Ophiopogonin B (BioDeep_00000011526)
natural product
代谢物信息卡片
化学式: C39H62O12 (722.4241)
中文名称: 麦冬皂苷B
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(C(CC(C6)O)OC7C(C(C(C(O7)C)O)O)OC8C(C(C(C(O8)C)O)O)O)C)C)C)OC1
InChI: InChI=1S/C39H62O12/c1-17-9-12-39(46-16-17)18(2)28-26(51-39)15-25-23-8-7-21-13-22(40)14-27(38(21,6)24(23)10-11-37(25,28)5)49-36-34(32(44)30(42)20(4)48-36)50-35-33(45)31(43)29(41)19(3)47-35/h7,17-20,22-36,40-45H,8-16H2,1-6H3/t17-,18+,19+,20-,22-,23-,24+,25+,26+,27-,28+,29+,30+,31-,32+,33-,34-,35+,36+,37+,38+,39-/m1/s1
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:80879
- KEGG: C17038
- PubChem: 46173857
- PubChem: 12313751
- Metlin: METLIN71516
- CAS: 38971-41-4
- PMhub: MS000109273
- PMhub: MS000025566
- MetaboLights: MTBLC80879
- PubChem: 96023516
- NIKKAJI: J18.371G
- KNApSAcK: 80879
- LOTUS: LTS0076230
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
13 个相关的物种来源信息
- 40552 - Asparagaceae: LTS0076230
- 2759 - Eukaryota: LTS0076230
- 4447 - Liliopsida: LTS0076230
- 39529 - Liriope muscari: 10.1142/S0192415X15500275
- 3398 - Magnoliopsida: LTS0076230
- 100502 - Ophiopogon: LTS0076230
- 100504 - Ophiopogon intermedius: 10.1248/CPB.41.566
- 100506 - Ophiopogon japonicus:
- 100506 - Ophiopogon japonicus: 10.1248/CPB.32.3994
- 100506 - Ophiopogon japonicus: LTS0076230
- 35493 - Streptophyta: LTS0076230
- 58023 - Tracheophyta: LTS0076230
- 33090 - Viridiplantae: LTS0076230
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Fang Yuan, Qian Gao, Hailin Tang, Jun Shi, Yiqun Zhou. Ophiopogonin‑B targets PTP1B to inhibit the malignant progression of hepatocellular carcinoma by regulating the PI3K/AKT and AMPK signaling pathways.
Molecular medicine reports.
2022 04; 25(4):. doi:
10.3892/mmr.2022.12638. [PMID: 35169857] - Shuang Yuan, Yuanyuan Xu, Tao Yi, Hongjing Wang. The anti-tumor effect of OP-B on ovarian cancer in vitro and in vivo, and its mechanism: An investigation using network pharmacology-based analysis.
Journal of ethnopharmacology.
2022 Jan; 283(?):114706. doi:
10.1016/j.jep.2021.114706. [PMID: 34614446] - Wenhui Dong, Qing Dong, Hairui Ding. Ophiopogonin B induces reactive oxygen species‑dependent apoptosis through the Hippo pathway in nasopharyngeal carcinoma.
Molecular medicine reports.
2021 Jul; 24(1):. doi:
10.3892/mmr.2021.12173. [PMID: 34080657] - Guang-Yi Gao, Jun Ma, Peng Lu, Xuan Jiang, Cheng Chang. Ophiopogonin B induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Dec; 108(?):1208-1215. doi:
10.1016/j.biopha.2018.06.172. [PMID: 30372822] - Meijuan Chen, Cheng Hu, Yuanyuan Guo, Rilei Jiang, Huimin Jiang, Yu Zhou, Haian Fu, Mianhua Wu, Xu Zhang. Ophiopogonin B suppresses the metastasis and angiogenesis of A549 cells in vitro and in vivo by inhibiting the EphA2/Akt signaling pathway.
Oncology reports.
2018 Sep; 40(3):1339-1347. doi:
10.3892/or.2018.6531. [PMID: 29956803] - Meijuan Chen, Yuanyuan Guo, Ruolin Zhao, Xiaoxia Wang, Miao Jiang, Haian Fu, Xu Zhang. Ophiopogonin B induces apoptosis, mitotic catastrophe and autophagy in A549 cells.
International journal of oncology.
2016 Jul; 49(1):316-24. doi:
10.3892/ijo.2016.3514. [PMID: 27175570] - Weiyue Zhang, Qiaoyan Zhang, Yiping Jiang, Feng Li, Hailiang Xin. Effects of ophiopogonin B on the proliferation and apoptosis of SGC‑7901 human gastric cancer cells.
Molecular medicine reports.
2016 Jun; 13(6):4981-6. doi:
10.3892/mmr.2016.5198. [PMID: 27121658] - Meijuan Chen, Yuhong Du, Min Qui, Mingyan Wang, Kejun Chen, Zhenzhou Huang, Miao Jiang, Fei Xiong, Jianping Chen, Jing Zhou, Fengrong Jiang, Lian Yin, Yuping Tang, Lihong Ye, Zhen Zhan, Jin-Αo Duan, Hai-Αn Fu, Xu Zhang. Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway.
Oncology reports.
2013 Feb; 29(2):430-6. doi:
10.3892/or.2012.2131. [PMID: 23151908] - K Fukuda, H Utsumi, J Shoji, A Hamada. Saponins can cause the agglutination of phospholipid vesicles.
Biochimica et biophysica acta.
1985 Nov; 820(2):199-206. doi:
10.1016/0005-2736(85)90113-0. [PMID: 4052419]
