L-Azetidine-2-carboxylic acid (BioDeep_00001868719)

Main id: BioDeep_00000003359

 

PANOMIX_OTCML-2023


代谢物信息卡片


2-Azetidinecarboxylic acid, (S)-

化学式: C4H7NO2 (101.0477)
中文名称: L-氮杂环丁烷-2-羧酸, (S) -氮杂环丁烷-2-羧酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CNC1C(=O)O
InChI: InChI=1S/C4H7NO2/c6-4(7)3-1-2-5-3/h3,5H,1-2H2,(H,6,7)/t3-/m0/s1

描述信息

The (S)-enantiomer of azetidine-2-carboxylic acid.
L-Azetidine-2-carboxylic acid is an endogenous metabolite.
L-Azetidine-2-carboxylic acid is an endogenous metabolite.

同义名列表

5 个代谢物同义名

2-Azetidinecarboxylic acid, (S)-; (S)-Azetidine-2-carboxylic acid; L-Azetidine-2-carboxylic acid; L-Azetidine 2-carboxylic acid; (S)-Azetidine-2-carboxylic acid



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ALB, ANG, BGLAP, CLU, HSF1, HSF2, NEDD4, PRKX
Peripheral membrane protein 2 CLU, NEDD4
Endosome membrane 1 TF
Endoplasmic reticulum membrane 2 ATF6, HSP90B1
Mitochondrion membrane 1 CLU
Nucleus 10 ALB, ANG, ATF6, CLU, HSF1, HSF2, HSP90B1, NEDD4, PRKX, UBE2S
cytosol 8 ALB, ANG, ATF6, CLU, HSF1, HSP90B1, NEDD4, UBE2S
dendrite 1 BGLAP
mitochondrial membrane 1 CLU
centrosome 2 ALB, HSF1
nucleoplasm 6 ATF6, HSF1, HSF2, PRKX, PRODH, UBE2S
RNA polymerase II transcription regulator complex 1 ATF6
Cell membrane 2 NEDD4, SLC36A1
Cytoplasmic side 1 CLU
Multi-pass membrane protein 1 SLC36A1
Golgi apparatus membrane 1 ATF6
Synapse 1 CLU
cell cortex 1 NEDD4
cell surface 4 AMELX, CLU, PLG, TF
glutamatergic synapse 1 PLG
Golgi apparatus 4 ALB, ATF6, CLU, NEDD4
Golgi membrane 1 ATF6
growth cone 1 ANG
lysosomal membrane 1 SLC36A1
mitochondrial inner membrane 2 CLU, PRODH
neuronal cell body 1 ANG
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 CLU
Lysosome 1 GALNS
plasma membrane 4 NEDD4, PLG, SLC36A1, TF
Membrane 3 ATF6, HSP90B1, SLC36A1
apical plasma membrane 2 SLC36A1, TF
extracellular exosome 7 ALB, CLU, GALNS, HSP90B1, NEDD4, PLG, TF
Lysosome membrane 1 SLC36A1
endoplasmic reticulum 5 ALB, ATF6, CLU, HSP90B1, SLC36A1
extracellular space 7 ALB, ANG, BGLAP, CLU, COL2A1, PLG, TF
lysosomal lumen 1 GALNS
perinuclear region of cytoplasm 5 CLU, HSF1, HSP90B1, NEDD4, TF
Schaffer collateral - CA1 synapse 1 PLG
apicolateral plasma membrane 1 NEDD4
mitochondrion 3 CLU, PRODH, PYCR1
protein-containing complex 4 ALB, CLU, HSP90B1, NEDD4
intracellular membrane-bounded organelle 2 CLU, PRODH
Secreted 7 ALB, ANG, BGLAP, CLU, COL2A1, PLG, TF
extracellular region 11 ALB, AMELX, ANG, BGLAP, CLU, COL2A1, DNAH9, GALNS, HSP90B1, PLG, TF
basal part of cell 1 TF
mitochondrial matrix 2 PRODH, PYCR1
anchoring junction 1 ALB
motile cilium 1 DNAH9
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 HSF1
external side of plasma membrane 1 PLG
Secreted, extracellular space, extracellular matrix 2 AMELX, COL2A1
actin cytoskeleton 1 ANG
dendritic spine 1 NEDD4
perikaryon 1 BGLAP
cytoplasmic vesicle 1 TF
nucleolus 1 ANG
midbody 1 HSP90B1
Early endosome 1 TF
clathrin-coated pit 1 TF
recycling endosome 1 TF
Single-pass type II membrane protein 1 ATF6
vesicle 2 BGLAP, TF
Apical cell membrane 1 SLC36A1
Cytoplasm, perinuclear region 2 CLU, HSF1
heterochromatin 1 HSF1
focal adhesion 1 HSP90B1
microtubule 1 DNAH9
basement membrane 2 ANG, COL2A1
collagen trimer 1 COL2A1
PML body 1 HSF1
collagen-containing extracellular matrix 5 AMELX, CLU, COL2A1, HSP90B1, PLG
axoneme 1 DNAH9
Late endosome 1 TF
ciliary basal body 1 ALB
chromatin 4 ATF6, HSF1, HSF2, NEDD4
Chromosome 1 ANG
centriole 1 ALB
Nucleus, nucleolus 1 ANG
spindle pole 1 ALB
blood microparticle 4 ALB, CLU, PLG, TF
Cytoplasm, cytoskeleton, cilium axoneme 1 DNAH9
Cytoplasm, cytoskeleton, spindle pole 1 HSF1
nuclear envelope 1 ATF6
Chromosome, centromere, kinetochore 1 HSF1
Nucleus, nucleoplasm 1 HSF1
Melanosome 1 HSP90B1
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
euchromatin 1 HSF1
sperm plasma membrane 1 HSP90B1
ubiquitin ligase complex 1 NEDD4
basal plasma membrane 1 TF
[Isoform 4]: Cytoplasm 1 CLU
Microsome 1 CLU
secretory granule lumen 1 TF
HFE-transferrin receptor complex 1 TF
Golgi lumen 1 BGLAP
endoplasmic reticulum lumen 6 ALB, AMELX, BGLAP, COL2A1, HSP90B1, TF
platelet alpha granule lumen 3 ALB, CLU, PLG
kinetochore 1 HSF1
mitotic spindle pole 1 HSF1
endocytic vesicle 3 AMELX, ANG, TF
azurophil granule lumen 1 GALNS
anaphase-promoting complex 1 UBE2S
9+2 motile cilium 1 DNAH9
dynein complex 1 DNAH9
clathrin-coated endocytic vesicle membrane 1 TF
Sarcoplasmic reticulum lumen 1 HSP90B1
ribonucleoprotein complex 1 HSF1
protein folding chaperone complex 1 HSF1
apical dendrite 1 CLU
vesicle coat 1 TF
spherical high-density lipoprotein particle 1 CLU
endocytic vesicle lumen 1 HSP90B1
[Isoform 1]: Secreted 1 CLU
collagen type II trimer 1 COL2A1
collagen type XI trimer 1 COL2A1
angiogenin-PRI complex 1 ANG
neurofibrillary tangle 1 CLU
vacuolar membrane 1 SLC36A1
endoplasmic reticulum chaperone complex 1 HSP90B1
Cytoplasmic vesicle, secretory vesicle, chromaffin granule 1 CLU
chromaffin granule 1 CLU
[Isoform 6]: Cytoplasm 1 CLU
perinuclear endoplasmic reticulum lumen 1 CLU
[Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Nucleus 1 ATF6
nuclear stress granule 1 HSF1
ciliary transition fiber 1 ALB
dense body 1 TF
outer dynein arm 1 DNAH9
distal portion of axoneme 1 DNAH9


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • David T Thwaites, Catriona M H Anderson. The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport. British journal of pharmacology. 2011 Dec; 164(7):1802-16. doi: 10.1111/j.1476-5381.2011.01438.x. [PMID: 21501141]
  • Mark R Faust, Georg Höfner, Jörg Pabel, Klaus T Wanner. Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship. European journal of medicinal chemistry. 2010 Jun; 45(6):2453-66. doi: 10.1016/j.ejmech.2010.02.029. [PMID: 20219271]