(R)-S-Lactoylglutathione (BioDeep_00001869107)

Main id: BioDeep_00000001432

 

PANOMIX_OTCML-2023


代谢物信息卡片


(R)-S-Lactoylglutathione

化学式: C13H21N3O8S (379.10493060000005)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C(=O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N)O
InChI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/t6-,7+,8+/m1/s1

描述信息

The S-[(R)-lactoyl] derivative of glutathione. It is an intermediate in the pyruvate metabolism.
D000970 - Antineoplastic Agents

同义名列表

1 个代谢物同义名

(R)-S-Lactoylglutathione



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Gerry Aplang Jana, Latifa Al Kharusi, Ramanjulu Sunkar, Rashid Al-Yahyai, Mahmoud W Yaish. Metabolomic analysis of date palm seedlings exposed to salinity and silicon treatments. Plant signaling & behavior. 2019; 14(11):1663112. doi: 10.1080/15592324.2019.1663112. [PMID: 31505987]
  • Ajit Ghosh, Ashwani Pareek, Sudhir K Sopory, Sneh L Singla-Pareek. A glutathione responsive rice glyoxalase II, OsGLYII-2, functions in salinity adaptation by maintaining better photosynthesis efficiency and anti-oxidant pool. The Plant journal : for cell and molecular biology. 2014 Oct; 80(1):93-105. doi: 10.1111/tpj.12621. [PMID: 25039836]
  • Miklós Péter Kalapos. S-D-lactoylglutathione as a potential state marker for hemolysis. Medical hypotheses. 2011 Oct; 77(4):479-80. doi: 10.1016/j.mehy.2011.06.014. [PMID: 21723671]
  • T Neuefeind, R Huber, H Dasenbrock, L Prade, B Bieseler. Crystal structure of herbicide-detoxifying maize glutathione S-transferase-I in complex with lactoylglutathione: evidence for an induced-fit mechanism. Journal of molecular biology. 1997 Dec; 274(4):446-53. doi: 10.1006/jmbi.1997.1402. [PMID: 9417926]
  • A C McLellan, S A Phillips, P J Thornalley. The assay of S-D-lactoylglutathione in biological systems. Biochemical Society transactions. 1993 May; 21(2):164S. doi: 10.1042/bst021164s. [PMID: 8359417]
  • L Edwards, J D Clelland, P J Thornalley. Characteristics of the inhibition of human promyelocytic leukaemia HL60 cell growth by S-D-lactoylglutathione in vitro. Leukemia research. 1993 Apr; 17(4):305-10. doi: 10.1016/0145-2126(93)90017-f. [PMID: 8487580]
  • M P Kalapos, T Garzó, F Antoni, J Mandl. Accumulation of S-D-lactoylglutathione and transient decrease of glutathione level caused by methylglyoxal load in isolated hepatocytes. Biochimica et biophysica acta. 1992 Jun; 1135(2):159-64. doi: 10.1016/0167-4889(92)90132-u. [PMID: 1616937]
  • P J Thornalley, V Della Bianca, P Bellavite, F Rossi. S-D-lactoylglutathione in resting and activated human neutrophils. Biochemical and biophysical research communications. 1987 Jun; 145(2):769-74. doi: 10.1016/0006-291x(87)91031-x. [PMID: 3593370]
  • I V Berezin, B M Kershengol'ts, N N Ugarova. [Microenvironment of enzymes as 1 of the factors determining enzyme stability. Stabilization of soluble and immobilized horseradish peroxidase]. Doklady Akademii nauk SSSR. 1975 Aug; 223(5):1256-9. doi: NULL. [PMID: 223]