Aconitate [cis or trans] (BioDeep_00000001309)

 

Secondary id: BioDeep_00000229692, BioDeep_00000400438, BioDeep_00000875156

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


(1Z)-prop-1-ene-1,2,3-tricarboxylic acid

化学式: C6H6O6 (174.0164)
中文名称: 顺式-乌头酸, 乌头酸, 顺式乌头酸, 顺乌头酸
谱图信息: 最多检出来源 Homo sapiens(blood) 15.18%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Aconitate [cis or trans]. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/aconitate_[cis_or_trans] (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001309). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(=C(\CC(=O)O)/C(=O)O)/C(=O)O
InChI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)

描述信息

cis-Aconitic acid is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid. The enzyme aconitase (aconitate hydratase; EC 4.2.1.3) catalyses the stereo-specific isomerization of citrate to isocitrate via cis-aconitate in the tricarboxylic acid cycle.

Present in apple fruits, maple syrup and passion fruit juice

cis-Aconitic acid, also known as (Z)-aconitic acid, plays several important biological roles:

Intermediate in the Citric Acid Cycle: cis-Aconitic acid is an intermediate in the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle or citric acid cycle. It is formed from citrate by the enzyme aconitase and is rapidly converted into isocitrate, another key intermediate in the cycle. The TCA cycle is central to cellular respiration, generating energy-rich molecules like NADH and FADH2.
Regulation of Aconitase Activity: The conversion of citrate to cis-aconitate and then to isocitrate by aconitase is an important regulatory step in the TCA cycle. This conversion helps in maintaining the balance of the cycle and is influenced by factors like the energy status of the cell.
Role in Cholesterol Synthesis: cis-Aconitic acid is also involved in the synthesis of cholesterol. It serves as a precursor for the synthesis of mevalonate, a key intermediate in the cholesterol biosynthesis pathway.
Potential Involvement in Disease: Altered metabolism or accumulation of cis-aconitic acid has been associated with certain diseases, including neurodegenerative disorders and cancer. Its role in these conditions is an area of ongoing research.
Plant Growth and Development: In plants, cis-aconitic acid has been found to play a role in growth and development, including seed germination and leaf senescence.
In summary, cis-aconitic acid is a crucial intermediate in the TCA cycle, impacting energy production and various metabolic pathways in cells. Its role extends to cholesterol synthesis and potentially to various disease processes, highlighting its importance in cellular metabolism and physiology.

cis-Aconitic acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=585-84-2 (retrieved 2024-07-01) (CAS RN: 585-84-2). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
(Z)-Aconitic acid (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.
(Z)-Aconitic acid (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.

同义名列表

40 个代谢物同义名

(1Z)-prop-1-ene-1,2,3-tricarboxylic acid; (1Z)-1-Propene-1,2,3-tricarboxylic acid; (Z)-1-Propene-1,2,3-tricarboxylic acid; cis-1-Propene-1,2,3-tricarboxylic acid; (1Z)-1-Propene-1,2,3-tricarboxylate; 1-cis-2,3-Propenetricarboxylic acid; cis-1-Propene-1,2,3-tricarboxylate; (Z)-1-Propene-1,2,3-tricarboxylate; 1-Propene-1,2,3-tricarboxylic acid; 1-cis-2,3-Propenetricarboxylate; 1-Propene-1,2,3-tricarboxylate; Acid, carboxyglutaconic; Carboxyglutaconic acid; cis-Oxaloacetic acid; cis-Aconitic acid; (Z)-Aconitic Acid; cis-Oxaloacetate; Acid, pyrocitric; Acid, citridinic; Pyrocitric acid; Citridinic acid; Acid, achilleic; cis-Aconic acid; Acid, equisetic; Equisetic acid; Acid, aconitic; Achilleic acid; Acid, citridic; Acid, acontic; Citridic acid; (Z)-Aconitate; Aconitic acid; cis-Aconitate; Acid, adonic; Acontic acid; cis-Aconate; Adonic acid; Aconitate; cis-Aconitate; cis-Aconitic acid



数据库引用编号

47 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

73 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(1)

Plant Reactome(0)

INOH(5)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(65)

PharmGKB(0)

95 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 17 ADIG, AHR, ALB, ANXA5, BCL2, BIRC5, CASP3, CDK1, CDK2, CDK5, CDKN3, CTNNB1, EIF2AK2, MAPK14, MAPK8, PTGS2, STAT3
Peripheral membrane protein 2 ANXA5, PTGS2
Endoplasmic reticulum membrane 3 BCL2, CDK1, PTGS2
Nucleus 16 ADIG, AHR, ALB, BCL2, BIRC5, CASP3, CDK1, CDK2, CDK5, CDK9, CDKN3, CTNNB1, EIF2AK2, MAPK14, MAPK8, STAT3
cytosol 16 ACO2, AHR, ALB, ANXA5, BCL2, BIRC5, CASP3, CDK1, CDK2, CDK5, CDKN3, CTNNB1, EIF2AK2, MAPK14, MAPK8, STAT3
dendrite 1 CDK5
centrosome 4 ALB, CDK1, CDK2, CTNNB1
nucleoplasm 12 AHR, BIRC5, CASP3, CDK1, CDK2, CDK5, CDK9, CTNNB1, EIF2AK2, MAPK14, MAPK8, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 2 CDK5, CTNNB1
lamellipodium 2 CDK5, CTNNB1
Cell projection, growth cone 1 CDK5
Synapse 3 CDK5, CTNNB1, MAPK8
cell cortex 1 CTNNB1
cell junction 2 CDK5, CTNNB1
glutamatergic synapse 3 CASP3, CTNNB1, MAPK14
Golgi apparatus 1 ALB
growth cone 1 CDK5
neuromuscular junction 1 CDK5
neuronal cell body 2 CASP3, CDK5
presynaptic membrane 1 CTNNB1
sarcolemma 1 ANXA5
Presynapse 1 CDK5
endosome 1 CDK2
plasma membrane 3 CDK5, CTNNB1, STAT3
Membrane 8 ADIG, ANXA5, BCL2, CDK1, CDK5, CDK9, CTNNB1, EIF2AK2
axon 2 CDK5, MAPK8
basolateral plasma membrane 1 CTNNB1
caveola 1 PTGS2
extracellular exosome 4 ALB, ANXA5, CDK1, CTNNB1
endoplasmic reticulum 3 ALB, BCL2, PTGS2
extracellular space 1 ALB
perinuclear region of cytoplasm 3 CDKN3, CTNNB1, EIF2AK2
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
mitochondrion 5 ACO2, ACOD1, BCL2, CDK1, MAPK14
protein-containing complex 6 AHR, ALB, BCL2, BIRC5, CTNNB1, PTGS2
Microsome membrane 1 PTGS2
filopodium 1 CDK5
postsynaptic density 2 CASP3, CDK5
protein kinase 5 complex 1 CDK5
Secreted 2 ADIG, ALB
extracellular region 4 ADIG, ALB, ANXA5, MAPK14
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 ADIG, BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 2 ACO2, CDK1
anchoring junction 1 ALB
transcription regulator complex 4 AHR, CDK2, CTNNB1, STAT3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 CDK1, CDK2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 ANXA5
perikaryon 1 CDK5
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
microtubule cytoskeleton 1 BIRC5
Wnt signalosome 1 CTNNB1
midbody 2 BIRC5, CDK1
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
postsynaptic membrane 1 CTNNB1
Cell projection, lamellipodium 1 CDK5
Cytoplasm, perinuclear region 2 CDKN3, EIF2AK2
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 CTNNB1
Cytoplasm, cytoskeleton, spindle 1 BIRC5
focal adhesion 2 ANXA5, CTNNB1
microtubule 1 BIRC5
spindle 1 BIRC5
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
PML body 1 CDK9
collagen-containing extracellular matrix 1 ANXA5
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
nuclear speck 1 MAPK14
interphase microtubule organizing center 1 BIRC5
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 2 CDK5, PTGS2
ciliary basal body 1 ALB
chromatin 2 AHR, STAT3
cell periphery 1 CTNNB1
mitotic spindle 1 CDK1
Chromosome 1 BIRC5
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
centriole 2 ALB, BIRC5
cytoplasmic ribonucleoprotein granule 1 CDK9
spindle pole 3 ALB, CTNNB1, MAPK14
chromosome, telomeric region 2 CDK1, CDK2
nuclear chromosome 1 BIRC5
blood microparticle 1 ALB
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
nuclear envelope 1 CDK2
Endomembrane system 1 CTNNB1
Lipid droplet 1 ADIG
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
aryl hydrocarbon receptor complex 1 AHR
euchromatin 1 CTNNB1
myelin sheath 1 BCL2
[Isoform 1]: Cytoplasm 1 CDK5
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 2 ALB, PTGS2
male germ cell nucleus 1 CDK2
platelet alpha granule lumen 1 ALB
kinetochore 1 BIRC5
transcription elongation factor complex 1 CDK9
beta-catenin-TCF complex 1 CTNNB1
chromosome, centromeric region 1 BIRC5
presynaptic active zone cytoplasmic component 1 CTNNB1
vesicle membrane 1 ANXA5
chromosome passenger complex 1 BIRC5
Cajal body 1 CDK2
cytoplasmic microtubule 1 BIRC5
protein-DNA complex 1 CTNNB1
spindle microtubule 2 BIRC5, CDK1
survivin complex 1 BIRC5
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
condensed chromosome 1 CDK2
cyclin/CDK positive transcription elongation factor complex 1 CDK9
P-TEFb complex 1 CDK9
catenin complex 1 CTNNB1
Nucleus, Cajal body 1 CDK2
X chromosome 1 CDK2
Y chromosome 1 CDK2
cyclin-dependent protein kinase holoenzyme complex 4 CDK1, CDK2, CDK5, CDKN3
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
ribosome 1 EIF2AK2
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 1 CDK1
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
beta-catenin-TCF7L2 complex 1 CTNNB1
cyclin A2-CDK2 complex 1 CDK2
cyclin A1-CDK2 complex 1 CDK2
nuclear aryl hydrocarbon receptor complex 1 AHR
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
cytosolic aryl hydrocarbon receptor complex 1 AHR
ciliary transition fiber 1 ALB


文献列表

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