Asparagine (BioDeep_00000001300)

 

Secondary id: BioDeep_00000014864, BioDeep_00000399883, BioDeep_00000405763, BioDeep_00000896607, BioDeep_00001872844

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


(2S)-2-Amino-3-carbamoylpropanoic acid

化学式: C4H8N2O3 (132.05348980000002)
中文名称: L-天冬酰胺, 天冬酰胺
谱图信息: 最多检出来源 Homo sapiens(blood) 0.14%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Asparagine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/asparagine (retrieved 2024-11-21) (BioDeep RN: BioDeep_00000001300). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(C(=O)O)N)C(=O)N
InChI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)

描述信息

Asparagine (Asn) or L-asparagine is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Amino acids are organic compounds that contain amino (–NH2) and carboxyl (–COOH) functional groups, along with a side chain (R group) specific to each amino acid. L-asparagine is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Asparagine is found in all organisms ranging from bacteria to plants to animals. In humans, asparagine is not an essential amino acid, which means that it can be synthesized from central metabolic pathway intermediates in humans and is not required in the diet. The precursor to asparagine is oxaloacetate. Oxaloacetate is converted to aspartate using a transaminase enzyme. This enzyme transfers the amino group from glutamate to oxaloacetate producing alpha-ketoglutarate and aspartate. The enzyme asparagine synthetase produces asparagine, AMP, glutamate, and pyrophosphate from aspartate, glutamine, and ATP. In the asparagine synthetase reaction, ATP is used to activate aspartate, forming beta-aspartyl-AMP. Glutamine donates an ammonium group which reacts with beta-aspartyl-AMP to form asparagine and free AMP. Since the asparagine side chain can make efficient hydrogen bond interactions with the peptide backbone, asparagines are often found near the beginning and end of alpha-helices, and in turn motifs in beta sheets. Its role can be thought as "capping" the hydrogen bond interactions which would otherwise need to be satisfied by the polypeptide backbone. Asparagine also provides key sites for N-linked glycosylation, a modification of the protein chain that is characterized by the addition of carbohydrate chains. A reaction between asparagine and reducing sugars or reactive carbonyls produces acrylamide (acrylic amide) in food when heated to sufficient temperature (i.e. baking). These occur primarily in baked goods such as French fries, potato chips, and roasted coffee. Asparagine was first isolated in 1806 from asparagus juice --hence its name. Asparagine was the first amino acid to be isolated. The smell observed in the urine of some individuals after the consumption of asparagus is attributed to a byproduct of the metabolic breakdown of asparagine, asparagine-amino-succinic-acid monoamide. However, some scientists disagree and implicate other substances in the smell, especially methanethiol.
[Spectral] L-Asparagine (exact mass = 132.05349) and L-Aspartate (exact mass = 133.03751) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.
One of the nonessential amino acids. Dietary supplement, nutrient. Widely distributed in the plant kingdom. Isolated from asparagus, beetroot, peas, beans, etc.

(-)-Asparagine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=70-47-3 (retrieved 2024-07-15) (CAS RN: 70-47-3). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.
L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

同义名列表

53 个代谢物同义名

(2S)-2-Amino-3-carbamoylpropanoic acid; (S)-2-Amino-3-carbamoylpropanoic acid; (2S)-2,4-Diamino-4-oxobutanoic acid; b2,4-(S)-Diamino-4-oxo-utanoic acid; (2S)-2-Amino-3-carbamoylpropanoate; (S)-2,4-Diamino-4-oxobutanoic acid; (S)-2-Amino-3-carbamoylpropanoate; L-2,4-Diamino-4-oxobutanoic acid; (2S)-2,4-Diamino-4-oxobutanoate; b2,4-(S)-Diamino-4-oxo-utanoate; (S)-2,4-Diamino-4-oxobutanoate; L-2,4-Diamino-4-oxobutanoate; alpha Amminosuccinamic acid; L-Aspartic acid beta-amide; alpha-Aminosuccinamic acid; Aspartic acid beta amide; L-2-Aminosuccinamic acid; L-Aspartic acid β-amide; alpha Amminosuccinamate; L-Aspartic acid b-amide; a-Aminosuccinamic acid; Α-aminosuccinamic acid; alpha-Aminosuccinamate; 2-Aminosuccinamic acid; L-Aspartate beta-amide; Aspartic acid b-amide; L-2-Aminosuccinamate; Aspartic acid amide; L-Aspartate b-amide; L-Aspartate β-amide; 2-Aminosuccinamate; a-Aminosuccinamate; Α-aminosuccinamate; L-beta-Asparagine; Aspartamic acid; Asparagine acid; (S)-Asparagine; (-)-Asparagine; L-b-Asparagine; L-Aspartamine; L-Asparagine; Aspartamate; L-Asparagin; ASPARAGINE; Asparamide; Crystal VI; Agedoite; Altheine; Asn; N; Asparagine; L-Asparagine; Asparagine



数据库引用编号

68 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(0)

代谢反应

39 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(5)

WikiPathways(0)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(32)

  • Asparagine Biosynthesis: Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water ⟶ Adenosine monophosphate + Hydrogen Ion + L-Asparagine + L-Glutamic acid + Pyrophosphate
  • Asparagine Metabolism: Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water ⟶ Adenosine monophosphate + Hydrogen Ion + L-Asparagine + L-Glutamic acid + Pyrophosphate
  • Asparagine Metabolism: Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water ⟶ Adenosine monophosphate + Hydrogen Ion + L-Asparagine + L-Glutamic acid + Pyrophosphate
  • Asparagine Biosynthesis: Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water ⟶ Adenosine monophosphate + Hydrogen Ion + L-Asparagine + L-Glutamic acid + Pyrophosphate
  • Aspartate Metabolism: N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
  • Ammonia Recycling: Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water ⟶ Adenosine monophosphate + L-Asparagine + L-Glutamic acid + Pyrophosphate
  • Canavan Disease: N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
  • Hypoacetylaspartia: N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
  • Aspartate Metabolism: Adenosine triphosphate + Ammonia + L-Aspartic acid ⟶ Adenosine monophosphate + L-Asparagine + Pyrophosphate
  • tRNA Charging: Adenosine triphosphate + Hydrogen Ion + L-Arginine ⟶ Adenosine monophosphate + Pyrophosphate
  • tRNA Charging 2: Adenosine triphosphate + Hydrogen Ion + L-Arginine ⟶ Adenosine monophosphate + Pyrophosphate
  • Ammonia Recycling: Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water ⟶ Adenosine monophosphate + L-Asparagine + L-Glutamic acid + Pyrophosphate
  • Aspartate Metabolism: N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
  • Hypoacetylaspartia: N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
  • Aspartate Metabolism: N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
  • Ammonia Recycling: Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water ⟶ Adenosine monophosphate + L-Asparagine + L-Glutamic acid + Pyrophosphate
  • Aspartate Metabolism: N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
  • Ammonia Recycling: Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water ⟶ Adenosine monophosphate + L-Asparagine + L-Glutamic acid + Pyrophosphate
  • Aspartate Metabolism: N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
  • Ammonia Recycling: Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water ⟶ Adenosine monophosphate + L-Asparagine + L-Glutamic acid + Pyrophosphate
  • Aspartate Metabolism: N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
  • Ammonia Recycling: Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water ⟶ Adenosine monophosphate + L-Asparagine + L-Glutamic acid + Pyrophosphate
  • Protein Synthesis: Asparagine: Adenosine triphosphate + L-Asparagine ⟶ Adenosine monophosphate + Pyrophosphate
  • Protein Synthesis: Asparagine: Adenosine triphosphate + L-Asparagine ⟶ Adenosine monophosphate + Pyrophosphate
  • Protein Synthesis: Asparagine: Adenosine triphosphate + L-Asparagine ⟶ Adenosine monophosphate + Pyrophosphate
  • Protein Synthesis: Asparagine: Adenosine triphosphate + L-Asparagine ⟶ Adenosine monophosphate + Pyrophosphate
  • Canavan Disease: N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
  • Hypoacetylaspartia: N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid
  • Aspartate Metabolism: Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water ⟶ Adenosine monophosphate + L-Asparagine + L-Glutamic acid + Pyrophosphate
  • tRNA Charging: Adenosine triphosphate + Hydrogen Ion + L-Arginine ⟶ Adenosine monophosphate + Pyrophosphate
  • tRNA Charging 2: Adenosine triphosphate + Hydrogen Ion + L-Arginine ⟶ Adenosine monophosphate + Pyrophosphate
  • Canavan Disease: N-Acetyl-L-aspartic acid + Water ⟶ Acetic acid + L-Aspartic acid

PharmGKB(0)

120 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qing Xiao, Qingrong Huang, Chi-Tang Ho. Asparagine-Glucose Amadori Compounds: Formation, Characterization, and Analysis in Dry Jujube Fruit. Journal of agricultural and food chemistry. 2024 Apr; 72(13):7344-7353. doi: 10.1021/acs.jafc.4c00526. [PMID: 38502793]
  • Sarah L Oliver, Abou Yobi, Sherry Flint-Garcia, Ruthie Angelovici. Reducing Acrylamide Formation Potential by Targeting Free Asparagine Accumulation in Seeds. Journal of agricultural and food chemistry. 2024 Mar; 72(12):6089-6095. doi: 10.1021/acs.jafc.3c09547. [PMID: 38483189]
  • Mélanie Lavoignat, Cédric Cassan, Pierre Pétriacq, Yves Gibon, Emmanuel Heumez, Céline Duque, Philippe Momont, Renaud Rincent, Justin Blancon, Catherine Ravel, Jacques Le Gouis. Different wheat loci are associated to heritable free asparagine content in grain grown under different water and nitrogen availability. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 2024 Feb; 137(2):46. doi: 10.1007/s00122-024-04551-x. [PMID: 38332254]
  • Amanda G A Sá, James D House. Adding pulse flours to cereal-based snacks and bakery products: An overview of free asparagine quantification methods and mitigation strategies of acrylamide formation in foods. Comprehensive reviews in food science and food safety. 2024 Jan; 23(1):1-20. doi: 10.1111/1541-4337.13260. [PMID: 38284574]
  • Gyeongik Ahn, Yeong Jun Ban, Gyeong-Im Shin, Song Yi Jeong, Ki Hun Park, Woe-Yeon Kim, Joon-Yung Cha. Ethylene enhances transcriptions of asparagine biosynthetic genes in soybean (Glycine max L. Merr) leaves. Plant signaling & behavior. 2023 Dec; 18(1):2287883. doi: 10.1080/15592324.2023.2287883. [PMID: 38019725]
  • Kaikai Zhu, Si Chen, Ming Gao, Yanying Wu, Xinqi Liu. Asparagine-rich protein (NRP) mediates stress response by regulating biosynthesis of plant secondary metabolites in Arabidopsis. Plant signaling & behavior. 2023 12; 18(1):2241165. doi: 10.1080/15592324.2023.2241165. [PMID: 37515751]
  • Karolina Wleklik, Szymon Stefaniak, Katarzyna Nuc, Małgorzata Pietrowska-Borek, Sławomir Borek. Identification and Potential Participation of Lipases in Autophagic Body Degradation in Embryonic Axes of Lupin (Lupinus spp.) Germinating Seeds. International journal of molecular sciences. 2023 Dec; 25(1):. doi: 10.3390/ijms25010090. [PMID: 38203260]
  • Xiaochao Wang, Wanling Cai, Yihan Liu, Yaoming Lu, Mange Liu, Xuewei Cao, Da Guo. Exploring biomarkers associated with severity of knee osteoarthritis in Southern China using widely targeted metabolomics. BMC musculoskeletal disorders. 2023 Dec; 24(1):953. doi: 10.1186/s12891-023-07084-4. [PMID: 38066443]
  • Joseph Oddy, Monika Chhetry, Rajani Awal, John Addy, Mark Wilkinson, Dan Smith, Robert King, Chris Hall, Rebecca Testa, Eve Murray, Sarah Raffan, Tanya Y Curtis, Luzie Wingen, Simon Griffiths, Simon Berry, J Stephen Elmore, Nicholas Cryer, Isabel Moreira de Almeida, Nigel G Halford. Genetic control of grain amino acid composition in a UK soft wheat mapping population. The plant genome. 2023 Dec; 16(4):e20335. doi: 10.1002/tpg2.20335. [PMID: 37138544]
  • Spenser Waller, Avery Powell, Randi Noel, Michael J Schueller, Richard A Ferrieri. Radiocarbon Flux Measurements Reveal Mechanistic Insight into Heat-Stress Induction of Nicotine Biosynthesis in Nicotiana attenuata. International journal of molecular sciences. 2023 Oct; 24(21):. doi: 10.3390/ijms242115509. [PMID: 37958493]
  • Bo-Yi Ke, Yu-Sheng Qin, Lu Cheng, Shu-Zhi Wang. Legumain: a potential biomarker for atherosclerosis. The Journal of pharmacy and pharmacology. 2023 Aug; ?(?):. doi: 10.1093/jpp/rgad073. [PMID: 37584490]
  • Sarah Raffan, Joseph Oddy, Andrew Mead, Gary Barker, Tanya Curtis, Sarah Usher, Christopher Burt, Nigel G Halford. Field assessment of genome-edited, low asparagine wheat: Europe's first CRISPR wheat field trial. Plant biotechnology journal. 2023 06; 21(6):1097-1099. doi: 10.1111/pbi.14026. [PMID: 36759345]
  • Chaoyu Zhai, Steven M Lonergan, Elisabeth J Huff-Lonergan, Logan G Johnson, Kitty Brown, Jessica E Prenni, Mahesh N Nair. Lipid Peroxidation Products Influence Calpain-1 Functionality In Vitro by Covalent Binding. Journal of agricultural and food chemistry. 2023 May; 71(20):7836-7846. doi: 10.1021/acs.jafc.3c01225. [PMID: 37167568]
  • Kohei Oda, Alexander Wlodawer. Overview of the Properties of Glutamic Peptidases That Are Present in Plant and Bacterial Pathogens and Play a Role in Celiac Disease and Cancer. Biochemistry. 2023 Feb; 62(3):672-694. doi: 10.1021/acs.biochem.2c00622. [PMID: 36705990]
  • Feng Huang, Tong Zhang, Bin Li, Shaosong Wang, Chang Xu, Caihua Huang, Donghai Lin. NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice. Journal of ethnopharmacology. 2023 Jan; 300(?):115626. doi: 10.1016/j.jep.2022.115626. [PMID: 36049653]
  • Jolanta Bugajska, Joanna Berska, Małgorzata Wójcik, Krystyna Sztefko. Amino acid profile in overweight and obese prepubertal children - can simple biochemical tests help in the early prevention of associated comorbidities?. Frontiers in endocrinology. 2023; 14(?):1274011. doi: 10.3389/fendo.2023.1274011. [PMID: 37964971]
  • Erhard Bieberich. Synthesis, Processing, and Function of N-Glycans in N-Glycoproteins. Advances in neurobiology. 2023; 29(?):65-93. doi: 10.1007/978-3-031-12390-0_3. [PMID: 36255672]
  • Yunan Hu, Mingxia Li, Yongjun Hu, Defu Han, Jian Wei, Tao Zhang, Jixun Guo, Lianxuan Shi. Wild soybean salt tolerance metabolic model: Assessment of storage protein mobilization in cotyledons and C/N balance in the hypocotyl/root axis. Physiologia plantarum. 2023 Jan; 175(1):e13863. doi: 10.1111/ppl.13863. [PMID: 36688582]
  • Hongzhao Yuan, Zhen He, Xiangbi Chen, Tida Ge, Liping Zhang, Jiurong Wang. Rapid, sensitive analysis method for determining the nitrogen stable isotope ratio of total free amino acids in soil. Rapid communications in mass spectrometry : RCM. 2022 Nov; 36(21):e9390. doi: 10.1002/rcm.9390. [PMID: 36056455]
  • Rui-Rui Guo, Tian-Chan Zhang, Thomas Ole Tandrup Lambert, Ting Wang, Josef Voglmeir, Kasper D Rand, Li Liu. PNGase H + variant from Rudaea cellulosilytica with improved deglycosylation efficiency for rapid analysis of eukaryotic N-glycans and hydrogen deuterium exchange mass spectrometry analysis of glycoproteins. Rapid communications in mass spectrometry : RCM. 2022 Nov; 36(21):e9376. doi: 10.1002/rcm.9376. [PMID: 35945033]
  • Adel Abdelrazek Abdelazim Mohdaly, Mohamed H H Roby, Seham Ahmed Rabea Sultan, Eberhard Groß, Iryna Smetanska. Potential of Low Cost Agro-Industrial Wastes as a Natural Antioxidant on Carcinogenic Acrylamide Formation in Potato Fried Chips. Molecules (Basel, Switzerland). 2022 Nov; 27(21):. doi: 10.3390/molecules27217516. [PMID: 36364343]
  • Meshal M Almutairi, Hany M Almotairy. Analysis of Heat Shock Proteins Based on Amino Acids for the Tomato Genome. Genes. 2022 11; 13(11):. doi: 10.3390/genes13112014. [PMID: 36360251]
  • Cengiz Kaya, Ferhat Ugurlar, Shahid Farooq, Muhammed Ashraf, Mohammed Nasser Alyemeni, Parvaiz Ahmad. Combined application of asparagine and thiourea improves tolerance to lead stress in wheat by modulating AsA-GSH cycle, lead detoxification and nitrogen metabolism. Plant physiology and biochemistry : PPB. 2022 Nov; 190(?):119-132. doi: 10.1016/j.plaphy.2022.08.014. [PMID: 36113307]
  • Mei Han, Shizhen Wang, Liangdan Wu, Junhu Feng, Yujia Si, Xiaoning Liu, Tao Su. Effects of Exogenous L-Asparagine on Poplar Biomass Partitioning and Root Morphology. International journal of molecular sciences. 2022 Oct; 23(21):. doi: 10.3390/ijms232113126. [PMID: 36361911]
  • Anjali Zaveri, Jacqueline Edwards, Simone Rochfort. Production of Primary Metabolites by Rhizopus stolonifer, Causal Agent of Almond Hull Rot Disease. Molecules (Basel, Switzerland). 2022 Oct; 27(21):. doi: 10.3390/molecules27217199. [PMID: 36364023]
  • Na Zhang, Yi Yang, Wei Li, Shenzhi Zhou, Weiwei Li, Ying Peng, Jiang Zheng. Asparagine and Glutamine Residues Participate in Protein Covalent Binding by Epoxide Metabolite of 8-Epidiosbulbin E Acetate In Vitro and In Vivo. Chemical research in toxicology. 2022 10; 35(10):1821-1830. doi: 10.1021/acs.chemrestox.2c00130. [PMID: 35839447]
  • Haifang Jiang, Yiting Shi, Jingyan Liu, Zhen Li, Diyi Fu, Shifeng Wu, Minze Li, Zijia Yang, Yunlu Shi, Jinsheng Lai, Xiaohong Yang, Zhizhong Gong, Jian Hua, Shuhua Yang. Natural polymorphism of ZmICE1 contributes to amino acid metabolism that impacts cold tolerance in maize. Nature plants. 2022 10; 8(10):1176-1190. doi: 10.1038/s41477-022-01254-3. [PMID: 36241735]
  • C Anilkumar, Rameswar Prasad Sah, T P Muhammed Azharudheen, Sasmita Behera, Namita Singh, Nitish Ranjan Prakash, N C Sunitha, B N Devanna, B C Marndi, B C Patra, Sunil Kumar Nair. Understanding complex genetic architecture of rice grain weight through QTL-meta analysis and candidate gene identification. Scientific reports. 2022 08; 12(1):13832. doi: 10.1038/s41598-022-17402-w. [PMID: 35974066]
  • Huchen Zhang, Shijie Yi, Yuan Zhang, Zhi Hong. A conserved asparagine residue in the inner surface of BRI1 superhelix is essential for protein native conformation. Biochemical and biophysical research communications. 2022 07; 615(?):49-55. doi: 10.1016/j.bbrc.2022.05.014. [PMID: 35605405]
  • Bo Cao, Rui-Yang Zhao, Hang-Hang Li, Xing-Ming Xu, Hao Cui, Huan Deng, Lin Chen, Bo Wei. Oral administration of asparagine and 3-indolepropionic acid prolongs survival time of rats with traumatic colon injury. Military Medical Research. 2022 07; 9(1):37. doi: 10.1186/s40779-022-00397-w. [PMID: 35791006]
  • Siew Hwei Yap, Cheng Siang Lee, Aogu Furusho, Chiharu Ishii, Syahirah Shaharudin, Nurul Syuhada Zulhaimi, Adeeba Kamarulzaman, Shahrul Bahyah Kamaruzzaman, Masashi Mita, Kok Hoong Leong, Kenji Hamase, Reena Rajasuriar. Plasma d-amino acids are associated with markers of immune activation and organ dysfunction in people with HIV. AIDS (London, England). 2022 Jun; 36(7):911-921. doi: 10.1097/qad.0000000000003207. [PMID: 35212669]
  • Ling Liu, Jing Wang, Haiyu Li, Yan Dong, Ying Li, Lei Xia, Bo Yang, Handuo Wang, Yiran Xu, Guomei Cheng, Kaixian Du, Xiaoli Zhang, Changlian Zhu, Shihong Cui, Chenchen Ren. An intractable epilepsy phenotype of ASNS novel mutation in two patients with asparagine synthetase deficiency. Clinica chimica acta; international journal of clinical chemistry. 2022 Jun; 531(?):331-336. doi: 10.1016/j.cca.2022.04.989. [PMID: 35469797]
  • Arthur J L Cooper, Thambi Dorai, John T Pinto, Travis T Denton. The metabolic importance of the overlooked asparaginase II pathway. Analytical biochemistry. 2022 05; 644(?):114084. doi: 10.1016/j.ab.2020.114084. [PMID: 33347861]
  • Tina Kollannoor Johny, Rinu Madhu Puthusseri, Bindiya Ellathuparambil Saidumohamed, Unnikrishnan Babukuttan Sheela, Saipriya Parol Puthusseri, Raghul Subin Sasidharan, Sarita Ganapathy Bhat. Appraisal of cytotoxicity and acrylamide mitigation potential of L-asparaginase SlpA from fish gut microbiome. Applied microbiology and biotechnology. 2022 May; 106(9-10):3583-3598. doi: 10.1007/s00253-022-11954-7. [PMID: 35579684]
  • Nawal E Al-Hazmi, Deyala M Naguib. Plant asparaginase versus microbial asparaginase as anticancer agent. Environmental science and pollution research international. 2022 Apr; 29(18):27283-27293. doi: 10.1007/s11356-021-17925-1. [PMID: 34978032]
  • William F Mueller, Lei Zhu, Brandon Tan, Selina Dwight, Brendan Beahm, Matt Wilsey, Thomas Wechsler, Justin Mak, Tina Cowan, Jake Pritchett, Eric Taylor, Brett E Crawford. GlcNAc-Asn is a biomarker for NGLY1 deficiency. Journal of biochemistry. 2022 Feb; 171(2):177-186. doi: 10.1093/jb/mvab111. [PMID: 34697629]
  • Peter Bults, Anna van der Voort, Coby Meijer, Gabe S Sonke, Rainer Bischoff, Nico C van de Merbel. Analytical and pharmacological consequences of the in vivo deamidation of trastuzumab and pertuzumab. Analytical and bioanalytical chemistry. 2022 Feb; 414(4):1513-1524. doi: 10.1007/s00216-021-03756-z. [PMID: 35001193]
  • Koshi Akahane, Shunsuke Kimura, Kunio Miyake, Atsushi Watanabe, Keiko Kagami, Kentaro Yoshimura, Tamao Shinohara, Daisuke Harama, Shin Kasai, Kumiko Goi, Tomoko Kawai, Kenichiro Hata, Nobutaka Kiyokawa, Katsuyoshi Koh, Toshihiko Imamura, Keizo Horibe, A Thomas Look, Masayoshi Minegishi, Kanji Sugita, Junko Takita, Takeshi Inukai. Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL. Blood advances. 2022 01; 6(1):212-224. doi: 10.1182/bloodadvances.2021004271. [PMID: 34535013]
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