Capsaicin (BioDeep_00000000112)

 

Secondary id: BioDeep_00000400282, BioDeep_00000861554

natural product human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


(E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide

化学式: C18H27NO3 (305.1991)
中文名称: 天然辣椒素, 天然辣椒碱, 辣椒素, 辣椒碱
谱图信息: 最多检出来源 Viridiplantae(plant) 12.25%

Reviewed

Last reviewed on 2024-08-14.

Cite this Page

Capsaicin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/capsaicin (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000112). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1=CC(CNC(=O)CCCC/C=C/C(C)C)=CC(OC)=C1O
InChI: InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+

描述信息

Capsaicin is a capsaicinoid. It has a role as a non-narcotic analgesic, a voltage-gated sodium channel blocker and a TRPV1 agonist.
Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements. Capsaicin is a naturally-occurring botanical irritant in chili peppers, synthetically derived for pharmaceutical formulations. The most recent capsaicin FDA approval was Qutenza, an 8\\\\\\% capsaicin patch dermal-delivery system, indicated for neuropathic pain associated with post-herpetic neuralgia.
Capsaicin is a natural product found in Capsicum pubescens, Capsicum, and Capsicum annuum with data available.
Capsaicin is a chili pepper extract with analgesic properties. Capsaicin is a neuropeptide releasing agent selective for primary sensory peripheral neurons. Used topically, capsaicin aids in controlling peripheral nerve pain. This agent has been used experimentally to manipulate substance P and other tachykinins. In addition, capsaicin may be useful in controlling chemotherapy- and radiotherapy-induced mucositis.
Capsaicin is identified as the primary pungent principle in Capsicum fruits. Hot chili peppers that belong to the plant genus Capsicum (family Solanaceae) are among the most heavily consumed spices throughout the world. The capsaicin content of green and red peppers ranges from 0.1 to 1\\\\\\%. Capsaicin evokes numerous biological effects and thus has been the target of extensive., investigations since its initial identification in 1919. One of the most recognized physiological properties of capsaicin is its selective effects on the peripheral part of the sensory nervous system, particularly on the primary afferent neurons. The compound is known to deplete the neurotransmitter of painful impulses known as substance P from the sensory nerve terminals, which provides a rationale for its use as a versatile experimental tool for studying pain mechanisms and also for pharmacotherapy to treat some peripheral painful states, such as rheumatoid arthritis, post-herpetic neuralgia, post-mastectomy pain syndrome and diabetic neuropathy. Considering the frequent consumption of capsaicin as a food additive and its current therapeutic application, correct assessment of any harmful effects of this compound is important from the public health standpoint. Ingestion of large amounts of capsaicin has been reported to cause histopathological and biochemical changes, including erosion of gastric mucosa and hepatic necrosis. However, there are contradictory data on the mutagenicity of capsaicin. A recent epidemiological study conducted in Mexico revealed that consumers of chili pepper were at higher risk for gastric cancer than non-consumers. However, it remains unclear whether capsaicin present in hot chili pepper is a major causative factor in the aetiology of gastric cancer in humans. A growing number of recent studies have focused on anticarcinogenic or antimutagenic phytochemicals, particularly those included in human diet. In summary, capsaicin has dual effects on chemically induced carcinogenesis and mutagenesis. Although a minute amount of capsaicin displays few or no deleterious effects, heavy ingestion of the compound has been associated with necrosis, ulceration and even carcinogenesis. Capsaicin is considered to be metabolized by cytochrome P-450-dependent mixed-function oxidases to reactive species. (A7835).
An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.
See also: Capsicum (part of); Capsicum Oleoresin (active moiety of); Paprika (part of) ... View More ...
Capsaicin is identified as the primary pungent principle in Capsicum fruits. Hot chili peppers that belong to the plant genus Capsicum (family Solanaceae) are among the most heavily consumed spices throughout the world. The capsaicin content of green and red peppers ranges from 0.1 to 1\\\\\\%. Capsaicin evokes numerous biological effects and thus has been the target of extensive., investigations since its initial identification in 1919. One of the most recognized physiological properties of capsaicin is its selective effects on the peripheral part of the sensory nervous system, particularly on the primary afferent neurons. The compound is known to deplete the neurotransmitter of painful impulses known as substance P from the sensory nerve terminals, which provides a rationale for its use as a versatile experimental tool for studying pain mechanisms and also for pharmacotherapy to treat some peripheral painful states, such as rheumatoid arthritis, post-herpetic neuralgia, post-mastectomy pain syndrome and diabetic neuropathy. Considering the frequent consumption of capsaicin as a food additive and its current therapeutic application, correct assessment of any harmful effects of this compound is important from the public health standpoint. Ingestion of large amounts of capsaicin has been reported to cause histopathological and biochemical changes, including erosion of gastric mucosa and hepatic necrosis. However, there are contradictory data on the mutagenicity of capsaicin. A recent epidemiological study conducted in Mexico revealed that consumers of chili pepper were at higher risk for gastric cancer than non-consumers. However, it remains unclear whether capsaicin present in hot chili pepper is a major causative factor in the aetiology of gastric cancer in humans. A growing number of recent studies have focused on anticarcinogenic or antimutagenic phytochemicals, particularly those included in human diet. In summary, capsaicin has dual effects on chemically induced carcinogenesis and mutagenesis. Although a minute amount of capsaicin displays few or no deleterious effects, heavy ingestion of the compound has been associated with necrosis, ulceration and even carcinogenesis. Capsaicin is considered to be metabolized by cytochrome P-450-dependent mixed-function oxidases to reactive species. (PMID: 8621114).
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AB - Capsaicin and similar agents
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
Flavouring ingredient. Pungent principle of various Capsicum subspecies (Solanaceae)
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
N - Nervous system > N01 - Anesthetics > N01B - Anesthetics, local
D003879 - Dermatologic Agents > D000982 - Antipruritics
Acquisition and generation of the data is financially supported in part by CREST/JST.
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.208
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.207
Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects[1][2].
Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects[1][2].
Capsaicinoid is a mixture of Capsaicin and Dihydrocapsaicin. Capsaicinoid is an capsaicin receptor (TRPV1) agonist[1][2].
Capsaicinoid is a mixture of Capsaicin and Dihydrocapsaicin. Capsaicinoid is an capsaicin receptor (TRPV1) agonist[1][2].

同义名列表

277 个代谢物同义名

Capsaicin, Pharmaceutical Secondary Standard; Certified Reference Material; 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (6E)-; (6E)-N-{[4-hydroxy-3-(methyloxy)phenyl]methyl}-8-methylnon-6-enamide; 6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (6E)-; 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (E)-; 6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (E)-; 6-nonenamide,n-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-,(6e)-; (E)-N-[(4-hydroxy-3-methoxy-phenyl)methyl]-8-methyl-non-6-enamide; trans-N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide; N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide, (E)-; 6-Nonenamide, (E)-N-((4-hydroxy-3-methoxy-phenyl)methyl)-8-methyl; (6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide; (E)-N-[(4-Hydroxy-3-methoxyphenyl)-methyl]-8-methyl-6-nonenamide; (E)-N-((4-Hydroxy-3-methoxyphenyl)-methyl)-8-methyl-6-nonenamide; (E)-N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-8-METHYL-6-NONENAMIDE; (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide; Capsaicin, United States Pharmacopeia (USP) Reference Standard; 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-; N-[(4-hydroxy-3-methoxyphenyl)methyl]-6E-8-methyl-nonenamide; N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide; Capsaicin; 8-Methyl-N-vanillyl-trans-6-nonenamide; NGX-4010; N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide; (6E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide #; N-(4-HYDROXY-3-METHOXYBENZYL)-8-METHYL-6-NONENAMIDE [FHFI]; Capsaicin, European Pharmacopoeia (EP) Reference Standard; N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-trans-6-enamide; (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide; (e)-n-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide; Capsaicin, certified reference material, TraceCERT(R); AVON HeXashield Arthritis Pain ReliefCream Capsaisin; N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide; Walgreens Arthritis Pain Relief Capsaicin Analgesic; Hempvana Ultra Strength Pain Relief Cream-Deep Heat; Rugby Arthritis Pain RelievingTopical Analgesic; Good Neighbor Capsaicin Heat Patch for Back; CAPSAICIN HEAT PATCHES BACK AND LARGE AREAS; Capsaicin, from Capsicum sp., >=50\\% (HPLC); ASTRAPHARM CHILLI BRAND EXTERNAL MEDICATED; Dusel Warm Arthritis Dead Sea Salt Therapy; CAPSAICIN (CONSTITUENT OF CAPSICUM) [DSC]; (E)-8-Methyl-N-vanillyl-6-nonenamide(8cl); 6-Nonenamide, 8-methyl-N-vanillyl-, (E)-; 8-Methyl-N-vanillyl-(trans)-6-nonenamide; 8-Methyl-N-vanillyl-trans-6-nonenamide; trans-8-Methyl-N-vanillyl-6-nonenamide; 8-Methyl-N-vanillyl-6-nonenamide, (E)-; Capsaicin 10 microg/mL in Acetonitrile; Dr. Harveys Herbal Motion Pain Formula; Nufabrx Medicine Infused Ankle Sleeve; Zostrix High Potency Foot Pain Relief; AVON HeXashield Arthritis Pain Relief; (E)-8-Methyl-N-vanillyl-6-nonenamide; Capsaicin, >=95\\%, from Capsicum sp.; Capsaicin (in oleoresin of capsicum); Miracle Plus OvernightPain Relieving; Capsaicin [in oleoresin of capsicum]; (E)8-methyl-N-vanillyl-6-Nonenamide; CAPSAICIN (CONSTITUENT OF CAPSICUM); Antiphlogistine rub a-535 capsaicin; CVS Capsaicin arthritis pain relief; Leader Capsaicin Pain Relief Cream; Zucapsaicin;Civamide;cis-Capsaicin; beeRX Muscle and Joint Pain Relief; Capsaicin HP Arthritis Pain Relief; Toplast Hot Capsaicin 0.025percent; CAPSAICIN HEAT PATCHES PAIN RELIEF; Pure ReliefPenetrating Pain Relief; Capzasin HP Arthritis Pain Relief; FYZICAL SPORTS Pain Relief 2 MILD; Frankie Avalons Zero Pain Roll On; DCH Arthritis Pain Relief Roll-On; Family Care Arthritis Pain Relief; Penetrex(r) Arthritis Pain Relief; Rugby CapsaicinExternal Analgesic; 8-Methyl-N-vanillyl-6E-nonenamide; Sherman and Clark Pain Relieving; 8-Methyl-N-Vanillyl-6-Nonenamide; Carter horner brand OF capsaicin; Good Neighbor Pharmacy Capsaicin; 8 Methyl N Vanillyl 6 Nonenamide; Fast Arthritis AidPain Relieving; Capsaicin 0.025\\% Topical Patch; Equate Capsaicin Pain Relieving; Methyl-N-vanillyl-6-noneneamide; Nufabrx Lower Leg Sleeve XL/XXL; Better Nature Pain Relief BalmX; Rugby Arthritis Pain Relieving; Capsaicin, analytical standard; Nufabrx Medicine Infused Socks; Capsaicin from Capsicum annuum; Isodecenoic acid vanillylamide; Nufabrx Lower Leg Sleeve XS/S; WellPatch Warming Pain Relief; Revlex Arthritis Pain Relief; CareALL Arthritis and Muscle; Nufabrx Lower Leg Sleeve M/L; Solstice Capsaicin Patch Hot; Flemming brand OF capsaicin; CapsaicinExternal Analgesic; Thompson brand OF capsaicin; HURT BLOCKER PROPain Relief; BRONSON SOOTHE Pain Relief; FYZICAL SPORTS Pain Relief; Centrum brand OF capsaicin; Medicated Compression Sock; Medicis brand OF capsaicin; Isodecenoate vanillylamide; Smaller brand OF capsaicin; CapsaicinTopical Analgesic; Wellness Products VictoRx; CAPSAICIN (USP MONOGRAPH); isoamyl4-methoxycinnamate; Nufabrx Foot/Ankle Sleeve; Nufabrx Hand/Wrist Sleeve; Alacan brand OF capsaicin; Zostrix Original Strength; CAPSAICIN [USP MONOGRAPH]; Vinas brand OF capsaicin; QC Arthritis Pain Relief; Nufabrx Lower Leg Sleeve; Wellness Products J-FLEX; Coralite Medicated Heat; Capsaicin 0.075 Percent; ASTRAPHARM CHILLI BRAND; Elan brand OF capsaicin; Link brand OF capsaicin; Campo pharma Muscle hot; CVS Medicated Heat 1 ct; CAPSAICIN [ORANGE BOOK]; Walgreens Capsaicin Hot; Capsaicin 0.1 Percent; RITE AID CAPSICUM HOT; Sure Result SR Relief; Rugby Capsaicin Cream; EARTHS CARE ARTHRITIS; FlexxSonicPain Relief; Capsaicin Pain Relief; CAPSAICIN HOT PATCHES; CANNAVERA PAIN RELIEF; Sure Relief SR Relief; Hot SpotPoint Relief; EQUI-BLOCKDT FORMULA; 2-Count HEAT PATCHES; CAPSAICIN [EMA EPAR]; depletes Substance P; LivReliefPain Relief; Nufabrx Ankle Sleeve; Nufabrx Wrist Sleeve; RETADOLORPain Relief; Capsaicin (Natural); Capsaicin (JAN/USP); Capsaicin (USP:INN); Nufabrx Calf Sleeve; Capsaicin [USP:INN]; Nufabrx Knee Sleeve; SINSINPAS HOT LARGE; CAPSAICIN [USP-RS]; CAPSAICIN [WHO-DD]; Nufabrx Arm Sleeve; 6-Nonenamide, (E)-; SCREAMIN HOT TOAST; trans-Capsaicin-d3; EQUI-BLOCKORIGINAL; Gellert Joint Care; CAPSAICIN (USP-RS); CAPSAICIN, NATURAL; CAPSAICIN (MART.); Nufabrx Neck Wrap; Nufabrx Back Wrap; Prestwick3_000879; CAPSAICIN [MART.]; CAPSAICIN [VANDF]; Qutenza;Vanilloid; epsilon-capsaicin; Prestwick2_000879; Capsaicin Extract; capsaicin 0.075\\%; Capsaicin 0.25\\%; Capsaicin 0.05\\%; NobleAid CapsAid; Capsaicin 0.15\\%; LEADER CAPSAICIN; Capsaicin [USAN]; Togarashi orenji; Isodecenoic acid; Spectrum5_000538; CAPSAICIN [HSDB]; Capsicum Farmaya; CAPSAICIN [INCI]; MEIJER CAPSAICIN; Ageranium Patch; HOT PAIN RELIEF; Capsaisin 0.1\\%; Castiva Warming; trans-Capsaicin; Capsaicin Cream; Rugby Capsaicin; CAPSAICIN [JAN]; Capsaicin Patch; CAPSAICIN [INN]; UNII-S07O44R1ZM; Guardania Pain; Capsaicin 0.15; Medicated Heat; CAPSAICIN [MI]; MediRelief Hot; Capsaicin Heat; SprayPain Away; Melt Pain Away; BPBio1_001053; Satogesic Hot; (E)-Capsaicin; Capsaicin,(S); CVS Capsaicin; A2A ARTHRITIS; MEGxp0_001448; Tox21_200315; Capsaicin-d3; Ratden pe 40; Isodecenoate; ZOSTRIX (TN); Capsaicinoid; Tox21_110817; Capzasin-hp; capsaicinum; CVS Roll-On; Painazin CP; IDI1_000354; SMP2_000337; IDI1_034018; E-CAPSAICIN; Pure Relief; capsacin(E); NA 18:5;O2; Capsaicina; neurotoxic; PainBloc24; Zostrix HP; Capsaicine; S07O44R1ZM; Capsimide; C18H27NO3; Vanilloid; Transacin; CAPSAISIN; Capsicine; Neuriterx; Styptysat; Capsaicin; Neuritrx; Capzasin; Capsidol; Bio-Sorb; Capsacin; Ausanil; Dolenon; (6E)-N-; Red Hot; Omega 3; BioMega; Zostrix; Qutenza; CAPZIX; Capsin; Mioton; Ovocap; Gelcen; Axsain; Katrum; Awaye; MR3H3; REZIL; Adlea; Zacin; 4DY; Capsaicin; Capsaicin



数据库引用编号

52 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(1)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(2)

  • capsaicin biosynthesis: H+ + NADPH + a malonyl-[acp] + isobutanoyl-CoA ⟶ 8-methyl-6-nonenoate + H2O + NADP+ + a holo-[acyl-carrier protein] + coenzyme A
  • capsaicin biosynthesis: 8-methyl-6-nonenoate + vanillylamine ⟶ H2O + capsaicin

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 AXIN2, NOS3, PRKCE, S100A12, TRPV2
Peripheral membrane protein 1 S100A12
Endosome membrane 1 NTRK1
Endoplasmic reticulum membrane 2 FAAH, TRPM8
Nucleus 5 AXIN2, NOS3, PLCZ1, PRKCE, S100A12
cytosol 6 AXIN2, NOS3, PLCZ1, PRKCE, S100A12, SST
dendrite 1 NTRK1
centrosome 1 AXIN2
nucleoplasm 2 NOS3, PLCZ1
Cell membrane 9 GPRC5A, NTRK1, P2RX3, PRKCE, S100A12, TRPM3, TRPM8, TRPV2, TRPV5
Early endosome membrane 1 NTRK1
Multi-pass membrane protein 9 FAAH, GPRC5A, KCNA3, P2RX3, TRPM3, TRPM8, TRPV2, TRPV5, UCP1
Synapse 1 PRKCE
cell surface 2 NTRK1, TRPV2
glutamatergic synapse 2 FAAH, KCNA3
Golgi apparatus 3 NOS3, NPY, PRKCE
Golgi membrane 1 NOS3
mitochondrial inner membrane 1 UCP1
neuronal cell body 2 NTRK1, SST
postsynapse 2 FAAH, P2RX3
presynaptic membrane 1 KCNA3
Presynapse 1 FAAH
plasma membrane 14 AXIN2, GCG, GPRC5A, KCNA3, KNG1, NOS3, NTRK1, P2RX3, PRKCE, S100A12, TRPM3, TRPM8, TRPV2, TRPV5
Membrane 8 FAAH, KCNA3, NTRK1, P2RX3, TRPM3, TRPM8, TRPV2, TRPV5
apical plasma membrane 1 TRPV5
axon 3 KCNA3, NTRK1, P2RX3
caveola 1 NOS3
extracellular exosome 2 GPRC5A, KNG1
endoplasmic reticulum 2 FAAH, PRKCE
extracellular space 4 GCG, KNG1, NPY, SST
perinuclear region of cytoplasm 4 KCNA3, NOS3, PLCZ1, PRKCE
Schaffer collateral - CA1 synapse 1 P2RX3
mitochondrion 3 NTRK1, PRKCE, UCP1
protein-containing complex 1 NTRK1
intracellular membrane-bounded organelle 2 GPRC5A, PRKCE
Microsome membrane 1 FAAH
pronucleus 1 PLCZ1
Single-pass type I membrane protein 1 NTRK1
Secreted 5 GCG, NPY, S100A12, SST, VIP
extracellular region 6 GCG, KNG1, NPY, S100A12, SST, VIP
Single-pass membrane protein 1 FAAH
hippocampal mossy fiber to CA3 synapse 1 P2RX3
external side of plasma membrane 1 TRPM8
beta-catenin destruction complex 1 AXIN2
nucleolus 2 GPRC5A, PLCZ1
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
Early endosome 1 NTRK1
vesicle 1 GPRC5A
postsynaptic membrane 1 KCNA3
Apical cell membrane 1 TRPV5
Cytoplasm, perinuclear region 2 PLCZ1, PRKCE
Mitochondrion inner membrane 1 UCP1
Membrane raft 2 KCNA3, TRPM8
Cytoplasm, cytoskeleton 3 FAAH, PRKCE, S100A12
GABA-ergic synapse 2 NPY, SST
collagen-containing extracellular matrix 1 KNG1
Late endosome 1 NTRK1
receptor complex 3 GPRC5A, NTRK1, P2RX3
neuron projection 1 VIP
axonal growth cone 1 TRPV2
Late endosome membrane 1 NTRK1
cell periphery 1 PRKCE
cytoskeleton 3 FAAH, NOS3, S100A12
Secreted, extracellular space 1 KNG1
blood microparticle 1 KNG1
[Isoform 2]: Cell membrane 1 KCNA3
organelle membrane 1 FAAH
Recycling endosome membrane 1 NTRK1
Endomembrane system 1 FAAH
Cytoplasmic vesicle membrane 1 GPRC5A
Melanosome 1 TRPV2
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
cell body 1 TRPV2
intermediate filament cytoskeleton 1 PRKCE
voltage-gated potassium channel complex 1 KCNA3
plasma membrane raft 1 TRPM8
secretory granule lumen 2 GCG, S100A12
endoplasmic reticulum lumen 2 GCG, KNG1
platelet alpha granule lumen 1 KNG1
endocytic vesicle membrane 1 NOS3
neuronal dense core vesicle 2 NPY, SST
calyx of Held 1 KCNA3
[Isoform 1]: Cell membrane 1 KCNA3
[Glucagon-like peptide 1]: Secreted 1 GCG
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
sperm head 1 PLCZ1
growth cone membrane 1 TRPV2
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3


文献列表

  • V V Sathibabu Uddandrao, Seshathri Eraniappan, Asokan Balakrishnan Ramajayam, Sengottuvelu Singaravel, Anitha Roy, Brahma Naidu Parim, Chandrasekaran Ponnusamy, Saravanan Ganapathy, Ponmurugan Ponnusamy, Vadivukkarasi Sasikumar. Hydroxycitric acid and capsaicin combination alleviates obesity-induced testicular apoptosis, oxidative stress and inflammation. Systems biology in reproductive medicine. 2024 Dec; 70(1):20-37. doi: 10.1080/19396368.2024.2306403. [PMID: 38323592]
  • Xueying Bai, Qin Zhang, Xiatao Zhou, Jingyu Yao, Peng Wan, De-Wei Chen. Use of egg yolk phospholipids to improve the thermal-oxidative stability of fatty acids, capsaicinoids and carotenoids in chili oil. Food chemistry. 2024 Sep; 451(?):139423. doi: 10.1016/j.foodchem.2024.139423. [PMID: 38677135]
  • Christina Vakh, Zarina Mallabaeva, Marek Tobiszewski. Smartphone-based digital image colorimetry for the determination of total capsaicinoid content in chili pepper extracts. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2024 Jul; 315(?):124238. doi: 10.1016/j.saa.2024.124238. [PMID: 38593543]
  • Zhuxian Wang, Hongkai Chen, Tao Liang, Yi Hu, Yaqi Xue, Yufan Wu, Quanfu Zeng, Yixin Zheng, Yinglin Guo, Zeying Zheng, Dan Zhai, Peiyi Liang, Chunyan Shen, Cuiping Jiang, Li Liu, Qun Shen, Hongxia Zhu, Qiang Liu. The implications of lipid mobility, drug-enhancers (surfactants)-skin interaction, and TRPV1 activation on licorice flavonoid permeability. Drug delivery and translational research. 2024 Jun; 14(6):1582-1600. doi: 10.1007/s13346-023-01473-x. [PMID: 37980702]
  • Xiao-Lu Jie, Zhe-Ren Tong, Xin-Yue Xu, Jia-Hui Wu, Xing-Liang Jiang, Yi Tao, Pei-Shi Feng, Jin Yu, Ji-Ping Lan, Ping Wang. Mechanic study based on untargeted metabolomics of Pi-pa-run-fei-tang on pepper combined with ammonia induced chronic cough model mice. Journal of ethnopharmacology. 2024 May; 326(?):117905. doi: 10.1016/j.jep.2024.117905. [PMID: 38364934]
  • Weikai Chen, Xiangfeng Wang, Jie Sun, Xinrui Wang, Zhangsheng Zhu, Dilay Hazal Ayhan, Shu Yi, Ming Yan, Lili Zhang, Tan Meng, Yu Mu, Jun Li, Dian Meng, Jianxin Bian, Ke Wang, Lu Wang, Shaoying Chen, Ruidong Chen, Jingyun Jin, Bosheng Li, Xingping Zhang, Xing Wang Deng, Hang He, Li Guo. Two telomere-to-telomere gapless genomes reveal insights into Capsicum evolution and capsaicinoid biosynthesis. Nature communications. 2024 May; 15(1):4295. doi: 10.1038/s41467-024-48643-0. [PMID: 38769327]
  • Yifei Wu, Xiaochuan Wang, Jiayu Zhang, Sha Du, Zhiqiong Wang, Jinrong Li, Wenhe Zhang, Jie Xiang, Renfu Li, Jing Liu, Xin Bi. Capsaicin combined with stem cells improved mitochondrial dysfunction in PIG3V cells, an immortalized human vitiligo melanocyte cell line, by inhibiting the HSP70/TLR4/mTOR/FAK signaling axis. Molecular biology reports. 2024 May; 51(1):650. doi: 10.1007/s11033-024-09592-5. [PMID: 38734811]
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