Glycyrrhetinic acid (BioDeep_00000000368)

 

Secondary id: BioDeep_00000034672, BioDeep_00000398553, BioDeep_00000863472

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite natural product


代谢物信息卡片


(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid

化学式: C30H46O4 (470.3396)
中文名称: 18-α-甘草次酸, 甘草次酸(β型), 甘草次酸(α型), 18β-甘草次酸, 甘草次酸
谱图信息: 最多检出来源 Viridiplantae(plant) 16.66%

Reviewed

Last reviewed on 2024-07-09.

Cite this Page

Glycyrrhetinic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/glycyrrhetinic_acid (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000368). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C1(C)C(O)=O)C(C=52)([H])C(CCC2(C(C3([H])C(=O)C5)(C)CCC(C(C)(C)4)([H])C(C)3CCC(O)4)C)(C)CC1
InChI: InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)

描述信息

Glycyrrhetinic acid is a pentacyclic triterpenoid that is olean-12-ene substituted by a hydroxy group at position 3, an oxo group at position 11 and a carboxy group at position 30. It has a role as an immunomodulator and a plant metabolite. It is a pentacyclic triterpenoid, a cyclic terpene ketone and a hydroxy monocarboxylic acid. It is a conjugate acid of a glycyrrhetinate. It derives from a hydride of an oleanane.
Enoxolone (glycyrrhetic acid) has been investigated for the basic science of Apparent Mineralocorticoid Excess (AME).
Enoxolone is a natural product found in Glycyrrhiza, Echinopora lamellosa, and other organisms with data available.
Enoxolone is a pentacyclic triterpenoid aglycone metabolite of glycyrrhizin, which is a product of the plant Glycyrrhiza glabra (licorice), with potential expectorant, and gastrokinetic activities. After administration, enoxolone inhibits the metabolism of prostaglandins by both 15-hydroxyprostaglandin dehydrogenase [NAD(+)] and prostaglandin reductase 2. Therefore, this agent potentiates the activity of prostaglandin E2 and F2alpha, which inhibits gastric secretion while stimulating pancreatic secretion and the secretion of intestinal and respiratory mucus, leading to increased intestinal motility and antitussive effects. Additionally, this agent inhibits 11 beta-hydroxysteroid dehydrogenase and other enzymes involved in the conversion of cortisol to cortisone in the kidneys.
An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.
See also: Glycyrrhizin (is active moiety of); Glycyrrhiza Glabra (part of).
Glycyrrhetinic acid is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was first obtained from the herb liquorice. It is used in flavouring and it masks the bitter taste of drugs like aloe and quinine. It is effective in the treatment of peptic ulcer and also has expectorant (antitussive) properties (PMID:32106571). In glycyrrhetinic acid the functional group (R) is a hydroxyl group. Research in 2005 demonstrated that with a proper functional group a very effective glycyrrhetinic artificial sweetener can be obtained. When R is an anionic NHCO(CH2)CO2K side chain, the sweetening effect is found to 1200 times that of sugar (human sensory panel data). A shorter or longer spacer reduces the sweetening effect. One explanation is that the taste bud cell receptor has 1.3 nanometers (13 angstroms) available for docking with the sweetener molecule. In addition the sweetener molecule requires three proton donor positions of which two reside at the extremities to be able to interact efficiently with the receptor cavity.
18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2].
18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2].
18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

同义名列表

106 个代谢物同义名

(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid; (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid;Enoxolone; (2S,4aS,6aS,6bR,10S,12aS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid; (2S,4AS,6as,6BR,10S,12as)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylate; (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid; (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylicacid; (5S,8S,15S,18S,1R,2R,10R,14R,20R)-18-hydroxy-1,2,5,8,15,19,19-heptamethyl-13-o xopentacyclo[12.8.0.0<2,11>.0<5,10>.0<15,20>]docos-11-ene-8-carboxylic acid; (2S,4aS,6aS,6bR,10S,12aS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,7,8,8a,10,11,12,12b,14b-dodecahydro-1H-picene-2-carboxylic acid; Enoxolone; 18beta-Glycyrrhetinic acid; 3?-Hydroxy-11-oxo-18?,20?-olean-12-en-29-oic acid; (3beta,5beta,14beta)-3-Hydroxy-11-Oxoolean-12-En-29-Oic Acid; Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3beta,20beta)-; 3beta-Hydroxy-11-oxo-18beta,20beta-olean-12-en-29-oic acid; Enoxolone, European Pharmacopoeia (EP) Reference Standard; (3beta,20beta)-3-Hydroxy-11-oxo-olean-12-en-29-oic acid; (3beta,20beta)-3-Hydroxy-11-oxoolean-12-en-29-oic acid; 3-Hydroxy-11-oxoolean-12-en-29-Oic acid (acd/name 4.0); 3ss-Hydroxy-11-oxo-18ss,20ss-olean-12-en-29-oic acid; Plantes et médecines brand OF glycyrrhetinic acid; 18beta-Glycyrrhetinic acid, purum, >=97.0\\% (T); (3beta)-3-hydroxy-11-oxoolean-12-en-30-oic acid; Olean-12-en-30-oic acid, 3-beta-hydroxy-11-oxo-; Olean-12-en-30-oic acid, 3beta-hydroxy-11-oxo-; Enoxolone (synonym: 18ss--Glycyrrhetinic acid); (3?)-3-Hydroxy-11-oxoolean-12-en-30-oic acid; 3-beta-Hydroxy-11-oxoolean-12-en-30-oic acid; 4-10-00-03775 (Beilstein Handbook Reference); 3beta-hydroxy-11-oxoolean-12-en-29-oic acid; 3beta-Hydroxy-11-oxoolean-12-en-30-oic acid; 3b-Hydroxy-11-oxo-olean-12-en-30-Oic acid; 3b-Hydroxy-11-oxoolean-12-en-30-Oic acid; Glycyrrhetin ;18beta Glycyrrhetinic acid; 3-Hydroxy-11-oxoolean-12-en-29-Oic acid; 3b-Hydroxy-11-oxo-olean-12-en-30-Oate; 3b-Hydroxy-11-oxoolean-12-en-30-Oate; 3-Hydroxy-11-oxoolean-12-en-29-Oate; Dexo brand OF glycyrrhetinic acid; 18beta-Glycyrrhetinic acid, 97\\%; Enoxolone, Glycyrrhetinic acid; 18 beta-Glycyrrhetintic Acid; 18 beta -Glycyrrhetinic Acid; 18-beta-Glycyrrhetinic acid; GLYCYRRHETINIC ACID [INCI]; 18beta-Glycyrrhetinic acid; Glycyrrhetinic acid [JAN]; 18-beta-Glycyrrhetic acid; Glycyrrhetinic acid (JAN); alpha-Glycyrrhetinic acid; 18beta-Glycyrrhetic acid; beta-Glycyrrhetinic acid; ENOXOLONE [EP MONOGRAPH]; ENOXOLONE (EP MONOGRAPH); 18|A-Glycyrrhetinic acid; Enoxolone (Glycyrrhetin); Enoxolona [INN-Spanish]; 18α-Glycyrrhetinic acid; 18β-Glycyrrhetinic acid; ENOXOLONE [EP IMPURITY]; Enoxolone [INN:BAN:DCF]; 18b-Glycyrrhetinic acid; ENOXOLONE (EP IMPURITY); beta-Glycyrrhetic acid; 18-Glycyrrhetinic acid; 18b-Glycyrrhtinic acid; Enoxolonum [INN-Latin]; a-Glycyrrhetinic acid; 3-Glycyrrhetinic acid; 18b-Glycyrrhetic acid; Acid, Glycyrrhetinic; b-Glycyrrhetic acid; Glycyrrhetinic Acid; Glycyrrhitinic acid; ENOXOLONE [WHO-DD]; GlycyrrhetinicAcid; Acid, Glycyrrhetic; ENOXOLONE (MART.); Glycyrrhetic acid; ENOXOLONE [MART.]; Glycyrrhetinate; Enoxolone (INN); ENOXOLONE [INN]; Hidermart (TN); ENOXOLONE [MI]; Acid, Uralenic; Acid, Rhetinic; Uralenic acid; Rhetinic Acid; Tox21_112726; Glycyrrhetin; Tox21_200799; Tox21_110804; Enoxolonum; Arthrodont; Hidermart; Enoxolone; Enoxolona; Enoloxone; Glyciram; Glycyram; D03AX10; Biosone; Jintan; 12, Po; Po 12; BX-1; CBW; Glycyrrhetinate



数据库引用编号

72 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

9 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(9)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

38 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ABCB1, AKT1, ALB, BCL2L1, CASP3, CASP9, CCND1, CYP3A4, MAPK8, NR3C2, PIK3CA, TLR4, VEGFA
Peripheral membrane protein 1 CYP1B1
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 3 CYP1B1, CYP3A4, NR3C2
Mitochondrion membrane 1 BCL2L1
Nucleus 8 AKT1, ALB, CASP3, CASP9, CCND1, MAPK8, NR3C2, VEGFA
cytosol 10 AKT1, ALB, BCL2L1, CASP3, CASP9, CCND1, GPT, MAPK8, NR3C2, PIK3CA
centrosome 3 ALB, BCL2L1, CCND1
nucleoplasm 5 AKT1, CASP3, CCND1, MAPK8, NR3C2
Cell membrane 4 ABCB1, AKT1, TLR4, TNF
Cytoplasmic side 1 BCL2L1
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 2 ABCB1, ABCC2
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 5 ABCB1, ABCC2, TLR4, TNF, VEGFA
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 2 ALB, VEGFA
mitochondrial inner membrane 1 BCL2L1
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 1 BCL2L1
plasma membrane 7 ABCB1, ABCC2, AKT1, PIK3CA, REN, TLR4, TNF
synaptic vesicle membrane 1 BCL2L1
Membrane 8 ABCB1, ABCC2, AKT1, CYP1B1, CYP3A4, REN, TLR4, VEGFA
apical plasma membrane 2 ABCB1, ABCC2
axon 1 MAPK8
extracellular exosome 3 ABCB1, ALB, GPT
endoplasmic reticulum 3 ALB, BCL2L1, VEGFA
extracellular space 6 ALB, IL10, IL6, REN, TNF, VEGFA
perinuclear region of cytoplasm 2 PIK3CA, TLR4
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
intercellular canaliculus 1 ABCC2
mitochondrion 3 BCL2L1, CASP9, CYP1B1
protein-containing complex 3 AKT1, ALB, CASP9
intracellular membrane-bounded organelle 2 CYP1B1, CYP3A4
Microsome membrane 2 CYP1B1, CYP3A4
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 TLR4
Secreted 5 ALB, IL10, IL6, REN, VEGFA
extracellular region 6 ALB, IL10, IL6, REN, TNF, VEGFA
Mitochondrion outer membrane 1 BCL2L1
Single-pass membrane protein 1 BCL2L1
mitochondrial outer membrane 1 BCL2L1
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 1 BCL2L1
anchoring junction 1 ALB
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 BCL2L1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 2 BCL2L1, CCND1
Bcl-2 family protein complex 1 BCL2L1
nuclear membrane 2 BCL2L1, CCND1
external side of plasma membrane 2 TLR4, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 1 AKT1
Early endosome 1 TLR4
apical part of cell 1 REN
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Apical cell membrane 2 ABCB1, ABCC2
Membrane raft 1 TNF
spindle 1 AKT1
extracellular matrix 1 VEGFA
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 2 NR3C2, TLR4
ciliary basal body 2 AKT1, ALB
chromatin 1 NR3C2
phagocytic cup 2 TLR4, TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
lipopolysaccharide receptor complex 1 TLR4
endoplasmic reticulum lumen 2 ALB, IL6
transcription repressor complex 1 CCND1
platelet alpha granule lumen 2 ALB, VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
apoptosome 1 CASP9
external side of apical plasma membrane 1 ABCB1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
ciliary transition fiber 1 ALB
caspase complex 1 CASP9
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Jianan Wei, Junhong Zhang, Fengju Hu, Wenjuan Zhang, Yunshan Wu, Bo Liu, Yue Lu, Li Li, Ling Han, Chuanjian Lu. Anti-psoriasis effect of 18β-glycyrrhetinic acid by breaking CCL20/CCR6 axis through its vital active group targeting GUSB/ATF2 signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155524. doi: 10.1016/j.phymed.2024.155524. [PMID: 38552435]
  • Bin Zou, Shuang Zhang, Fengling Li, Fengyi Weng, Jing Zhao, Jingyi Jin, Dongming Yan, Xiaoqing Xu, Gaofeng Chen, Chenghai Liu, Chengzeng Yao, Yue Li, Furong Qiu. Gancao decoction attenuates hepatic necroptosis via activating caspase 8 in cholestatic liver injury. Journal of ethnopharmacology. 2024 May; 326(?):117909. doi: 10.1016/j.jep.2024.117909. [PMID: 38350503]
  • Ibrahim Bayav, Ekrem Darendelioğlu, Cuneyt Caglayan. 18β-Glycyrrhetinic acid exerts cardioprotective effects against BPA-induced cardiotoxicity through antiapoptotic and antioxidant mechanisms. Journal of biochemical and molecular toxicology. 2024 Feb; 38(2):e23655. doi: 10.1002/jbt.23655. [PMID: 38348715]
  • Jinrong Kong, Qingzhen Xiang, Wanyue Ge, Yunlai Wang, Fan Xu, Gaoxiang Shi. Network pharmacology mechanisms and experimental verification of licorice in the treatment of ulcerative colitis. Journal of ethnopharmacology. 2024 Jan; 324(?):117691. doi: 10.1016/j.jep.2023.117691. [PMID: 38176667]
  • Xiao Mi, Yang Lou, Yutian Wang, Mingran Dong, Hongwei Xue, Shuyang Li, Juan Lu, Xi Chen. Glycyrrhetinic Acid Receptor-Mediated Zeolitic Imidazolate Framework-8 Loaded Doxorubicin as a Nanotherapeutic System for Liver Cancer Treatment. Molecules (Basel, Switzerland). 2023 Dec; 28(24):. doi: 10.3390/molecules28248131. [PMID: 38138618]
  • Bin Zou, Shuang Zhang, Jing Zhao, Guochao Song, Fengyi Weng, Xiaoqing Xu, Fengling Li, Jingyi Jin, Dongming Yan, Kai Huang, Chenghai Liu, Yue Li, Furong Qiu. Glycyrrhetinic acid attenuates endoplasmic reticulum stress-induced hepatocyte apoptosis via CHOP/DR5/Caspase 8 pathway in cholestasis. European journal of pharmacology. 2023 Dec; 961(?):176193. doi: 10.1016/j.ejphar.2023.176193. [PMID: 37981257]
  • Ruchi Sharma, Rajeev K Singla, Subhadip Banerjee, Rohit Sharma. Revisiting Licorice as a functional food in the management of neurological disorders: bench to trend. Neuroscience and biobehavioral reviews. 2023 Nov; ?(?):105452. doi: 10.1016/j.neubiorev.2023.105452. [PMID: 37925093]
  • Xiu-Li Wang, Hui-da Guan, Shu-Xian Qu, Bo-Wen Xue, Geng Li, Xing-Yu Liu, Li-Sha Chen, Heng Gu. [Liver targeting of compound liposomes mediated by glycyrrhetinic acid derivative receptor and its effect on hepatic stellate cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Oct; 48(19):5195-5204. doi: 10.19540/j.cnki.cjcmm.20230605.301. [PMID: 38114109]
  • Kangchen Li, Xinguang Liu, Runsu Hou, Hulei Zhao, Peng Zhao, Yange Tian, Jiansheng Li. Uncovering mechanisms of Baojin Chenfei formula treatment for silicosis by inhibiting inflammation and fibrosis based on serum pharmacochemistry and network analysis. Ecotoxicology and environmental safety. 2023 May; 260(?):115082. doi: 10.1016/j.ecoenv.2023.115082. [PMID: 37257350]
  • Xia Li, Yuhua Du, Shicong Huang, Yi Yang, Doudou Lu, Junfei Zhang, Yan Chen, Lei Zhang, Yi Nan, Ling Yuan. Exploring the molecular mechanism of glycyrrhetinic acid in the treatment of gastric cancer based on network pharmacology and experimental validation. Aging. 2023 May; 15(9):3839-3856. doi: 10.18632/aging.204718. [PMID: 37171392]
  • Xuejiao Yuan, Yanfeng Zhou, Jinli Sun, Shanshan Wang, Xingjie Hu, Jiyu Li, Jing Huang, Nan Chen. Preventing acute liver injury via hepatocyte-targeting nano-antioxidants. Cell proliferation. 2023 May; ?(?):e13494. doi: 10.1111/cpr.13494. [PMID: 37139662]
  • Liu Cui, Xi Wang, Zhaoyun Liu, Ziqi Li, Ziwei Bai, Kui Lin, Jian Yang, Yuanlu Cui, Fei Tian. Metal-organic framework decorated with glycyrrhetinic acid conjugated chitosan as a pH-responsive nanocarrier for targeted drug delivery. International journal of biological macromolecules. 2023 Apr; 240(?):124370. doi: 10.1016/j.ijbiomac.2023.124370. [PMID: 37044320]
  • Mingxing Qiu, Jiong Wang, Jiaojiao Bai, Xiaoxu Li, Cuiqing Tian, Zhi Liu, Chaoran Zheng, Andrew R Clark, Xinwei Cheng, Xiaoyan Liao, Song Wu, Robert J Lee, Xiaoju Zhou. Dual-Ligand-Functionalized Liposomes Based on Glycyrrhetinic Acid and cRGD for Hepatocellular Carcinoma Targeting and Therapy. Molecular pharmaceutics. 2023 Apr; 20(4):1951-1963. doi: 10.1021/acs.molpharmaceut.2c00842. [PMID: 36952242]
  • W Caré, G Grenet, C Schmitt, S Michel, J Langrand, G Le Roux, D Vodovar. [Adverse effects of licorice consumed as food: An update]. La Revue de medecine interne. 2023 Mar; ?(?):. doi: 10.1016/j.revmed.2023.03.004. [PMID: 37005098]
  • Dongju Lin, Jie Liu, Xiaojin Chang, Bufan Yang, Xiaofei Gu, Weiwei Li. Glycyrrhetinic acid ameliorates diosbulbin B-induced hepatotoxicity in mice by modulating metabolic activation of diosbulbin B. Journal of applied toxicology : JAT. 2023 Feb; ?(?):. doi: 10.1002/jat.4450. [PMID: 36807597]
  • Shasha Kong, Pengyue Li, Robert Verpoorte, Mingqian Li, Yuntao Dai. Chemical and pharmacological difference between honey-fried licorice and fried licorice. Journal of ethnopharmacology. 2023 Feb; 302(Pt A):115841. doi: 10.1016/j.jep.2022.115841. [PMID: 36270557]
  • Ulises Zendejas-Hernandez, Nemi Alcántara-Martínez, Diana Tovar Vivar, Fermín Valenzuela, Alejandro Sosa Espinoza, Eduardo Emir Cervera Ceballos. Nebulized glycyrrhizin/enoxolone drug modulates IL-17A in COVID-19 patients: a randomized clinical trial. Frontiers in immunology. 2023; 14(?):1282280. doi: 10.3389/fimmu.2023.1282280. [PMID: 38283346]
  • Hany Khalil, Alaa H Nada, Hoda Mahrous, Amr Hassan, Patricia Rijo, Ibrahim A Ibrahim, Dalia D Mohamed, Fawziah A Al-Salmi, Doaa D Mohamed, Ahmed I Abd Elmaksoud. Amelioration effect of 18β-Glycyrrhetinic acid on methylation inhibitors in hepatocarcinogenesis -induced by diethylnitrosamine. Frontiers in immunology. 2023; 14(?):1206990. doi: 10.3389/fimmu.2023.1206990. [PMID: 38322013]
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