15-HETE (BioDeep_00000003302)

 

Secondary id: BioDeep_00001868162

human metabolite Endogenous blood metabolite


代谢物信息卡片


15-Hydroxy-5,8,11,13-eicosatetraenoic acid, (S-(e,Z,Z,Z))-isomer

化学式: C20H32O3 (320.2351)
中文名称: 15-羟基二十碳四烯酸
谱图信息: 最多检出来源 Homo sapiens(blood) 15.75%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

15-HETE. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/15-hete (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000003302). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(CC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCCC)O)C(=O)O
InChI: InChI=1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/t19-/m0/s1

描述信息

15-HETE is a hydroxyeicosatetraenoic acid. Hydroxyeicosatetraenoic acids (HETEs) are formed by the 5-, 12-, and 15-lipoxygenase (LO) pathways. The 5- and 12-LO products are mainly proinflammatory in the skin whereas the main 15-LO product 15-HETE has antiinflammatory capacities. In vitro, 15-HETE has been shown to inhibit LTB4 formation, 12-HETE formation, and specifically inhibits the neutrophil chemotactic effect of LTB4. The inhibition of LTB4 formation is probably due to modulation of the 5-LO because no changes in PGE2 formation have been determined. In vivo, 15-HETE inhibits LTB4-induced erythema and edema, and reduces LTB4 in the synovial fluid of carragheenan-induced experimental arthritis in dogs. 15-HETE also has some immunomodulatory effects. It inhibits the mixed lymphocyte reaction, induces generation of murine cytotoxic suppressor T cells, and it decreases interferon production by murine lymphoma cells. Furthermore, IL-4 and IL-13 have recently been shown to be potent activators of the 15-LO in mononuclear cells (PMID: 11104340). 15(S)-HETE is found to be associated with Zellweger syndrome, which is an inborn error of metabolism.
15(S)-HETE is a hydroxyeicosatetraenoic acid. Hydroxyeicosatetraenoic acids (HETEs) are formed by the 5-, 12- and 15-lipoxygenase (LO) pathways. 5- and 12-LO products are mainly proinflammatory in the skin whereas the main 15-LO product 15-HETE has antiinflammatory capacities. In vitro 15-HETE has been shown to inhibit LTB4 formation, 12-HETE formation and specifically inhibits the neutrophil chemotactic effect of LTB4. The inhibition of LTB4 formation is probably due to modulation of the 5-LO because no changes in PGE2 formation have been determined. In vivo, 15-HETE inhibits LTB4-induced erythema and edema, and reduces LTB4 in the synovial fluid of carragheenan-induced experimental arthritis in dogs. 15-HETE has also some immunomodulatory effects. It inhibits the mixed lymphocyte reaction, induces generation of murine cytotoxic suppressor T cells, and it decreases interferon production by murine lymphoma cells. Furthermore, IL-4 and IL-13 have recently been shown to be potent activators of the 15-LO in mononuclear cells. (PMID: 11104340) [HMDB]

15(S)-HETE. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=54845-95-3 (retrieved 2024-07-10) (CAS RN: 54845-95-3). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

42 个代谢物同义名

15-Hydroxy-5,8,11,13-eicosatetraenoic acid, (S-(e,Z,Z,Z))-isomer; (5Z,8Z,11Z,13E)-(15S)-15-Hydroxyicosa-5,8,11,13-tetraenoic acid; (5Z,8Z,11Z,13E,15S)-15-Hydroxyeicosa-5,8,11,13-tetraenoic acid; (5Z,8Z,11Z,13E,15S)-15-Hydroxy-5,8,11,13-eicosatetraenoic acid; (5Z,8Z,11Z,13E,15S)-15-hydroxyicosa-5,8,11,13-tetraenoic acid; (5Z,8Z,11Z,13E)-(15S)-15-Hydroxyicosa-5,8,11,13-tetraenoate; (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid; (5Z,8Z,11Z,13E,15S)-15-Hydroxyeicosa-5,8,11,13-tetraenoate; (5Z,8Z,11Z,13E,15S)-15-Hydroxy-5,8,11,13-eicosatetraenoate; (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoic acid; 15(S)-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid; (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate; 15S-Hydroxy-5,8,11,13-(Z,Z,Z,e)-eicosatetraenoic acid; (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate; (5Z,8Z,11Z,13E,15S)-15-Hydroxyeicosatetraenoic acid; 15(S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid; (15S,5Z,8Z,11Z,13E)-15-Hydroxyeicosatetraenoic acid; (15S)-Hydroxyeicosa-(5Z,8Z,11Z,13E)-tetraenoic acid; (15S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid; 15(S)-Hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid; (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosic acid; (15S,5Z,8Z,11Z,13E)-15-Hydroxyeicosatetraenoate; (15S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate; 15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid; 15(S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate; (15S)-Hydroxyeicosa-(5Z,8Z,11Z,13E)-tetraenoate; 15S-Hydroxy-5Z,8Z,11Z,13E-eicosatetraenoate; 15-Hydroxy-5,8,11,13-eicosatetraenoic acid; 15(S)-Hydroxyeicosatetraenoic acid; 15-Hydroxyeicosatetraenoic acid; 15(S)-Hydroxyeicosatetraenoate; FA(20:4(5Z,8Z,11Z,13E,15S-OH)); FA(20:4(5Z,8Z,11Z,13E,15-OH)); 15-Hydroxyarachidonic acid; (S)-15-HETE; 15(S)-HETE; 15(R)-HETE; Icomucret; 15S-HETE; 15 Hete; 15-HETE; (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

79 个相关的代谢反应过程信息。

Reactome(29)

BioCyc(0)

WikiPathways(4)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(46)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AKT1, ALOX15B, ALOX5, ANG, MAPK14, MAPK8, PIK3CA, PPARG, PTGS1, PTGS2, STAT3, VEGFA
Peripheral membrane protein 4 ALOX15B, ALOX5, PTGS1, PTGS2
Endoplasmic reticulum membrane 2 PTGS1, PTGS2
Nucleus 9 AKT1, ALOX15B, ANG, FOSB, MAPK14, MAPK8, PPARG, STAT3, VEGFA
cytosol 11 AKT1, ALOX15B, ALOX5, ANG, FOSB, MAPK14, MAPK8, PIK3CA, PPARG, PRKCQ, STAT3
nucleoplasm 7 AKT1, ALOX5, FOSB, MAPK14, MAPK8, PPARG, STAT3
RNA polymerase II transcription regulator complex 2 PPARG, STAT3
Cell membrane 3 AKT1, ALOX15B, CYSLTR2
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 1 CYSLTR2
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 1 VEGFA
glutamatergic synapse 2 AKT1, MAPK14
Golgi apparatus 2 PTGS1, VEGFA
growth cone 1 ANG
neuronal cell body 1 ANG
postsynapse 1 AKT1
Cytoplasm, cytosol 2 ALOX15B, ALOX5
plasma membrane 8 AKT1, ALOX15B, CYSLTR2, F2, LTB, PIK3CA, PRKCQ, STAT3
Membrane 4 AKT1, ALOX15B, LTB, VEGFA
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 3 ALOX15B, F2, PTGS1
endoplasmic reticulum 2 PTGS2, VEGFA
extracellular space 8 ALOX5, ANG, CXCL8, F2, IL4, IL6, LTB, VEGFA
perinuclear region of cytoplasm 3 ALOX5, PIK3CA, PPARG
adherens junction 2 ALOX15B, VEGFA
intercalated disc 1 PIK3CA
mitochondrion 1 MAPK14
protein-containing complex 2 AKT1, PTGS2
intracellular membrane-bounded organelle 3 FOSB, PPARG, PTGS1
Microsome membrane 2 PTGS1, PTGS2
Secreted 6 ANG, CXCL8, F2, IL4, IL6, VEGFA
extracellular region 8 ALOX5, ANG, CXCL8, F2, IL4, IL6, MAPK14, VEGFA
transcription regulator complex 1 STAT3
centriolar satellite 1 PRKCQ
photoreceptor outer segment 1 PTGS1
Nucleus membrane 1 ALOX5
nuclear membrane 1 ALOX5
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
microtubule cytoskeleton 1 AKT1
nucleolus 1 ANG
cell-cell junction 1 AKT1
Single-pass type II membrane protein 1 LTB
vesicle 1 AKT1
Cytoplasm, perinuclear region 1 ALOX5
Cell junction, focal adhesion 1 ALOX15B
Cytoplasm, cytoskeleton 1 ALOX15B
focal adhesion 1 ALOX15B
spindle 1 AKT1
Cell junction, adherens junction 1 ALOX15B
extracellular matrix 1 VEGFA
basement membrane 1 ANG
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 F2
secretory granule 1 VEGFA
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 PPARG
neuron projection 2 PTGS1, PTGS2
ciliary basal body 1 AKT1
chromatin 3 FOSB, PPARG, STAT3
Chromosome 1 ANG
cytoskeleton 1 ALOX15B
Nucleus, nucleolus 1 ANG
spindle pole 1 MAPK14
blood microparticle 1 F2
nuclear envelope 1 ALOX5
Nucleus envelope 1 ALOX5
Endomembrane system 1 PTGS1
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
ficolin-1-rich granule lumen 2 ALOX5, MAPK14
secretory granule lumen 2 ALOX5, MAPK14
Golgi lumen 1 F2
endoplasmic reticulum lumen 3 F2, IL6, PTGS2
nuclear matrix 1 ALOX5
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle 1 ANG
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
[Isoform a]: Nucleus 1 ALOX15B
basal dendrite 1 MAPK8
angiogenin-PRI complex 1 ANG
interleukin-6 receptor complex 1 IL6
Nucleus intermembrane space 1 ALOX5
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Jana H Badrani, Kellen Cavagnero, Jacqueline J Eastman, Alex S Kim, Allyssa Strohm, Carol Yan, Adam Deconde, Bruce L Zuraw, Andrew A White, Sandra C Christiansen, Taylor A Doherty. Lower serum 15-HETE predicts nasal ILC2 accumulation during COX-1 inhibition in AERD. The Journal of allergy and clinical immunology. 2023 Aug; ?(?):. doi: 10.1016/j.jaci.2023.06.028. [PMID: 37543185]
  • Kristen J Polinski, Elizabeth A Bemis, Fan Yang, Tessa Crume, M Kristen Demoruelle, Marie Feser, Jennifer Seifert, James R O'Dell, Ted R Mikuls, Michael H Weisman, Peter K Gregersen, Richard M Keating, Jane Buckner, Nichole Reisdorph, Kevin D Deane, Michael Clare-Salzler, V Michael Holers, Jill M Norris. Association of Lipid Mediators With Development of Future Incident Inflammatory Arthritis in an Anti-Citrullinated Protein Antibody-Positive Population. Arthritis & rheumatology (Hoboken, N.J.). 2021 06; 73(6):955-962. doi: 10.1002/art.41631. [PMID: 33381911]
  • Anna-Karin Johnsson, Elin Rönnberg, David Fuchs, Johan Kolmert, Jesper Säfholm, Hans-Erik Claesson, Mats Hamberg, Craig E Wheelock, Gunnar Nilsson, Sven-Erik Dahlén. COX-1 dependent biosynthesis of 15-hydroxyeicosatetraenoic acid in human mast cells. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2021 05; 1866(5):158886. doi: 10.1016/j.bbalip.2021.158886. [PMID: 33450390]
  • Laura Niederstaetter, Benjamin Neuditschko, Julia Brunmair, Lukas Janker, Andrea Bileck, Giorgia Del Favero, Christopher Gerner. Eicosanoid Content in Fetal Calf Serum Accounts for Reproducibility Challenges in Cell Culture. Biomolecules. 2021 01; 11(1):. doi: 10.3390/biom11010113. [PMID: 33467719]
  • Miriam C Wolters, Julia Schmetzer, Christine V Möser, Lisa Hahnefeld, Carlo Angioni, Dominique Thomas, Nerea Ferreirós, Gerd Geisslinger, Ellen Niederberger. Exercise-Induced Changes in Bioactive Lipids Might Serve as Potential Predictors of Post-Exercise Hypotension. A Pilot Study in Healthy Volunteers. Cells. 2020 09; 9(9):. doi: 10.3390/cells9092111. [PMID: 32948055]
  • Elżbieta Cecerska-Heryć, Rafał Heryć, Magda Wiśniewska, Natalia Serwin, Bartłomiej Grygorcewicz, Barbara Dołęgowska. Effect of renal replacement therapy on selected arachidonic acid derivatives concentration. BMC nephrology. 2020 09; 21(1):394. doi: 10.1186/s12882-020-02053-8. [PMID: 32917166]
  • Grégoire Ruffenach, Ellen O'Connor, Mylène Vaillancourt, Jason Hong, Nancy Cao, Shervin Sarji, Shayan Moazeni, Jeremy Papesh, Victor Grijalva, Christine M Cunningham, Le Shu, Arnab Chattopadhyay, Shuchita Tiwari, Olaf Mercier, Frédéric Perros, Soban Umar, Xia Yang, Aldrin V Gomes, Alan M Fogelman, Srinivasa T Reddy, Mansoureh Eghbali. Oral 15-Hydroxyeicosatetraenoic Acid Induces Pulmonary Hypertension in Mice by Triggering T Cell-Dependent Endothelial Cell Apoptosis. Hypertension (Dallas, Tex. : 1979). 2020 09; 76(3):985-996. doi: 10.1161/hypertensionaha.120.14697. [PMID: 32713273]
  • Alaleh Bayat Barooni, Mohammad Ghorbani, Vahid Salimi, Alimohammad Alimohammadi, Mohammad E Khamseh, Hamideh Akbari, Mehrnaz Imani, Mitra Nourbakhsh, Alireza Sheikhi, Farzad Izak Shirian, Maryam Ameri, Masoumeh Tavakoli-Yaraki. Up-regulation of 15-lipoxygenase enzymes and products in functional and non-functional pituitary adenomas. Lipids in health and disease. 2019 Jul; 18(1):152. doi: 10.1186/s12944-019-1089-1. [PMID: 31288808]
  • Amanda H Kahn-Kirby, Akiko Amagata, Celine I Maeder, Janet J Mei, Steve Sideris, Yuko Kosaka, Andrew Hinman, Stephanie A Malone, Joel J Bruegger, Leslie Wang, Virna Kim, William D Shrader, Kevin G Hoff, Joey C Latham, Euan A Ashley, Matthew T Wheeler, Enrico Bertini, Rosalba Carrozzo, Diego Martinelli, Carlo Dionisi-Vici, Kimberly A Chapman, Gregory M Enns, William Gahl, Lynne Wolfe, Russell P Saneto, Simon C Johnson, Jeffrey K Trimmer, Matthew B Klein, Charles R Holst. Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy. PloS one. 2019; 14(3):e0214250. doi: 10.1371/journal.pone.0214250. [PMID: 30921410]
  • Lin Yang, Cui Ma, Lixin Zhang, Min Zhang, Fei Li, Chen Zhang, Xiufeng Yu, Xiaoying Wang, Siyu He, Daling Zhu, Yinli Song. 15-Lipoxygenase-2/15(S)-hydroxyeicosatetraenoic acid regulates cell proliferation and metastasis via the STAT3 pathway in lung adenocarcinoma. Prostaglandins & other lipid mediators. 2018 09; 138(?):31-40. doi: 10.1016/j.prostaglandins.2018.07.003. [PMID: 30110652]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • C Morgantini, S Trifirò, D Tricò, D Meriwether, S Baldi, A Mengozzi, S T Reddy, A Natali. A short-term increase in dietary cholesterol and fat intake affects high-density lipoprotein composition in healthy subjects. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2018 06; 28(6):575-581. doi: 10.1016/j.numecd.2018.03.005. [PMID: 29699812]
  • Mikael Sandstedt, Victoria Rotter Sopasakis, Annika Lundqvist, Kristina Vukusic, Anders Oldfors, Göran Dellgren, Joakim Sandstedt, Lillemor Mattsson Hultén. Hypoxic cardiac fibroblasts from failing human hearts decrease cardiomyocyte beating frequency in an ALOX15 dependent manner. PloS one. 2018; 13(8):e0202693. doi: 10.1371/journal.pone.0202693. [PMID: 30138423]
  • Scott H Randell, Darryl C Zeldin. A Slippery Cause of a Slimy Problem: Mucin Induction by an Esterified Lipid. American journal of respiratory cell and molecular biology. 2017 12; 57(6):633-634. doi: 10.1165/rcmb.2017-0275ed. [PMID: 29192828]
  • Keng Po Lai, Jetty Chung-Yung Lee, Hin Ting Wan, Jing Woei Li, Aman Yi-Man Wong, Ting Fung Chan, Camille Oger, Jean-Marie Galano, Thierry Durand, Kin Sum Leung, Cherry C Leung, Rong Li, Chris Kong-Chu Wong. Effects of in Utero PFOS Exposure on Transcriptome, Lipidome, and Function of Mouse Testis. Environmental science & technology. 2017 Aug; 51(15):8782-8794. doi: 10.1021/acs.est.7b02102. [PMID: 28654245]
  • Nicoletta Basilico, Yolanda Corbett, Sarah D' Alessandro, Silvia Parapini, Mauro Prato, Daniela Girelli, Paola Misiano, Piero Olliaro, Donatella Taramelli. Malaria pigment stimulates chemokine production by human microvascular endothelium. Acta tropica. 2017 Aug; 172(?):125-131. doi: 10.1016/j.actatropica.2017.05.002. [PMID: 28476599]
  • Elina Jerschow, Matthew L Edin, Teresa Pelletier, Waleed M Abuzeid, Nadeem A Akbar, Marc Gibber, Marvin Fried, Fred B Lih, Artiom Gruzdev, J Alyce Bradbury, Weiguo Han, Golda Hudes, Taha Keskin, Victor L Schuster, Simon Spivack, Darryl C Zeldin, David Rosenstreich. Plasma 15-Hydroxyeicosatetraenoic Acid Predicts Treatment Outcomes in Aspirin-Exacerbated Respiratory Disease. The journal of allergy and clinical immunology. In practice. 2017 Jul; 5(4):998-1007.e2. doi: 10.1016/j.jaip.2016.11.021. [PMID: 28159558]
  • A L Peters, M A T Vervaart, R van Bruggen, D de Korte, R Nieuwland, W Kulik, A P J Vlaar. Non-polar lipids accumulate during storage of transfusion products and do not contribute to the onset of transfusion-related acute lung injury. Vox sanguinis. 2017 Jan; 112(1):25-32. doi: 10.1111/vox.12453. [PMID: 28097705]
  • Francesca Rauzi, Nicholas S Kirkby, Matthew L Edin, James Whiteford, Darryl C Zeldin, Jane A Mitchell, Timothy D Warner. Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 12; 30(12):4256-4266. doi: 10.1096/fj.201600530r. [PMID: 27633788]
  • Qiaoxia Bian, Weihui Wang, Nannan Wang, Yan Peng, Wen Ma, Ronghua Dai. Arachidonic acid metabolomic study of BPH in rats and the interventional effects of Zishen pill, a traditional Chinese medicine. Journal of pharmaceutical and biomedical analysis. 2016 Sep; 128(?):149-157. doi: 10.1016/j.jpba.2016.05.027. [PMID: 27262108]
  • Sabrina Coquenlorge, Laurianne Van Landeghem, Julie Jaulin, Nicolas Cenac, Nathalie Vergnolle, Emilie Duchalais, Michel Neunlist, Malvyne Rolli-Derkinderen. The arachidonic acid metabolite 11β-ProstaglandinF2α controls intestinal epithelial healing: deficiency in patients with Crohn's disease. Scientific reports. 2016 05; 6(?):25203. doi: 10.1038/srep25203. [PMID: 27140063]
  • Sandra L Pfister, Peter G Klimko, Raymond E Conrow. (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid: A stable isomer of 15(S)-HETE that retains key vasoconstrictive and antiproliferative activity. Prostaglandins & other lipid mediators. 2016 03; 123(?):33-9. doi: 10.1016/j.prostaglandins.2016.04.001. [PMID: 27117058]
  • Yong-Seok Song, Dong Hun Lee, Jae-Hyuk Yu, Deok-Kun Oh, Jin Tae Hong, Do-Young Yoon. Promotion of adipogenesis by 15-(S)-hydroxyeicosatetraenoic acid. Prostaglandins & other lipid mediators. 2016 03; 123(?):1-8. doi: 10.1016/j.prostaglandins.2016.02.001. [PMID: 26905195]
  • Annika Lundqvist, Mikael Sandstedt, Joakim Sandstedt, Ruth Wickelgren, Göran I Hansson, Anders Jeppsson, Lillemor Mattsson Hultén. The Arachidonate 15-Lipoxygenase Enzyme Product 15-HETE Is Present in Heart Tissue from Patients with Ischemic Heart Disease and Enhances Clot Formation. PloS one. 2016; 11(8):e0161629. doi: 10.1371/journal.pone.0161629. [PMID: 27552229]
  • Mukundan Attur, Svetlana Krasnokutsky, Alexander Statnikov, Jonathan Samuels, Zhiguo Li, Olga Friese, Marie-Pierre Hellio Le Graverand-Gastineau, Leon Rybak, Virginia B Kraus, Joanne M Jordan, Constantin F Aliferis, Steven B Abramson. Low-grade inflammation in symptomatic knee osteoarthritis: prognostic value of inflammatory plasma lipids and peripheral blood leukocyte biomarkers. Arthritis & rheumatology (Hoboken, N.J.). 2015 Nov; 67(11):2905-15. doi: 10.1002/art.39279. [PMID: 26195278]
  • Jelena Klawitter, Kim McFann, Alexander T Pennington, Wei Wang, Jost Klawitter, Uwe Christians, Robert W Schrier, Berenice Gitomer, Melissa A Cadnapaphornchai. Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease. Clinical journal of the American Society of Nephrology : CJASN. 2015 Sep; 10(9):1534-41. doi: 10.2215/cjn.11331114. [PMID: 26224879]
  • Åsa Brunnström, Ylva Tryselius, Stina Feltenmark, Erik Andersson, Helene Leksell, Anna James, Bengt Mannervik, Barbro Dahlén, Hans-Erik Claesson. On the biosynthesis of 15-HETE and eoxin C4 by human airway epithelial cells. Prostaglandins & other lipid mediators. 2015 Sep; 121(Pt A):83-90. doi: 10.1016/j.prostaglandins.2015.04.010. [PMID: 26026713]
  • Li Zhang, Yumei Li, Yumei Liu, Xiaoyan Wang, Minggang Chen, Yan Xing, Daling Zhu. STAT3-mediated MMP-2 expression is required for 15-HETE-induced vascular adventitial fibroblast migration. The Journal of steroid biochemistry and molecular biology. 2015 May; 149(?):106-17. doi: 10.1016/j.jsbmb.2015.01.015. [PMID: 25623089]
  • Li Sun, Yan-Wei Xu, Jing Han, Hao Liang, Ning Wang, Yan Cheng. 12/15-Lipoxygenase metabolites of arachidonic acid activate PPARγ: a possible neuroprotective effect in ischemic brain. Journal of lipid research. 2015 Mar; 56(3):502-514. doi: 10.1194/jlr.m053058. [PMID: 25605873]
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