3,4-Dihydroxymandelaldehyde (BioDeep_00001869259)

Main id: BioDeep_00000005873

 


代谢物信息卡片


3,4-Dihydroxymandelaldehyde

化学式: C8H8O4 (168.0423)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1C(C=O)O)O)O
InChI: InChI=1S/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H

描述信息

A hydroxyaldehyde consisting of phenylacetaldehyde having three hydroxy substituents located at the alpha-, 3- and 4-positions. It is a metabolite of noradrenaline.
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同义名列表

2 个代谢物同义名

3,4-Dihydroxymandelaldehyde; 3,4-Dihydroxymandelaldehyde



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AKR1B1, ALB, CAT, DBH, ELANE, IGHMBP2, MAPT, PFDN5, STAT3, TH, TYR
Peripheral membrane protein 2 ACHE, MAPT
Endoplasmic reticulum membrane 1 PNMT
Mitochondrion membrane 2 MAOA, PNMT
Nucleus 8 ACHE, ALB, DNTT, IGHMBP2, MAPT, PFDN5, STAT3, TH
cytosol 12 AKR1A1, AKR1B1, ALB, CAT, DNTT, ELANE, MAOA, MAPT, PFDN5, PNMT, STAT3, TH
dendrite 3 MAPT, SLC18A2, TH
mitochondrial membrane 1 PNMT
nuclear body 1 IGHMBP2
phagocytic vesicle 1 ELANE
centrosome 2 ALB, SLC18A2
nucleoplasm 4 AKR1B1, DNTT, IGHMBP2, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 3 ACHE, MAPT, SLC6A2
Cytoplasmic side 2 MAOA, MAPT
Cell projection, axon 4 IGHMBP2, MAPT, SLC18A2, TH
Multi-pass membrane protein 3 PNMT, SLC18A2, SLC6A2
Synapse 3 ACHE, AKR1A1, DBH
cell junction 1 AGER
cell surface 4 ACHE, AGER, ELANE, SLC6A2
Golgi apparatus 2 ACHE, ALB
growth cone 2 IGHMBP2, MAPT
neuromuscular junction 1 ACHE
neuronal cell body 1 MAPT
postsynapse 1 AGER
presynaptic membrane 1 SLC6A2
smooth endoplasmic reticulum 1 TH
synaptic vesicle 2 SLC18A2, TH
Cytoplasm, cytosol 2 AKR1A1, MAPT
Lysosome 1 TYR
plasma membrane 6 ACHE, AGER, MAPT, SLC18A2, SLC6A2, STAT3
synaptic vesicle membrane 2 SLC18A2, SLC6A2
terminal bouton 2 SLC18A2, TH
Membrane 8 ACHE, AGER, CAT, DBH, IGHMBP2, MAOA, SLC18A2, SLC6A2
apical plasma membrane 2 AGER, AKR1A1
axon 5 IGHMBP2, MAPT, SLC18A2, SLC6A2, TH
extracellular exosome 6 AKR1A1, AKR1B1, ALB, ALDH2, CAT, ELANE
endoplasmic reticulum 3 ALB, DBH, PNMT
extracellular space 6 ACHE, AKR1A1, AKR1B1, ALB, DBH, ELANE
perinuclear region of cytoplasm 3 ACHE, TH, TYR
mitochondrion 7 AKR1B1, ALDH2, CAT, MAOA, MAPT, PNMT, TH
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 5 CAT, DBH, PNMT, SLC18A2, TYR
Single-pass type I membrane protein 2 AGER, TYR
Secreted 4 ACHE, ALB, DBH, MAPT
extracellular region 7 ACHE, AGER, ALB, CAT, DBH, ELANE, MAPT
cytoplasmic side of plasma membrane 1 TH
Mitochondrion outer membrane 1 MAOA
Single-pass membrane protein 1 MAOA
mitochondrial outer membrane 1 MAOA
neuronal cell body membrane 1 SLC6A2
Mitochondrion matrix 1 ALDH2
mitochondrial matrix 2 ALDH2, CAT
Extracellular side 1 ACHE
anchoring junction 1 ALB
transcription regulator complex 1 STAT3
centriolar satellite 1 DBH
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 SLC18A2
dendritic spine 1 MAPT
perikaryon 1 TH
cytoplasmic vesicle 1 TH
microtubule cytoskeleton 1 MAPT
axon cytoplasm 1 MAPT
Melanosome membrane 2 TH, TYR
Golgi-associated vesicle 1 TYR
Single-pass type II membrane protein 1 DBH
Apical cell membrane 1 AKR1A1
Cytoplasm, perinuclear region 1 TH
Membrane raft 1 MAPT
Cytoplasm, cytoskeleton 1 MAPT
focal adhesion 1 CAT
microtubule 1 MAPT
axolemma 1 MAPT
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 ELANE
secretory granule 1 ELANE
nuclear speck 1 MAPT
neuron projection 2 MAPT, TH
ciliary basal body 1 ALB
chromatin 1 STAT3
centriole 1 ALB
cytoplasmic ribonucleoprotein granule 1 MAPT
spindle pole 1 ALB
blood microparticle 1 ALB
Lipid-anchor, GPI-anchor 1 ACHE
fibrillar center 1 AGER
[Isoform 1]: Endoplasmic reticulum membrane 1 PNMT
Cell projection, dendrite 2 MAPT, SLC18A2
Melanosome 1 TYR
euchromatin 1 DNTT
cell body 1 MAPT
side of membrane 1 ACHE
intermediate filament cytoskeleton 1 PFDN5
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, DBH
secretory granule membrane 2 DBH, SLC18A2
endoplasmic reticulum lumen 1 ALB
nuclear matrix 1 DNTT
transcription repressor complex 1 ELANE
platelet alpha granule lumen 1 ALB
specific granule lumen 1 ELANE
azurophil granule lumen 1 ELANE
Single-pass type IV membrane protein 1 MAOA
ribonucleoprotein complex 1 IGHMBP2
prefoldin complex 1 PFDN5
synaptic cleft 1 ACHE
[Isoform 1]: Cell membrane 1 AGER
dopaminergic synapse 1 SLC18A2
Cytoplasmic vesicle, secretory vesicle membrane 2 DBH, SLC18A2
somatodendritic compartment 1 MAPT
[Isoform 2]: Endoplasmic reticulum membrane 1 PNMT
Cytoplasmic vesicle, phagosome 1 ELANE
nuclear periphery 1 MAPT
glial cell projection 1 MAPT
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen 1 DBH
chromaffin granule lumen 1 DBH
transport vesicle membrane 1 DBH
catalase complex 1 CAT
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
neurofibrillary tangle 1 MAPT
[Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen 1 DBH
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane 1 DBH
chromaffin granule membrane 1 DBH
main axon 1 MAPT
tubulin complex 1 MAPT
clathrin-sculpted monoamine transport vesicle membrane 1 SLC18A2
[Isoform H]: Cell membrane 1 ACHE
ciliary transition fiber 1 ALB
[Isoform 10]: Cell membrane 1 AGER


文献列表

  • Margaret-Ann M Nelson, Zachariah J Builta, T Blake Monroe, Jonathan A Doorn, Ethan J Anderson. Biochemical characterization of the catecholaldehyde reactivity of L-carnosine and its therapeutic potential in human myocardium. Amino acids. 2019 Jan; 51(1):97-102. doi: 10.1007/s00726-018-2647-y. [PMID: 30191330]
  • Jayan Narayanan, Yoshio Hayakawa, Junfa Fan, Kenneth L Kirk. Convenient syntheses of biogenic aldehydes, 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde. Bioorganic chemistry. 2003 Apr; 31(2):191-7. doi: 10.1016/s0045-2068(03)00019-1. [PMID: 12729575]
  • W J Burke, H D Chung, S W Li. Quantitation of 3,4-dihydroxyphenylacetaldehyde and 3, 4-dihydroxyphenylglycolaldehyde, the monoamine oxidase metabolites of dopamine and noradrenaline, in human tissues by microcolumn high-performance liquid chromatography. Analytical biochemistry. 1999 Aug; 273(1):111-6. doi: 10.1006/abio.1999.4196. [PMID: 10452806]