Metanephrine (BioDeep_00000001341)

 

Secondary id: BioDeep_00000055112, BioDeep_00000402986, BioDeep_00001869369

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


4-[1-hydroxy-2-(methylamino)ethyl]-2-methoxyphenol

化学式: C10H15NO3 (197.1052)
中文名称: DL-变肾上腺素盐酸盐
谱图信息: 最多检出来源 Homo sapiens(blood) 22.38%

Reviewed

Last reviewed on 2024-07-09.

Cite this Page

Metanephrine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/metanephrine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001341). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CNCC(C1=CC(=C(C=C1)O)OC)O
InChI: InChI=1S/C10H15NO3/c1-11-6-9(13)7-3-4-8(12)10(5-7)14-2/h3-5,9,11-13H,6H2,1-2H3

描述信息

Metanephrine is a metabolite of epinephrine created by action of catechol O-methyltransferase on epinephrine. Technically it is a product of epinephrine O-methylation. It is a commonly occurring, pharmacologically and physiologically inactive metabolite of epinephrine. The measurement of plasma free metanephrines is considered to be the best tool in the diagnosis of pheochromocytoma, a rare kind of adrenal medullary neoplasm. In adrenal chromaffin cells, leakage of norepinephrine and epinephrine from storage granules leads to substantial intracellular production of the O-methylated metabolite metanephrine. In fact, the adrenals constitute the single largest source out of any organ system including the liver for circulating metanephrine. In humans, about 93 percent of circulating metanephrine is derived from catecholamines metabolized within adrenal chromaffin cells. (PMID 15317907).
Metanephrine is a metabolite of epinephrine created by action of catechol O-methyltransferase on epinephrine. Technically it is a product of epinephrine O-methylation. It is a commonly occurring, pharmacologically and physiologically inactive metabolite of epinephrine. The measurement of plasma free metanephrines is considered to be the best tool in the diagnosis of pheochromocytoma, a rare kind of adrenal medullary neoplasm.

同义名列表

15 个代谢物同义名

4-[1-hydroxy-2-(methylamino)ethyl]-2-methoxyphenol; 4-Hydroxy-3-methoxy-N-methylphenethanolamine; DL-3-O-Methyladrenaline; 3-O-Methyl-adrenaline; 3-O-Methylepinephrine; 3-Methoxy-adrenaline; m-O-Methyladrenaline; 3-Methoxyadrenaline; (+/-)-metanephrine; (±)-Metanephrine; DL-Metanephrine; L-Metanephrine; Metadrenaline; Metanephrine; Metanephrine



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

28 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(2)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(24)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 CALCA, NF1, POMC, TH
Peripheral membrane protein 2 SDHB, VHL
Endosome membrane 1 RET
Endoplasmic reticulum membrane 1 PNMT
Mitochondrion membrane 1 PNMT
Nucleus 3 NF1, TH, VHL
cytosol 6 COMT, NF1, PNMT, SST, TH, VHL
dendrite 4 COMT, NF1, RET, TH
mitochondrial membrane 2 PNMT, SDHB
nucleoplasm 3 NF1, SDHB, VHL
Cell membrane 5 COMT, NF1, RET, TNF, VHL
Cell projection, axon 1 TH
Multi-pass membrane protein 3 ATP4A, PNMT, SDHD
Synapse 1 COMT
cell surface 1 TNF
glutamatergic synapse 1 NF1
Golgi membrane 1 INS
mitochondrial inner membrane 2 SDHB, SDHD
neuronal cell body 4 CALCA, RET, SST, TNF
smooth endoplasmic reticulum 1 TH
synaptic vesicle 1 TH
Cytoplasmic vesicle, secretory vesicle 1 CHGA
Presynapse 1 NF1
plasma membrane 9 ATP4A, COMT, GCG, NF1, REN, RET, SDHB, TNF, VHL
terminal bouton 2 CALCA, TH
Membrane 5 ATP4A, COMT, NF1, REN, RET
apical plasma membrane 1 ATP4A
axon 4 COMT, NF1, RET, TH
extracellular exosome 1 COMT
endoplasmic reticulum 2 PNMT, VHL
extracellular space 12 ATP4A, CALCA, CHGA, CRP, GCG, IL10, IL6, INS, POMC, REN, SST, TNF
perinuclear region of cytoplasm 2 CHGA, TH
mitochondrion 5 PNMT, SDHB, SDHD, TH, VHL
intracellular membrane-bounded organelle 2 COMT, PNMT
Single-pass type I membrane protein 1 RET
Secreted 10 CALCA, CHGA, CRP, GCG, IL10, IL6, INS, POMC, REN, SST
extracellular region 11 CALCA, CHGA, CRP, GCG, IL10, IL6, INS, POMC, REN, SST, TNF
cytoplasmic side of plasma membrane 1 TH
hippocampal mossy fiber to CA3 synapse 1 CALCA
mitochondrial matrix 1 SDHB
Extracellular side 1 COMT
external side of plasma membrane 1 TNF
perikaryon 1 TH
cytoplasmic vesicle 1 TH
nucleolus 1 NF1
Melanosome membrane 1 TH
Early endosome 1 RET
apical part of cell 1 REN
recycling endosome 1 TNF
Single-pass type II membrane protein 2 COMT, TNF
Apical cell membrane 1 ATP4A
Cytoplasm, perinuclear region 1 TH
Mitochondrion inner membrane 2 SDHB, SDHD
Matrix side 1 SDHB
Membrane raft 1 TNF
GABA-ergic synapse 1 SST
secretory granule 2 CHGA, POMC
receptor complex 1 RET
neuron projection 1 TH
phagocytic cup 1 TNF
plasma membrane protein complex 1 RET
Nucleus, nucleolus 1 NF1
endosome lumen 1 INS
[Isoform 1]: Endoplasmic reticulum membrane 1 PNMT
[Isoform 1]: Cytoplasm 1 VHL
[Isoform 3]: Cytoplasm 1 VHL
secretory granule lumen 3 GCG, INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 GCG, IL6, INS
transport vesicle 2 CHGA, INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
mitochondrial envelope 1 SDHD
respiratory chain complex II (succinate dehydrogenase) 2 SDHB, SDHD
neuronal dense core vesicle 3 CALCA, CHGA, SST
intracellular non-membrane-bounded organelle 1 VHL
[Isoform 2]: Endoplasmic reticulum membrane 1 PNMT
[Glucagon-like peptide 1]: Secreted 1 GCG
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 CHGA
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
chromaffin granule 1 CHGA
[Serpinin]: Secreted 1 CHGA
potassium:proton exchanging ATPase complex 1 ATP4A
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Joanna Kokoszka, Marta Opalinska, Katarzyna Sitarz, Magdalena Kolasa, Monika Szewczyk, Jolanta Bugajska, Joanna Berska, Krystyna Sztefko, Alicja Hubalewska-Dydejczyk. 24-hours urine metanephrines excretion in patients diagnosed with adrenal incidentaloma: impact of commonly used drugs on clinical decision. Polish archives of internal medicine. 2024 Jan; ?(?):. doi: 10.20452/pamw.16646. [PMID: 38164744]
  • Jongsung Noh, Chaelin Lee, Jung Hee Kim, Seung Woon Myung, Man Ho Choi. LC-MS based simultaneous profiling of adrenal hormones of steroids, catecholamines, and metanephrines. Journal of lipid research. 2023 Oct; ?(?):100453. doi: 10.1016/j.jlr.2023.100453. [PMID: 37806496]
  • Rachel Churm, Liam M Williams, Gareth Dunseath, Sarah L Prior, Richard M Bracken. The polyphenol epigallocatechin gallate lowers circulating catecholamine concentrations and alters lipid metabolism during graded exercise in man: a randomized cross-over study. European journal of nutrition. 2023 Apr; 62(3):1517-1526. doi: 10.1007/s00394-023-03092-1. [PMID: 36695951]
  • Yuhang Deng, Qingxiang Liu, Zhenni Liu, Haijian Zhao, Weiyan Zhou, Chuanbao Zhang. Commutability Assessment of Processed Human Plasma Samples for Normetanephrine and Metanephrine Measurements Based on the Candidate Reference Measurement Procedure. Annals of laboratory medicine. 2022 Sep; 42(5):575-584. doi: 10.3343/alm.2022.42.5.575. [PMID: 35470275]
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