beta-Glycyrrhetinic acid (BioDeep_00000034672)

Main id: BioDeep_00000000368

 

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid

化学式: C30H46O4 (470.3396)
中文名称: 甘草次酸(β型), 甘草次酸(α型)
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1[C@@H](C([C@H]2[C@](C1)([C@@H]1[C@@](CC2)([C@]2(C(=CC1=O)[C@H]1[C@@](CC2)(CC[C@@](C1)(C(=O)O)C)C)C)C)C)(C)C)O
InChI: InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21+,22+,23-,26-,27+,28+,29-,30-/m1/s1

描述信息

beta-Glycyrrhetinic acid is found in herbs and spices. beta-Glycyrrhetinic acid is a constituent of licorice (Glycyrrhiza glabra) root
Constituent of licorice (Glycyrrhiza glabra) root. beta-Glycyrrhetinic acid is found in herbs and spices.
18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2].
18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2].
18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

同义名列表

28 个代谢物同义名

(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid; (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,7,8,8a,10,11,12,12b,14b-dodecahydro-1H-picene-2-carboxylic acid; 18alpha-Olean-12-en-30-Oic acid, 3beta-hydroxy-11-oxo- (6ci,7ci,8ci); 3-Hydroxy-11-oxo-(3beta,18alpha,20beta)-olean-12-en-29-Oic acid; 18 alpha-Glycyrrhetinic acid; 18alpha-Glycyrrhetinic acid; 18beta-Glycyrrhetinic acid; 18-Isoglycyrrhetinic acid; beta-Glycyrrhetinic acid; 18α-Glycyrrhetinic acid; 18alpha-Glycyrrhetinate; 18a-Glycyrrhetinic acid; Isoglycyrrhetinic acid; b-Glycyrrhetinic acid; Β-glycyrrhetinic acid; 18a-Glycyrrhetic acid; beta-Glycyrrhetinate; 18Α-glycyrrhetinate; Glycyrrhetinic Acid; 18a-Glycyrrhetinate; Glycyrrhitinic acid; Β-glycyrrhetinate; b-Glycyrrhetinate; 18alpha-GA; Enoxolone; 18beta-GA; 18β-Glycyrrhetinic acid; Glycyrrhetinate



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Jianan Wei, Junhong Zhang, Fengju Hu, Wenjuan Zhang, Yunshan Wu, Bo Liu, Yue Lu, Li Li, Ling Han, Chuanjian Lu. Anti-psoriasis effect of 18β-glycyrrhetinic acid by breaking CCL20/CCR6 axis through its vital active group targeting GUSB/ATF2 signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155524. doi: 10.1016/j.phymed.2024.155524. [PMID: 38552435]
  • Ibrahim Bayav, Ekrem Darendelioğlu, Cuneyt Caglayan. 18β-Glycyrrhetinic acid exerts cardioprotective effects against BPA-induced cardiotoxicity through antiapoptotic and antioxidant mechanisms. Journal of biochemical and molecular toxicology. 2024 Feb; 38(2):e23655. doi: 10.1002/jbt.23655. [PMID: 38348715]
  • Bo-Wen Pan, Liang-Liang Zheng, Yang Shi, Zhang-Chao Dong, Ting-Ting Feng, Jian Yang, Ying Wei, Ying Zhou. Synthesis and Antiviral and Antitumor Activities of Novel 18β-Glycyrrhetinic Acid Derivatives. International journal of molecular sciences. 2023 Oct; 24(19):. doi: 10.3390/ijms241915012. [PMID: 37834459]
  • Hanyue Luo, Caishi Zhang, Lujuan He, Zefang Lin, Ji-Chun Zhang, Qi Qi, Jia-Xu Chen, Wei Yao. 18β-glycyrrhetinic acid ameliorates MPTP-induced neurotoxicity in mice through activation of microglial anti-inflammatory phenotype. Psychopharmacology. 2023 Jul; ?(?):. doi: 10.1007/s00213-023-06415-6. [PMID: 37436491]
  • Xia Li, Xiao-Ling Ma, Yi Nan, Yu-Hua Du, Yi Yang, Dou-Dou Lu, Jun-Fei Zhang, Yan Chen, Lei Zhang, Yang Niu, Ling Yuan. 18β-glycyrrhetinic acid inhibits proliferation of gastric cancer cells through regulating the miR-345-5p/TGM2 signaling pathway. World journal of gastroenterology. 2023 Jun; 29(23):3622-3644. doi: 10.3748/wjg.v29.i23.3622. [PMID: 37398884]
  • Xia Li, Yuhua Du, Shicong Huang, Yi Yang, Doudou Lu, Junfei Zhang, Yan Chen, Lei Zhang, Yi Nan, Ling Yuan. Exploring the molecular mechanism of glycyrrhetinic acid in the treatment of gastric cancer based on network pharmacology and experimental validation. Aging. 2023 May; 15(9):3839-3856. doi: 10.18632/aging.204718. [PMID: 37171392]
  • W Caré, G Grenet, C Schmitt, S Michel, J Langrand, G Le Roux, D Vodovar. [Adverse effects of licorice consumed as food: An update]. La Revue de medecine interne. 2023 Mar; ?(?):. doi: 10.1016/j.revmed.2023.03.004. [PMID: 37005098]
  • Fanli Shi, Ruilong Li, Wenjing Wang, Xiangyu Yu, Fenxia Zhu, Yiping Huang, Jing Wang, Zhenhai Zhang. Carboxymethyl starch as a solid dispersion carrier to enhance the dissolution and bioavailability of piperine and 18β-glycyrrhetinic acid. Drug development and industrial pharmacy. 2023 Jan; 49(1):30-41. doi: 10.1080/03639045.2023.2182120. [PMID: 36803327]
  • Hany Khalil, Alaa H Nada, Hoda Mahrous, Amr Hassan, Patricia Rijo, Ibrahim A Ibrahim, Dalia D Mohamed, Fawziah A Al-Salmi, Doaa D Mohamed, Ahmed I Abd Elmaksoud. Amelioration effect of 18β-Glycyrrhetinic acid on methylation inhibitors in hepatocarcinogenesis -induced by diethylnitrosamine. Frontiers in immunology. 2023; 14(?):1206990. doi: 10.3389/fimmu.2023.1206990. [PMID: 38322013]
  • Yamei Jiang, Chengzhe Cai, Pingbao Zhang, Yongsheng Luo, Jingjing Guo, Jiawei Li, Ruiming Rong, Yi Zhang, Tongyu Zhu. Transcriptional profile changes after treatment of ischemia reperfusion injury-induced kidney fibrosis with 18β-glycyrrhetinic acid. Renal failure. 2022 Dec; 44(1):660-671. doi: 10.1080/0886022x.2022.2061998. [PMID: 35699239]
  • Cuneyt Caglayan, Fatih Mehmet Kandemir, Adnan Ayna, Cihan Gür, Sefa Küçükler, Ekrem Darendelioğlu. Neuroprotective effects of 18β-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway. Metabolic brain disease. 2022 08; 37(6):1931-1940. doi: 10.1007/s11011-022-01027-z. [PMID: 35699857]
  • Zhangting Wang, Jiang Ma, Yisheng He, Kai-Kei Miu, Sheng Yao, Chunping Tang, Yang Ye, Ge Lin. Nrf2-mediated liver protection by 18β-glycyrrhetinic acid against pyrrolizidine alkaloid-induced toxicity through PI3K/Akt/GSK3β pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 102(?):154162. doi: 10.1016/j.phymed.2022.154162. [PMID: 35598524]
  • Jia-Ling Wang, Hui Liu, Zhi-Cheng Jing, Fang Zhao, Ru Zhou. 18β-Glycyrrhetinic acid ameliorates endoplasmic reticulum stress-induced inflammation in pulmonary arterial hypertension through PERK/eIF2α/NF-κB signaling. The Chinese journal of physiology. 2022 Jul; 65(4):187-198. doi: 10.4103/0304-4920.354801. [PMID: 36073567]
  • Ling Yuan, Yi Yang, Xia Li, Xin Zhou, Yu-Hua Du, Wen-Jing Liu, Lei Zhang, Lei Yu, Ting-Ting Ma, Jia-Xin Li, Yan Chen, Yi Nan. 18β-glycyrrhetinic acid regulates mitochondrial ribosomal protein L35-associated apoptosis signaling pathways to inhibit proliferation of gastric carcinoma cells. World journal of gastroenterology. 2022 Jun; 28(22):2437-2456. doi: 10.3748/wjg.v28.i22.2437. [PMID: 35979263]
  • K Buvanesvaragurunathan, J Ganesh, S Nagul Kumar, V Porchezhiyan, A Radha, P Azhahianambi, P Pandikumar, S Ignacimuthu. In vitro growth inhibitory effect of selected 18β-glycyrrhetinic acid esters on Theileriaannulata. Experimental parasitology. 2022 May; 236-237(?):108258. doi: 10.1016/j.exppara.2022.108258. [PMID: 35421387]
  • Xiaoyan Wang, Fang Xie, Xiaofeng Zhou, Ting Chen, Ye Xue, Wei Wang. 18β-Glycyrrhetinic acid inhibits the apoptosis of cells infected with rotavirus SA11 via the Fas/FasL pathway. Pharmaceutical biology. 2021 Dec; 59(1):1098-1105. doi: 10.1080/13880209.2021.1961821. [PMID: 34411493]
  • Ibtesam S Alanazi, Mohamed Emam, Mabrouk Elsabagh, Saad Alkahtani, Mohamed M Abdel-Daim. The protective effects of 18β-glycyrrhetinic acid against acrylamide-induced cellular damage in diabetic rats. Environmental science and pollution research international. 2021 Nov; 28(41):58322-58330. doi: 10.1007/s11356-021-14742-4. [PMID: 34117542]
  • Tao Yang, Jing Zhou, Lei Fang, Minmin Wang, Maimaitiyiming Dilinuer, Aikemu Ainiwaer. Protection function of 18β-glycyrrhetinic acid on rats with high-altitude pulmonary hypertension based on 1H NMR metabonomics technology. Analytical biochemistry. 2021 10; 631(?):114342. doi: 10.1016/j.ab.2021.114342. [PMID: 34419454]
  • Shouyan Wu, Henglei Lu, Wenjie Wang, Luyao Song, Meng Liu, Yuhan Cao, Xinming Qi, Jianhua Sun, Likun Gong. Prevention of D-GalN/LPS-induced ALI by 18β-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation. Cell death & disease. 2021 05; 12(5):480. doi: 10.1038/s41419-021-03768-8. [PMID: 33986260]
  • Kai-Xia Zhang, Peng-Ru Wang, Fei Chen, Xi-Jing Qian, Lin Jia, Xiao-Juan Liu, Lin Li, Yong-Sheng Jin. Synthesis and Anti-HCV Activities of 18β-Glycyrrhetinic Acid Derivatives and Their In-Silico ADMET Analysis. Current computer-aided drug design. 2021; 17(6):831-837. doi: 10.2174/1573409916666200827104008. [PMID: 32860363]
  • Min Huang, Ping Gong, Yuetong Wang, Xiaorui Xie, Zhuangshi Ma, Qihao Xu, Dan Liu, Yongkui Jing, Linxiang Zhao. Synthesis and antitumor effects of novel 18β-glycyrrhetinic acid derivatives featuring an exocyclic α,β-unsaturated carbonyl moiety in ring A. Bioorganic chemistry. 2020 10; 103(?):104187. doi: 10.1016/j.bioorg.2020.104187. [PMID: 32890994]
  • Meng Yang, Minyi Zhang, Qingli Liu, Tingting Xu, Tongling Huang, Dongsheng Yao, Chi-Wai Wong, Jinsong Liu, Min Guan. 18β-Glycyrrhetinic acid acts through hepatocyte nuclear factor 4 alpha to modulate lipid and carbohydrate metabolism. Pharmacological research. 2020 07; 157(?):104840. doi: 10.1016/j.phrs.2020.104840. [PMID: 32353589]
  • Xiaoli Cheng, Linwei Qiu, Fen Wang. 18α-Glycyrrhetinic acid (GA) ameliorates fructose-induced nephropathy in mice by suppressing oxidative stress, dyslipidemia and inflammation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 May; 125(?):109702. doi: 10.1016/j.biopha.2019.109702. [PMID: 32106383]
  • Seon Yu Lee, Ji Hyun Jeong, Bo Na Kim, So Jung Park, Yang-Chun Park, Guk Yeo Lee. LC-MS/MS analysis of puerarin and 18β-glycyrrhetinic acid in human plasma after oral administration of Samso-eum and its application to pharmacokinetic study. Biomedical chromatography : BMC. 2020 Apr; 34(4):e4774. doi: 10.1002/bmc.4774. [PMID: 31813157]
  • Shao-Hua Xu, Hai-Lan Chen, Yong Fan, Wei Xu, Jian Zhang. Application of tandem biotransformation for biosynthesis of new pentacyclic triterpenoid derivatives with neuroprotective effect. Bioorganic & medicinal chemistry letters. 2020 02; 30(4):126947. doi: 10.1016/j.bmcl.2019.126947. [PMID: 31924497]
  • Haiming Chen, Huazhen Liu, Bin Tang, Yuchao Chen, Ling Han, Jingjie Yu, Yuhong Yan, Chuanjian Lu. The Protective Effects of 18β-Glycyrrhetinic Acid on Imiquimod-Induced Psoriasis in Mice via Suppression of mTOR/STAT3 Signaling. Journal of immunology research. 2020; 2020(?):1980456. doi: 10.1155/2020/1980456. [PMID: 32908937]
  • Meng Xiang, Xiang Zhou, Ting-Rong Luo, Pei-Yi Wang, Li-Wei Liu, Zhong Li, Zhi-Bing Wu, Song Yang. Design, Synthesis, Antibacterial Evaluation, and Induced Apoptotic Behaviors of Epimeric and Chiral 18β-Glycyrrhetinic Acid Ester Derivatives with an Isopropanolamine Bridge against Phytopathogens. Journal of agricultural and food chemistry. 2019 Dec; 67(48):13212-13220. doi: 10.1021/acs.jafc.9b06147. [PMID: 31702905]
  • Peng Zhang, Zhi Chang, Jiamei Yang, Jun Feng, Yang Yu, Yanmin Pei, Jialing Wang, Fang Zhao, Zhou Ru. Vasorelaxation effect of 18β-glycyrrhetinic acid on the thoracic aorta of rats: proposed mechanism. Die Pharmazie. 2019 12; 74(12):751-754. doi: 10.1691/ph.2019.9724. [PMID: 31907117]
  • Jennifer A Easton, Ahmad K Albuloushi, Miriam A F Kamps, Gladys H M R Brouns, Jos L V Broers, Barry J Coull, Vincent Oji, Michel van Geel, Maurice A M van Steensel, Patricia E Martin. A rare missense mutation in GJB3 (Cx31G45E) is associated with a unique cellular phenotype resulting in necrotic cell death. Experimental dermatology. 2019 10; 28(10):1106-1113. doi: 10.1111/exd.13542. [PMID: 29570224]
  • Juan Sun, Han-Yu Liu, Cheng-Zhi Lv, Jie Qin, Yuan-Feng Wu. Modification, Antitumor Activity, and Targeted PPARγ Study of 18β-Glycyrrhetinic Acid, an Important Active Ingredient of Licorice. Journal of agricultural and food chemistry. 2019 Aug; 67(34):9643-9651. doi: 10.1021/acs.jafc.9b03442. [PMID: 31390199]
  • A Kowalska, U Kalinowska-Lis. 18β-Glycyrrhetinic acid: its core biological properties and dermatological applications. International journal of cosmetic science. 2019 Aug; 41(4):325-331. doi: 10.1111/ics.12548. [PMID: 31166601]
  • Zih-Ying Li, Yu-Tang Tung, Sheng-Yi Chen, Gow-Chin Yen. Novel findings of 18β-glycyrrhetinic acid on sRAGE secretion through inhibition of transient receptor potential canonical channels in high-glucose environment. BioFactors (Oxford, England). 2019 Jul; 45(4):607-615. doi: 10.1002/biof.1517. [PMID: 31120605]
  • Boyi Fan, Baocheng Jiang, Sensen Yan, Bohui Xu, Huilian Huang, Guangtong Chen. Anti-Inflammatory 18β-Glycyrrhetinin Acid Derivatives Produced by Biocatalysis. Planta medica. 2019 Jan; 85(1):56-61. doi: 10.1055/a-0662-0296. [PMID: 30086557]
  • Shou-Yan Wu, Shi-Chao Cui, Le Wang, Yi-Ting Zhang, Xiao-Xia Yan, Heng-Lei Lu, Guo-Zhen Xing, Jin Ren, Li-Kun Gong. 18β-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway. Acta pharmacologica Sinica. 2018 Dec; 39(12):1865-1873. doi: 10.1038/s41401-018-0110-y. [PMID: 30061734]
  • Suat Kamisli, Osman Ciftci, Asli Taslidere, Nese Basak Turkmen, Cemal Ozcan. The beneficial effects of 18β-glycyrrhetinic acid on the experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mouse model. Immunopharmacology and immunotoxicology. 2018 Aug; 40(4):344-352. doi: 10.1080/08923973.2018.1490318. [PMID: 30052483]
  • Jin Chen, Zhao-Qi Zhang, Jia Song, Qiu-Meng Liu, Chao Wang, Zhao Huang, Liang Chu, Hui-Fang Liang, Bi-Xiang Zhang, Xiao-Ping Chen. 18β-Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy and apoptosis in hepatocellular carcinoma. Scientific reports. 2018 06; 8(1):9365. doi: 10.1038/s41598-018-27142-5. [PMID: 29921924]
  • Zehe Ge, Haipeng Diao, Xiaoli Ji, Qingping Liu, Xiaoyan Zhang, Qing Wu. Gap junctional intercellular communication and endoplasmic reticulum stress regulate chronic cadmium exposure induced apoptosis in HK-2 cells. Toxicology letters. 2018 May; 288(?):35-43. doi: 10.1016/j.toxlet.2018.02.013. [PMID: 29444456]
  • Hidayat Hussain, Ivan R Green, Umair Shamraiz, Muhammad Saleem, Amin Badshah, Ghulam Abbas, Najeeb Ur Rehman, Muhammad Irshad. Therapeutic potential of glycyrrhetinic acids: a patent review (2010-2017). Expert opinion on therapeutic patents. 2018 05; 28(5):383-398. doi: 10.1080/13543776.2018.1455828. [PMID: 29558289]
  • Rosanna Marsella, Luisa Cornegliani, Ibrahim Ozmen, Mary Bohannon, Kim Ahrens, Domenico Santoro. Randomized, double-blinded, placebo-controlled pilot study on the effects of topical blackcurrant emulsion enriched in essential fatty acids, ceramides and 18-beta glycyrrhetinic acid on clinical signs and skin barrier function in dogs with atopic dermatitis. Veterinary dermatology. 2017 Dec; 28(6):577-e140. doi: 10.1111/vde.12467. [PMID: 28736984]
  • Yu-Qi Sun, Chun-Mei Dai, Yan Zheng, Shu-Dan Shi, Hai-Yang Hu, Da-Wei Chen. Binding effect of fluorescence labeled glycyrrhetinic acid with GA receptors in hepatocellular carcinoma cells. Life sciences. 2017 Nov; 188(?):186-191. doi: 10.1016/j.lfs.2017.07.032. [PMID: 28768154]
  • Ayman M Mahmoud, Omnia E Hussein, Walaa G Hozayen, Sanaa M Abd El-Twab. Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPARγ and Nrf2: Protective effect of 18β-Glycyrrhetinic acid. Chemico-biological interactions. 2017 May; 270(?):59-72. doi: 10.1016/j.cbi.2017.04.009. [PMID: 28414158]
  • Rui He, Yongsong Xu, Jingjing Peng, Tingting Ma, Jing Li, Muxin Gong. The effects of 18β-glycyrrhetinic acid and glycyrrhizin on intestinal absorption of paeoniflorin using the everted rat gut sac model. Journal of natural medicines. 2017 Jan; 71(1):198-207. doi: 10.1007/s11418-016-1049-2. [PMID: 27747446]
  • Md Ataur Rahman, Kausik Bishayee, Khadija Habib, Ali Sadra, Sung-Oh Huh. 18α-Glycyrrhetinic acid lethality for neuroblastoma cells via de-regulating the Beclin-1/Bcl-2 complex and inducing apoptosis. Biochemical pharmacology. 2016 10; 117(?):97-112. doi: 10.1016/j.bcp.2016.08.006. [PMID: 27520483]
  • Yasushi Ikarashi, Kazushige Mizoguchi. Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients. Pharmacology & therapeutics. 2016 10; 166(?):84-95. doi: 10.1016/j.pharmthera.2016.06.018. [PMID: 27373856]
  • Sanaa M Abd El-Twab, Walaa G Hozayen, Omnia E Hussein, Ayman M Mahmoud. 18β-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2/ARE/HO-1 pathway and endogenous antioxidants. Renal failure. 2016 Oct; 38(9):1516-1527. doi: 10.1080/0886022x.2016.1216722. [PMID: 27499091]
  • Yi Zhu, Yong Gao, Caroline Tao, Mengle Shao, Shangang Zhao, Wei Huang, Ting Yao, Joshua A Johnson, Tiemin Liu, Aaron M Cypess, Olga Gupta, William L Holland, Rana K Gupta, David C Spray, Herbert B Tanowitz, Lei Cao, Matthew D Lynes, Yu-Hua Tseng, Joel K Elmquist, Kevin W Williams, Hua V Lin, Philipp E Scherer. Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. Cell metabolism. 2016 09; 24(3):420-433. doi: 10.1016/j.cmet.2016.08.005. [PMID: 27626200]
  • Xu Fu, Zhihua Wang, Lixin Li, Shishang Dong, Zhucui Li, Zhenzuo Jiang, Yuefei Wang, Wenqing Shui. Novel Chemical Ligands to Ebola Virus and Marburg Virus Nucleoproteins Identified by Combining Affinity Mass Spectrometry and Metabolomics Approaches. Scientific reports. 2016 07; 6(?):29680. doi: 10.1038/srep29680. [PMID: 27403722]
  • Kasper Moller Boje Rasmussen, Thomas Hartig Braunstein, Max Salomonsson, Jens Christian Brasen, Charlotte Mehlin Sorensen. Contribution of K(+) channels to endothelium-derived hypolarization-induced renal vasodilation in rats in vivo and in vitro. Pflugers Archiv : European journal of physiology. 2016 07; 468(7):1139-1149. doi: 10.1007/s00424-016-1805-x. [PMID: 26965146]
  • Taotao Ma, Cheng Huang, Xiaoming Meng, Xiaofeng Li, Yilong Zhang, Shuai Ji, Jun Li, Min Ye, Hong Liang. A potential adjuvant chemotherapeutics, 18β-glycyrrhetinic acid, inhibits renal tubular epithelial cells apoptosis via enhancing BMP-7 epigenetically through targeting HDAC2. Scientific reports. 2016 05; 6(?):25396. doi: 10.1038/srep25396. [PMID: 27145860]
  • Syed Kazim Hasan, Aisha Siddiqi, Sana Nafees, Nemat Ali, Summya Rashid, Rashid Ali, Ayaz Shahid, Sarwat Sultana. Chemopreventive effect of 18β-glycyrrhetinic acid via modulation of inflammatory markers and induction of apoptosis in human hepatoma cell line (HepG2). Molecular and cellular biochemistry. 2016 May; 416(1-2):169-77. doi: 10.1007/s11010-016-2705-2. [PMID: 27116616]
  • Li-Wei Zou, Yao-Guang Li, Ping Wang, Kun Zhou, Jie Hou, Qiang Jin, Da-Cheng Hao, Guang-Bo Ge, Ling Yang. Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2. European journal of medicinal chemistry. 2016 Apr; 112(?):280-288. doi: 10.1016/j.ejmech.2016.02.020. [PMID: 26900660]
  • Shuai Ji, Ziwei Li, Wei Song, Yongrui Wang, Wenfei Liang, Kai Li, Shunan Tang, Qi Wang, Xue Qiao, Demin Zhou, Siwang Yu, Min Ye. Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine. Journal of natural products. 2016 Feb; 79(2):281-92. doi: 10.1021/acs.jnatprod.5b00877. [PMID: 26841168]
  • Sang-Bum Kim, Hyun-Jong Cho, Yeong Shik Kim, Dae-Duk Kim, In-Soo Yoon. Modulation of Cytochrome P450 Activity by 18β-Glycyrrhetic Acid and its Consequence on Buspirone Pharmacokinetics in Rats. Phytotherapy research : PTR. 2015 Aug; 29(8):1188-94. doi: 10.1002/ptr.5365. [PMID: 26010440]
  • Hiroyuki Kitagawa, Masaya Munekage, Kengo Ichikawa, Ian Fukudome, Eri Munekage, Yuka Takezaki, Takashi Matsumoto, Yasushi Igarashi, Haruo Hanyu, Kazuhiro Hanazaki. Pharmacokinetics of Active Components of Yokukansan, a Traditional Japanese Herbal Medicine after a Single Oral Administration to Healthy Japanese Volunteers: A Cross-Over, Randomized Study. PloS one. 2015; 10(7):e0131165. doi: 10.1371/journal.pone.0131165. [PMID: 26151135]
  • Komal Kalani, Vinita Chaturvedi, Sarfaraz Alam, Feroz Khan, Santosh Kumar Srivastava. Anti-tubercular agents from Glycyrrhiza glabra. Current topics in medicinal chemistry. 2015; 15(11):1043-9. doi: 10.2174/1568026615666150317223323. [PMID: 25786503]
  • Yi Ma, Yan Gui, Youhu Wang, Kehu Xi, Xiaowan Chen, Fuhong Zhang, Chunxia Ma, Hao Hong, Xiangyi Liu, Ying Jiang, Ming Dong, Guijun Yang, Xiaobing Zhang. [The effect of 18β-glycyrrhetinic acid on tight junctions of the nasal mucosa epithelial cells in rat models with allergic rhinitis]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. 2014 Oct; 28(20):1590-4. doi: NULL. [PMID: 25764760]
  • Pravat Kumar Parida, Abhijit Sau, Tamashree Ghosh, Kuladip Jana, Kaushik Biswas, Sanghamitra Raha, Anup Kumar Misra. Synthesis and evaluation of triazole linked glycosylated 18β-glycyrrhetinic acid derivatives as anticancer agents. Bioorganic & medicinal chemistry letters. 2014 Aug; 24(16):3865-8. doi: 10.1016/j.bmcl.2014.06.054. [PMID: 25027936]
  • M Namik Oztanir, Osman Ciftci, Aslı Cetin, M Akif Durak, Nese Basak, Yener Akyuva. The beneficial effects of 18β-glycyrrhetinic acid following oxidative and neuronal damage in brain tissue caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse model. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2014 Aug; 35(8):1221-8. doi: 10.1007/s10072-014-1685-9. [PMID: 24554419]
  • Miyoung Park, Ji-Hae Lee, Jin Kyu Choi, Yong Deog Hong, Il-Hong Bae, Kyung-Min Lim, Young-Ho Park, Hunjoo Ha. 18β-glycyrrhetinic acid attenuates anandamide-induced adiposity and high-fat diet induced obesity. Molecular nutrition & food research. 2014 Jul; 58(7):1436-46. doi: 10.1002/mnfr.201300763. [PMID: 24687644]
  • O V Astaf'eva, L T Sukhenko. Comparative analysis of antibacterial properties and chemical composition of Glycyrrhiza glabra L. from Astrakhan region (Russia) and Calabria region (Italy). Bulletin of experimental biology and medicine. 2014 Apr; 156(6):829-32. doi: 10.1007/s10517-014-2462-8. [PMID: 24824709]
  • Xue Li, Jinping Hu, Baolian Wang, Li Sheng, Zhihao Liu, Shuang Yang, Yan Li. Inhibitory effects of herbal constituents on P-glycoprotein in vitro and in vivo: herb-drug interactions mediated via P-gp. Toxicology and applied pharmacology. 2014 Mar; 275(2):163-75. doi: 10.1016/j.taap.2013.12.015. [PMID: 24380838]
  • M Ahmad, B P Panda. Alginate immobilization of Escherichia coli MTCC 1652 whole cells for bioconversion of glycyrrhizinic acid and into 18-beta glycyrrhetinic acid. Pakistan journal of biological sciences : PJBS. 2013 Dec; 16(24):2046-9. doi: 10.3923/pjbs.2013.2046.2049. [PMID: 24517027]
  • Sung Bum Park, Won Hoon Jung, Nam Sook Kang, Ji Seon Park, Gyu Hwan Bae, Hee Youn Kim, Sang Dal Rhee, Seung Kyu Kang, Jin Hee Ahn, Hye Gwang Jeong, Ki Young Kim. Anti-diabetic and anti-inflammatory effect of a novel selective 11β-HSD1 inhibitor in the diet-induced obese mice. European journal of pharmacology. 2013 Dec; 721(1-3):70-9. doi: 10.1016/j.ejphar.2013.09.052. [PMID: 24135201]
  • Tsukasa Ishida, Ikuya Miki, Toshihito Tanahashi, Saori Yagi, Yasuyuki Kondo, Jun Inoue, Shoji Kawauchi, Sin Nishiumi, Masaru Yoshida, Hideko Maeda, Chisato Tode, Atsuko Takeuchi, Hirokazu Nakayama, Takeshi Azuma, Shigeto Mizuno. Effect of 18β-glycyrrhetinic acid and hydroxypropyl γcyclodextrin complex on indomethacin-induced small intestinal injury in mice. European journal of pharmacology. 2013 Aug; 714(1-3):125-31. doi: 10.1016/j.ejphar.2013.06.007. [PMID: 23792039]
  • Jeonghyeon Kim, Inkyung Joo, Hayan Kim, Yongmoon Han. 18β-glycyrrhetinic acid induces immunological adjuvant activity of Th1 against Candida albicans surface mannan extract. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Aug; 20(11):951-5. doi: 10.1016/j.phymed.2013.04.008. [PMID: 23746951]
  • Chia Feng Yeh, Kuo Chih Wang, Lien Chai Chiang, Den En Shieh, Ming Hong Yen, Jung San Chang. Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. Journal of ethnopharmacology. 2013 Jul; 148(2):466-73. doi: 10.1016/j.jep.2013.04.040. [PMID: 23643542]
  • Mi Eun Kim, Hyung Keun Kim, Dong Hwan Kim, Ju Hwa Yoon, Jun Sik Lee. 18β-Glycyrrhetinic acid from licorice root impairs dendritic cells maturation and Th1 immune responses. Immunopharmacology and immunotoxicology. 2013 Jun; 35(3):329-35. doi: 10.3109/08923973.2013.768636. [PMID: 23438306]
  • Huadong Chen, Dominique Soroka, Yingdong Zhu, Shengmin Sang. Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human. Molecular nutrition & food research. 2013 May; 57(5):865-76. doi: 10.1002/mnfr.201200708. [PMID: 23322474]
  • Benjamin Lallemand, Moustapha Ouedraogo, Nathalie Wauthoz, Touria Lamkami, Veronique Mathieu, Ivan Jabin, Karim Amighi, Robert Kiss, Jacques Dubois, Jonathan Goole. Synthesis and plasma pharmacokinetics in CD-1 mice of a 18β-glycyrrhetinic acid derivative displaying anti-cancer activity. The Journal of pharmacy and pharmacology. 2013 Mar; 65(3):402-10. doi: 10.1111/j.2042-7158.2012.01603.x. [PMID: 23356849]
  • Tzu-Chien Kao, Chi-Hao Wu, Gow-Chin Yen. Glycyrrhizic acid and 18β-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1, CRE and NFAT activation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Feb; 20(3-4):295-302. doi: 10.1016/j.phymed.2012.10.013. [PMID: 23218403]
  • Komal Kalani, Jyoti Agarwal, Sarfaraz Alam, Feroz Khan, Anirban Pal, Santosh Kumar Srivastava. In silico and in vivo anti-malarial studies of 18β glycyrrhetinic acid from Glycyrrhiza glabra. PloS one. 2013; 8(9):e74761. doi: 10.1371/journal.pone.0074761. [PMID: 24086367]
  • Masahiro Tabuchi, Sachiko Imamura, Zenji Kawakami, Yasushi Ikarashi, Yoshio Kase. The blood-brain barrier permeability of 18β-glycyrrhetinic acid, a major metabolite of glycyrrhizin in Glycyrrhiza root, a constituent of the traditional Japanese medicine yokukansan. Cellular and molecular neurobiology. 2012 Oct; 32(7):1139-46. doi: 10.1007/s10571-012-9839-x. [PMID: 22488528]
  • Tsuyoshi Matsumoto, Kenichi Sakurai, Asami Tanaka, Takayuki Ishibashi, Kaori Tachibana, Ko Ishikawa, Koutaro Yokote. The anti-ulcer agent, irsogladine, increases insulin secretion by MIN6 cells. European journal of pharmacology. 2012 Jun; 685(1-3):213-7. doi: 10.1016/j.ejphar.2012.04.005. [PMID: 22542662]
  • Myung-Hee Moon, Jae-Kyo Jeong, You-Jin Lee, Jae-Won Seol, Dong-Choon Ahn, In-Shik Kim, Sang-Youel Park. 18β-Glycyrrhetinic acid inhibits adipogenic differentiation and stimulates lipolysis. Biochemical and biophysical research communications. 2012 Apr; 420(4):805-10. doi: 10.1016/j.bbrc.2012.03.078. [PMID: 22465130]
  • Antonia Puchner, Silvia Hayer, Birgit Niederreiter, Anastasiya Hladik, Stephan Blueml, Michael Bonelli, Clemens Scheinecker, Josef Smolen, Kurt Redlich. Effects of 18β-Glycyrrhetinic acid in hTNFtg mice - a model of rheumatoid arthritis. Wiener klinische Wochenschrift. 2012 Mar; 124(5-6):170-6. doi: 10.1007/s00508-011-0103-z. [PMID: 22210441]
  • Kai Zhao, Weili Wang, Caihong Guan, Jie Cai, Ping Wang. Inhibition of gap junction channel attenuates the migration of breast cancer cells. Molecular biology reports. 2012 Mar; 39(3):2607-13. doi: 10.1007/s11033-011-1013-x. [PMID: 21674188]
  • Hao-Yang Sun, Qing Li, Wei Chen, Lu-Lu Geng, Xi Li, Xiao-Hui Chen, Kai-Shun Bi. Pharmacokinetic analysis of alpha and beta epimers of glycyrrhetinic acid in rat plasma: differences in singly and combined administrations. Yao xue xue bao = Acta pharmaceutica Sinica. 2012 Jan; 47(1):94-100. doi: NULL. [PMID: 22493812]
  • S Li, Y Q Qiu, S H Zhang, Y H Gao. A novel transdermal fomulation of 18β-glycyrrhetic acid with lysine for improving bioavailability and efficacy. Skin pharmacology and physiology. 2012; 25(5):257-68. doi: 10.1159/000339652. [PMID: 22832704]
  • Jay M Hendricks, Carol Hoffman, David W Pascual, Michele E Hardy. 18β-glycyrrhetinic acid delivered orally induces isolated lymphoid follicle maturation at the intestinal mucosa and attenuates rotavirus shedding. PloS one. 2012; 7(11):e49491. doi: 10.1371/journal.pone.0049491. [PMID: 23152913]
  • Chung-Yi Wang, Tzu-Chien Kao, Wen-Hsieh Lo, Gow-Chin Yen. Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions. Journal of agricultural and food chemistry. 2011 Jul; 59(14):7726-33. doi: 10.1021/jf2013265. [PMID: 21644799]
  • Honglan Piao, Ayako Sato, Yukiko Nozawa, Wei Sun, Tetsuo Morioka, Takashi Oite. Effects of connexin-mimetic peptides on perfusion pressure in response to phenylephrine in isolated, perfused rat kidneys. Clinical and experimental nephrology. 2011 Apr; 15(2):203-11. doi: 10.1007/s10157-010-0382-0. [PMID: 21153751]
  • Weizhi Sun, Weibing Peng, Guoqiang Li, Tao Jiang. Design, synthesis, and sustained-release property of 1,3-cyclic propanyl phosphate ester of 18β-glycyrrhetinic acid. Chemical biology & drug design. 2011 Mar; 77(3):206-11. doi: 10.1111/j.1747-0285.2010.01077.x. [PMID: 21244638]
  • Egor Y Plotnikov, Tatyana G Khryapenkova, Svetlana I Galkina, Gennady T Sukhikh, Dmitry B Zorov. Cytoplasm and organelle transfer between mesenchymal multipotent stromal cells and renal tubular cells in co-culture. Experimental cell research. 2010 Sep; 316(15):2447-55. doi: 10.1016/j.yexcr.2010.06.009. [PMID: 20599955]
  • Zenji Kawakami, Yasushi Ikarashi, Yoshio Kase. Glycyrrhizin and its metabolite 18 beta-glycyrrhetinic acid in glycyrrhiza, a constituent herb of yokukansan, ameliorate thiamine deficiency-induced dysfunction of glutamate transport in cultured rat cortical astrocytes. European journal of pharmacology. 2010 Jan; 626(2-3):154-8. doi: 10.1016/j.ejphar.2009.09.046. [PMID: 19818347]
  • Yichuan Xiao, Jingwei Xu, Chaoming Mao, Min Jin, Qiong Wu, Jie Zou, Qiaoli Gu, Yi Zhang, Yanyun Zhang. 18Beta-glycyrrhetinic acid ameliorates acute Propionibacterium acnes-induced liver injury through inhibition of macrophage inflammatory protein-1alpha. The Journal of biological chemistry. 2010 Jan; 285(2):1128-37. doi: 10.1074/jbc.m109.037705. [PMID: 19897483]
  • Panneerselvam Kalaiarasi, Kuppuswamy Kaviarasan, Kodukkur Viswanathan Pugalendi. Hypolipidemic activity of 18beta-glycyrrhetinic acid on streptozotocin-induced diabetic rats. European journal of pharmacology. 2009 Jun; 612(1-3):93-7. doi: 10.1016/j.ejphar.2009.04.003. [PMID: 19361497]
  • Donatella Pellati, Cristina Fiore, Decio Armanini, Mario Rassu, Giulio Bertoloni. In vitro effects of glycyrrhetinic acid on the growth of clinical isolates of Candida albicans. Phytotherapy research : PTR. 2009 Apr; 23(4):572-4. doi: 10.1002/ptr.2693. [PMID: 19067381]
  • Panneerselvam Kalaiarasi, Kodukkur Viswanathan Pugalendi. Antihyperglycemic effect of 18 beta-glycyrrhetinic acid, aglycone of glycyrrhizin, on streptozotocin-diabetic rats. European journal of pharmacology. 2009 Mar; 606(1-3):269-73. doi: 10.1016/j.ejphar.2008.12.057. [PMID: 19374864]
  • Thomas C Clarke, Oliver J S Williams, Patricia E M Martin, W Howard Evans. ATP release by cardiac myocytes in a simulated ischaemia model: inhibition by a connexin mimetic and enhancement by an antiarrhythmic peptide. European journal of pharmacology. 2009 Mar; 605(1-3):9-14. doi: 10.1016/j.ejphar.2008.12.005. [PMID: 19101539]
  • Vandana Verma, Maurice B Hallett, Luc Leybaert, Patricia E Martin, W Howard Evans. Perturbing plasma membrane hemichannels attenuates calcium signalling in cardiac cells and HeLa cells expressing connexins. European journal of cell biology. 2009 Feb; 88(2):79-90. doi: 10.1016/j.ejcb.2008.08.005. [PMID: 18951659]
  • Qiaogen Zou, Ping Wei, Jing Li, Zheng-Xiang Ge, Pingkai Ouyang. Simultaneous determination of 18alpha- and 18beta-glycyrrhetic acid in human plasma by LC-ESI-MS and its application to pharmacokinetics. Biomedical chromatography : BMC. 2009 Jan; 23(1):54-62. doi: 10.1002/bmc.1082. [PMID: 18850581]
  • Xudong Wu, Luyong Zhang, Emily Gurley, Elaine Studer, Jing Shang, Tao Wang, Cuifen Wang, Ming Yan, Zhenzhou Jiang, Phillip B Hylemon, Arun J Sanyal, William M Pandak, Huiping Zhou. Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways. Hepatology (Baltimore, Md.). 2008 Jun; 47(6):1905-15. doi: 10.1002/hep.22239. [PMID: 18452148]
  • Richard J Lang, Hikaru Hashitani, Mary A Tonta, Helena C Parkington, Hikaru Suzuki. Spontaneous electrical and Ca2+ signals in typical and atypical smooth muscle cells and interstitial cell of Cajal-like cells of mouse renal pelvis. The Journal of physiology. 2007 Sep; 583(Pt 3):1049-68. doi: 10.1113/jphysiol.2007.137034. [PMID: 17656432]
  • Jose L Perez Velazquez, Larisa Kokarovtseva, Raheleh Sarbaziha, Zina Jeyapalan, Yevgen Leshchenko. Role of gap junctional coupling in astrocytic networks in the determination of global ischaemia-induced oxidative stress and hippocampal damage. The European journal of neuroscience. 2006 Jan; 23(1):1-10. doi: 10.1111/j.1460-9568.2005.04523.x. [PMID: 16420410]
  • B F De Blasio, J-A Røttingen, K L Sand, I Giaever, J-G Iversen. Global, synchronous oscillations in cytosolic calcium and adherence in bradykinin-stimulated Madin-Darby canine kidney cells. Acta physiologica Scandinavica. 2004 Apr; 180(4):335-46. doi: 10.1111/j.1365-201x.2004.01261.x. [PMID: 15030375]
  • Marwan E El-Sabban, Agnel J Sfeir, Myriam H Daher, Nada Y Kalaany, Rola A Bassam, Rabih S Talhouk. ECM-induced gap junctional communication enhances mammary epithelial cell differentiation. Journal of cell science. 2003 Sep; 116(Pt 17):3531-41. doi: 10.1242/jcs.00656. [PMID: 12893812]
  • Jorge E Contreras, Helmut A Sánchez, Eliseo A Eugenin, Dina Speidel, Martin Theis, Klaus Willecke, Feliksas F Bukauskas, Michael V L Bennett, Juan C Sáez. Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proceedings of the National Academy of Sciences of the United States of America. 2002 Jan; 99(1):495-500. doi: 10.1073/pnas.012589799. [PMID: 11756680]
  • A Krazeisen, R Breitling, G Möller, J Adamski. Phytoestrogens inhibit human 17beta-hydroxysteroid dehydrogenase type 5. Molecular and cellular endocrinology. 2001 Jan; 171(1-2):151-62. doi: 10.1016/s0303-7207(00)00422-6. [PMID: 11165023]