Cholestenone (BioDeep_00000001251)

 

Secondary id: BioDeep_00000405402, BioDeep_00000413212, BioDeep_00001868267

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite natural product


代谢物信息卡片


(1S,2R,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one

化学式: C27H44O (384.3392)
中文名称: 胆甾烯酮
谱图信息: 最多检出来源 Homo sapiens(feces) 22.7%

Reviewed

Last reviewed on 2024-09-26.

Cite this Page

Cholestenone. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/cholestenone (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001251). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
InChI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25H,6-16H2,1-5H3/t19-,22+,23-,24+,25+,26+,27-/m1/s1

描述信息

Cholestenone belongs to the class of organic compounds known as cholesterols and derivatives. Cholesterols and derivatives are compounds containing a 3-hydroxylated cholestane core. Thus, cholestenone is considered to be a sterol lipid molecule. Cholestenone is a very hydrophobic molecule, practically insoluble in water, and relatively neutral.
Cholestenone is a dehydrocholestanone. It is a product of cholesterol oxidase {EC 1.1.3.6] in the Bile acid biosynthesis pathway (KEGG). [HMDB]
Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells[1][2].
Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells[1][2].

同义名列表

21 个代谢物同义名

(1S,2R,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one; (17beta)-17-Octylandrost-4-en-3-one; (17b)-17-Octylandrost-4-en-3-one; (17Β)-17-octylandrost-4-en-3-one; (+)-3-Oxo-4-cholestene; delta4-Cholesten-3-one; (+)-4-Cholesten-3-one; 3-Keto-4-cholestene; delta4-Cholestenone; 3-Oxocholest-4-ene; Cholest-4-en-3-one; Δ4-cholesten-3-one; D4-Cholesten-3-one; 3-Oxo-4-cholestene; 4-Cholesten-3-one; Δ4-cholestenone; D4-Cholestenone; 4-Cholestenone; Cholesterone; Cholestenone; Cholest-4-en-3-one



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(4)

PlantCyc(0)

代谢反应

15 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(14)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

104 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AXIN2, BCL2, CAT, CTH, FASN, FOXA2, HMGB1, NR1H2, PDGFRB
Peripheral membrane protein 6 CAV1, CYP1B1, CYP27A1, FDXR, FLOT2, HMGB1
Endoplasmic reticulum membrane 8 ABCA1, ABCG1, BCL2, CAV1, CYP1B1, CYP7A1, HMGCR, HSP90B1
Mitochondrion membrane 1 CYP27A1
Nucleus 8 AXIN2, BCL2, FOXA2, HMGB1, HSP90B1, NR1H2, PDGFRB, TET1
cytosol 7 AXIN2, BCL2, CAT, CTH, FASN, HSP90B1, NR1H2
phagocytic vesicle 1 ABCA1
centrosome 1 AXIN2
nucleoplasm 3 FOXA2, HMGB1, NR1H2
RNA polymerase II transcription regulator complex 1 NR1H2
Cell membrane 5 ABCA1, ABCG1, CAV1, FLOT2, HMGB1
Lipid-anchor 1 FLOT2
lamellipodium 1 FLOT2
Early endosome membrane 1 CAV1
Multi-pass membrane protein 3 ABCA1, ABCG1, HMGCR
Golgi apparatus membrane 2 ABCG1, CAV1
cell cortex 1 CAV1
cell junction 1 FOXA2
cell surface 1 HMGB1
glutamatergic synapse 1 FLOT2
Golgi apparatus 5 ABCA1, ABCG1, CAV1, FASN, PDGFRB
Golgi membrane 2 ABCG1, CAV1
mitochondrial inner membrane 2 CYP27A1, FDXR
smooth endoplasmic reticulum 1 HSP90B1
endosome 5 ABCA1, ABCG1, CAV1, FLOT2, HMGB1
plasma membrane 9 ABCA1, ABCG1, AXIN2, CAV1, CTH, FASN, FLOT2, HMGB1, PDGFRB
Membrane 12 ABCA1, ABCG1, BCL2, CAT, CAV1, CTH, CYP1B1, FASN, FLOT2, HMGCR, HSP90B1, PDGFRB
apical plasma membrane 2 CAV1, PDGFRB
basolateral plasma membrane 3 ABCA1, CAV1, FLOT2
caveola 2 CAV1, FLOT2
extracellular exosome 5 CAT, CTH, FASN, FLOT2, HSP90B1
endoplasmic reticulum 5 BCL2, CAV1, HMGB1, HMGCR, HSP90B1
extracellular space 1 HMGB1
lysosomal lumen 1 PDGFRB
perinuclear region of cytoplasm 4 ABCA1, CAV1, FLOT2, HSP90B1
adherens junction 1 FLOT2
mitochondrion 6 ABCG1, BCL2, CAT, CYP1B1, CYP27A1, FDXR
protein-containing complex 4 BCL2, CAT, CAV1, HSP90B1
intracellular membrane-bounded organelle 6 ABCA1, CAT, CYP1B1, CYP7A1, FLOT2, PDGFRB
Microsome membrane 2 CYP1B1, CYP7A1
Single-pass type I membrane protein 1 CTH
Secreted 1 HMGB1
extracellular region 3 CAT, HMGB1, HSP90B1
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, CYP7A1
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 3 CAT, CYP27A1, FDXR
Extracellular side 1 HMGB1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ABCA1, ABCG1
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 3 CAV1, FLOT2, PDGFRB
midbody 1 HSP90B1
recycling endosome 1 ABCG1
vesicle 1 FLOT2
Mitochondrion inner membrane 2 CYP27A1, FDXR
Membrane raft 2 ABCA1, CAV1
pore complex 1 BCL2
focal adhesion 5 CAT, CAV1, FLOT2, HSP90B1, PDGFRB
flotillin complex 1 FLOT2
Peroxisome 1 CAT
intracellular vesicle 1 ABCA1
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 2 CAT, HMGCR
collagen-containing extracellular matrix 1 HSP90B1
dendrite cytoplasm 1 FLOT2
receptor complex 1 PDGFRB
cilium 1 CAV1
chromatin 2 FOXA2, NR1H2
Chromosome 2 HMGB1, TET1
Golgi apparatus, trans-Golgi network 1 CAV1
Lipid droplet 1 CAV1
Membrane, caveola 2 CAV1, FLOT2
Melanosome 2 FASN, HSP90B1
myelin sheath 1 BCL2
sperm plasma membrane 1 HSP90B1
Peroxisome membrane 1 HMGCR
ficolin-1-rich granule lumen 2 CAT, HMGB1
secretory granule lumen 2 CAT, HMGB1
endoplasmic reticulum lumen 1 HSP90B1
transcription repressor complex 1 HMGB1
endocytic vesicle membrane 1 CAV1
endocytic vesicle 2 ABCA1, FLOT2
Sarcoplasmic reticulum lumen 1 HSP90B1
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
uropod 1 FLOT2
[Isoform 2]: Nucleus 1 TET1
[Isoform 1]: Nucleus 1 TET1
Sin3-type complex 1 TET1
acrosomal membrane 2 CAV1, FLOT2
condensed chromosome 1 HMGB1
cell-cell contact zone 1 FLOT2
endocytic vesicle lumen 1 HSP90B1
catalase complex 1 CAT
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
endoplasmic reticulum chaperone complex 1 HSP90B1
BAD-BCL-2 complex 1 BCL2
glycogen granule 1 FASN
caveolar macromolecular signaling complex 1 CAV1


文献列表

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