Serotonin (BioDeep_00000001200)

 

Secondary id: BioDeep_00000229640, BioDeep_00000398749, BioDeep_00000861295

natural product human metabolite Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


3-(b-Aminoethyl)-5-hydroxyindole

化学式: C10H12N2O (176.095)
中文名称: 血清素, 5-羟色胺(盐酸盐), 3-(2-氨乙酸)吲哚盐酸盐, 5-羟基色胺
谱图信息: 最多检出来源 Homo sapiens(plant) 11.93%

Reviewed

Last reviewed on 2024-07-01.

Cite this Page

Serotonin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/serotonin (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001200). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: c1(ccc2c(c1)c(c[nH]2)CCN)O
InChI: InChI=1/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2

描述信息

Serotonin or 5-hydroxytryptamine (5-HT) is a molecule that belongs to the class of compounds known as indoleamines. An indoleamine consists of an indole ring that bears an amino group or an alkyl amino group attached to the indole ring. Serotonin has an aminoethyl at position 2 and a hydroxyl group at position 5 of the indole ring. Serotonin exists in all living organisms, ranging from bacteria to plants to humans. In mammals, serotonin functions as a monoamine neurotransmitter, a biochemical messenger and regulator. It is synthesized from the essential amino acid L-Tryptophan. Approximately 90\\\\% of the human bodys total serotonin is located in the enterochromaffin cells in the GI tract, where it regulates intestinal movements. About 8\\\\% is found in platelets and 1–2\\\\% in the CNS. Serotonin in the nervous system acts as a local transmitter at synapses, and as a paracrine or hormonal modulator of circuits upon diffusion, allowing a wide variety of "state-dependent" behavioral responses to different stimuli. Serotonin is widely distributed in the nervous system of vertebrates and invertebrates and some of its behavioral effects have been preserved along evolution. Such is the case of aggressive behavior and rhythmic motor patterns, including those responsible for feeding. In vertebrates, which display a wider and much more sophisticated behavioral repertoire, serotonin also modulates sleep, the arousal state, sexual behavior, and others. Deficiencies of the serotonergic system causes disorders such as depression, obsessive-compulsive disorder, phobias, posttraumatic stress disorder, epilepsy, and generalized anxiety disorder. Serotonin has three different modes of action in the nervous system: as transmitter, acting locally at synaptic boutons; upon diffusion at a distance from its release sites, producing paracrine (also called volume) effects, and by circulating in the blood stream, producing hormonal effects. The three modes can affect a single neuronal circuit. (PMID: 16047543). Serotonin is also a microbial metabolite that can be found in the feces and urine of mammals. Urinary serotonin is produced by Candida, Streptococcus, Escherichia, and Enterococcus (PMID: 24621061). In plants, serotonin was first found and reported in a legume called Mucuna pruriens. The greatest concentration of serotonin in plants has been found in walnuts and hickory. In pineapples, banana, kiwi fruit, plums and tomatoes the concentration of serotonin is around 3 to 30 mg/kg.
Isolated from bananas and other fruitsand is also from cotton (Gossypium hirsutum) [DFC]. Serotonin is found in many foods, some of which are common pea, eggplant, swiss chard, and dill.

Serotonin. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=50-67-9 (retrieved 2024-07-01) (CAS RN: 50-67-9). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

24 个代谢物同义名

3-(b-Aminoethyl)-5-hydroxyindole; 5-Hydroxy-3-(b-aminoethyl)indole; 3-(2-Aminoethyl)-1H-indol-5-ol; 3-(2-Aminoethyl)indol-5-ol; Serotonin hydrochloride; 5-Hydroxyltryptamine; 5-Hydroxy-tryptamine; 5 Hydroxytryptamine; 5-Hydroxytryptamine; 5-Hydroxytriptamine; Hydroxytryptamine; DS substance; Thrombocytin; Thrombotonin; Hippophaine; Serotonine; Enteramine; Serotonin; Enteramin; Antemovis; 5-HTA; 5-HT; Serotonin; Serotonin



数据库引用编号

38 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

164 个相关的代谢反应过程信息。

Reactome(32)

BioCyc(0)

WikiPathways(5)

Plant Reactome(120)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(5)

PharmGKB(1)

161 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 CALCA, ENO2, GAL, NTRK2, POMC, PPY, PRL, TH
Endosome membrane 1 NTRK2
Nucleus 2 PRL, TH
cytosol 7 AVP, ENO2, LEP, NGF, NTRK2, PRKCQ, TH
dendrite 6 AVP, MAOB, NGF, NTRK2, SLC18A2, TH
centrosome 1 SLC18A2
nucleoplasm 1 PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 4 ENO2, GAL, NTRK2, OPRD1
Cytoplasmic side 1 MAOB
Cell projection, axon 3 NTRK2, SLC18A2, TH
Early endosome membrane 1 NTRK2
Multi-pass membrane protein 2 OPRD1, SLC18A2
Synapse 1 HCRT
glutamatergic synapse 1 GHRL
neuronal cell body 3 CALCA, GAL, MAOB
postsynapse 2 GHRL, HCRT
presynaptic membrane 1 OPRD1
smooth endoplasmic reticulum 1 TH
synaptic vesicle 4 HCRT, NGF, SLC18A2, TH
Cytoplasmic vesicle, secretory vesicle 1 NTS
plasma membrane 8 ENO2, F2, GAL, IFNLR1, NTRK2, OPRD1, PRKCQ, SLC18A2
synaptic vesicle membrane 2 OPRD1, SLC18A2
terminal bouton 4 CALCA, NTRK2, SLC18A2, TH
Membrane 5 ENO2, IFNLR1, NTRK2, OPRD1, SLC18A2
axon 5 GHRL, NGF, NTRK2, SLC18A2, TH
extracellular exosome 2 ENO2, F2
extracellular space 11 AVP, CALCA, ENO2, F2, GAL, GHRL, LEP, NGF, POMC, PPY, PRL
perinuclear region of cytoplasm 3 HCRT, NTRK2, TH
Schaffer collateral - CA1 synapse 1 GHRL
mitochondrion 2 MAOB, TH
intracellular membrane-bounded organelle 2 NTS, SLC18A2
postsynaptic density 1 NTRK2
Single-pass type I membrane protein 2 IFNLR1, NTRK2
Secreted 11 AVP, CALCA, F2, GAL, GHRL, LEP, NGF, NTS, POMC, PPY, PRL
extracellular region 12 AVP, CALCA, F2, GAL, GHRL, HCRT, LEP, NGF, NTS, POMC, PPY, PRL
cytoplasmic side of plasma membrane 1 TH
Mitochondrion outer membrane 1 MAOB
mitochondrial outer membrane 1 MAOB
hippocampal mossy fiber to CA3 synapse 1 CALCA
centriolar satellite 1 PRKCQ
photoreceptor inner segment 1 ENO2
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 SLC18A2
dendritic spine 1 NTRK2
neuronal dense core vesicle lumen 2 GHRL, HCRT
perikaryon 2 ENO2, TH
cytoplasmic vesicle 2 HCRT, TH
Melanosome membrane 1 TH
Early endosome 1 NTRK2
Cytoplasm, perinuclear region 2 NTRK2, TH
collagen-containing extracellular matrix 1 F2
secretory granule 3 AVP, GAL, POMC
receptor complex 1 NTRK2
neuron projection 2 OPRD1, TH
chromatin 1 PRL
blood microparticle 1 F2
endosome lumen 2 NGF, PRL
Cell projection, dendrite 2 NTRK2, SLC18A2
secretory granule lumen 2 GHRL, POMC
secretory granule membrane 1 SLC18A2
Golgi lumen 2 F2, NGF
endoplasmic reticulum lumen 2 F2, GHRL
axon terminus 3 NTRK2, NTS, OPRD1
transport vesicle 1 NTS
mitochondrial envelope 1 MAOB
postsynaptic density membrane 1 OPRD1
immunological synapse 1 PRKCQ
neuronal dense core vesicle 3 AVP, CALCA, OPRD1
aggresome 1 PRKCQ
Single-pass type IV membrane protein 1 MAOB
clathrin-coated endocytic vesicle membrane 1 AVP
dopaminergic synapse 1 SLC18A2
dendrite membrane 1 OPRD1
Cytoplasmic vesicle, secretory vesicle membrane 1 SLC18A2
Rough endoplasmic reticulum 1 HCRT
phosphopyruvate hydratase complex 1 ENO2
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
clathrin-sculpted monoamine transport vesicle membrane 1 SLC18A2
spine apparatus 1 OPRD1
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Ning Xia, Jie Wang, Qiuting Guo, Jiawei Duan, Xuan Wang, Peijie Zhou, Jinkai Li, Tiantian Tang, Taotao Li, Huiting Li, Zhenfeng Wu, Ming Yang, Jing Sun, Dongyan Guo, Xing Chang, Xiaofei Zhang. Deciphering the antidepressant effects of Rosa damascena essential oil mediated through the serotonergic synapse signaling pathway. Journal of ethnopharmacology. 2024 Jun; 328(?):118007. doi: 10.1016/j.jep.2024.118007. [PMID: 38492791]
  • Yuchen Bao, Hailun Zhou, Yue Fu, Chao Wang, Qinwan Huang. Zhumian Granules improves PCPA-induced insomnia by regulating the expression level of neurotransmitters and reducing neuronal apoptosis. Journal of ethnopharmacology. 2024 Jun; 327(?):118048. doi: 10.1016/j.jep.2024.118048. [PMID: 38484955]
  • L I Ruibai, Chen Ke, M A Wei, Zhang Yayue, Hou Li, Chen Xinyi. Hemostatic mechanism of Jianpi Yiqi Shexue decoction in treatment of immune thrombocytopenia. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Jun; 44(3):537-544. doi: 10.19852/j.cnki.jtcm.20240423.003. [PMID: 38767638]
  • Yayun Wu, Lijuan Liu, Ya Zhao, Xiong Li, Junhong Hu, Hanlin Li, Ruizhi Zhao. Xiaoyaosan promotes neurotransmitter transmission and alleviates CUMS-induced depression by regulating the expression of Oct1 and Oct3 in astrocytes of the prefrontal cortex. Journal of ethnopharmacology. 2024 May; 326(?):117923. doi: 10.1016/j.jep.2024.117923. [PMID: 38367929]
  • Debsankar Saha Roy, Ankur Gupta, Vicky Vishvakarma, Pawel Krupa, Mai Suan Li, Sudipta Maiti. Serotonin Promotes Vesicular Association and Fusion by Modifying Lipid Bilayers. The journal of physical chemistry. B. 2024 May; 128(20):4975-4985. doi: 10.1021/acs.jpcb.4c00115. [PMID: 38743687]
  • Tian-Ji Xia, Su-Wei Jin, Yong-Guang Liu, Shan-Shan Zhang, Zhi Wang, Xin-Min Liu, Rui-Le Pan, Ning Jiang, Yong-Hong Liao, Ming-Zhu Yan, Qi Chang. Shen Yuan extract exerts a hypnotic effect via the tryptophan/5-hydroxytryptamine/melatonin pathway in mice. Journal of ethnopharmacology. 2024 May; 326(?):117992. doi: 10.1016/j.jep.2024.117992. [PMID: 38428654]
  • Xinying Fu, Siyang Yan, Zongren Hu, Wen Sheng, Wanyu Li, Shida Kuang, Xue Feng, Lumei Liu, Wei Zhang, Qinghu He. Guhan Yangsheng Jing mitigates hippocampal neuronal pyroptotic injury and manifies learning and memory capabilities in sleep deprived mice via the NLRP3/Caspase1/GSDMD signaling pathway. Journal of ethnopharmacology. 2024 May; 326(?):117972. doi: 10.1016/j.jep.2024.117972. [PMID: 38403005]
  • Shuichiro Kurita, Mika Sasaki, Moegi Tanaka, Yoshinori Kuwabara, Yukino Ogasawara, Hiroshi Baba, Yoshinori Kamiya. Analgesic effects of oral Yokukansan on acute postoperative pain and involvement of the serotonin nervous system: a mouse model study. BMC complementary medicine and therapies. 2024 May; 24(1):198. doi: 10.1186/s12906-024-04501-6. [PMID: 38773460]
  • Yihan Liu, Chen Chen, Hanbin Du, Mengzhou Xue, Ning Zhu. Impact of Baduanjin exercise combined with rational emotive behavior therapy on sleep and mood in patients with poststroke depression: A randomized controlled trial. Medicine. 2024 May; 103(19):e38180. doi: 10.1097/md.0000000000038180. [PMID: 38728460]
  • Ning Jiang, Caihong Yao, Yiwen Zhang, Yuzhen Chen, Fang Chen, Yanqin Luo, Muhammad Iqbal Choudhary, Ruile Pan, Xinmin Liu. Antidepressant effects of Parishin C in chronic social defeat stress-induced depressive mice. Journal of ethnopharmacology. 2024 May; 325(?):117891. doi: 10.1016/j.jep.2024.117891. [PMID: 38331122]
  • Fei Yi, Wanchun Wang, Yuliu Yi, Zhenhui Wu, Rui Li, Yonggui Song, Hao Chen, Li Zhou, Yingzhou Tao. Research on the mechanism of regulating spleen-deficient obesity in rats by bawei guben huashi jiangzhi decoction based on multi-omics analysis. Journal of ethnopharmacology. 2024 May; 325(?):117826. doi: 10.1016/j.jep.2024.117826. [PMID: 38296174]
  • Annalisa Chiavaroli, Simonetta Cristina Di Simone, Alessandra Acquaviva, Nilofar Nilofar, Maria Loreta Libero, Luigi Brunetti, Lucia Recinella, Sheila Leone, Giustino Orlando, Gokhan Zengin, Maura Di Vito, Luigi Menghini, Claudio Ferrante. Neuromodulatory Effects Induced by the Association of Moringa oleifera Lam., Tribulus terrestris L., Rhodiola rosea Lam., and Undaria pinnatidifida Extracts in the Hypothalamus. Chemistry & biodiversity. 2024 May; 21(5):e202302075. doi: 10.1002/cbdv.202302075. [PMID: 38527165]
  • Siming Ding, Kan Li, Xing Han, Wenting Lin, Yingjun Qin, Renjuan Cao, Yuan Ren. Long-term use of etomidate disrupts the intestinal homeostasis and nervous system in mice. Toxicology. 2024 May; 504(?):153802. doi: 10.1016/j.tox.2024.153802. [PMID: 38604439]
  • Yan Cai, Xiaodan Zhang, Jiaying Li, Wei Yang. Effect of acupuncture combined with Ningshen mixture on climacteric insomnia: A randomized controlled trial. Medicine. 2024 Apr; 103(17):e37930. doi: 10.1097/md.0000000000037930. [PMID: 38669364]
  • Shang-Heng Tsai, Yu-Chun Wu, Diana Fajardo Palomino, Frank C Schroeder, Chun-Liang Pan. Peripheral peroxisomal β-oxidation engages neuronal serotonin signaling to drive stress-induced aversive memory in C. elegans. Cell reports. 2024 Apr; 43(4):113996. doi: 10.1016/j.celrep.2024.113996. [PMID: 38520690]
  • Ke-Xin Hao, Chun-Yan Shen, Jian-Guo Jiang. Sedative and hypnotic effects of Polygala tenuifolia willd. saponins on insomnia mice and their targets. Journal of ethnopharmacology. 2024 Apr; 323(?):117618. doi: 10.1016/j.jep.2023.117618. [PMID: 38141791]
  • Liubov S Kalinichenko, Johannes Kornhuber, Steffen Sinning, Jana Haase, Christian P Müller. Serotonin Signaling through Lipid Membranes. ACS chemical neuroscience. 2024 Apr; 15(7):1298-1320. doi: 10.1021/acschemneuro.3c00823. [PMID: 38499042]
  • Jun Chang, Huimin Yang, Xiaoqian Shan, Lan Zhao, Yujiao Li, Zhao Zhang, Joseph Kofi Abankwah, Mingxing Zhang, Yuhong Bian, Yi Guo. Bergamot essential oil improves CUMS-induced depression-like behaviour in rats by protecting the plasticity of hippocampal neurons. Journal of cellular and molecular medicine. 2024 Apr; 28(8):e18178. doi: 10.1111/jcmm.18178. [PMID: 38553964]
  • Zhifang Wang, Menglin Kou, Qiyue Deng, Haotian Yu, Jilin Mei, Jing Gao, Wen Fu, Baile Ning. Acupuncture activates IRE1/XBP1 endoplasmic reticulum stress pathway in Parkinson's disease model rats. Behavioural brain research. 2024 Mar; 462(?):114871. doi: 10.1016/j.bbr.2024.114871. [PMID: 38266778]
  • Hye-Youn Kim, Cho-Een Kim, Dool-Ri Oh, Yonguk Kim, Chul-Yung Choi, Jaeyong Kim. Development and Validation of a High-Performance Liquid Chromatography Method to Quantify Marker Compounds in Lysimachia vulgaris var. davurica and Its Effects in Diarrhea-Predominant Irritable Bowel Syndrome. Molecules (Basel, Switzerland). 2024 Mar; 29(7):. doi: 10.3390/molecules29071489. [PMID: 38611770]
  • Ling-Ling Qin, Meng Yu, Peng Yang, Zhong-Mei Zou. The rhizomes of Atractylodes macrocephala relieve loperamide-induced constipation in rats by regulation of tryptophan metabolism. Journal of ethnopharmacology. 2024 Mar; 322(?):117637. doi: 10.1016/j.jep.2023.117637. [PMID: 38135226]
  • Hugo Moro, Demetrio Raldúa, Carlos Barata. Developmental defects in cognition, metabolic and cardiac function following maternal exposures to low environmental levels of selective serotonin re-uptake inhibitors and tributyltin in Daphnia magna. The Science of the total environment. 2024 Mar; 917(?):170463. doi: 10.1016/j.scitotenv.2024.170463. [PMID: 38290680]
  • Guangzhao Shu, Yang He, Jin Suo, Chunhui Wu, Xudong Gong, Yangyang Xiang, Wenjiao Yang, Jiaxin Cheng, Yu Wang, Weiming Chen, Jingshan Shen. Cannabidiol exhibits anxiolytic-like effects and antipsychotic-like effects in mice models. Neuroscience letters. 2024 Mar; 826(?):137723. doi: 10.1016/j.neulet.2024.137723. [PMID: 38467272]
  • Anika, Shamsher Singh, Rimpi. Neuroprotective effects of Embelin in an ethidium bromide-induced multiple sclerosis in rats: Modulation of p38 MAPK signaling pathway. International immunopharmacology. 2024 Mar; 129(?):111639. doi: 10.1016/j.intimp.2024.111639. [PMID: 38335654]
  • Ping Yang, Sheng Huang, Zhihong Luo, Shaoming Zhou, Changjuan Zhang, Yong Zhu, Jingjing Yang, Liang Li. Radix Bupleuri aqueous extract attenuates MK801-induced schizophrenia-like symptoms in mice: Participation of intestinal flora. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Mar; 172(?):116267. doi: 10.1016/j.biopha.2024.116267. [PMID: 38364739]
  • Debsankar Saha Roy, Marta Gozzi, Oskar Engberg, Juliane Adler, Daniel Huster, Sudipta Maiti. Membrane-Mediated Allosteric Action of Serotonin on a Noncognate G-Protein-Coupled Receptor. The journal of physical chemistry letters. 2024 Feb; 15(6):1711-1718. doi: 10.1021/acs.jpclett.3c02340. [PMID: 38319949]
  • Shizhuang Zhu, Qingyu Song, Changyue Liu, Dianhui Yang. Acupoint application for postherpetic neuralgia with qi stagnation and blood stasis and its effect on related inflammatory factors and 5-HT. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2024 Feb; 44(2):158-162. doi: 10.13703/j.0255-2930.20230628-k0004. [PMID: 38373761]
  • Wenhui Duan, Lingxi Zhou, Yilin Ren, Fei Liu, Yuzheng Xue, Fang-Zhou Wang, Ran Lu, Xiao-Juan Zhang, Jin-Song Shi, Zheng-Hong Xu, Yan Geng. Lactic acid fermentation of goji berries (Lycium barbarum) prevents acute alcohol liver injury and modulates gut microbiota and metabolites in mice. Food & function. 2024 Feb; 15(3):1612-1626. doi: 10.1039/d3fo03324d. [PMID: 38240339]
  • Wenjiao Yang, Xudong Gong, Haiguo Sun, Chunhui Wu, Jin Suo, Jing Ji, Xiangrui Jiang, Jingshan Shen, Yang He, Haji Akber Aisa. Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety. European journal of medicinal chemistry. 2024 Feb; 265(?):116048. doi: 10.1016/j.ejmech.2023.116048. [PMID: 38150961]
  • Rubi Barman, Pranjit Kumar Bora, Jadumoni Saikia, Parthapratim Konwar, Aditya Sarkar, Phirose Kemprai, Siddhartha Proteem Saikia, Saikat Haldar, Adrian Slater, Dipanwita Banik. Hypothetical biosynthetic pathways of pharmaceutically potential hallucinogenic metabolites in Myristicaceae, mechanistic convergence and co-evolutionary trends in plants and humans. Phytochemistry. 2024 Feb; 218(?):113928. doi: 10.1016/j.phytochem.2023.113928. [PMID: 38035973]
  • Han-Chuan Yu, Yang-Yang Meng, En-Kang Wang, Jian-Ye Yuan, Ying Peng, Xiao-Bo Li. [Buzhong Yiqi Decoction ameliorates spleen deficiency syndrome by regulating gut microbiota]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Feb; 49(4):1028-1043. doi: 10.19540/j.cnki.cjcmm.20231013.701. [PMID: 38621910]
  • Esmaeel Ghasemi Gojani, Bo Wang, Dong-Ping Li, Olga Kovalchuk, Igor Kovalchuk. The Impact of Psilocybin on High Glucose/Lipid-Induced Changes in INS-1 Cell Viability and Dedifferentiation. Genes. 2024 Jan; 15(2):. doi: 10.3390/genes15020183. [PMID: 38397173]
  • Elodie Baranek, Cécile Heraud, Laurence Larroquet, Anne Surget, Anthony Lanuque, Frederic Terrier, Sandrine Skiba-Cassy, Roy Jérôme. Long-term regulation of fat sensing in rainbow trout (Oncorhynchus mykiss) fed a vegetable diet from the first feeding: focus on free fatty acid receptors and their signalling. The British journal of nutrition. 2024 01; 131(1):1-16. doi: 10.1017/s0007114523001599. [PMID: 37469170]
  • Dinara Sadykova, Razina Nigmatullina, Karina Salakhova, Evgeniia Slastnikova, Liliya Galimova, Chulpan Khaliullina, Ildaria Valeeva. Membrane Transporter of Serotonin and Hypercholesterolemia in Children. International journal of molecular sciences. 2024 Jan; 25(2):. doi: 10.3390/ijms25020767. [PMID: 38255840]
  • Xin-Jue Shan, Dan Kang, Zhe Chen, Shi-Yu Zhang, Chun-Xiang Liu. [Systematic review and Meta-analysis of efficacy and safety of Shumian Capsules in treatment of insomnia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Jan; 49(1):268-278. doi: 10.19540/j.cnki.cjcmm.20230825.501. [PMID: 38403359]
  • Yanlin Tao, Houyuan Zhou, Zikang Li, Hui Wu, Fanggeng Wu, Zhiguo Miao, Hailian Shi, Fei Huang, Xiaojun Wu. TGR5 deficiency-induced anxiety and depression-like behaviors: The role of gut microbiota dysbiosis. Journal of affective disorders. 2024 01; 344(?):219-232. doi: 10.1016/j.jad.2023.10.072. [PMID: 37839469]
  • Severina Cassia de Andrade Silva, Maria Daniele Teixeira de Lemos, Osmar Henrique Dos Santos Junior, Thyago Oliveira Rodrigues, Tercya Lucidi Silva, Aline Isabel da Silva, Jarlei Fiamoncini, Claudia J Lagranha. Overweight during development dysregulates cellular metabolism and critical genes that control food intake in the prefrontal cortex. Physiology & behavior. 2023 Dec; ?(?):114453. doi: 10.1016/j.physbeh.2023.114453. [PMID: 38159589]
  • Ru-Hong Tu, Sheng-Ze Wu, Ze-Ning Huang, Qing Zhong, Yin-Hua Ye, Chao-Hui Zheng, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Chang-Ming Huang, Mi Lin, Jun Lu, Long-Long Cao, Ping Li. Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer. Cancer research. 2023 12; 83(23):3868-3885. doi: 10.1158/0008-5472.can-23-1012. [PMID: 38037454]
  • Yanrong Gong, Xiaoxia Liang, Yanting Dai, Xiang Huang, Qiaozhen Su, Yan Ma, Fenglian Chen, Shuling Wang. Prokinetic effects of Citrus reticulata and Citrus aurantium extract with/without Bupleurum chinense using multistress-induced delayed gastric emptying models. Pharmaceutical biology. 2023 Dec; 61(1):345-355. doi: 10.1080/13880209.2023.2173249. [PMID: 36728913]
  • Yu Fang, Yanqing Li, Xin Liao, Jie Deng, Qiannan Wang, Jingtao Liang, Bohua Yan. Corydalis yanhusuo Polysaccharides Ameliorate Chronic Stress-Induced Depression in Mice through Gut Microbiota-Derived Short-Chain Fatty Acid Activation of 5-Hydroxytryptamine Signaling. Journal of medicinal food. 2023 Dec; 26(12):890-901. doi: 10.1089/jmf.2023.k.0050. [PMID: 38010856]
  • Chan Li, Yingbo Lin, Rukun Lin, Zhijie Chen, Qichun Zhou, Chaohua Luo, Zhixian Mo. Host miR-129-5p reverses effects of ginsenoside Rg1 on morphine reward possibly mediated by changes in B. vulgatus and serotonin metabolism in hippocampus. Gut microbes. 2023 12; 15(2):2254946. doi: 10.1080/19490976.2023.2254946. [PMID: 37698853]
  • Yunting Xie, Linlin Cai, Mengzhen Ding, Kai Shan, Di Zhao, Guanghong Zhou, Chunbao Li. Plant-based meat analogues enhance the gastrointestinal motility function and appetite of mice by specific volatile compounds and peptides. Food research international (Ottawa, Ont.). 2023 12; 174(Pt 1):113551. doi: 10.1016/j.foodres.2023.113551. [PMID: 37986430]
  • Dhananjaya Pratap Singh, Sudarshan Maurya, Suresh Reddy Yerasu, Mansi Singh Bisen, Mohamed A Farag, Ratna Prabha, Renu Shukla, Krishna Kumar Chaturvedi, Md Samir Farooqi, Sudhir Srivastava, Anil Rai, Birinchi Kumar Sarma, Nagendra Rai, Tusar Kanti Behera. Metabolomics of early blight (Alternaria solani) susceptible tomato (Solanum lycopersicum) unfolds key biomarker metabolites and involved metabolic pathways. Scientific reports. 2023 11; 13(1):21023. doi: 10.1038/s41598-023-48269-0. [PMID: 38030710]
  • Zemin Wu, Zui Shen, Yingling Xu, Shaozong Chen, Siqi Xiao, Jiayu Ye, Haiyan Zhang, Xinyi Ma, Yichen Zhu, Xixiao Zhu, Yongliang Jiang, Junfan Fang, Boyi Liu, Xiaofen He, Shuzhong Gao, Xiaomei Shao, Jinggen Liu, Jianqiao Fang. A neural circuit associated with anxiety-like behaviors induced by chronic inflammatory pain and the anxiolytic effects of electroacupuncture. CNS neuroscience & therapeutics. 2023 Nov; ?(?):. doi: 10.1111/cns.14520. [PMID: 38018559]
  • Wei Li, Zuqi Shen, Xuan Yin, Weiqi Chang, Xiaorong Chen, Jin Yu, Shifen Xu. Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors. Translational psychiatry. 2023 Nov; 13(1):359. doi: 10.1038/s41398-023-02664-3. [PMID: 37993435]
  • Pu Yang, Haiyan Chen, Tian Wang, Hong Su, Jing Li, Yujun He, Shengyong Su. Electroacupuncture promotes synaptic plasticity in rats with chronic inflammatory pain-related depression by upregulating BDNF/TrkB/CREB signaling pathway. Brain and behavior. 2023 Nov; ?(?):e3310. doi: 10.1002/brb3.3310. [PMID: 37948105]
  • Nitasana Rajkumari, Soni Chowrasia, Jyoti Nishad, Showkat Ahmad Ganie, Tapan Kumar Mondal. Metabolomics-mediated elucidation of rice responses to salt stress. Planta. 2023 Nov; 258(6):111. doi: 10.1007/s00425-023-04258-1. [PMID: 37919614]
  • Yan Wang, Yuzhen Huang, Min Zhao, Lu Yang, Kunhan Su, Hao Wu, Yuting Wang, Qing Chang, Wanli Liu. Zuojin pill improves chronic unpredictable stress-induced depression-like behavior and gastrointestinal dysfunction in mice via the theTPH2/5-HT pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Nov; 120(?):155067. doi: 10.1016/j.phymed.2023.155067. [PMID: 37716030]
  • Yi Yang, Yan-E Hu, Yu-Qing Huang, Yi-Fang Jiang, Xi Fu, Feng-Ming You. [Tongxie Yaofang regulates tumor-associated macrophage polarization in colorectal cancer under chronic stress]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Nov; 48(22):6142-6153. doi: 10.19540/j.cnki.cjcmm.20230811.703. [PMID: 38114221]
  • Muhammed Majeed, Kalyanam Nagabhushanam, Avinash Murali, Devarajan T Vishwanathan, Ramamohan V Mamidala, Lakshmi Mundkur. A Standardized Withania somniferra (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study. Journal of integrative and complementary medicine. 2023 Oct; ?(?):. doi: 10.1089/jicm.2023.0279. [PMID: 37878284]
  • Dinesh Kumar Patel, Kanika Patel. Therapeutic Potential and Pharmacological Activities of (+)-Nantenine in Medicine: An Aporphine Class phytocomponent of Nandina domestica Thunberg. Infectious disorders drug targets. 2023 Oct; ?(?):. doi: 10.2174/0118715265244269231010090316. [PMID: 37881077]
  • Xinye Li, Chao He, Min Shen, Mingyun Wang, Jingwen Zhou, Dongying Chen, Tong Zhang, Yiqiong Pu. Effects of aqueous extracts and volatile oils prepared from Huaxiang Anshen decoction on p-chlorophenylalanine-induced insomnia mice. Journal of ethnopharmacology. 2023 Oct; 319(Pt 3):117331. doi: 10.1016/j.jep.2023.117331. [PMID: 37858748]
  • Gopal Banerjee, Dhanraj Singh, Chandana Pandey, Sarvesh Jonwal, Udita Basu, Swarup K Parida, Ashutosh Pandey, Alok Krishna Sinha. Rice Mitogen-Activated Protein Kinase regulates serotonin accumulation and interacts with cell cycle regulators under prolonged UV-B exposure. Plant physiology and biochemistry : PPB. 2023 Oct; 203(?):108078. doi: 10.1016/j.plaphy.2023.108078. [PMID: 37832368]
  • Weifen Li, Tahir Ali, Shengnan Mou, Qichao Gong, Ningning Li, Liangliang Hao, Zhi-Jian Yu, Shupeng Li. D1R-5-HT2AR Uncoupling Reduces Depressive Behaviours via HDAC Signalling. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2023 Oct; ?(?):. doi: 10.1007/s13311-023-01436-7. [PMID: 37782408]
  • Diego Freitas de Araujo, Bianca Feitosa Holanda, Francisco Lucas Faustino do Nascimento, Alice Brito Martins, Alefe Lopes Macario Silva, Maria Gonçalves Pereira, Alana de Freitas Pires, Ana Maria Sampaio Assreuy. Polysaccharide-rich extract of Genipa americana leaves exerts anti-inflammatory effects modulated by platelet mediators. Journal of ethnopharmacology. 2023 Oct; 319(Pt 2):117234. doi: 10.1016/j.jep.2023.117234. [PMID: 37793578]
  • Hang-Yu Li, Si-Yu Huang, Dan-Dan Zhou, Ruo-Gu Xiong, Min Luo, Adila Saimaiti, Mu-Ke Han, Ren-You Gan, Hui-Lian Zhu, Hua-Bin Li. Theabrownin inhibits obesity and non-alcoholic fatty liver disease in mice via serotonin-related signaling pathways and gut-liver axis. Journal of advanced research. 2023 10; 52(?):59-72. doi: 10.1016/j.jare.2023.01.008. [PMID: 36639024]
  • Yi-Ming Li, Gui-Mei Lin, Yuan-Pan Yu, Yi Yao. [A comparative study of raw Aurantii Fructus Immaturus and bran-fried products on dryness of rats with slow-transit constipation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Oct; 48(20):5558-5564. doi: 10.19540/j.cnki.cjcmm.20230522.301. [PMID: 38114148]
  • Ruiting Huang, Min Gong, Xue Tan, Jianying Shen, You Wu, Xiaoshi Cai, Suying Wang, Li Min, Lin Gong, Wenna Liang. Effects of Chaihu Shugan San on Brain Functional Network Connectivity in the Hippocampus of a Perimenopausal Depression Rat Model. Molecular neurobiology. 2023 Sep; ?(?):. doi: 10.1007/s12035-023-03615-1. [PMID: 37751044]
  • Miao Ma, Hongfeng Quan, Shujuan Chen, Xueyan Fu, Lingling Zang, Lin Dong. The Anxiolytic Effect of Polysaccharides from Stellariae Radix through Monoamine Neurotransmitters, HPA Axis, and ECS/ERK/CREB/BDNF Signaling Pathway in Stress-induced Male Rats. Brain research bulletin. 2023 Sep; 203(?):110768. doi: 10.1016/j.brainresbull.2023.110768. [PMID: 37739234]
  • Bingqian He, Wenqin Guo, Rongzhen Shi, Robert D Hoffman, Qihan Luo, Yuan-Jia Hu, Jianli Gao. Ruyong formula improves thymus function of CUMS-stimulated breast cancer mice. Journal of ethnopharmacology. 2023 Sep; ?(?):117164. doi: 10.1016/j.jep.2023.117164. [PMID: 37717843]
  • Jinhu Li, Xiang Yao, Yurou Wu, Chengwei Wang, Jincheng Yang, Chunjie Wu. The anticonvulsant effect of saiga horn on febrile seizures by regulating brain serotonin content and inhibiting neuroinflammation. Journal of ethnopharmacology. 2023 Sep; 319(Pt 1):117180. doi: 10.1016/j.jep.2023.117180. [PMID: 37709104]
  • Burcu Ersoy, Marie-Louise Herzog, Wen Pan, Simone Schilling, Matthias Endres, Ria Göttert, Golo D Kronenberg, Karen Gertz. The atypical antidepressant tianeptine confers neuroprotection against oxygen-glucose deprivation. European archives of psychiatry and clinical neuroscience. 2023 Sep; ?(?):. doi: 10.1007/s00406-023-01685-9. [PMID: 37653354]
  • Long Wang, Haiping Lu, Xiaoyan Zhang, Yuxin He, Jiarun Zhang, Xiaohao Guo, Haowei Fu, Gongyin Ye, Qingyao Shu. Disruption of serotonin biosynthesis increases resistance to striped stem borer without changing innate defense response in rice. Journal of pineal research. 2023 Sep; 75(2):e12895. doi: 10.1111/jpi.12895. [PMID: 37392131]
  • Bruno Anderson Fernandes da Silva, Renata Torres Pessoa, Roger Henrique Sousa da Costa, Maria Rayane Correia de Oliveira, Andreza Guedes Barbosa Ramos, Maria Gabriely de Lima Silva, Lucas Yure Santos da Silva, Cassio Rocha Medeiros, Sloana Giesta Lemos Florencio, Jaime Ribeiro-Filho, Henrique Douglas Melo Coutinho, António Raposo, Sunghoon Yoo, Heesup Han, Irwin Rose Alencar de Menezes, Lucindo José Quintans Júnior. Evaluation of the antiedematogenic and anti-inflammatory properties of Ximenia americana L. (Olacaceae) bark extract in experimental models of inflammation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Aug; 166(?):115249. doi: 10.1016/j.biopha.2023.115249. [PMID: 37597323]
  • Qing Ye, Si-Si Lin, Henning Ulrich, Yong Tang. Decoupling SERT-nNOS Interaction to Generate Fast-Onset Antidepressants. Neuroscience bulletin. 2023 08; 39(8):1327-1329. doi: 10.1007/s12264-023-01049-2. [PMID: 36973477]
  • Ruixin Wang, Xiaofang Lu, Luqing Zhao, Weixi Zhang, Shengsheng Zhang. Houpo paiqi mixture promotes intestinal motility in constipated rats by modulating gut microbiota and activating 5-HT-cAMP-PKA signal pathway. Journal of applied microbiology. 2023 Aug; 134(8):. doi: 10.1093/jambio/lxad153. [PMID: 37481692]
  • Yun Liao, Shuang Tao, Shiqi Wang, Gaohui Wu, Wenkai Yao, Liteng Yang, Qinmiao Huang, Yu Liu, Gui Yang, Pingchang Yang. 5-HT modulates the properties of dendritic cells to interfere with the development of type 1 regulating T cells. Molecular immunology. 2023 08; 160(?):161-167. doi: 10.1016/j.molimm.2023.07.001. [PMID: 37451234]
  • Taotao Li, Wenfei Wang, Qiuting Guo, Jia Li, Tiantian Tang, Yujiao Wang, Ding Liu, Kai Yang, Jiayi Li, Kaixue Deng, Fang Wang, Huiting Li, Zhenfeng Wu, Jianbo Guo, Dongyan Guo, Yajun Shi, Junbo Zou, Jing Sun, Xiaofei Zhang, Ming Yang. Rosemary (Rosmarinus officinalis L.) hydrosol based on serotonergic synapse for insomnia. Journal of ethnopharmacology. 2023 Jul; ?(?):116984. doi: 10.1016/j.jep.2023.116984. [PMID: 37532071]
  • Zhitao Hou, Xinyu Yang, Ling Jiang, Liying Song, Yang Li, Dongdong Li, Yanning Che, Xiuling Zhang, Zhongren Sun, Hongcai Shang, Jing Chen. Active components and molecular mechanisms of Sagacious Confucius' Pillow Elixir to treat cognitive impairment based on systems pharmacology. Aging. 2023 07; 15(14):7278-7307. doi: 10.18632/aging.204912. [PMID: 37517091]
  • Shujun Wang, Leilei Liu, Shuzhi Liang, Jinni Yang, Yan Zhang, Xijian Liu. Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice. Journal of ethnopharmacology. 2023 Jul; 318(Pt B):116973. doi: 10.1016/j.jep.2023.116973. [PMID: 37517566]
  • An-An Zhang, Qing-Li He, Qunfei Zhao. Mining and Characterization of Indolethylamine N-Methyltransferases in Amphibian Toad Bufo gargarizans. Biochemistry. 2023 Jul; ?(?):. doi: 10.1021/acs.biochem.3c00229. [PMID: 37490721]
  • Jialie Luo, Zuojia Chen, David Castellano, Bin Bao, Wenyan Han, Jian Li, Girak Kim, Dingding An, Wei Lu, Chuan Wu. Lipids regulate peripheral serotonin release via gut CD1d. Immunity. 2023 07; 56(7):1533-1547.e7. doi: 10.1016/j.immuni.2023.06.001. [PMID: 37354904]
  • Haining Yu, Bixian Yu, Xiuyuan Qin, Weiguang Shan. A unique inflammation-related mechanism by which high-fat diets induce depression-like behaviors in mice. Journal of affective disorders. 2023 Jul; 339(?):180-193. doi: 10.1016/j.jad.2023.07.005. [PMID: 37437725]
  • Yi Huang, Yuhang Hong, Shu Wu, Xiaozhen Yang, Qiang Huang, Yanzhen Dong, Dayong Xu, Zhiqiu Huang. Prolonged darkness attenuates imidacloprid toxicity through the brain-gut-microbiome axis in zebrafish, Danio rerio. The Science of the total environment. 2023 Jul; 881(?):163481. doi: 10.1016/j.scitotenv.2023.163481. [PMID: 37068676]
  • Vishnu Mishra, Ananda K Sarkar. Serotonin: A frontline player in plant growth and stress responses. Physiologia plantarum. 2023 Jul; 175(4):e13968. doi: 10.1111/ppl.13968. [PMID: 37402164]
  • Haoran Wang, Yanqiu Gu, Rahman Khalid, Xiaofei Chen, Ting Han. Herbal medicines for insomnia through regulating 5-hydroxytryptamine receptors: a systematic review. Chinese journal of natural medicines. 2023 Jul; 21(7):483-498. doi: 10.1016/s1875-5364(23)60405-4. [PMID: 37517817]
  • Shangyue Yu, Chunlan Fan, Yilin Li, Hailuan Pei, Yingying Tian, Zeping Zuo, Zijian Wang, Chuang Liu, Xinyue Zhao, Zhibin Wang. Network pharmacology and experimental verification to explore the anti-migraine mechanism of Yufeng Ningxin Tablet. Journal of ethnopharmacology. 2023 Jun; 310(?):116384. doi: 10.1016/j.jep.2023.116384. [PMID: 36924863]
  • Yen T H Lam, Jana Hoppe, Quang N Dang, Andrea Porzel, Alena Soboleva, Wolfgang Brandt, Robert Rennert, Hidayat Hussain, Mehdi D Davari, Ludger Wessjohann, Norbert Arnold. Purpurascenines A-C, Azepino-Indole Alkaloids from Cortinarius purpurascens: Isolation, Biosynthesis, and Activity Studies on the 5-HT2A Receptor. Journal of natural products. 2023 06; 86(6):1373-1384. doi: 10.1021/acs.jnatprod.2c00716. [PMID: 37306303]
  • Nian Liu, Jilei Li, Yichong Wang, Shengsheng Zhang. Different therapies of Chinese herbal medicine for diarrhea-predominant irritable bowel syndrome: A network meta-analysis of double-blinded, placebo-controlled trials. Journal of ethnopharmacology. 2023 Jun; ?(?):116672. doi: 10.1016/j.jep.2023.116672. [PMID: 37328079]
  • Chen Song, Yishu Yin, Yue Qin, Tianzhu Li, Deyong Zeng, Ting Ju, Fangyuan Duan, Yingchun Zhang, Weihong Lu. Acanthopanax senticosus extract alleviates radiation-induced learning and memory impairment based on neurotransmitter-gut microbiota communication. CNS neuroscience & therapeutics. 2023 06; 29 Suppl 1(?):129-145. doi: 10.1111/cns.14134. [PMID: 36971202]
  • Matthew Meyer, Jason Slot. The evolution and ecology of psilocybin in nature. Fungal genetics and biology : FG & B. 2023 06; 167(?):103812. doi: 10.1016/j.fgb.2023.103812. [PMID: 37210028]
  • Feng Min, Jia Ziming, Wan Ming, Fan Bolin, Tang Xiaoqiao, Cheng Wenhua, Sun Fanzhong. Effectiveness of Fuling () and its extracts against spleen deficiency in rats tonifying spleen. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2023 Jun; 43(3):501-506. doi: 10.19852/j.cnki.jtcm.2023.03.002. [PMID: 37147751]
  • Qidi Yang, Yizhou Zhao, Xiangyu Zhao, Sishen Sun, Yifei Chen, Jiayin Chen, Duowu Zou, Ling Zhang. Exploring the potential targets of Biling Weitong Granules on visceral hypersensitivity through integration of network pharmacology and in vivo analysis. Journal of ethnopharmacology. 2023 May; ?(?):116701. doi: 10.1016/j.jep.2023.116701. [PMID: 37257703]
  • Caihong Yao, Yiwen Zhang, Xinran Sun, Haiyue Pei, Shanshan Wei, Mengdi Wang, Qi Chang, Xinmin Liu, Ning Jiang. Areca catechu L. ameliorates chronic unpredictable mild stress-induced depression behavior in rats by the promotion of the BDNF signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 May; 164(?):114459. doi: 10.1016/j.biopha.2023.114459. [PMID: 37245336]
  • Yuxiao Chen, Jie Sun, Zhen Yang, Hongyan Bi. Efficacy and safety of negative allosteric modulators of 5-hydroxytryptamine 2A receptors in the treatment of Alzheimer's disease psychosis: A systematic review and meta-analysis. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2023 May; ?(?):. doi: 10.17219/acem/161159. [PMID: 37166012]
  • Fu-Guang Wang, Yi Sun, Juan Cao, Xu-Ri Shen, Fu-Wang Liu, Shuang-Shuang Song, Xue-Qin Hou, Lei Yin. Effects of Danggui-Shaoyao-San on central neuroendocrine and pharmacokinetics in female ovariectomized rats. Journal of ethnopharmacology. 2023 May; ?(?):116609. doi: 10.1016/j.jep.2023.116609. [PMID: 37150422]
  • Hui-Yu Zhang, Dan-Fei Yue, Xiao-Jiao Pan, Lu-Lu Hao, Wei-Cheng Liu, Chun-Fang Zheng. Effects of 5-HT on the cold resistance of mangrove Kandelia obovata seedlings. Ying yong sheng tai xue bao = The journal of applied ecology. 2023 May; 34(5):1263-1271. doi: 10.13287/j.1001-9332.202305.013. [PMID: 37236943]
  • Tapan Behl, Tarapati Rana, Aayush Sehgal, Neelam Sharma, Ali Albarrati, Mohammed Albratty, Hafiz A Makeen, Asim Najmi, Raman Verma, Simona Gabriela Bungau. Exploring the multifocal role of phytoconstituents as antidepressants. Progress in neuro-psychopharmacology & biological psychiatry. 2023 04; 123(?):110693. doi: 10.1016/j.pnpbp.2022.110693. [PMID: 36509251]
  • Lili Zou, Yaling Tian, Yuanfei Wang, Dongliang Chen, Xiaomin Lu, Ze Zeng, Zumin Chen, Chenli Lin, Yinji Liang. High-cholesterol diet promotes depression- and anxiety-like behaviors in mice by impact gut microbe and neuroinflammation. Journal of affective disorders. 2023 04; 327(?):425-438. doi: 10.1016/j.jad.2023.01.122. [PMID: 36738999]
  • Yifan Zhang, Chen Hong, Chenqi Zhang, Huiliang Li, Wenting Lv, Kang Cheng, Zhi Lv, Yiming Li, Huali Wu. SP/5-HT functional cross-talk in melanin biosynthesis: interaction between NK1R and 5-HT2AR. European journal of dermatology : EJD. 2023 04; 33(2):160-162. doi: 10.1684/ejd.2023.4446. [PMID: 37431119]
  • Xiao-Na Wang, Jiu-Cheng Zhang, Hai-Yuan Zhang, Xiao-Fei Wang, Chun-Xiang You. Ectopic expression of MmSERT, a mouse serotonin transporter gene, regulates salt tolerance and ABA sensitivity in apple and Arabidopsis. Plant physiology and biochemistry : PPB. 2023 Apr; 197(?):107627. doi: 10.1016/j.plaphy.2023.03.004. [PMID: 36940523]
  • Hui-Hao Tang, Yi-Fan Zhang, Li-Li Yang, Chen Hong, Kai-Xian Chen, Yi-Ming Li, Hua-Li Wu. Serotonin/5-HT7 receptor provides an adaptive signal to enhance pigmentation response to environmental stressors through cAMP-PKA-MAPK, Rab27a/RhoA, and PI3K/AKT signaling pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023 04; 37(4):e22893. doi: 10.1096/fj.202201352rr. [PMID: 36961387]
  • Yan Xu, Dong-Guang Liu, Ting-Bo Ning, Jian-Guo Zhu, Ru Yao, Xue Meng, Jing-Chun Yao, Wen-Xue Zhao. [Antidepressant mechanism of Shenling Kaixin Granules based on BDNF/TrkB/CREB pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Apr; 48(8):2184-2192. doi: 10.19540/j.cnki.cjcmm.20221114.402. [PMID: 37282906]
  • Xu Zhang, Xiaotong Wang, Rui Shi, Xiaoku Ran, Xiahong He, Deqiang Dou. Effective substances and mechanism of red ginseng on rats with spleen-deficiency syndrome based on the substance and energy metabolism as well as the "brain-gut" axis. Journal of ethnopharmacology. 2023 Mar; 311(?):116438. doi: 10.1016/j.jep.2023.116438. [PMID: 37003398]
  • Aaron L Nichols, Zack Blumenfeld, Laura Luebbert, Hailey J Knox, Anand K Muthusamy, Jonathan S Marvin, Charlene H Kim, Stephen N Grant, David P Walton, Bruce N Cohen, Rebekkah Hammar, Loren Looger, Per Artursson, Dennis A Dougherty, Henry A Lester. Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023 03; 43(13):2222-2241. doi: 10.1523/jneurosci.1519-22.2022. [PMID: 36868853]
  • Wei Shen, Yanlin Tao, Fang Zheng, Houyuan Zhou, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu. The alteration of gut microbiota in venlafaxine-ameliorated chronic unpredictable mild stress-induced depression in mice. Behavioural brain research. 2023 Mar; 446(?):114399. doi: 10.1016/j.bbr.2023.114399. [PMID: 36963638]
  • Xiaoju Liu, Haijuan Wang, Xiaoyu Wang, Yinxia Ning, Wei Liu, Jie Gao. Baixiangdan capsule and Shuyu capsule regulate anger-out and anger-in, respectively: GB1-mediated GABA can regulate 5-HT levels in multiple brain regions. Aging. 2023 Mar; 15(6):2046-2065. doi: 10.18632/aging.204589. [PMID: 36988497]
  • Mengnan Huang, Yuanyuan He, Lin Tian, Lu Yu, Qi Cheng, Zhu Li, Lina Gao, Shan Gao, Chunquan Yu. Gut microbiota-SCFAs-brain axis associated with the antidepressant activity of berberine in CUMS rats. Journal of affective disorders. 2023 Mar; 325(?):141-150. doi: 10.1016/j.jad.2022.12.166. [PMID: 36610597]
  • Berna Çayli, Gülay Çiftci, Alper Çiftci, Sadık Savaşan. Effects of Lactobacillus acidophilus administration to anorexigenic neuropeptides and some biochemical parameters on rats fed with a high-fat diet. Prostaglandins & other lipid mediators. 2023 Mar; 166(?):106729. doi: 10.1016/j.prostaglandins.2023.106729. [PMID: 36914021]