Gnetol (BioDeep_00000000687)
PANOMIX_OTCML-2023 Antitumor activity
代谢物信息卡片
化学式: C14H12O4 (244.0736)
中文名称: 买麻藤醇, 2,6,3',5'-四羟基二苯乙烯
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 78.57%
Last reviewed on 2024-12-11.
Cite this Page
Gnetol. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/gnetol (retrieved
2024-12-22) (BioDeep RN: BioDeep_00000000687). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C1=CC(=C(C(=C1)O)C=CC2=CC(=CC(=C2)O)O)O
InChI: InChI=1S/C14H12O4/c15-10-6-9(7-11(16)8-10)4-5-12-13(17)2-1-3-14(12)18/h1-8,15-18H/b5-4+
描述信息
Gnetol is a natural product found in Gnetum edule, Gnetum hainanense, and other organisms with data available.
Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC50 of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC50 of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities[1][2][3].
Gnetol. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=86361-55-9 (retrieved 2024-12-11) (CAS RN: 86361-55-9). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
同义名列表
8 个代谢物同义名
1,3-Benzenediol, 2-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]-; 2-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol; 5-[(1E)-2-(2,6-dihydroxyphenyl)ethenyl]benzene-1,3-diol; 2-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol; 2-[2-(3,5-dihydroxyphenyl)vinyl]benzene-1,3-diol; (E)-2-(3,5-Dihydroxystyryl)benzene-1,3-diol; 2,3,5,6-tetrahydroxy-trans-stilbene; Gnetol
数据库引用编号
7 个数据库交叉引用编号
- KEGG: C76801
- PubChem: 45382232
- MeSH: 2,3,5,6-tetrahydroxy-trans-stilbene
- CAS: 86361-55-9
- medchemexpress: HY-126052
- LOTUS: LTS0250623
- wikidata: Q76616065
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
7 个相关的物种来源信息
- 3382 - Gnetum gnemon: 10.1016/S0031-9422(02)00670-2
- 225590 - Gnetum hainanense: 10.1016/S0031-9422(00)00151-5
- 225591 - Gnetum klossii:
- 225593 - Gnetum macrostachyum: 10.1016/J.FITOTE.2010.12.008
- 3381 - Gnetum montanum: 10.1016/S0367-326X(01)00370-7
- 33153 - Gnetum parvifolium: 10.1016/0031-9422(92)90050-Z
- 33090 - Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kei Shimoda, Naoji Kubota, Daisuke Uesugi, Yusuke Kobayashi, Hatsuyuki Hamada, Hiroki Hamada. Glycosylation of Stilbene Compounds by Cultured Plant Cells.
Molecules (Basel, Switzerland).
2020 Mar; 25(6):. doi:
10.3390/molecules25061437. [PMID: 32235774] - Bolanle C Akinwumi, Kimberly-Ann M Bordun, Hope D Anderson. Biological Activities of Stilbenoids.
International journal of molecular sciences.
2018 Mar; 19(3):. doi:
10.3390/ijms19030792. [PMID: 29522491] - Connie M Remsberg, Stephanie E Martinez, Bolanle C Akinwumi, Hope D Anderson, Jody K Takemoto, Casey L Sayre, Neal M Davies. Preclinical Pharmacokinetics and Pharmacodynamics and Content Analysis of Gnetol in Foodstuffs.
Phytotherapy research : PTR.
2015 Aug; 29(8):1168-79. doi:
10.1002/ptr.5363. [PMID: 25939395] - Thiendanai Sermboonpaisarn, Pattara Sawasdee. Potent and selective butyrylcholinesterase inhibitors from Ficus foveolata.
Fitoterapia.
2012 Jun; 83(4):780-4. doi:
10.1016/j.fitote.2012.03.009. [PMID: 22450264] - Connie M Remsberg, Jody K Takemoto, Rebecca M Bertram, Neal M Davies. High-performance liquid chromatography assay of gnetol in rat serum and application to pre-clinical pharmacokinetic studies.
Journal of pharmaceutical and biomedical analysis.
2011 Mar; 54(4):878-81. doi:
10.1016/j.jpba.2010.10.028. [PMID: 21126844]
