Luciculine (BioDeep_00000001072)

 

Secondary id: BioDeep_00000410486, BioDeep_00001473736, BioDeep_00001734675

PANOMIX_OTCML-2023 PANOMIX_OTCML-2025


代谢物信息卡片


(1R,2R,4S,5S,7R,8R,9R,13R,16S,17R)-11-ethyl-13-methyl-6-methylidene-11-azahexacyclo[7.7.2.15,8.01,10.02,8.013,17]nonadecane-4,7,16-triol

  化学式: C22H33NO3 (359.246)
中文名称: 12-表-欧乌头碱, 12-表欧乌头碱
  谱图信息: 最多检出来源 Viridiplantae(otcml) 10.22%

Reviewed

Last reviewed on 2025-06-03.

Cite this Page

Luciculine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/luciculine (retrieved 2025-07-30) (BioDeep RN: BioDeep_00000001072). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C=C1C2CC3(C1O)C1CC4C5(C)CCC(O)C4(C1N(CC)C5)C3CC2O
InChI: InChI=1S/C22H33NO3/c1-4-23-10-20(3)6-5-17(25)22-15(20)7-13(18(22)23)21-9-12(11(2)19(21)26)14(24)8-16(21)22/h12-19,24-26H,2,4-10H2,1,3H3


描述信息

LSM-1634 is a kaurane diterpenoid.
Napelline is a natural product found in Aconitum karakolicum, Aconitum baicalense, and other organisms with data available.
12-Epinapelline is a kaurane diterpenoid.
12-Epinapelline is a natural product found in Aconitum napellus, Delphinium leroyi, and other organisms with data available.
Annotation level-1
12-Epinapelline is a diterpene alkaloid isolated from Aconitum baikalense. 12-Epinapelline exhibits Anti-inflammatory activity and stimulates the growth of colonies from fibroblast precursors[1][2].
12-Epinapelline is a diterpene alkaloid isolated from Aconitum baikalense. 12-Epinapelline exhibits Anti-inflammatory activity and stimulates the growth of colonies from fibroblast precursors[1][2].

同义名列表

13 个代谢物同义名

(1R,2R,4S,5S,7R,8R,9R,13R,16S,17R)-11-ethyl-13-methyl-6-methylidene-11-azahexacyclo[7.7.2.15,8.01,10.02,8.013,17]nonadecane-4,7,16-triol; Prestwick3_000690; BPBio1_000901; napelline; 11-ethyl-13-methyl-6-methylidene-11-azahexacyclo[7.7.2.15,8.01,10.02,8.013,17]nonadecane-4,7,16-triol; 12-epi-Napelline; 12-epinapelline; Oprea1_157914; Oprea1_176735; Napelline; 11-ethyl-13-methyl-6-methylidene-11-azahexacyclo[7.7.2.1?,?.0(1),(1)?.0(2),?.0(1)(3),(1)?]nonadecane-4,7,16-triol; 11-ethyl-13-methyl-6-methylidene-11-azahexacyclo[7.7.2.1~5,8~.0~1,10~.0~2,8~.0~13,17~]nonadecane-4,7,16-triol (non-preferred name); 1ST161139



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 BCL2, CA1, CASP9, FGF2, HIF1A, MTOR, PIK3CA, PTGS2, TLR4, VEGFA
Peripheral membrane protein 3 ACHE, MTOR, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 3 BCL2, MTOR, PTGS2
Nucleus 8 ACHE, BCL2, CASP9, FGF2, HIF1A, MTOR, SOX9, VEGFA
cytosol 6 BCL2, CA1, CASP9, HIF1A, MTOR, PIK3CA
dendrite 1 MTOR
nuclear body 1 HIF1A
phagocytic vesicle 1 MTOR
nucleoplasm 3 HIF1A, MTOR, SOX9
RNA polymerase II transcription regulator complex 1 HIF1A
Cell membrane 5 ACHE, KCNH2, OPRD1, TLR4, TNF
Cytoplasmic side 1 MTOR
lamellipodium 1 PIK3CA
Multi-pass membrane protein 3 KCNH2, KCNJ3, OPRD1
Golgi apparatus membrane 1 MTOR
Synapse 2 ACAN, ACHE
cell surface 5 ACHE, KCNH2, TLR4, TNF, VEGFA
glutamatergic synapse 1 ACAN
Golgi apparatus 2 ACHE, VEGFA
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
neuromuscular junction 1 ACHE
neuronal cell body 1 TNF
presynaptic membrane 2 KCNJ3, OPRD1
Lysosome 1 MTOR
plasma membrane 7 ACHE, KCNH2, KCNJ3, OPRD1, PIK3CA, TLR4, TNF
synaptic vesicle membrane 1 OPRD1
Membrane 8 ACHE, BCL2, KCNH2, KCNJ3, MTOR, OPRD1, TLR4, VEGFA
axon 1 CCK
caveola 1 PTGS2
extracellular exosome 1 CA1
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BCL2, PTGS2, VEGFA
extracellular space 7 ACAN, ACHE, CCK, FGF2, IGF1, TNF, VEGFA
lysosomal lumen 1 ACAN
perinuclear region of cytoplasm 4 ACHE, KCNH2, PIK3CA, TLR4
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, CASP9
protein-containing complex 5 BCL2, CASP9, HIF1A, PTGS2, SOX9
Microsome membrane 2 MTOR, PTGS2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TLR4
Secreted 5 ACHE, CCK, FGF2, IGF1, VEGFA
extracellular region 7 ACAN, ACHE, CCK, FGF2, IGF1, TNF, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
Extracellular side 1 ACHE
transcription regulator complex 1 SOX9
motile cilium 1 HIF1A
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 3 KCNJ3, TLR4, TNF
Secreted, extracellular space, extracellular matrix 2 ACAN, VEGFA
T-tubule 1 KCNJ3
axon cytoplasm 1 HIF1A
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
pore complex 1 BCL2
GABA-ergic synapse 1 ACAN
extracellular matrix 1 VEGFA
basement membrane 2 ACAN, ACHE
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 ACAN
secretory granule 1 VEGFA
nuclear speck 1 HIF1A
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 2 OPRD1, PTGS2
chromatin 2 HIF1A, SOX9
phagocytic cup 2 TLR4, TNF
Lipid-anchor, GPI-anchor 1 ACHE
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
monoatomic ion channel complex 2 KCNH2, KCNJ3
Nucleus speckle 1 HIF1A
euchromatin 1 HIF1A
side of membrane 1 ACHE
myelin sheath 1 BCL2
inward rectifier potassium channel complex 1 KCNH2
voltage-gated potassium channel complex 2 KCNH2, KCNJ3
exocytic vesicle 1 IGF1
lipopolysaccharide receptor complex 1 TLR4
Golgi lumen 1 ACAN
endoplasmic reticulum lumen 1 PTGS2
platelet alpha granule lumen 2 IGF1, VEGFA
axon terminus 1 OPRD1
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
postsynaptic density membrane 1 OPRD1
perineuronal net 1 ACAN
neuronal dense core vesicle 1 OPRD1
apoptosome 1 CASP9
parallel fiber to Purkinje cell synapse 1 KCNJ3
synaptic cleft 1 ACHE
dendrite membrane 1 OPRD1
Cytoplasmic vesicle, phagosome 1 MTOR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
perisynaptic extracellular matrix 1 ACAN
spine apparatus 1 OPRD1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
I(KACh) inward rectifier potassium channel complex 1 KCNJ3
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Qi Wang, Jing Peng, Yang Liu, Yang Tian, Jie Li, Yao-Yao Ren, Jian Gu, Rui Tan. [Therapeutic effects of alkaloids in Tibetan medicine Bangna (Aconiti Penduli et Aconiti Flavi Radix) on osteoarthritis rats and mechanisms]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(17):4715-4722. doi: 10.19540/j.cnki.cjcmm.20220207.704. [PMID: 36164879]
  • Ahmatbeck Samanbay, Bo Zhao, Haji Akber Aisa. A new denudatine type C20-diterpenoid alkaloid from Aconitum sinchiangense W. T. Wang. Natural product research. 2018 Oct; 32(19):2319-2324. doi: 10.1080/14786419.2017.1410814. [PMID: 29212360]
  • Yu V Nesterova, T N Povet'yeva, N I Suslov, G N Zyuz'kov, S V Pushkarskii, S G Aksinenko, E E Schultz, S S Kravtsova, A V Krapivin. Analgesic activity of diterpene alkaloids from Aconitum baikalensis. Bulletin of experimental biology and medicine. 2014 Aug; 157(4):488-91. doi: 10.1007/s10517-014-2598-6. [PMID: 25110090]
  • Tivadar Kiss, Péter Orvos, Száva Bánsághi, Peter Forgo, Nikoletta Jedlinszki, László Tálosi, Judit Hohmann, Dezső Csupor. Identification of diterpene alkaloids from Aconitum napellus subsp. firmum and GIRK channel activities of some Aconitum alkaloids. Fitoterapia. 2013 Oct; 90(?):85-93. doi: 10.1016/j.fitote.2013.07.010. [PMID: 23876370]
  • Yu V Nesterova, T N Povetieva, N I Suslov, V V Zhdanov, T Yu Hrichkova, E V Udut, A S Chaykovskiy, N N Gaydamovich, T I Andreeva, A M Dygai. Regeneratory characteristics of complex extract and isolated diterpene alkaloids of Aconitum baikalense. Bulletin of experimental biology and medicine. 2012 Feb; 152(4):439-43. doi: 10.1007/s10517-012-1548-4. [PMID: 22803106]
  • Sang Hee Shim, Ju Sun Kim, Sam Sik Kang, Kun Ho Son, KiHwan Bae. Alkaloidal constituents from Aconitum jaluense. Archives of pharmacal research. 2003 Sep; 26(9):709-15. doi: 10.1007/bf02976678. [PMID: 14560917]