Olanzapine (BioDeep_00000002533)
Secondary id: BioDeep_00000275606
human metabolite Chemicals and Drugs
代谢物信息卡片
5-methyl-8-(4-methylpiperazin-1-yl)-4-thia-2,9-diazatricyclo[8.4.0.0³,⁷]tetradeca-1(14),3(7),5,8,10,12-hexaene
化学式: C17H20N4S (312.1409)
中文名称: 奥氮平
谱图信息:
最多检出来源 Viridiplantae(plant) 13.08%
Reviewed
Last reviewed on 2024-09-14.
Cite this Page
Olanzapine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/olanzapine (retrieved
2024-12-23) (BioDeep RN: BioDeep_00000002533). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CC1=CC(C(N2CCN(C)CC2)=N3)=C(S1)NC4=C3C=CC=C4
InChI: InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
描述信息
Olanzapine was the third atypical antipsychotic to gain approval by the Food and Drug Administration (FDA) and has become one of the most commonly used atypical antipsychotics. Olanzapine has been approved by the FDA for the treatment of schizophrenia, acute mania in bipolar disorder, agitation associated with schizophrenia and bipolar disorder, and as maintenance treatment in bipolar disorder and psychotic depression. It has also been established in treating depression off-label because of its mood-stabilizing properties and its ability to increase the efficacy of antidepressants. Olanzapine is manufactured and marketed by the pharmaceutical company Eli Lilly and Company. It is available as a pill that comes in the strengths of 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, and 20 mg and as as Zydis orally disintegrating tablets in the strengths of 5 mg, 10 mg, 15 mg, and 20 mg. It is also available as a rapid-acting intramuscular injection for short term acute use. Olanzapine (oh-LAN-za-peen, sold as Zyprexa, Zydis, or in combination with fluoxetine, as Symbyax) was the third atypical antipsychotic to gain approval by the Food and Drug Administration (FDA) and has become one of the most commonly used atypical antipsychotics. Olanzapine has been approved by the FDA for the treatment of schizophrenia, acute mania in bipolar disorder, agitation associated with schizophrenia and bipolar disorder, and as maintenance treatment in bipolar disorder and psychotic depression.
Olanzapine was the third atypical antipsychotic to gain approval by the Food and Drug Administration (FDA) and has become one of the most commonly used atypical antipsychotics. Olanzapine has been approved by the FDA for the treatment of schizophrenia, acute mania in bipolar disorder, agitation associated with schizophrenia and bipolar disorder, and as maintenance treatment in bipolar disorder and psychotic depression.
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AH - Diazepines, oxazepines, thiazepines and oxepines
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017367 - Selective Serotonin Reuptake Inhibitors
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
CONFIDENCE standard compound; INTERNAL_ID 1517
D049990 - Membrane Transport Modulators
Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic[1][2].
同义名列表
13 个代谢物同义名
5-methyl-8-(4-methylpiperazin-1-yl)-4-thia-2,9-diazatricyclo[8.4.0.0³,⁷]tetradeca-1(14),3(7),5,8,10,12-hexaene; 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine; Zyprexa intramuscular; Olanzapine pamoate; Zyprexa zydis; Olanzapinum; olanzapine; Olanzapina; Zolafren; Zyprexa; Lanzac; LY170053; Olanzapine
数据库引用编号
30 个数据库交叉引用编号
- ChEBI: CHEBI:94534
- ChEBI: CHEBI:7735
- KEGG: C07322
- KEGGdrug: D00454
- PubChem: 135398745
- HMDB: HMDB0005012
- Metlin: METLIN58286
- DrugBank: DB00334
- ChEMBL: CHEMBL715
- Wikipedia: Olanzapine
- MeSH: Olanzapine
- foodb: FDB023585
- chemspider: 10442212
- CAS: 132539-06-1
- MoNA: AU151701
- MoNA: AU151707
- MoNA: AU151708
- MoNA: AU151705
- MoNA: AU151703
- MoNA: AU151709
- MoNA: AU151702
- MoNA: AU151710
- MoNA: AU151711
- MoNA: AU151704
- PMhub: MS000003435
- PubChem: 9530
- NIKKAJI: J489.991A
- RefMet: Olanzapine
- medchemexpress: HY-14541
- KNApSAcK: 7735
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tong Zhu, Hongxia Zhao, Yufan Chao, Songyan Gao, Xin Dong, Zuowei Wang. Olanzapine-induced weight gain and lipid dysfunction in mice between different gender.
Biomedical chromatography : BMC.
2024 Jun; 38(6):e5864. doi:
10.1002/bmc.5864. [PMID: 38551083] - Rupinder Kaur Sodhi, Hemant Kumar, Raghunath Singh, Yashika Bansal, Yuvraj Singh, Kanthi Kiran Kondepudi, Mahendra Bishnoi, Anurag Kuhad. Allyl isothiocyanate, a TRPA1 agonist, protects against olanzapine-induced hypothalamic and hepatic metabolic aberrations in female mice.
Biochemical pharmacology.
2024 Apr; 222(?):116074. doi:
10.1016/j.bcp.2024.116074. [PMID: 38395265] - Lu Liu, Lei Tang, Jia-Ming Luo, Si-Yu Chen, Chun-Yan Yi, Xue-Mei Liu, Chang-Hua Hu. Activation of the PERK-CHOP signaling pathway during endoplasmic reticulum stress contributes to olanzapine-induced dyslipidemia.
Acta pharmacologica Sinica.
2024 Mar; 45(3):502-516. doi:
10.1038/s41401-023-01180-w. [PMID: 37880338] - Cuirong Zeng, Hui Chen, Ting Cao, Liwei Wang, Shimeng Jiao, Chenquan Lin, Bikui Zhang, Hualin Cai. B-GOS alleviates olanzapine-induced lipid disturbances in mice by enriching Akkermansia and upregulation of PGRMC1-Wnt signaling.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2024 Mar; 185(?):114490. doi:
10.1016/j.fct.2024.114490. [PMID: 38325638] - Piaopiao Huang, Juanli Ran, Wenqiang Zhu, Wen Dai, Yaxin Tang, Pingan Lian, Xiansheng Huang, Rong Li. PCSK9 dysregulates cholesterol homeostasis and triglyceride metabolism in olanzapine-induced hepatic steatosis via both receptor-dependent and receptor-independent pathways.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2024 Feb; 38(4):e23464. doi:
10.1096/fj.202301748r. [PMID: 38358343] - Katerina Horska, Silje Skrede, Jan Kucera, Gabriela Kuzminova, Pavel Suchy, Vincenzo Micale, Jana Ruda-Kucerova. Olanzapine, but not haloperidol, exerts pronounced acute metabolic effects in the methylazoxymethanol rat model.
CNS neuroscience & therapeutics.
2024 02; 30(2):e14565. doi:
10.1111/cns.14565. [PMID: 38421095] - Reham H Mohyeldin, Walaa Yehia Abdelzaher, Ehab E Sharata, Hamza M A Mohamed, Mohamed Y M Ahmed, Josef Zekry Attia, Medhat Atta, Rabeh Khairy Saleh, Elshimaa A Ghallab, Heba Marey, Mahmoud A Elrehany, Remon Roshdy Rofaeil. Aprepitant boasted a protective effect against olanzapine-induced metabolic syndrome and its subsequent hepatic, renal, and ovarian dysfunction; Role of IGF1/p-AKT/FOXO1 and NFκB/IL-1β/TNF-α signaling pathways in female Wistar albino rats.
Biochemical pharmacology.
2024 Jan; 221(?):116020. doi:
10.1016/j.bcp.2024.116020. [PMID: 38237301] - Marco Pozzi, Chiara Vantaggiato, Francesca Brivio, Genny Orso, Maria Teresa Bassi. Olanzapine, risperidone and ziprasidone differently affect lysosomal function and autophagy, reflecting their different metabolic risk in patients.
Translational psychiatry.
2024 Jan; 14(1):13. doi:
10.1038/s41398-023-02686-x. [PMID: 38191558] - Yu-Feng Zuo, Bao-Hua Zhang, Ming-Rui Guo, Ben-Ben Li, Bao-Cui Wang, Deng Duan, Yu-Xin Wang, Jing Xi, Meng He, Tao-Lei Sun. HFD-exacerbated Metabolic Side Effects of Olanzapine Are Suppressed by ER Stress Inhibitor.
Current medical science.
2023 Dec; 43(6):1116-1132. doi:
10.1007/s11596-023-2781-y. [PMID: 38079053] - Hesham Shamshoum, Kyle D Medak, Greg L McKie, Stewart Jeromson, Margaret K Hahn, David C Wright. Salsalate and/or metformin therapy confer beneficial metabolic effects in olanzapine treated female mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Dec; 168(?):115671. doi:
10.1016/j.biopha.2023.115671. [PMID: 37839107] - Ruili Dang, Jing Wang, Mimi Tang, Wenxiu Han, Pei Jiang. Vitamin D Receptor Activation Attenuates Olanzapine-Induced Dyslipidemia in Mice Through Alleviating Hepatic Endoplasmic Reticulum Stress.
Advanced biology.
2023 Dec; 7(12):e2300228. doi:
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Molecular biology reports.
2023 Sep; ?(?):. doi:
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Metabolic syndrome and related disorders.
2023 Jun; ?(?):. doi:
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The international journal of neuropsychopharmacology.
2023 Jun; ?(?):. doi:
10.1093/ijnp/pyad029. [PMID: 37326421] - Yueqing Su, Chao Deng, Xuemei Liu, Jiamei Lian. Epigenetic Histone Methylation of PPARγ and CPT1A Signaling Contributes to Betahistine Preventing Olanzapine-Induced Dyslipidemia.
International journal of molecular sciences.
2023 May; 24(11):. doi:
10.3390/ijms24119143. [PMID: 37298094] - Zhe Lu, Yuyanan Zhang, Yaoyao Sun, Yundan Liao, Zhewei Kang, Xiaoyang Feng, Hao Yan, Lifang Wang, Tianlan Lu, Dai Zhang, Weihua Yue. Therapeutic Outcomes Wide Association Scan of different antipsychotics in patients with schizophrenia: randomized clinical trials and multi-ancestry validation.
Psychiatry and clinical neurosciences.
2023 May; ?(?):. doi:
10.1111/pcn.13567. [PMID: 37210704] - Vitor Ferreira, Cintia Folgueira, María García-Altares, Maria Guillén, Mónica Ruíz-Rosario, Giada DiNunzio, Irma Garcia-Martinez, Rosa Alen, Christoph Bookmeyer, John G Jones, Juan C Cigudosa, Pilar López-Larrubia, Xavier Correig-Blanchar, Roger J Davis, Guadalupe Sabio, Patricia Rada, Ángela M Valverde. Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition.
Redox biology.
2023 May; 63(?):102741. doi:
10.1016/j.redox.2023.102741. [PMID: 37230004] - Mehmet Alper Arslan, Özgür Korhan Tunçel, Birşen Bilgici, Arzu Karaustaoğlu, Taner İlker Gümrükçüoğlu. Increased levels of lipid and protein oxidation in rat prefrontal cortex after treatment by lithium, valproic acid, and olanzapine.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Apr; ?(?):. doi:
10.1007/s00210-023-02494-6. [PMID: 37093250] - ZhenYu Zhu, Ting Cao, Hui Chen, BiKui Zhang, ChenQuan Lin, HuaLin Cai. Olanzapine-induced nonalcoholic fatty liver disease: The effects of differential food pattern and the involvement of PGRMC1 signaling.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2023 Apr; ?(?):113757. doi:
10.1016/j.fct.2023.113757. [PMID: 37019375] - Xiufen Jiang, Xifeng Teng, Huiwen Shi, Liudan Cao, Lin He, Qiong Gu. Discovery and optimization of olanzapine derivatives as new ferroptosis inhibitors.
Bioorganic chemistry.
2023 04; 133(?):106393. doi:
10.1016/j.bioorg.2023.106393. [PMID: 36731296] - Flávia Natividade da Silva, Priscila Laiz Zimath, Thais Alves do Amaral, José Rodrigo Nascimento Martins, Alex Rafacho. Coadministration of olanzapine causes minor impacts on the diabetogenic outcomes induced by dexamethasone treatment in rats.
Life sciences.
2023 Apr; 322(?):121660. doi:
10.1016/j.lfs.2023.121660. [PMID: 37011876] - Jingda Cai, Li Li, Tiannan Shao, Mengxi Sun, Weiyan Wang, Peng Xie, Xiaoyi Wang, Ye Yang, Yujun Long, Dongyu Kang, Jingmei Xiao, Yuhan Su, Xingjie Peng, Yuyan Huang, Menghui Gao, Qiongqiong Wu, Chuhan Song, Furu Liu, Ping Shao, Jianjun Ou, Yidong Shen, Jing Huang, Renrong Wu. Relapse in patients with schizophrenia and amisulpride-induced hyperprolactinemia or olanzapine-induced metabolic disturbance after switching to other antipsychotics.
Psychiatry research.
2023 Mar; 322(?):115138. doi:
10.1016/j.psychres.2023.115138. [PMID: 36871411] - Milica Vranic, Fozia Ahmed, Susanne Hetty, Assel Sarsenbayeva, Vitor Ferreira, Giovanni Fanni, Ángela M Valverde, Jan W Eriksson, Maria J Pereira. Effects of the second-generation antipsychotic drugs aripiprazole and olanzapine on human adipocyte differentiation.
Molecular and cellular endocrinology.
2023 Feb; 561(?):111828. doi:
10.1016/j.mce.2022.111828. [PMID: 36526026] - Marie Reeberg Sass, Andreas Aalkjær Danielsen, Ole Köhler-Forsberg, Heidi Storgaard, Filip K Knop, Mette Ødegaard Nielsen, Anders Mikael Sjödin, Ole Mors, Christoph U Correll, Claus Ekstrøm, Maj Vinberg, Jimmi Nielsen, Tina Vilsbøll, Anders Fink-Jensen. Effect of the GLP-1 receptor agonist semaglutide on metabolic disturbances in clozapine-treated or olanzapine-treated patients with a schizophrenia spectrum disorder: study protocol of a placebo-controlled, randomised clinical trial (SemaPsychiatry).
BMJ open.
2023 01; 13(1):e068652. doi:
10.1136/bmjopen-2022-068652. [PMID: 36720576] - Xulu Chang, Yihao Shen, Lili Yun, Xianfeng Wang, Junchang Feng, Guokun Yang, Xiaolin Meng, Jianxin Zhang, Xi Su. The antipsychotic drug olanzapine altered lipid metabolism in the common carp (Cyprinus carpio L.): Insight from the gut microbiota-SCFAs-liver axis.
The Science of the total environment.
2023 Jan; 856(Pt 1):159054. doi:
10.1016/j.scitotenv.2022.159054. [PMID: 36170916] - Mariana Alves Soares, André Luiz A Costa, Natália L C Silva, Aline França Martins, Daiane Oliveira Matias, Olga M O Araujo, Ricardo Tadeu Lopes, Christina Maeda Takiya, Ana Luisa P Miranda, Leandro Miranda-Alves, Jorge L M Tributino. Atypical antipsychotics olanzapine and clozapine increase bone loss in female rats with experimental periodontitis.
Journal of periodontal research.
2022 Dec; ?(?):. doi:
10.1111/jre.13090. [PMID: 36575324] - Madhura P Dixit, Shivkumar S Sammeta, Mrunali D Dhokne, Shubhada Mangrulkar, Manoj A Upadhya, Milind J Umekar, Brijesh G Taksande, Nandkishor R Kotagale. Chronic agmatine treatment prevents olanzapine-induced obesity and metabolic dysregulation in female rats.
Brain research bulletin.
2022 12; 191(?):69-77. doi:
10.1016/j.brainresbull.2022.10.013. [PMID: 36272666] - Hezhong Ouyang, Jinquan Hu, XingYing Qiu, Shaochang Wu, Fudong Guo, Youguo Tan. Improved biopharmaceutical performance of antipsychotic drug using lipid nanoparticles via intraperitoneal route.
Pharmaceutical development and technology.
2022 Sep; 27(7):853-863. doi:
10.1080/10837450.2022.2124521. [PMID: 36124550] - Reeha Sharon, Theis Lange, Mia Aakjær, Sarah Brøgger Kristiansen, Morten Baltzer Houlind, Morten Andersen. Incidence of hospital contacts with acute kidney injury after initiation of second-generation antipsychotics in older adults: a Danish population-based cohort study.
European journal of clinical pharmacology.
2022 Aug; 78(8):1341-1349. doi:
10.1007/s00228-022-03339-6. [PMID: 35639132] - Xuan Wang, Meihong Xiu, Keqiang Wang, Xiuru Su, Xirong Li, Fengchun Wu. Plasma linoelaidyl carnitine levels positively correlated with symptom improvement in olanzapine-treated first-episode drug-naïve schizophrenia.
Metabolomics : Official journal of the Metabolomic Society.
2022 07; 18(7):50. doi:
10.1007/s11306-022-01909-4. [PMID: 35819637] - Snežana Đorđević, Nataša Perković Vukčević, Marko Antunović, Vesna Kilibarda, Gordana Vuković Ercegović, Jasmina Jović Stošić, Slavica Vučinić. Olanzapine poisoning in patients treated at the National Poison Control Centre in Belgrade, Serbia in 2017 and 2018: a brief review of serum concentrations and clinical symptoms.
Arhiv za higijenu rada i toksikologiju.
2022 Jul; 73(2):126-130. doi:
10.2478/aiht-2022-73-3635. [PMID: 35792773] - Adebola Oluwabusayo Adetiloye, Wael Abdelmottaleb, Mirza Fawad Ahmed, Ana Maria Victoria, Mustafa Bilal Ozbay, Julio C Valencia Manrique, Rasha Alaameri, Olurotimi Badero, Savi Mushiyev. Clozapine-Induced Myocarditis in a Young Man with Refractory Schizophrenia: Case Report of a Rare Adverse Event and Review of the Literature.
The American journal of case reports.
2022 Jul; 23(?):e936306. doi:
10.12659/ajcr.936306. [PMID: 35793273] - Mohamed Ismail, Thomas Straubinger, Hiroyuki Uchida, Ariel Graff-Guerrero, Shinichiro Nakajima, Takefumi Suzuki, Fernando Caravaggio, Philip Gerretsen, David Mamo, Benoit H Mulsant, Bruce G Pollock, Robert Bies. MAP Bayesian modelling combining striatal dopamine receptor occupancy and plasma concentrations to optimize antipsychotic dose regimens in individual patients.
British journal of clinical pharmacology.
2022 07; 88(7):3341-3350. doi:
10.1111/bcp.15260. [PMID: 35112390] - Rong Li, Wenqiang Zhu, Piaopiao Huang, Chen Ding, Yaxin Tang, Ping'an Lian, Xiansheng Huang. Olanzapine causes non-alcoholic fatty liver disease via inhibiting the secretion of apolipoprotein A5.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2022 Jun; 47(6):730-738. doi:
10.11817/j.issn.1672-7347.2022.210269. [PMID: 35837772] - Theocharis Chr Kyziridis. [Clinical pharmacokinetics and pharmaceutical forms of long-acting injectable antipsychotics].
Psychiatrike = Psychiatriki.
2022 Jun; 33(2):139-148. doi:
10.22365/jpsych.2021.035. [PMID: 34390562] - Hesham Salem, Ebtihal Samir, Dina Z Mazen, Hoda Madian, Alshimaa E Elkhateeb, Manar Elaraby, Manar I Rasekh, Aliaa Gamal. Spectrofluorimetric first derivative synchronous approach for determination of olanzapine and samidorphan used for treatment of schizophrenia in pharmaceutical formulations and human plasma.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Jun; 274(?):121105. doi:
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CNS spectrums.
2022 06; 27(3):347-354. doi:
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The Journal of physiology.
2022 06; 600(11):2713-2728. doi:
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The Psychiatric quarterly.
2022 06; 93(2):627-635. doi:
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Scientific reports.
2022 04; 12(1):5639. doi:
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Psychiatry research.
2022 04; 310(?):114443. doi:
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Basic & clinical pharmacology & toxicology.
2022 Apr; 130(4):531-541. doi:
10.1111/bcpt.13715. [PMID: 35150056] - Jacopo Pruccoli, Antonia Parmeggiani. Inpatient treatment of anorexia nervosa with adjunctive valproate: a case series of 14 young and adolescent patients.
Eating and weight disorders : EWD.
2022 Apr; 27(3):1209-1215. doi:
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BMC psychiatry.
2022 03; 22(1):210. doi:
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Schizophrenia research.
2022 03; 241(?):140-141. doi:
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Revue medicale de Liege.
2022 Feb; 77(2):80-84. doi:
NULL. [PMID: 35143126] - Frederico G S Toledo, William F Martin, Linda Morrow, Carine Beysen, Daiva Bajorunas, Ying Jiang, Bernard L Silverman, David McDonnell, Mark N Namchuk, John W Newcomer, Christine Graham. Insulin and glucose metabolism with olanzapine and a combination of olanzapine and samidorphan: exploratory phase 1 results in healthy volunteers.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2022 02; 47(3):696-703. doi:
10.1038/s41386-021-01244-7. [PMID: 34887529] - Shivprakash Nagaraj Kanagali, B M Patil, Pukar Khanal, Banappa S Unger. Cyperus rotundus L. reverses the olanzapine-induced weight gain and metabolic changes-outcomes from network and experimental pharmacology.
Computers in biology and medicine.
2022 02; 141(?):105035. doi:
10.1016/j.compbiomed.2021.105035. [PMID: 34802711] - Mostafa M Abbas, Paul Soto, Latha Ramalingam, Yasser El-Manzalawy, Halima Bensmail, Naima Moustaid-Moussa. Sex Differences in Fish Oil and Olanzapine Effects on Gut Microbiota in Diet-Induced Obese Mice.
Nutrients.
2022 Jan; 14(2):. doi:
10.3390/nu14020349. [PMID: 35057526] - Jing Huang, Jingmei Xiao, Zhuang Peng, Ping Shao, Mengxi Sun, Yujun Long, Xiaoyi Wang, Manjun Shen, Dongyu Kang, Ye Yang, Xingjie Peng, Weiyan Wang, Peng Xie, Tiannan Shao, Jingping Zhao, Renrong Wu. PCSK9 mediates dyslipidemia induced by olanzapine treatment in schizophrenia patients.
Psychopharmacology.
2022 Jan; 239(1):83-91. doi:
10.1007/s00213-021-06042-z. [PMID: 35029705] - Aya Galal, Wesam M El-Bakly, Sara S El-Kilany, Azza A Ali, Ebtehal El-Demerdash. Fenofibrate ameliorates olanzapine's side effects without altering its central effect: emphasis on FGF-21-adiponectin axis.
Behavioural pharmacology.
2021 12; 32(8):615-629. doi:
10.1097/fbp.0000000000000656. [PMID: 34637209] - S Wang, J Li, M Song, P Yan, X Ju, J Liu, C Wang, J Shi. Effect of CYP2C19 polymorphisms on serum valproic level acid in Chinese Han patients with schizophrenia.
Scientific reports.
2021 11; 11(1):23150. doi:
10.1038/s41598-021-02628-x. [PMID: 34848811] - Armita Abolghasemi, Claudia Manca, Fabio A Iannotti, Melissa Shen, Nadine Leblanc, Sébastien Lacroix, Cyril Martin, Nicolas Flamand, Vincenzo Di Marzo, Cristoforo Silvestri. Assessment of the Effects of Dietary Vitamin D Levels on Olanzapine-Induced Metabolic Side Effects: Focus on the Endocannabinoidome-Gut Microbiome Axis.
International journal of molecular sciences.
2021 Nov; 22(22):. doi:
10.3390/ijms222212361. [PMID: 34830242] - Yuan Xu, Jian Lu, Bingyi Yao, Yuanjin Zhang, Shengbo Huang, Jie Liu, Yanfang Zhang, Yuanqing Guo, Xin Wang. P-glycoprotein mediates the pharmacokinetic interaction of olanzapine with fluoxetine in rats.
Toxicology and applied pharmacology.
2021 11; 431(?):115735. doi:
10.1016/j.taap.2021.115735. [PMID: 34610281] - Dongmei Han, Daliang Sun, Meihong Xiu, Xiu Su, Jun Wang, Jun Li, Dong Wang. Association between the improvement in depressive symptoms and serum BDNF levels in drug-naive first episode patients with schizophrenia: A longitudinal follow-up.
Psychoneuroendocrinology.
2021 11; 133(?):105392. doi:
10.1016/j.psyneuen.2021.105392. [PMID: 34428640] - Andrea Del Campo, Catalina Salamanca, Angelo Fajardo, Francisco Díaz-Castro, Catalina Bustos, Camila Calfío, Rodrigo Troncoso, Edgar R Pastene-Navarrete, Claudio Acuna-Castillo, Luis A Milla, Carlos A Villarroel, Francisco A Cubillos, Mario Aranda, Leonel E Rojo. Anthocyanins from Aristotelia chilensis Prevent Olanzapine-Induced Hepatic-Lipid Accumulation but Not Insulin Resistance in Skeletal Muscle Cells.
Molecules (Basel, Switzerland).
2021 Oct; 26(20):. doi:
10.3390/molecules26206149. [PMID: 34684731] - Julia Sagahón-Azúa, Susanna Edith Medellín-Garibay, Cinthya Eloisa Chávez-Castillo, César Guillermo González-Salinas, Rosa Del Carmen Milán-Segovia, Silvia Romano-Moreno. Factors associated with fluoxetine and norfluoxetine plasma concentrations and clinical response in Mexican patients with mental disorders.
Pharmacology research & perspectives.
2021 10; 9(5):e00864. doi:
10.1002/prp2.864. [PMID: 34523245] - Ghada S Mahmoud, Ghada Hosny, Sally A Sayed. Hepatoprotective effect of trypsin/chymotrypsin against olanzapine-induced non-alcoholic steatohepatitis in rats.
Canadian journal of physiology and pharmacology.
2021 Oct; 99(10):1088-1096. doi:
10.1139/cjpp-2021-0075. [PMID: 34473596] - Lei Sun, Zoe Barter, Lisa von Moltke, Karen Rowland Yeo. Using physiologically-based pharmacokinetic modeling for predicting the effects of hepatic impairment on the pharmacokinetics of olanzapine and samidorphan given as a combination tablet.
CPT: pharmacometrics & systems pharmacology.
2021 09; 10(9):1071-1080. doi:
10.1002/psp4.12675. [PMID: 34185436] - Rong Li, Wenqiang Zhu, Piaopiao Huang, Yang Yang, Fei Luo, Wen Dai, Li Shen, Wenjing Pei, Xiansheng Huang. Olanzapine leads to nonalcoholic fatty liver disease through the apolipoprotein A5 pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Sep; 141(?):111803. doi:
10.1016/j.biopha.2021.111803. [PMID: 34146854] - Dongquan Huang, Jie Gao, Chong Li, Caihong Nong, Wenting Huang, Xifen Zheng, Sirou Li, Yongzheng Peng. A potential probiotic bacterium for antipsychotic-induced metabolic syndrome: mechanisms underpinning how Akkermansia muciniphila subtype improves olanzapine-induced glucose homeostasis in mice.
Psychopharmacology.
2021 Sep; 238(9):2543-2553. doi:
10.1007/s00213-021-05878-9. [PMID: 34046717] - Jia Hong Liu, Nan Chen, Yan Hong Guo, Xiao Ni Guan, Jun Wang, Dong Wang, Mei Hong Xiu. Metabolomics-based understanding of the olanzapine-induced weight gain in female first-episode drug-naïve patients with schizophrenia.
Journal of psychiatric research.
2021 08; 140(?):409-415. doi:
10.1016/j.jpsychires.2021.06.001. [PMID: 34144444] - Alastair J Flint, Anthony J Rothschild, Ellen M Whyte, George S Alexopoulos, Benoit H Mulsant, Patricia Marino, Samprit Banerjee, Cristina D Pollari, Yiyuan Wu, Aristotle N Voineskos, Barnett S Meyers. Effect of Older vs Younger Age on Anthropometric and Metabolic Variables During Treatment of Psychotic Depression With Sertraline Plus Olanzapine: The STOP-PD II Study.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.
2021 07; 29(7):645-654. doi:
10.1016/j.jagp.2020.11.003. [PMID: 33268022] - Chengliang Wang, Liying Ren, Shankang Chen, Huihui Zheng, Yifan Yang, Tieguang Gu, Yuhao Li, Chunxia Wang. Longdan Xiegan Tang attenuates liver injury and hepatic insulin resistance by regulating the angiotensin-converting enzyme 2/Ang (1-7)/Mas axis-mediated anti-inflammatory pathway in rats.
Journal of ethnopharmacology.
2021 Jun; 274(?):114072. doi:
10.1016/j.jep.2021.114072. [PMID: 33781876] - René S Kahn, Bernard L Silverman, Lauren DiPetrillo, Christine Graham, Ying Jiang, Jiani Yin, Adam Simmons, Vasudev Bhupathi, Bei Yu, Sergey Yagoda, Craig Hopkinson, David McDonnell. A phase 3, multicenter study to assess the 1-year safety and tolerability of a combination of olanzapine and samidorphan in patients with schizophrenia: Results from the ENLIGHTEN-2 long-term extension.
Schizophrenia research.
2021 06; 232(?):45-53. doi:
10.1016/j.schres.2021.04.009. [PMID: 34015555] - Ali Nowrouzi, Sepideh Kafiabasabadi, Mario Rodriguez-Calzadilla, Javier Benitez-Del-Castillo, Alejandro Soto-Guerrero, Antonio Diaz-Ramos, Kyara Vaneska Marques-Cavalcante. Central retinal vein occlusion in a patient using the antipsychotic drug olanzapine: a case report.
Journal of medical case reports.
2021 May; 15(1):307. doi:
10.1186/s13256-021-02865-8. [PMID: 34049568] - Yan-Nan Zang, Fang Dong, An-Ning Li, Chuan-Yue Wang, Gui-Xin Guo, Qian Wang, Yan-Fang Zhang, Lei Zhang, Jose de Leon, Can-Jun Ruan. The Impact of Smoking, Sex, Infection, and Comedication Administration on Oral Olanzapine: A Population Pharmacokinetic Model in Chinese Psychiatric Patients.
European journal of drug metabolism and pharmacokinetics.
2021 May; 46(3):353-371. doi:
10.1007/s13318-021-00673-5. [PMID: 33677821] - Lei Sun, Lisa von Moltke, Karen Rowland Yeo. Application of Physiologically Based Pharmacokinetic Modeling to Predict the Effect of Renal Impairment on the Pharmacokinetics of Olanzapine and Samidorphan Given in Combination.
Clinical pharmacokinetics.
2021 05; 60(5):637-647. doi:
10.1007/s40262-020-00969-w. [PMID: 33313995] - Chengfang Zhang, Xiaodan Wang, Chengping Hu, Wenhua Ding, Han Li, Meng Wu, Manji Hu, Qiang Wang, Xirong Sun. The effect of prohibiting outside food during COVID-19 pandemic on the body weight of schizophrenic patients taking olanzapine or clozapine: a retrospective self-controlled study.
Annals of palliative medicine.
2021 May; 10(5):5010-5016. doi:
10.21037/apm-20-2513. [PMID: 33894724] - Huimei An, Hongzhen Fan, Song Chen, Siyuan Qi, Botao Ma, Jing Shi, Zhiren Wang, Fude Yang. Effects of Dose, Age, Sex, Body Weight, and Smoking on Plasma Concentrations of Olanzapine and N-desmethyl Olanzapine in Inpatients With Schizophrenia.
Journal of clinical psychopharmacology.
2021 May; 41(3):255-259. doi:
10.1097/jcp.0000000000001390. [PMID: 33814547] - Kyriaki Marouda, Leonidas Mantonakis, Konstantinos Kollias. Brief psychotic disorder with delusion content related to the COVID-19 outbreak.
Psychiatrike = Psychiatriki.
2021 Apr; 32(1):79-82. doi:
10.22365/jpsych.2021.004. [PMID: 33759811] - Alberto Canfrán-Duque, Óscar Pastor, David García-Seisdedos, Yessenia L Molina, Bohdan Babiy, Milagros Lerma, Carmen Sánchez-Castellano, Javier Martínez-Botas, Diego Gómez-Coronado, Miguel A Lasunción, Alfonso J Cruz-Jentoft, Rebeca Busto. The Antipsychotic Risperidone Alters Dihydroceramide and Ceramide Composition and Plasma Membrane Function in Leukocytes In Vitro and In Vivo.
International journal of molecular sciences.
2021 Apr; 22(8):. doi:
10.3390/ijms22083919. [PMID: 33920193] - Marcelo S Fernandes, Alencar K Machado, Charles E Assmann, Eduardo N Andrade, Verônica F Azzolin, Marta M M F Duarte, Pedro A S do Prado-Lima, Rogerio T Riffel, Ednea A Maia-Ribeiro, Francine C Cadoná, Raquel Praia, Fernanda Barbisan, Ivana B M da Cruz. Açaí (Euterpe oleracea Mart.) reduces the inflammatory response triggered in vitro by the antipsychotic drug olanzapine in RAW 264.7 macrophage cells.
Acta scientiarum polonorum. Technologia alimentaria.
2021 Apr; 20(2):149-163. doi:
10.17306/j.afs.0857. [PMID: 33884853] - Hussein O Ammar, Mahmoud M Ghorab, Marwa S Saleh, Amira M Ghoneim. Olanzapine Mesoporous Nanostructured Lipid Carrier: Optimization, Characterization, In Vivo Assessment, and Physiologically Based Pharmacokinetic Modeling.
IEEE transactions on nanobioscience.
2021 04; 20(2):166-174. doi:
10.1109/tnb.2021.3052080. [PMID: 33493118] - Sofia Cussotto, Jacinta Walsh, Anna V Golubeva, Alexander V Zhdanov, Conall R Strain, Fiona Fouhy, Catherine Stanton, Timothy G Dinan, Niall P Hyland, Gerard Clarke, John F Cryan, Brendan T Griffin. The gut microbiome influences the bioavailability of olanzapine in rats.
EBioMedicine.
2021 Apr; 66(?):103307. doi:
10.1016/j.ebiom.2021.103307. [PMID: 33819741] - Chunxia Wang, Chengliang Wang, Liying Ren, Shankang Chen, Wen-Hua Chen, Yuhao Li. The protein kinase D1-mediated inflammatory pathway is involved in olanzapine-induced impairment of skeletal muscle insulin signaling in rats.
Life sciences.
2021 Apr; 270(?):119037. doi:
10.1016/j.lfs.2021.119037. [PMID: 33497738] - Emina Mrkalić, Ratomir Jelić, Stefan Stojanović, Miroslav Sovrlić. Interaction between olanzapine and human serum albumin and effect of metal ions, caffeine and flavonoids on the binding: A spectroscopic study.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Mar; 249(?):119295. doi:
10.1016/j.saa.2020.119295. [PMID: 33338934] - Ilijana Babic, Dominic Sellers, Paul L Else, Jessica Nealon, Ashleigh L Osborne, Nagesh Pai, Katrina Weston-Green. Effect of liraglutide on neural and peripheral markers of metabolic function during antipsychotic treatment in rats.
Journal of psychopharmacology (Oxford, England).
2021 03; 35(3):284-302. doi:
10.1177/0269881120981377. [PMID: 33570012] - Assel Sarsenbayeva, Priya Dipta, Martin Lundqvist, Kristina E Almby, Boaz Tirosh, Giada Di Nunzio, Jan W Eriksson, Maria J Pereira. Human macrophages stimulate expression of inflammatory mediators in adipocytes; effects of second-generation antipsychotics and glucocorticoids on cellular cross-talk.
Psychoneuroendocrinology.
2021 03; 125(?):105071. doi:
10.1016/j.psyneuen.2020.105071. [PMID: 33360972] - J A Arnaiz, C Rodrigues-Silva, G Mezquida, S Amoretti, M J Cuesta, D Fraguas, A Lobo, A González-Pinto, M C Díaz-Caneja, I Corripio, E Vieta, I Baeza, A Mané, C García-Rizo, M Bioque, J Saiz, M Bernardo, S Mas. The usefulness of Olanzapine plasma concentrations in monitoring treatment efficacy and metabolic disturbances in first-episode psychosis.
Psychopharmacology.
2021 Mar; 238(3):665-676. doi:
10.1007/s00213-020-05715-5. [PMID: 33230696] - Cankız Mina Ardıç, Sinem Ilgın, Merve Baysal, A Burak Karaduman, Volkan Kılıç, Gözde Aydoğan-Kılıç, Şeyda Uçarcan, Özlem Atlı-Eklioğlu. Olanzapine induced reproductive toxicity in male rats.
Scientific reports.
2021 02; 11(1):4739. doi:
10.1038/s41598-021-84235-4. [PMID: 33637793] - Hesham Shamshoum, Kyle D Medak, David C Wright. Peripheral mechanisms of acute olanzapine induced metabolic dysfunction: A review of in vivo models and treatment approaches.
Behavioural brain research.
2021 02; 400(?):113049. doi:
10.1016/j.bbr.2020.113049. [PMID: 33290757] - Dora Koller, Susana Almenara, Gina Mejía, Miriam Saiz-Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Marcos Navares-Gómez, Elena Santos-Molina, Elena Pintos-Sánchez, Francisco Abad-Santos. Metabolic Effects of Aripiprazole and Olanzapine Multiple-Dose Treatment in a Randomised Crossover Clinical Trial in Healthy Volunteers: Association with Pharmacogenetics.
Advances in therapy.
2021 02; 38(2):1035-1054. doi:
10.1007/s12325-020-01566-w. [PMID: 33278020] - Hesham Shamshoum, Greg L McKie, Kyle D Medak, Kristen E Ashworth, Bruce E Kemp, David C Wright. Voluntary physical activity protects against olanzapine-induced hyperglycemia.
Journal of applied physiology (Bethesda, Md. : 1985).
2021 02; 130(2):466-478. doi:
10.1152/japplphysiol.00876.2020. [PMID: 33382959] - Anil R Maharaj, Huali Wu, Kanecia O Zimmerman, Julie Autmizguine, Rohit Kalra, Amira Al-Uzri, Catherine M T Sherwin, Stuart L Goldstein, Kevin Watt, Jinson Erinjeri, Elizabeth H Payne, Michael Cohen-Wolkowiez, Christoph P Hornik. Population pharmacokinetics of olanzapine in children.
British journal of clinical pharmacology.
2021 02; 87(2):542-554. doi:
10.1111/bcp.14414. [PMID: 32497307] - Srinivas Pramod Junutula, Sai Kiran Dubasi, Sai Geethika Reddy Padide, Gireesh Kumar Miryala, Manasa Soumya Koppolu, Sharvana Bhava Bandaru Sheshagiri, Venkateshwarlu Eggadi. Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation.
Indian journal of pharmacology.
2021 Jan; 53(1):2-5. doi:
10.4103/ijp.ijp_114_20. [PMID: 33975992] - Dora Koller, Susana Almenara, Gina Mejía, Miriam Saiz-Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Aneta Wojnicz, Samuel Martín, Daniel Romero-Palacián, Marcos Navares-Gómez, Francisco Abad-Santos. Safety and cardiovascular effects of multiple-dose administration of aripiprazole and olanzapine in a randomised clinical trial.
Human psychopharmacology.
2021 01; 36(1):1-12. doi:
10.1002/hup.2761. [PMID: 32991788] - Chao Luo, Xu Wang, Han-Xue Huang, Xiao-Yuan Mao, Hong-Hao Zhou, Zhao-Qian Liu. Coadministration of metformin prevents olanzapine-induced metabolic dysfunction and regulates the gut-liver axis in rats.
Psychopharmacology.
2021 Jan; 238(1):239-248. doi:
10.1007/s00213-020-05677-8. [PMID: 33095288] - Sarbjot Kaur, Ujjwal Nautiyal, Pooja A Chawla, Viney Chawla. Nanostructured Lipid Carriers for Intranasal Administration of Olanzapine in the Management of Schizophrenia.
Current molecular pharmacology.
2021; 14(3):439-447. doi:
10.2174/1874467214666210120160016. [PMID: 33494693] - Cuilian Guo, Jinxin Liu, Huqun Li. Metformin ameliorates olanzapine-induced insulin resistance via suppressing macrophage infiltration and inflammatory responses in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jan; 133(?):110912. doi:
10.1016/j.biopha.2020.110912. [PMID: 33217690] - Zhengping Pu, Yunying Sun, Hongxia Jiang, Qingmei Hou, Hui Yan, Hui Wen, Guorong Li. Effects of Berberine on Gut Microbiota in Patients with Mild Metabolic Disorders Induced by Olanzapine.
The American journal of Chinese medicine.
2021; 49(8):1949-1963. doi:
10.1142/s0192415x21500920. [PMID: 34961418] - Ashraf M Mahmoud, Mater H Mahnashi, Saad A Alkahtani, Mohamed M El-Wekil. Nitrogen and sulfur co-doped graphene quantum dots/nanocellulose nanohybrid for electrochemical sensing of anti-schizophrenic drug olanzapine in pharmaceuticals and human biological fluids.
International journal of biological macromolecules.
2020 Dec; 165(Pt B):2030-2037. doi:
10.1016/j.ijbiomac.2020.10.084. [PMID: 33096171] - Shaojia Lu, Ning Wei, Jiajun Jiang, Lingling Wu, Jifang Sheng, Jianying Zhou, Qiang Fang, Yu Chen, Shufa Zheng, Feng Chen, Tingbo Liang, Shaohua Hu. First report of manic-like symptoms in a COVID-19 patient with no previous history of a psychiatric disorder.
Journal of affective disorders.
2020 12; 277(?):337-340. doi:
10.1016/j.jad.2020.08.031. [PMID: 32858315] - Kyle D Medak, Hesham Shamshoum, Willem T Peppler, David C Wright. GLP1 receptor agonism protects against acute olanzapine-induced hyperglycemia.
American journal of physiology. Endocrinology and metabolism.
2020 12; 319(6):E1101-E1111. doi:
10.1152/ajpendo.00309.2020. [PMID: 33017220] - Alka A Subramanyam, Hrishikesh B Nachane, Niraj N Mahajan, Snehal Shinde, Smita D Mahale, Rahul K Gajbhiye. Postpartum psychosis in mothers with SARS-CoV-2 infection: A case series from India.
Asian journal of psychiatry.
2020 Dec; 54(?):102406. doi:
10.1016/j.ajp.2020.102406. [PMID: 33271702] - Katerina Horska, Hana Kotolova, Michal Karpisek, Zuzana Babinska, Tomas Hammer, Jiri Prochazka, Tibor Stark, Vincenzo Micale, Jana Ruda-Kucerova. Metabolic profile of methylazoxymethanol model of schizophrenia in rats and effects of three antipsychotics in long-acting formulation.
Toxicology and applied pharmacology.
2020 11; 406(?):115214. doi:
10.1016/j.taap.2020.115214. [PMID: 32866524] - Erik Johnsen, Rune A Kroken, Else-Marie Løberg, Maria Rettenbacher, Inge Joa, Tor Ketil Larsen, Solveig Klæbo Reitan, Berit Walla, Renata Alisauskiene, Liss Gøril Anda, Christoffer Bartz-Johannessen, Jan Øystein Berle, Jill Bjarke, Farivar Fathian, Kenneth Hugdahl, Eirik Kjelby, Igne Sinkeviciute, Silje Skrede, Lena Stabell, Vidar M Steen, W Wolfgang Fleischhacker. Amisulpride, aripiprazole, and olanzapine in patients with schizophrenia-spectrum disorders (BeSt InTro): a pragmatic, rater-blind, semi-randomised trial.
The lancet. Psychiatry.
2020 11; 7(11):945-954. doi:
10.1016/s2215-0366(20)30341-2. [PMID: 33069317] - Monalisa Jena, Archana Mishra, Biswa Ranjan Mishra, Santanu Nath, Rituparna Maiti. Effect of lurasidone versus olanzapine on cardiometabolic parameters in unmedicated patients with schizophrenia: a randomized controlled trial.
Psychopharmacology.
2020 Nov; 237(11):3471-3480. doi:
10.1007/s00213-020-05628-3. [PMID: 32740676] - Rami Bou Khalil, Elie Atallah, Elina Dirani, Maya Kallab, Anthony Kassab, Marc Mourad, Rhéa El Khoury. Can atypical dysgeusia in depression be related to a deafferentation syndrome?.
Medical hypotheses.
2020 Nov; 144(?):110047. doi:
10.1016/j.mehy.2020.110047. [PMID: 32758885]
