Ryanodine (BioDeep_00000000608)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,6aS,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo(1,2)pentaleno(1,6-bc)furan-8-yl ester

化学式: C25H35NO9 (493.2312)
中文名称: 鱼尼汀
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 87.61%

Reviewed

Last reviewed on 2024-08-14.

Cite this Page

Ryanodine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/ryanodine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000608). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(C)[C@@]1(O)[C@@H](OC(=O)c2ccc[nH]2)[C@@]2(O)[C@@]3(C)C[C@]4(O)O[C@@]5([C@H](O)[C@@H](C)CC[C@]35O)[C@@]2(O)[C@@]41C
InChI: InChI=1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19+,20-,21-,22+,23+,24+,25+/m0/s1

描述信息

An insecticide alkaloid isolated from South American plant Ryania speciosa.
Ryania is a natural product found in Ryania speciosa and Spigelia anthelmia with data available.
Ryanodine is a poisonous alkaloid found in the South American plant Ryania speciosa (Flacourtiaceae). It was originally used as an insecticide. The compound has extremely high affinity to the open-form ryanodine receptor, a group of calcium channels found in skeletal muscle, smooth muscle, and heart muscle cells. It binds with such high affinity to the receptor that it was used as a label for the first purification of that class of ion channels and gave its name to it.
A methylpyrrole-carboxylate from RYANIA that disrupts the RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL to modify CALCIUM release from SARCOPLASMIC RETICULUM resulting in alteration of MUSCLE CONTRACTION. It was previously used in INSECTICIDES. It is used experimentally in conjunction with THAPSIGARGIN and other inhibitors of CALCIUM ATPASE uptake of calcium into SARCOPLASMIC RETICULUM.

同义名列表

18 个代谢物同义名

Ryanodine; 1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,6aS,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo(1,2)pentaleno(1,6-bc)furan-8-yl ester; 6-(1alpha,5Abeta,8abeta,9-pentahydroxy-7beta-isopropyl-2beta,5beta,8beta-trimethylperhydro-8balpha,9-epoxy-5,8-ethanocyclopenta(1,2-b)indenyl) pyrrole-2-carboxylate; Ground ryania specisa(vahl) stemwood (alkoloid ryanodine); Ryania speciosa, powdered stems of; Ryanodine, >=98\\% (HPLC); UNII-37H6ATE4SA; RYANODINE [MI]; Bonide ryatox; (+)-RYANODINE; Ryania powder; Ryania [ISO]; 37H6ATE4SA; Ryanicide; Ryanexel; Ryanex; Ryania; Ryanodine



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

25 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 AXIN2, CA1, CA3, FKBP1A, ITPR3, RYR1
Peripheral membrane protein 1 FKBP1A
Endoplasmic reticulum membrane 4 HSP90B1, ITPR1, ITPR3, PLN
Mitochondrion membrane 1 PLN
Nucleus 3 AXIN2, HSP90B1, PLCZ1
cytosol 7 AXIN2, CA1, CA3, FKBP1A, HSP90B1, PLCZ1, PRKCQ
dendrite 1 SLC8A1
mitochondrial membrane 1 PLN
centrosome 1 AXIN2
nucleoplasm 5 ATP2B1, CD2, ITPR3, PLCZ1, SLC8A1
Cell membrane 4 ADRB3, ATP2B1, CD2, SLC8A1
Cytoplasmic side 1 FKBP1A
Multi-pass membrane protein 9 ADRB3, ATP2B1, CACNA1I, ITPR1, ITPR3, RYR1, RYR2, RYR3, SLC8A1
Synapse 2 ATP2B1, SLC8A1
cell cortex 1 RYR1
cell junction 1 SLC8A1
cell surface 1 CD2
glutamatergic synapse 1 ATP2B1
Golgi apparatus 1 CD2
Golgi membrane 1 INS
neuronal cell body 2 ITPR3, SLC8A1
postsynapse 1 SLC8A1
presynaptic membrane 1 ATP2B1
sarcolemma 4 RYR1, RYR2, RYR3, SLC8A1
smooth endoplasmic reticulum 4 HSP90B1, RYR1, RYR2, RYR3
Cytoplasm, cytosol 1 FKBP1A
plasma membrane 12 ADRB3, ATP2B1, AXIN2, CACNA1I, CD2, ITPR1, ITPR3, KNG1, PRKCQ, RYR1, RYR2, SLC8A1
synaptic vesicle membrane 1 ATP2B1
Membrane 11 ATP2B1, CACNA1I, FKBP1A, HSP90B1, ITPR1, ITPR3, PLN, RYR1, RYR2, RYR3, SLC8A1
axon 1 SLC8A1
basolateral plasma membrane 1 ATP2B1
brush border 1 ITPR3
extracellular exosome 5 ATP2B1, CA1, HSP90B1, KNG1, RYR1
endoplasmic reticulum 4 HSP90B1, ITPR1, ITPR3, PLN
extracellular space 2 INS, KNG1
perinuclear region of cytoplasm 4 HSP90B1, ITPR1, PLCZ1, PLN
Schaffer collateral - CA1 synapse 1 ITPR1
intercalated disc 1 SLC8A1
mitochondrion 1 PLN
protein-containing complex 3 CD2, HSP90B1, RYR2
intracellular membrane-bounded organelle 1 ATP2B1
postsynaptic density 2 ITPR1, SLC8A1
pronucleus 1 PLCZ1
Single-pass type I membrane protein 1 CD2
Secreted 1 INS
extracellular region 4 CD2, HSP90B1, INS, KNG1
cytoplasmic side of plasma membrane 1 CD2
Single-pass membrane protein 1 PLN
centriolar satellite 1 PRKCQ
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 CD2
T-tubule 1 SLC8A1
calcineurin complex 1 ITPR1
Z disc 5 FKBP1A, RYR1, RYR2, RYR3, SLC8A1
beta-catenin destruction complex 1 AXIN2
nucleolus 3 ITPR1, ITPR3, PLCZ1
midbody 1 HSP90B1
apical part of cell 1 ITPR3
cell-cell junction 1 CD2
Cytoplasm, perinuclear region 2 ITPR1, PLCZ1
focal adhesion 1 HSP90B1
sarcoplasmic reticulum 6 FKBP1A, ITPR1, ITPR3, PLN, RYR1, RYR2
collagen-containing extracellular matrix 2 HSP90B1, KNG1
lateral plasma membrane 1 ATP2B1
nuclear inner membrane 1 ITPR1
nuclear outer membrane 1 ITPR3
receptor complex 2 ADRB3, ITPR3
cell projection 1 ATP2B1
cell periphery 1 SLC8A1
Secreted, extracellular space 1 KNG1
blood microparticle 1 KNG1
Basolateral cell membrane 1 ATP2B1
organelle membrane 1 RYR1
Endomembrane system 1 ITPR1
endosome lumen 1 INS
I band 1 RYR1
Melanosome 1 HSP90B1
Presynaptic cell membrane 1 ATP2B1
sperm plasma membrane 1 HSP90B1
platelet dense granule membrane 1 ITPR1
secretory granule lumen 1 INS
secretory granule membrane 2 ITPR1, ITPR3
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 HSP90B1, INS, KNG1
platelet alpha granule lumen 1 KNG1
axon terminus 1 SLC8A1
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
Sarcoplasmic reticulum membrane 5 FKBP1A, PLN, RYR1, RYR2, RYR3
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 2 ATP2B1, PRKCQ
aggresome 1 PRKCQ
Sarcoplasmic reticulum lumen 1 HSP90B1
calcium channel complex 3 RYR1, RYR2, RYR3
junctional sarcoplasmic reticulum membrane 2 RYR1, RYR2
platelet dense tubular network membrane 2 ITPR1, ITPR3
Cytoplasmic vesicle, secretory vesicle membrane 2 ITPR1, ITPR3
terminal cisterna 2 FKBP1A, RYR1
endocytic vesicle lumen 1 HSP90B1
transport vesicle membrane 2 ITPR1, ITPR3
sperm head 1 PLCZ1
platelet dense tubular network 1 ITPR1
endoplasmic reticulum chaperone complex 1 HSP90B1
photoreceptor ribbon synapse 1 ATP2B1
calcium ion-transporting ATPase complex 1 PLN
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
ryanodine receptor complex 2 FKBP1A, RYR1
cytoplasmic side of membrane 1 FKBP1A


文献列表

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  • Zhuang Zhang, Kaixin Li, Wei Xu, Ni Liang, Dong Chu, Lei Guo. Characterization of the ryanodine receptor gene in Encarsia formosa (Gahan) and its expression profile in response to diamide insecticides. Pesticide biochemistry and physiology. 2021 Oct; 178(?):104921. doi: 10.1016/j.pestbp.2021.104921. [PMID: 34446197]
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