NCBI Taxonomy: 26495
Spigelia (ncbi_taxid: 26495)
found 4 associated metabolites at genus taxonomy rank level.
Ancestor: Loganiaceae
Child Taxonomies: Spigelia anthelmia, Spigelia texana, Spigelia marilandica, Spigelia speciosa, Spigelia pulchella, Spigelia genuflexa, Spigelia scabrella, Spigelia splendens, Spigelia hedyotidea, Spigelia loganioides, Spigelia hamelioides, Spigelia linarioides, Spigelia gentianoides, Spigelia humboldtiana, unclassified Spigelia, Spigelia paraguariensis, Spigelia coelostylioides
Ryanodine
An insecticide alkaloid isolated from South American plant Ryania speciosa. Ryania is a natural product found in Ryania speciosa and Spigelia anthelmia with data available. Ryanodine is a poisonous alkaloid found in the South American plant Ryania speciosa (Flacourtiaceae). It was originally used as an insecticide. The compound has extremely high affinity to the open-form ryanodine receptor, a group of calcium channels found in skeletal muscle, smooth muscle, and heart muscle cells. It binds with such high affinity to the receptor that it was used as a label for the first purification of that class of ion channels and gave its name to it. A methylpyrrole-carboxylate from RYANIA that disrupts the RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL to modify CALCIUM release from SARCOPLASMIC RETICULUM resulting in alteration of MUSCLE CONTRACTION. It was previously used in INSECTICIDES. It is used experimentally in conjunction with THAPSIGARGIN and other inhibitors of CALCIUM ATPASE uptake of calcium into SARCOPLASMIC RETICULUM.
