Chemical Formula: C30H46O4
Chemical Formula C30H46O4
Found 393 metabolite its formula value is C30H46O4
Glycyrrhetinic acid
Glycyrrhetinic acid is a pentacyclic triterpenoid that is olean-12-ene substituted by a hydroxy group at position 3, an oxo group at position 11 and a carboxy group at position 30. It has a role as an immunomodulator and a plant metabolite. It is a pentacyclic triterpenoid, a cyclic terpene ketone and a hydroxy monocarboxylic acid. It is a conjugate acid of a glycyrrhetinate. It derives from a hydride of an oleanane. Enoxolone (glycyrrhetic acid) has been investigated for the basic science of Apparent Mineralocorticoid Excess (AME). Enoxolone is a natural product found in Glycyrrhiza, Echinopora lamellosa, and other organisms with data available. Enoxolone is a pentacyclic triterpenoid aglycone metabolite of glycyrrhizin, which is a product of the plant Glycyrrhiza glabra (licorice), with potential expectorant, and gastrokinetic activities. After administration, enoxolone inhibits the metabolism of prostaglandins by both 15-hydroxyprostaglandin dehydrogenase [NAD(+)] and prostaglandin reductase 2. Therefore, this agent potentiates the activity of prostaglandin E2 and F2alpha, which inhibits gastric secretion while stimulating pancreatic secretion and the secretion of intestinal and respiratory mucus, leading to increased intestinal motility and antitussive effects. Additionally, this agent inhibits 11 beta-hydroxysteroid dehydrogenase and other enzymes involved in the conversion of cortisol to cortisone in the kidneys. An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation. See also: Glycyrrhizin (is active moiety of); Glycyrrhiza Glabra (part of). Glycyrrhetinic acid is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was first obtained from the herb liquorice. It is used in flavouring and it masks the bitter taste of drugs like aloe and quinine. It is effective in the treatment of peptic ulcer and also has expectorant (antitussive) properties (PMID:32106571). In glycyrrhetinic acid the functional group (R) is a hydroxyl group. Research in 2005 demonstrated that with a proper functional group a very effective glycyrrhetinic artificial sweetener can be obtained. When R is an anionic NHCO(CH2)CO2K side chain, the sweetening effect is found to 1200 times that of sugar (human sensory panel data). A shorter or longer spacer reduces the sweetening effect. One explanation is that the taste bud cell receptor has 1.3 nanometers (13 angstroms) available for docking with the sweetener molecule. In addition the sweetener molecule requires three proton donor positions of which two reside at the extremities to be able to interact efficiently with the receptor cavity. 18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2]. 18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2]. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
Gypsogenin
Gypsogenin is a sapogenin that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3 and an oxo group at position 23. It is a pentacyclic triterpenoid, a sapogenin, an aldehyde and a monocarboxylic acid. It is functionally related to an oleanolic acid. It is a conjugate acid of a gypsogenin(1-). Gypsogenin is a natural product found in Silene firma, Gypsophila bicolor, and other organisms with data available. Gypsogenin shows antiangiogenic activity and the significant cytotoxicity against H460[1]. Gypsogenin shows antiangiogenic activity and the significant cytotoxicity against H460[1].
11-Keto-beta-boswellic acid
11-Keto-beta-boswellic acid is a natural product found in Boswellia papyrifera, Boswellia sacra, and Boswellia serrata with data available. See also: Indian frankincense (part of). 11-Keto-beta-boswellic acid is found in herbs and spices. 11-Keto-beta-boswellic acid is a constituent of Boswellia serrata (Indian olibanum). Constituent of Boswellia serrata (Indian olibanum). 11-Keto-beta-boswellic acid is found in herbs and spices. 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production[1]. 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production[1]. 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production[1].
Pomonic acid
Pomonic acid is a triterpenoid. Pomonic acid is a natural product found in Lantana strigocamara with data available. Pomonic acid is found in pomes. Pomonic acid is isolated as the Me ester from apple (Pyrus malus Isol. as the Me ester from apple (Pyrus malus). Pomonic acid is found in pomes.
Ganodermic acid Jb
Ganodermic acid Ja is found in mushrooms. Ganodermic acid Ja is a metabolite of Ganoderma lucidum (reishi). Ganodermic acid Jb is a triterpenoid.
Colubrinic acid
Colubrinic acid is found in fruits. Colubrinic acid is a constituent of Zizyphus jujuba (Chinese date). Constituent of Zizyphus jujuba (Chinese date). Colubrinic acid is found in fruits.
28-Hydroxymangiferonic acid
28-Hydroxymangiferonic acid is found in fruits. 28-Hydroxymangiferonic acid is a constituent of Mangifera indica (mango). Constituent of Mangifera indica (mango). 28-Hydroxymangiferonic acid is found in fruits.
Secobryononic acid
Secobryononic acid is found in fruits. Secobryononic acid is a constituent of Sandoricum koetjape (santol). Constituent of Sandoricum koetjape (santol). Secobryononic acid is found in fruits.
Rubinic acid
Rubinic acid is found in fruits. Rubinic acid is a constituent of Rubus fruticosus (blackberry). Constituent of Rubus fruticosus (blackberry). Rubinic acid is found in fruits.
Ganoderiol B
Ganoderiol B is found in mushrooms. Ganoderiol B is a constituent of Ganoderma lucidum (reishi). Constituent of Ganoderma lucidum (reishi). Ganoderiol B is found in mushrooms.
23-Hydroxy-3-oxocycloart-24-en-26-oic acid
23-Hydroxy-3-oxocycloart-24-en-26-oic acid is found in fruits. 23-Hydroxy-3-oxocycloart-24-en-26-oic acid is a constituent of Mangifera indica (mango) Constituent of Mangifera indica (mango). 23-Hydroxy-3-oxocycloart-24-en-26-oic acid is found in fruits.
6beta-Hydroxy-3-oxo-12-oleanen-28-oic acid
6beta-Hydroxy-3-oxo-12-oleanen-28-oic acid is a constituent of Myroxylon balsamum (Tolu balsam) Constituent of Myroxylon balsamum (Tolu balsam)
Koetjapic acid
Koetjapic acid is found in fruits. Koetjapic acid is a constituent of Sandoricum koetjape (santol). Constituent of Sandoricum koetjape (santol). Koetjapic acid is found in fruits.
(3alpha,20R,24Z)-3-Hydroxy-21-oxoeupha-8,24-dien-26-oic acid
3-Hydroxy-21-oxotirucalla-8,24-dien-26-oic acid is found in beverages. 3-Hydroxy-21-oxotirucalla-8,24-dien-26-oic acid is a constituent of Schinus molle (California peppertree).
Lansic acid
Lansic acid is found in fruits. Lansic acid is a constituent of Lansium domesticum (langsat). Constituent of Lansium domesticum (langsat). Lansic acid is found in fruits.
Murrayenol
Murrayenol is found in herbs and spices. Murrayenol is isolated from roots of Murraya koenigii (curry leaf tree
Secoisobryononic acid
Secoisobryononic acid is found in fruits. Secoisobryononic acid is a constituent of Sandoricum koetjape (santol). Constituent of Sandoricum koetjape (santol). Secoisobryononic acid is found in fruits.
3beta-3,24-Dihydroxy-9(11),12-oleanadien-30-oic acid
3beta-3,24-Dihydroxy-9(11),12-oleanadien-30-oic acid is found in herbs and spices. 3beta-3,24-Dihydroxy-9(11),12-oleanadien-30-oic acid is isolated from Glycyrrhiza glabra (licorice). Isolated from Glycyrrhiza glabra (licorice). 3beta-3,24-Dihydroxy-9(11),12-oleanadien-30-oic acid is found in tea and herbs and spices.
beta-Glycyrrhetinic acid
beta-Glycyrrhetinic acid is found in herbs and spices. beta-Glycyrrhetinic acid is a constituent of licorice (Glycyrrhiza glabra) root Constituent of licorice (Glycyrrhiza glabra) root. beta-Glycyrrhetinic acid is found in herbs and spices. 18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2]. 18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2]. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
Liquiritic acid
Liquiritic acid is found in herbs and spices. Liquiritic acid is isolated from Glycyrrhiza glabra (licorice Isolated from Glycyrrhiza glabra (licorice). Liquiritic acid is found in tea and herbs and spices.
2-Hydroxy-3-oxo-12-oleanen-28-oic acid
2-Hydroxy-3-oxo-12-oleanen-28-oic acid is found in herbs and spices. 2-Hydroxy-3-oxo-12-oleanen-28-oic acid is a constituent of Salvia officinalis (sage). Constituent of Salvia officinalis (sage). 2-Hydroxy-3-oxo-12-oleanen-28-oic acid is found in tea and herbs and spices.
16-Hydroxy-3-oxo-12-oleanen-28-oic acid
16-Hydroxy-3-oxo-12-oleanen-28-oic acid is found in alcoholic beverages. 16-Hydroxy-3-oxo-12-oleanen-28-oic acid is isolated from Vitis vinifera (wine grape). Isolated from Vitis vinifera (wine grape). 16-Hydroxy-3-oxo-12-oleanen-28-oic acid is found in alcoholic beverages and fruits.
18a-Glycyrrhetinic acid
Kuguacin A
Kuguacin a is practically insoluble (in water) and an extremely weak acidic compound (based on its pKa). Kuguacin a can be found in bitter gourd, which makes kuguacin a a potential biomarker for the consumption of this food product.
A-Homo-3a-oxa-5beta-olean-12-en-3-one-28-oic acid
16a-Hydroxydehydrotrametenolic acid
16alpha-Hydroxydehydrotrametenolic acid is a natural product found in Wolfiporia cocos with data available.
(24Z)-3-Oxo-12alpha-hydroxylanosta-8,24-dien-26-oic acid
Karavilagenin D
2,2,4,4,10,13a-Hexamethyl-6,7-isopropylidene-10,11-epoxy-14-isobutyl-1,2,3,4,5a,6,7,8,9,10,11,12,13,13a,14-pentadecahydro-5-oxacyclodeca[b]naphthalene-1,3-dione
Hyperinol B
A hexacyclic triterpenoid that is 13,28-epoxyursan-28-one with a terminal double bond between positions 20(30) and is substituted by hydroxy groups at position 3 and 22 (the 3beta,19alpha,22alpha stereoisomer). It is a taraxastane-type triterpene isolated from Hypericum oblongifolium and exhibits enzyme inhibitory activity against chymotrypsin.
Ganoderone C
A tetracyclic triterpenoid that is 5alpha-lanosta-8-ene with an epoxy group across positions 24 and 25, a hydroxy group at position 26 and oxo groups at positions 3 and 7. Isolated from the fruiting bodies of Ganoderma pfeifferi, it exhibits antiviral activity against influenza A virus.
Kuguacin N
Kuguacin N is a natural product found in Momordica charantia with data available.
Virgatic acid
A pentacyclic triterpenoid that is olean-12-ene substituted by a carboxy group at position 28, a beta-hydroxy group at position 3 and an oxo group at position 1. It has been isolated from Juglans sinensis.
(E,6S)-7-hydroxy-2-methyl-6-[(10S,13S,14S,17S)-4,4,10,13,14-pentamethyl-3-oxo-1,2,5,6,7,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]hept-2-enoic acid
2alpha,3beta-dihydroxy-13alpha,27-cyclours-11-en-28-oic acid|euscaphic acid E
4,4,8-Trimethyl-3??,7??,23-trihydroxy-chola-14,24-dien-21-oic acid-21,23-lactone
(3beta,11alpha,12alpha,13beta)-11,12-Epoxy-3-hydroxy-28,13-ursanolide|(3beta,11alpha,12alpha,13beta)-11,12-Epoxy-3-hydroxypregn-28,13-ursanolide|3beta,13-dihydroxy-11alpha,12alpha-epoxyursan-28-oic acid gamma-lactone|3beta-hydroxy-11alpha,12alpha-epoxyurs-13beta,28-olide
25-Hydroxy-3-oxo-12-oleanen-30-oic acid|3-oxo-25-hydroxy-olean-12-en-30-oic acid
2,3-(2,2-dimethyl-3,4-dihydro-2H-pyran)-6-(1-oxopropyl)-4,8-diprenyl-8beta-H-cis-bicyclo[3.3.1]non-1,5-dione|garcinielliptone B
3,4;19,21-di-seco-lupa-4(23),20(29)-diene-21,19-lacton-3-oic acid|lippiolidolic acid
(E)-4-(3,4-dimethoxyphenyl)-but-3-en-1-yl linoleate
(23R,24E)-3-oxo-9beta-lanosta-7,24-dien-23-hydroxy-26-oic acid|abiesatrine G
3alpha-hydroxy-11alpha,12alpha-epoxyoleanane-28,13beta-olide
(3R,14R,17R,28R)-1,12,18,29-triacontatetrayne-3,14,17,28-tetrol|(all-R)-form-1,12,18,29-Triacontatetrayne-3,14,17,28-tetrol
(2alpha,3alpha,19alpha)-2,3,19-trihydroxyurs-13(18)-en-28-oic acid gamma-lactone|serrulatin C
2-ethoxycarbonyl-2beta-hydroxy-A-nor-ergosta-5,24(28)-dien-4-one
3,4-Secotirucalla-4(28),7,24-triene-3,26-dioic acid
3alpha-hydroxy-6-oxo-7,24Z-tirucalladien-26-oic acid
3alpha-Hydroxy-29-oxo-12-oleanen-27-oic acid|3alpha-Hydroxy-29-oxoolean-12-en-27-oic acid
(1S,1S,2S,2S,5R,5S)-2,2-{5,5-[Butane-1,4-diylidene]bis[(2R,5Z)-tetrahydropyran-2-yl]}bis[5-(1-methylethenyl)cyclopentanol]|Testudinariol B
19alpha-hydroxy-3-oxo-olean-12-en-28-oic acid|19alpha-hydroxyoleanonic acid
21beta,22beta-dihydroxy-3-oxours-12-en-28-al|cordianal B
(23S,25R)-3alpha-hydroxy-17,23-epoxy-9,19-cyclo-9beta-lanostan-26,23-olide|desmethylabietospiran
(22E)-2-ethoxycarbonyl-2-beta-hydroxy-24-methyl-A-nor-cholest-5,22-diene-4-one|2-ethoxycarbonyl-2beta-hydroxy-24-methyl-A-nor-cholesta-5,22-dien-4-one
(23R,25R)-3,4-seco-9betaH-lanosta-4(28),7-dien-26,23-olid-3-oic acid|abiesolidic acid
(17R,20R)-29-hydroxy-23,26-epoxy-3,4-secocycloarta-23(24),25(26)-dien-3-oic acid|dikamaliartane F
(3beta,21alpha)--3,21-Dihydroxy-11,13(18)-oleanadien-28-oic acid|3beta,21alpha-dihydroxy-oleane-11,13-dien-28-oic acid|3beta-21alpha-dihydroxyoleana-11,13(18)-diene-28-oic acid
3beta-hydroxy-12-oxo-13Halpha-olean-28,19beta-olide
(+)-3,4-secolanosta-4(28),8,24-trien-3,21-dioic acid|pinicolic acid C
(2alpha,3alpha)-2,3-Dihydroxy-5,12-oleanadien-28-oic acid
3,4-seco-olean-4(23),12(13)-dien-3,27-dioic acid|sentulic acid
(3R,25R)-3-hydroxy-23-oxomariesia-7,14-dien-26-oic acid|neoabiestrine A
3beta-hydroxy-7beta,8beta-epoxy-5alpha-lanost-24-en-30,9alpha-olide
21,23-epoxy-7alpha-21alpha-dihydroxyapotirucalla-14,24-dien-3-one
2,3-secotirucalla-2,3;2,29-diepoxy-7-ene-3,23-dione|aphanamgrandin A
3alpha-hydroxy-cycloarta-23-on-7-en-26beta-oic acid|neoabiestrine G
(+)-rel-3alpha-hydroxy-23-oxocycloart-25(27)-en-26-oic acid
24E-3-oxo-22-hydroxylanosta-8,24-dien-26-oic acid|astraodoric acid B
3beta,16beta-hydroxytirucalla-7,24(25)-dien-21,23-olide
7-Oxo-ganoderic acid Z
7-Oxo-ganoderic acid Z is a natural product found in Ganoderma lucidum with data available.
16alpha,23alpha-epoxy-3beta,20beta-dihydroxy-10alphaH,23betaH-cucurbit-5,24-dien-11-one
26,27-dihydroxy-5alpha-lanosta-8,24-dien-3,7-dione|ganoderiol J
3,4-seco-29-nortirucalla-4,23-dione-7,24-diene-3-oic acid 3-methyl ester|aphanamgrandin I
24(S)-hydroxy-3-oxocycloart-25-en-30-oic acid|caloncobic acid A
2alpha-hydroxy-3-oxoolean-12-en-30-oic acid|dillenic acid A
holosta-7,9(11)-diene-3beta,17alpha-diol|holosta-7,9-diene-3beta,17alpha-diol|Holothurinogenin
(24E)-3,4-secodammara-4(28),20,24-trien-3,26-dioic acid|(24E)-3,4-secodammara-4(28),20,24-triene-3,26-dioic acid|3,4-Secodammara-4(28),20,24-triene-3,26-dioic acid
3beta-hydroxyholost-9(11)-en-16-one|3beta-hydroxyholosta-9(11)-en-16-one|dihydroholotoxigenin
(6S)-hydroxy-24-oxo-29-nor-3,4-seco-cycloart-4(30),25-dien-3-oic acid methyl ester
1alpha,5alpha-dioxy-11alpha-hydroxyurs-12-en-3-one
(7alpha)-7-hydroxy-3-oxoolean-12-en-28-oic acid|camarin
3beta,19alpha-dihydroxy-13alpha,27-cyclours-11-en-28-oic acid|euscaphic acid A
(22E,24E)-1beta,3beta-dihydroxylanosta-5,22,24-trien-27-oic acid|cashmirol B
2-alpha-hydroxy-3-oxours-12-en-28-oic acid|2-hydroxy-3-oxo-12-ursen-28-oic acid
3beta,28beta-dihydroxy-ursa-12,20-dien-23alpha-oic acid|lawnermis acid
3,4-Seco-5alpha-tirucalla-4(28),7,24-triene-3,21-dioic acid|3,4-secotirucalla-4(28),7,24-trien-3,21-dioic acid|3,4-secotirucalla-4(28),7,24-triene-3,21-dioic acid
3,24-Dioxo-29-friedelanoic acid|3,24-Dioxo-friedelan-29-oic acid
21,22beta-epoxy-3beta-hydroxy olean-12-en-28-oic acid
(3beta)-cucurbita-5,24-diene-7,23-dione-3,29-diol|balsaminol C
3beta,15beta,22alpha-trihydroxy-olean-12-en-28-oic acid-15-lactone|3beta,15beta,22alpha-Trihydroxy-olean-12-en-28-saeure-15-lacton
(16beta,23R)-23,25-Epidioxy-16,23-epoxycycloartan-3-one|(16S,23R)-16,23-epoxy-23,25-epidioxycycloartan-3-one
3beta,25-epoxy-3alpha-hydroxy-19,21-seco-lup-20(29)-en-21,19-lactone|lippiolide
3beta,23-dihydroxy-oleana-11,13(18)-dien-28-oic acid|3beta.23-dihydroxy-oleanadien-(11.13(18))-oic acid-(28)|3beta.23-Dihydroxy-oleanadien-(11.13(18))-saeure-(28)
13,17-friedo-13,23-epoxy-3alpha-hydroxy-9beta-lanosta-7-ene-23,27-olide|abiesatrine A
25-Aldehyde-3beta-3,25-Dihydroxy-12-oleanen-30-oic acid|periandric acid II
22beta-hydroxy-3-oxo-olean-12-en-28-oic acid|22beta-Hydroxy-3-oxo-olean-12-en-28-saeure|22beta-hydroxy-3-oxoolean-12-en-28-oic acid|22beta-hydroxyoleanonic acid|3-Ketone-(3beta,22beta)-3,22-Dihydroxy-12-oleanen-28-oic acid
(17R,20R)-29-hydroxy-23-oxo-3,4-secocycloarta-4(28),24(25)-dien-3-oic acid|dikamakiartane C|dikamaliartane D
1beta,3beta-dihydroxy-olean-11,13(18)dien-28-oic acid|atricin A
Nigranoic acid
Nigranoic acid is a tetracyclic triterpenoid that is 3,4-secocycloarta-4(28),24-(Z)-diene substituted by carboxy groups at positions 3 and 26. Isolated from Schisandra henryi and Schisandra propinqua, it exhibits cytotoxic and anti-HIV activities. It has a role as a metabolite, an antineoplastic agent and a HIV-1 reverse transcriptase inhibitor. It is a tetracyclic triterpenoid and a dicarboxylic acid. Nigranoic acid is a natural product found in Kadsura angustifolia, Kadsura heteroclita, and other organisms with data available. A tetracyclic triterpenoid that is 3,4-secocycloarta-4(28),24-(Z)-diene substituted by carboxy groups at positions 3 and 26. Isolated from Schisandra henryi and Schisandra propinqua, it exhibits cytotoxic and anti-HIV activities.
Coronalolic acid
Coronalolic acid is a natural product found in Gardenia coronaria with data available.
Enoxolone
Glycyrrhetinic acid is a pentacyclic triterpenoid that is olean-12-ene substituted by a hydroxy group at position 3, an oxo group at position 11 and a carboxy group at position 30. It has a role as an immunomodulator and a plant metabolite. It is a pentacyclic triterpenoid, a cyclic terpene ketone and a hydroxy monocarboxylic acid. It is a conjugate acid of a glycyrrhetinate. It derives from a hydride of an oleanane. Enoxolone (glycyrrhetic acid) has been investigated for the basic science of Apparent Mineralocorticoid Excess (AME). Enoxolone is a natural product found in Glycyrrhiza, Echinopora lamellosa, and other organisms with data available. Enoxolone is a pentacyclic triterpenoid aglycone metabolite of glycyrrhizin, which is a product of the plant Glycyrrhiza glabra (licorice), with potential expectorant, and gastrokinetic activities. After administration, enoxolone inhibits the metabolism of prostaglandins by both 15-hydroxyprostaglandin dehydrogenase [NAD(+)] and prostaglandin reductase 2. Therefore, this agent potentiates the activity of prostaglandin E2 and F2alpha, which inhibits gastric secretion while stimulating pancreatic secretion and the secretion of intestinal and respiratory mucus, leading to increased intestinal motility and antitussive effects. Additionally, this agent inhibits 11 beta-hydroxysteroid dehydrogenase and other enzymes involved in the conversion of cortisol to cortisone in the kidneys. An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation. See also: Glycyrrhizin (is active moiety of); Glycyrrhiza Glabra (part of). A pentacyclic triterpenoid that is olean-12-ene substituted by a hydroxy group at position 3, an oxo group at position 11 and a carboxy group at position 30. D - Dermatologicals > D03 - Preparations for treatment of wounds and ulcers > D03A - Cicatrizants C471 - Enzyme Inhibitor > C54678 - Hydroxysteroid Dehydrogenase Inhibitor D000893 - Anti-Inflammatory Agents relative retention time with respect to 9-anthracene Carboxylic Acid is 1.588 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.587 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.585 18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2]. 18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2]. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
MLS001146949-01!18-BETA-GLYCYRRHETINIC ACID471-53-4
C30H46O4_Dicyclopenta[a,i]phenanthrene-3a(1H)-carboxylic acid, 10-formyloctadecahydro-9-hydroxy-5a,5b,8,8,10a-pentamethyl-1-(1-methylethenyl)
C30H46O4_(23E)-5,25-Dihydroxy-4,4-dimethylergosta-8,23-diene-3,22-dione
C30H46O4_Lanosta-8,24-dien-26-oic acid, 21-hydroxy-3-oxo-, (5xi,13alpha,14beta,17alpha,20S,24E)
C30H46O4_Lup-20(29)-en-28-oic acid, 6-hydroxy-3-oxo-, (5xi,9xi,18xi)
C30H46O4_Olean-12-en-30-oic acid, 3-hydroxy-11-oxo-, (3beta,5xi,9xi,18alpha)
15-formyl-16-hydroxy-1,2,14,17,17-pentamethyl-8-(prop-1-en-2-yl)pentacyclo[11.7.0.0²,¹⁰.0⁵,⁹.0¹⁴,¹⁸]icosane-5-carboxylic acid
(1R,3aS,5aR,5bR,11aR,13aR)-7-hydroxy-5a,5b,8,8,11a-pentamethyl-9-oxo-1-prop-1-en-2-yl-2,3,4,5,6,7,7a,10,11,11b,12,13,13a,13b-tetradecahydro-1H-cyclopenta[a]chrysene-3a-carboxylic acid
Glycyrrhetinic Acid
Origin: Plant; SubCategory_DNP: Triterpenoids 18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2]. 18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2].
15-formyl-16-hydroxy-1,2,14,17,17-pentamethyl-8-(prop-1-en-2-yl)pentacyclo[11.7.0.0²,¹⁰.0⁵,⁹.0¹⁴,¹⁸]icosane-5-carboxylic acid_16.1\\%
(E,6S)-7-hydroxy-2-methyl-6-[(10S,13S,14S,17S)-4,4,10,13,14-pentamethyl-3-oxo-1,2,5,6,7,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]hept-2-enoic acid_major
15-formyl-16-hydroxy-1,2,14,17,17-pentamethyl-8-(prop-1-en-2-yl)pentacyclo[11.7.0.0²,¹⁰.0⁵,⁹.0¹⁴,¹⁸]icosane-5-carboxylic acid_major
15-formyl-16-hydroxy-1,2,14,17,17-pentamethyl-8-(prop-1-en-2-yl)pentacyclo[11.7.0.0²,¹⁰.0⁵,⁹.0¹⁴,¹⁸]icosane-5-carboxylic acid_80.1\\%
(1R,3aS,5aR,5bR,11aR,13aR)-7-hydroxy-5a,5b,8,8,11a-pentamethyl-9-oxo-1-prop-1-en-2-yl-2,3,4,5,6,7,7a,10,11,11b,12,13,13a,13b-tetradecahydro-1H-cyclopenta[a]chrysene-3a-carboxylic acid_98.1\\%
(1R,3aS,5aR,5bR,11aR,13aR)-7-hydroxy-5a,5b,8,8,11a-pentamethyl-9-oxo-1-prop-1-en-2-yl-2,3,4,5,6,7,7a,10,11,11b,12,13,13a,13b-tetradecahydro-1H-cyclopenta[a]chrysene-3a-carboxylic acid_major
(E,6S)-7-hydroxy-2-methyl-6-[(10S,13S,14S,17S)-4,4,10,13,14-pentamethyl-3-oxo-1,2,5,6,7,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]hept-2-enoic acid_38.5\\%
(5Z,7E)-(1S,3R,22R)-22-methoxy-26,27-dimethyl-9,10-seco-5,7,10(19)-cholestatrien-23-yne-1,3,25-triol
(5Z,7E)-(1S,3R,20R,22S)-26,27-dimethyl-22-methoxy-9,10-seco-5,7,10(19)-cholestatrien-23-yne-1,3,25-triol
(5Z,7E)-(1S,3R,20R,22R)-26,27-dimethyl-24a-homo-9,10-seco-5,7,10(19)-cholestatrien-23-yne-1,3,22,25-tetrol
(5Z,7E)-(1S,3R,22S)-26,27-dimethyl-24a-homo-9,10-seco-5,7,10(19)-cholestatrien-23-yne-1,3,22,25-tetrol
(5Z,7E)-(1S,3R,20R,22S)-26,27-dimethyl-24a-homo-9,10-seco-5,7,10(19)-cholestatrien-23-yne-1,3,22,25-tetrol
(5Z,7E)-(1S,3R)-18-(4-hydroxy-4-ethyl-2-hexynyloxy)-23,24-dinor-9,10-seco-5,7,10(19)-cholatriene-1,3-diol
Murrayenol
(3alpha,20R,24Z)-3-Hydroxy-21-oxoeupha-8,24-dien-26-oic acid
6b-Hydroxy-3-oxo-12-oleanen-28-oic acid
23-Hydroxy-3-oxocycloart-24-en-26-oic acid
3beta-3,24-Dihydroxy-9(11),12-oleanadien-30-oic acid
Ganoderiol B
Ganodermic acid Jb
Liquiritic acid
Pomonic acid
Rubinic acid
11-Keto β-Boswellic Acid
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production[1]. 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production[1]. 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production[1].
Lansic acid
A triterpenoid of the class of onoceranoid-type terpenoids isolated from the twigs of Lansium domesticum.
Colubrinic acid
Koetjapic acid
28-Hydroxymangiferonic acid
2-Hydroxy-3-oxo-12-oleanen-28-oic acid
16-Hydroxy-3-oxo-12-oleanen-28-oic acid
Secoisobryononic acid
Secobryononic acid
(1R,3aS,5aR,5bR,11aR,13aR)-7-hydroxy-5a,5b,8,8,11a-pentamethyl-9-oxo-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylic acid
(22S)-1alpha,25-dihydroxy-22-methoxy-26,27-dimethyl-23,24-tetradehydro-20-epivitamin D3
(22R)-1alpha,22,25-trihydroxy-26,27-dimethyl-23,24-tetradehydro-24a-homo-20-epivitamin D3
(22S)-1alpha,22,25-trihydroxy-26,27-dimethyl-23,24-tetradehydro-24a-homo-20-epivitamin D3
Fatsicarpain G
A terpene lactone that is 13,28-epoxyolean-11-en-28-one substituted by hydroxy groups at positions 3 and 23. Isolated from the leaves and twigs of Fatsia polycarpa, it exhibits anti-HBV activity.
fatsicarpain A
A pentacyclic triterpenoid that is oleana-11,13(18)-diene substituted by hydroxy groups at positions 3 and 23 and a carboxy group at position 28 (the 3alpha stereoisomer). Isolated from the leaves and twigs of Fatsia polycarpa, it exhibits antibacterial and anti-HBV activities.
Hidermart
D - Dermatologicals > D03 - Preparations for treatment of wounds and ulcers > D03A - Cicatrizants C471 - Enzyme Inhibitor > C54678 - Hydroxysteroid Dehydrogenase Inhibitor D000893 - Anti-Inflammatory Agents 18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2]. 18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2]. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
Glycyrrhetinic Acid
18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2]. 18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2].
Gypsogenin
Gypsogenin shows antiangiogenic activity and the significant cytotoxicity against H460[1]. Gypsogenin shows antiangiogenic activity and the significant cytotoxicity against H460[1].
(4aS,6aS,6bR,9S,10S,12aR)-9-formyl-10-hydroxy-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
(2S,4aS,6aS,6bR,10R,12aS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid
(3S,8S,9R,10R,13R,14S,17R)-3-hydroxy-17-[(E)-6-hydroxy-6-methylhept-4-en-2-yl]-4,4,13,14-tetramethyl-7-oxo-1,2,3,8,10,11,12,15,16,17-decahydrocyclopenta[a]phenanthrene-9-carbaldehyde
Maytenfolone A
A hexacyclic triterpenoid that is a lactone of friedelin. Isolated from Celastrus hindsii, it exhibits anti-HIV and antineoplastic activities.
3-Oxo-23-hydroxyurs-12-en-28-oic acid
A pentacyclic triterpenoid that is urs-12-ene substituted by an oxo group at position 3, a carboxy group at position 28 and a hydroxy group at position 23. It has been isolated from Juglans sinensis.
triptotritepenonic acid A
A pentacyclic triterpenoid with formula C30H46O4, originally isolated from Tripterygium wilfordii.