loxtidine (BioDeep_00001871540)
Main id: BioDeep_00000008886
Volatile Flavor Compounds
代谢物信息卡片
化学式: C19H29N5O2 (359.2321134)
中文名称: 拉伏替丁
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C(=NC(=N1)CO)NCCCOC2=CC=CC(=C2)CN3CCCCC3
InChI: InChI=1S/C19H29N5O2/c1-23-19(21-18(15-25)22-23)20-9-6-12-26-17-8-5-7-16(13-17)14-24-10-3-2-4-11-24/h5,7-8,13,25H,2-4,6,9-12,14-15H2,1H3,(H,20,21,22)
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29702 - Histamine-2 Receptor Antagonist
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
同义名列表
3 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:6550
- KEGG: C11805
- PubChem: 55473
- DrugBank: DB12884
- ChEMBL: CHEMBL2110857
- CAS: 76956-02-0
- PubChem: 13969
- NIKKAJI: J32.883I
- RefMet: Loxtidine
- KNApSAcK: 6550
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Karin E Bakkelund, Helge L Waldum, Ivar Skjåk Nordrum, Øyvind Hauso, Reidar Fossmark. Long-term gastric changes in achlorhydric H(+)/K(+)-ATPase beta subunit deficient mice.
Scandinavian journal of gastroenterology.
2010 Sep; 45(9):1042-7. doi:
10.3109/00365521.2010.490952. [PMID: 20476858] - M Kidd, Z-L Siddique, I Drozdov, B I Gustafsson, R L Camp, J W Black, M Boyce, I M Modlin. The CCK(2) receptor antagonist, YF476, inhibits Mastomys ECL cell hyperplasia and gastric carcinoid tumor development.
Regulatory peptides.
2010 Jun; 162(1-3):52-60. doi:
10.1016/j.regpep.2010.01.009. [PMID: 20144901] - J Tsutsumi, S Takayama, H Nimura. [Biochemical and immunohistological changes in the gastric mucosa of rats with long-term administration of histamine H2-receptor antagonist].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.
1998 Dec; 95(12):1333-42. doi:
NULL. [PMID: 9889541] - L Kölby, B Wängberg, H Ahlman, I M Modlin, O Nilsson. Histamine metabolism of gastric carcinoids in Mastomys natalensis.
The Yale journal of biology and medicine.
1998 May; 71(3-4):207-15. doi:
. [PMID: 10461353] - I M Modlin, Z Zhu, L H Tang, M Kidd, G P Lawton, K Miu, R E Powers, J R Goldenring, D Pasikhov, C J Soroka. Evidence for a regulatory role for histamine in gastric enterochromaffin-like cell proliferation induced by hypergastrinemia.
Digestion.
1996; 57(5):310-21. doi:
10.1159/000201351. [PMID: 8886574] - O Nilsson, B Wängberg, L Johansson, E Theodorsson, A Dahlström, I M Modlin, H Ahlman. Rapid induction of enterochromaffinlike cell tumors by histamine2-receptor blockade.
The American journal of pathology.
1993 Apr; 142(4):1173-85. doi:
. [PMID: 8097370] - I M Modlin, R Kumar, A Nangia, C J Soroka, D Pasikhov, J R Goldenring. Gastrin-dependent inhibitory effects of octreotide on the genesis of gastric ECLomas.
Surgery.
1992 Dec; 112(6):1048-56; discussion 1056. doi:
. [PMID: 1360710] - J Calam, R A Goodlad, C Y Lee, B Ratcliffe, M E Coates, G W Stamp, N A Wright. Achlorhydria-induced hypergastrinaemia: the role of bacteria.
Clinical science (London, England : 1979).
1991 Apr; 80(4):281-4. doi:
10.1042/cs0800281. [PMID: 1673881] - B Burlinson, S Morriss, D G Gatehouse, D J Tweats, M R Jackson. Uptake of tritiated thymidine by cells of the rat gastric mucosa after exposure to loxtidine or omeprazole.
Mutagenesis.
1991 Jan; 6(1):11-8. doi:
10.1093/mutage/6.1.11. [PMID: 2038267] - G Martinez, R W Hart, H M Hill, J R Lang, D Lessard, J M Houle. Determination of loxtidine in human serum by capillary column gas chromatography with nitrogen-phosphorus detection.
Journal of chromatography.
1990 Nov; 533(?):235-40. doi:
10.1016/s0378-4347(00)82208-2. [PMID: 1982002] - A J Bilchik, O Nilsson, I M Modlin, J Sussman, K A Zucker, T E Adrian. H2-receptor blockade induces peptide YY and enteroglucagon-secreting gastric carcinoids in mastomys.
Surgery.
1989 Dec; 106(6):1119-26; discussion 1026. doi:
. [PMID: 2573958] - R E Bland, C Harrison, L E Martin, J Oxford, R J Tanner. Automated extraction of drugs from biological fluids.
International journal of environmental analytical chemistry.
1984; 18(1-2):25-35. doi:
10.1080/03067318408076989. [PMID: 6530328]