloylglycine; O-Hydroxyhippurate; 2-Hydroxyhippurate; Salicyloylglycine; Salicyluric acid; O-Hydroxyhippate; Salicylic Acid; Salicylglycine; Salicylurate; Salicylate; Salicyluric acid; Salicyluric acid; Salicyluric acid



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

54 个相关的代谢反应过程信息。

Reactome(54)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AKT1, ALB, DMD, MAPK1, PTGS1, PTGS2, STAT3, TP53
Peripheral membrane protein 3 DMD, PTGS1, PTGS2
Endosome membrane 1 TF
Endoplasmic reticulum membrane 3 PTGS1, PTGS2, UGT1A6
Nucleus 6 AKT1, ALB, DMD, MAPK1, STAT3, TP53
cytosol 7 AKT1, ALB, DMD, KRT32, MAPK1, STAT3, TP53
centrosome 3 ALB, MAPK1, TP53
nucleoplasm 4 AKT1, MAPK1, STAT3, TP53
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 3 AKT1, GPR35, GPRC5A
Cytoplasmic side 1 DMD
lamellipodium 1 AKT1
Multi-pass membrane protein 4 ABCC3, GPR35, GPRC5A, SLC22A6
Synapse 2 DMD, MAPK1
cell cortex 1 AKT1
cell surface 2 DMD, TF
glutamatergic synapse 1 AKT1
Golgi apparatus 3 ALB, MAPK1, PTGS1
Golgi membrane 1 INS
postsynapse 1 AKT1
sarcolemma 1 DMD
plasma membrane 10 ABCC3, AKT1, DMD, GPR35, GPRC5A, IGHE, MAPK1, SLC22A6, STAT3, TF
Membrane 6 ABCC3, AKT1, DMD, SLC22A6, TP53, UGT1A6
apical plasma membrane 1 TF
basolateral plasma membrane 2 ABCC3, SLC22A6
caveola 3 MAPK1, PTGS2, SLC22A6
extracellular exosome 6 ALB, GPRC5A, KRT32, PTGS1, SLC22A6, TF
endoplasmic reticulum 4 ALB, PTGS2, TP53, UGT1A6
extracellular space 4 ALB, IGHE, INS, TF
perinuclear region of cytoplasm 1 TF
mitochondrion 2 MAPK1, TP53
protein-containing complex 6 AKT1, ALB, DMD, PTGS2, SLC22A6, TP53
intracellular membrane-bounded organelle 3 GPRC5A, PTGS1, UGT1A6
Microsome membrane 2 PTGS1, PTGS2
filopodium 1 DMD
Single-pass type I membrane protein 1 IGHE
Secreted 3 ALB, INS, TF
extracellular region 5 ALB, IGHE, INS, MAPK1, TF
Single-pass membrane protein 1 UGT1A6
basal part of cell 1 TF
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
anchoring junction 1 ALB
transcription regulator complex 2 STAT3, TP53
photoreceptor outer segment 1 PTGS1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 MAPK1, TP53
Z disc 1 DMD
cytoplasmic vesicle 1 TF
microtubule cytoskeleton 1 AKT1
nucleolus 2 GPRC5A, TP53
Early endosome 2 MAPK1, TF
cell-cell junction 1 AKT1
clathrin-coated pit 1 TF
recycling endosome 1 TF
vesicle 3 AKT1, GPRC5A, TF
postsynaptic membrane 1 DMD
Cell membrane, sarcolemma 1 DMD
Membrane raft 1 DMD
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton 2 DMD, TP53
Cytoplasm, cytoskeleton, spindle 1 MAPK1
focal adhesion 1 MAPK1
spindle 2 AKT1, MAPK1
Nucleus, PML body 1 TP53
PML body 1 TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
intermediate filament 1 KRT32
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 2 DMD, PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 2 DMD, PTGS2
Postsynaptic cell membrane 1 DMD
Late endosome 2 MAPK1, TF
receptor complex 1 GPRC5A
neuron projection 2 PTGS1, PTGS2
ciliary basal body 2 AKT1, ALB
chromatin 2 STAT3, TP53
IgE immunoglobulin complex 1 IGHE
mitotic spindle 1 MAPK1
cytoskeleton 3 DMD, KRT32, MAPK1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, TF
Basolateral cell membrane 2 ABCC3, SLC22A6
[Isoform 2]: Cell membrane 1 IGHE
site of double-strand break 1 TP53
Endomembrane system 1 PTGS1
endosome lumen 1 INS
Membrane, caveola 1 MAPK1
Cytoplasmic vesicle membrane 1 GPRC5A
germ cell nucleus 1 TP53
replication fork 1 TP53
pseudopodium 1 MAPK1
filopodium membrane 1 DMD
basal plasma membrane 3 ABCC3, SLC22A6, TF
ficolin-1-rich granule lumen 1 MAPK1
secretory granule lumen 2 INS, TF
HFE-transferrin receptor complex 1 TF
Golgi lumen 1 INS
endoplasmic reticulum lumen 5 ALB, INS, MAPK1, PTGS2, TF
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 ALB
endocytic vesicle 1 TF
transport vesicle 1 INS
azurophil granule lumen 1 MAPK1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 DMD
clathrin-coated endocytic vesicle membrane 1 TF
[Isoform 1]: Nucleus 1 TP53
costamere 1 DMD
Basal cell membrane 2 ABCC3, SLC22A6
dystrophin-associated glycoprotein complex 1 DMD
cell-substrate junction 1 DMD
[Isoform 3]: Cell membrane 1 IGHE
vesicle coat 1 TF
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
neuron projection terminus 1 DMD
syntrophin complex 1 DMD
ciliary transition fiber 1 ALB
dense body 1 TF
organelle 1 DMD
plasma membrane bounded cell projection 1 DMD


文献列表

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