SCM 3B (BioDeep_00000859618)

Main id: BioDeep_00000000599

 

PANOMIX_OTCML-2023


代谢物信息卡片


(2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8aR,9R,12aS,14aR,14bR)-9-hydroxy-4-(hydroxymethyl)-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-5-[[(2S,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[[(2S,3R,4

化学式: C48H78O18 (942.5188)
中文名称: 大豆皂苷Bb
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(C(C(O1)OC2C(C(C(OC2OC3C(C(C(OC3OC4CCC5(C(C4(C)CO)CCC6(C5CC=C7C6(CCC8(C7CC(CC8O)(C)C)C)C)C)C)C(=O)O)O)O)CO)O)O)O)O)O
InChI: InChI=1S/C48H78O18/c1-21-29(52)31(54)35(58)40(61-21)65-37-32(55)30(53)24(19-49)62-41(37)66-38-34(57)33(56)36(39(59)60)64-42(38)63-28-12-13-45(5)25(46(28,6)20-50)11-14-48(8)26(45)10-9-22-23-17-43(2,3)18-27(51)44(23,4)15-16-47(22,48)7/h9,21,23-38,40-42,49-58H,10-20H2,1-8H3,(H,59,60)/t21-,23-,24+,25+,26+,27+,28-,29-,30-,31+,32-,33-,34-,35+,36-,37+,38+,40-,41-,42+,44+,45-,46+,47+,48+/m0/s1

描述信息

soyasaponin Bb is a soyasaponin isolated from Phaseolus vulgaris, acting as an aldose reductase differential inhibitor (ARDI)[1].
soyasaponin Bb is a soyasaponin isolated from Phaseolus vulgaris, acting as an aldose reductase differential inhibitor (ARDI)[1].

同义名列表

17 个代谢物同义名

(2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8aR,9R,12aS,14aR,14bR)-9-hydroxy-4-(hydroxymethyl)-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-5-[[(2S,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[[(2S,3R,4; (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8aR,9R,12aS,14aR,14bR)-9-hydroxy-4,6a,6b,8a,11,11,14b-heptamethyl-4-methylol-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-5-[(2S,3R,4S,5R,6R)-4,5-dihydroxy-6-methylol-3-[(2S,3R,4R,5R,6S)-3,4,5-t; (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8aR,9R,12aS,14aR,14bR)-9-hydroxy-4-(hydroxymethyl)-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-5-[(2S,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,; beta-D-Glucopyranosiduronic acid, (3beta,4beta,22beta)-22,23-dihydroxyolean-12-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-beta-D-galactopyranosyl-(1-2)-; b-D-Glucopyranosiduronic acid, (3b,4b,22b)-22,23-dihydroxyolean-12-en-3-yl O-6-deoxy-.alpha.-L-mannopyranosyl-(1.2)-O-.beta.-D-galactopyranosyl-(1.2)-; Oleanane, b-D-glucopyranosiduronic acid deriv.; Soybean saponin fraction B1; Soyasaponin Bb; SOYASAPONIN I; AIDS-000571; CCRIS 6617; 55366-25-1; AIDS000571; 51330-27-9; C08983; SCM 3B; Soyasaponin I



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

48 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ACE, BCL2, MAPK3, PDLIM4, PIK3R6, PTGS2, RUNX2, TLR4, TRIM69
Golgi apparatus, trans-Golgi network membrane 1 ST3GAL1
Peripheral membrane protein 4 FLOT1, PDLIM4, PIK3R6, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 3 BCL2, HMOX1, PTGS2
Nucleus 7 BCL2, DNMT1, HMOX1, MAPK3, PDLIM4, RUNX2, TRIM69
cytosol 7 BCL2, GPT, HMOX1, MAPK3, PIK3R6, RUNX2, TRIM69
centrosome 1 TRIM69
nucleoplasm 4 DNMT1, HMOX1, MAPK3, RUNX2
Cell membrane 5 ACE, FLOT1, PIK3R6, TLR4, TNF
Cytoplasmic side 2 HMOX1, PDLIM4
lamellipodium 2 FLOT1, PDLIM4
Early endosome membrane 1 PDLIM4
Multi-pass membrane protein 1 FLOT1
Golgi apparatus membrane 1 ST3GAL1
Synapse 1 PDLIM4
cell surface 3 BMP2, TLR4, TNF
glutamatergic synapse 2 FLOT1, MAPK3
Golgi apparatus 2 MAPK3, ST3GAL1
Golgi membrane 1 ST3GAL1
lysosomal membrane 1 FLOT1
neuronal cell body 1 TNF
sarcolemma 1 FLOT1
Lysosome 1 ACE
endosome 2 ACE, FLOT1
plasma membrane 8 ACE, BMP2, FLOT1, MAPK3, PIK3R6, REN, TLR4, TNF
presynaptic active zone 1 FLOT1
Membrane 8 ACE, BCL2, FLOT1, HMOX1, PIK3R6, REN, ST3GAL1, TLR4
apical plasma membrane 1 FLOT1
basolateral plasma membrane 1 FLOT1
caveola 3 FLOT1, MAPK3, PTGS2
extracellular exosome 6 ACE, AGT, BMP3, FLOT1, GPT, ST3GAL1
endoplasmic reticulum 3 BCL2, HMOX1, PTGS2
extracellular space 7 ACE, AGT, BMP2, BMP3, HMOX1, REN, TNF
perinuclear region of cytoplasm 3 HMOX1, PDLIM4, TLR4
adherens junction 2 FLOT1, PDLIM4
mitochondrion 3 BCL2, DNMT1, MAPK3
protein-containing complex 2 BCL2, PTGS2
intracellular membrane-bounded organelle 1 BMP2
Microsome membrane 1 PTGS2
pericentric heterochromatin 1 DNMT1
Single-pass type I membrane protein 2 ACE, TLR4
Secreted 5 ACE, AGT, BMP2, BMP3, REN
extracellular region 6 ACE, AGT, BMP2, BMP3, REN, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
transcription regulator complex 1 RUNX2
centriolar satellite 1 FLOT1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TRIM69
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 4 ACE, FLOT1, TLR4, TNF
dendritic spine 1 PDLIM4
Z disc 1 PDLIM4
cytoplasmic vesicle 1 FLOT1
Early endosome 3 FLOT1, MAPK3, TLR4
apical part of cell 1 REN
cell-cell junction 1 FLOT1
recycling endosome 1 TNF
Single-pass type II membrane protein 2 ST3GAL1, TNF
postsynaptic membrane 1 PDLIM4
Apical cell membrane 1 FLOT1
Cell projection, lamellipodium 1 PDLIM4
Cytoplasm, perinuclear region 1 PDLIM4
Membrane raft 2 FLOT1, TNF
pore complex 1 BCL2
Cell junction, focal adhesion 1 MAPK3
Cytoplasm, cytoskeleton 1 PDLIM4
focal adhesion 2 FLOT1, MAPK3
GABA-ergic synapse 1 FLOT1
flotillin complex 1 FLOT1
Cell projection, dendritic spine 1 PDLIM4
collagen-containing extracellular matrix 1 AGT
nuclear speck 1 TRIM69
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
Late endosome 1 MAPK3
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 1 PTGS2
chromatin 1 RUNX2
phagocytic cup 2 TLR4, TNF
cytoskeleton 2 MAPK3, PDLIM4
brush border membrane 2 ACE, FLOT1
blood microparticle 1 AGT
sperm midpiece 1 ACE
Basolateral cell membrane 1 FLOT1
nuclear envelope 1 MAPK3
Recycling endosome membrane 1 PDLIM4
Endomembrane system 2 FLOT1, PDLIM4
Membrane, caveola 2 FLOT1, MAPK3
filamentous actin 1 PDLIM4
microtubule organizing center 1 FLOT1
female germ cell nucleus 1 DNMT1
Melanosome 1 FLOT1
Nucleus speckle 1 TRIM69
replication fork 1 DNMT1
myelin sheath 1 BCL2
pseudopodium 1 MAPK3
stress fiber 1 PDLIM4
basal plasma membrane 1 ACE
trans-Golgi network membrane 1 ST3GAL1
lipopolysaccharide receptor complex 1 TLR4
endoplasmic reticulum lumen 2 MAPK3, PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3R6
phosphatidylinositol 3-kinase complex, class IA 1 PIK3R6
Golgi apparatus, Golgi stack membrane 1 ST3GAL1
Single-pass type IV membrane protein 1 HMOX1
[Isoform 2]: Cytoplasm 1 PDLIM4
uropod 1 FLOT1
Synapse, synaptosome 1 PDLIM4
[Isoform 1]: Cytoplasm, cytoskeleton 1 PDLIM4
dopaminergic synapse 1 FLOT1
cell-cell contact zone 1 FLOT1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
BAD-BCL-2 complex 1 BCL2
BMP receptor complex 1 BMP2
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
phosphatidylinositol 3-kinase complex, class IB 1 PIK3R6
early endosome lumen 1 PDLIM4
recycling endosome lumen 1 PDLIM4
Golgi medial cisterna membrane 1 ST3GAL1
Golgi trans cisterna membrane 1 ST3GAL1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Manami Sakanishi, Soo Yeon Chung, Kentaro Fujiwara, Mareshige Kojoma, Toshiya Muranaka, Hikaru Seki. Disruption of a licorice cellulose synthase-derived glycosyltransferase gene demonstrates its in planta role in soyasaponin biosynthesis. Plant cell reports. 2023 Dec; 43(1):15. doi: 10.1007/s00299-023-03095-6. [PMID: 38135741]
  • Wei-Ting Tsai, Yuki Nakamura, Taiki Akasaka, Yoshinori Katakura, Yasutake Tanaka, Bungo Shirouchi, Zhe Jiang, Xingyu Yuan, Masao Sato. Soyasaponin ameliorates obesity and reduces hepatic triacylglycerol accumulation by suppressing lipogenesis in high-fat diet-fed mice. Journal of food science. 2021 May; 86(5):2103-2117. doi: 10.1111/1750-3841.15696. [PMID: 33864648]
  • Junbin Chen, Hidayat Ullah, Zhongdaixi Zheng, Xiangfu Gu, Chuhong Su, Lingyu Xiao, Xinglong Wu, Fei Xiong, Qing Li, Longying Zha. Soyasaponins reduce inflammation by downregulating MyD88 expression and suppressing the recruitments of TLR4 and MyD88 into lipid rafts. BMC complementary medicine and therapies. 2020 Jun; 20(1):167. doi: 10.1186/s12906-020-2864-2. [PMID: 32493316]
  • Qunying Xie, Xiangfu Gu, Junbin Chen, Minshun Liu, Fei Xiong, Xinglong Wu, Yajie Zhang, Fengping Chen, Honger Chen, Meijuan Li, Suxia Sun, Xinwei Chu, Longying Zha. Soyasaponins Reduce Inflammation and Improve Serum Lipid Profiles and Glucose Homeostasis in High Fat Diet-Induced Obese Mice. Molecular nutrition & food research. 2018 10; 62(19):e1800205. doi: 10.1002/mnfr.201800205. [PMID: 30070430]
  • Edward C MacDonell, Istvan Rajcan. Identification of quantitative trait loci associated with soyasaponin I concentration in soybean seed. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 2018 Oct; 131(10):2157-2165. doi: 10.1007/s00122-018-3144-0. [PMID: 30051334]
  • Safa M Shams Eldin, Mohamed M Radwan, Amira S Wanas, Abdel-Azim M Habib, Fahima F Kassem, Hala M Hammoda, Shabana I Khan, Michael L Klein, Khaled M Elokely, Mahmoud A ElSohly. Bioactivity-Guided Isolation of Potential Antidiabetic and Antihyperlipidemic Compounds from Trigonella stellata. Journal of natural products. 2018 05; 81(5):1154-1161. doi: 10.1021/acs.jnatprod.7b00707. [PMID: 29676912]
  • Raymond Malabed, Shinya Hanashima, Michio Murata, Kaori Sakurai. Sterol-recognition ability and membrane-disrupting activity of Ornithogalum saponin OSW-1 and usual 3-O-glycosyl saponins. Biochimica et biophysica acta. Biomembranes. 2017 Dec; 1859(12):2516-2525. doi: 10.1016/j.bbamem.2017.09.019. [PMID: 28947142]
  • Pilar Vila-Donat, Celia Fernández-Blanco, Gianni Sagratini, Guillermina Font, María-José Ruiz. Effects of soyasaponin I and soyasaponins-rich extract on the alternariol-induced cytotoxicity on Caco-2 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2015 Mar; 77(?):44-9. doi: 10.1016/j.fct.2014.12.016. [PMID: 25542527]
  • Jing Lu, Jia-Hong Sun, Yao Tan, Yoshihiro Kano, Dan Yuan. New triterpenoid saponins from the flowers of Pueraria thomsonii. Journal of Asian natural products research. 2013; 15(10):1065-72. doi: 10.1080/10286020.2013.802690. [PMID: 24168266]
  • In-Ah Lee, Young-Jun Park, Hee-Kyung Yeo, Myung Joo Han, Dong-Hyun Kim. Soyasaponin I attenuates TNBS-Induced colitis in mice by inhibiting NF-κB pathway. Journal of agricultural and food chemistry. 2010 Oct; 58(20):10929-34. doi: 10.1021/jf102296y. [PMID: 20923188]
  • Wei Zhang, David G Popovich. Group B oleanane triterpenoid extract containing soyasaponins I and III from soy flour induces apoptosis in Hep-G2 cells. Journal of agricultural and food chemistry. 2010 May; 58(9):5315-9. doi: 10.1021/jf9037979. [PMID: 20345167]
  • Gianni Sagratini, Yanting Zuo, Giovanni Caprioli, Gloria Cristalli, Dario Giardinà, Filippo Maggi, Laura Molin, Massimo Ricciutelli, Piero Traldi, Sauro Vittori. Quantification of soyasaponins I and betag in Italian lentil seeds by solid-phase extraction (SPE) and high-performance liquid chromatography-mass spectrometry (HPLC-MS). Journal of agricultural and food chemistry. 2009 Dec; 57(23):11226-33. doi: 10.1021/jf901707z. [PMID: 19950999]
  • Wei Zhang, Mei Ching Yeo, Fang Yin Tang, David G Popovich. Bioactive responses of Hep-G2 cells to soyasaponin extracts differs with respect to extraction conditions. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2009 Sep; 47(9):2202-8. doi: 10.1016/j.fct.2009.06.006. [PMID: 19520140]
  • Wei Zhang, Su Ping Teng, David G Popovich. Generation of group B soyasaponins I and III by hydrolysis. Journal of agricultural and food chemistry. 2009 May; 57(9):3620-5. doi: 10.1021/jf803663j. [PMID: 19338335]
  • Wei Wang, Li-Qian Hai, Yu-Ying Zhao, Hu-Biao Chen, Bin Wang, Hong Liang. [Saponins from roots of Hedysarum multijugum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Feb; 32(4):315-7. doi: . [PMID: 17455466]
  • Wesley G Taylor, Paul G Fields, Daniel H Sutherland. Insecticidal components from field pea extracts: soyasaponins and lysolecithins. Journal of agricultural and food chemistry. 2004 Dec; 52(25):7484-90. doi: 10.1021/jf0308051. [PMID: 15675793]
  • Jiang Hu, Manju B Reddy, Suzanne Hendrich, Patricia A Murphy. Soyasaponin I and sapongenol B have limited absorption by Caco-2 intestinal cells and limited bioavailability in women. The Journal of nutrition. 2004 Aug; 134(8):1867-73. doi: 10.1093/jn/134.8.1867. [PMID: 15284368]
  • Jiang Hu, Yan L Zheng, Walter Hyde, Suzanne Hendrich, Patricia A Murphy. Human fecal metabolism of soyasaponin I. Journal of agricultural and food chemistry. 2004 May; 52(9):2689-96. doi: 10.1021/jf035290s. [PMID: 15113177]
  • Hiroaki Hayashi, Pengyu Huang, Kenichiro Inoue. Up-regulation of soyasaponin biosynthesis by methyl jasmonate in cultured cells of Glycyrrhiza glabra. Plant & cell physiology. 2003 Apr; 44(4):404-11. doi: 10.1093/pcp/pcg054. [PMID: 12721381]
  • H Miyao, T Arao, M Udayama, J Kinjo, T Nohara. Kaikasaponin III and soyasaponin I, major triterpene saponins of Abrus cantoniensis, act on GOT and GPT: influence on transaminase elevation of rat liver cells concomitantly exposed to CCl4 for one hour. Planta medica. 1998 Feb; 64(1):5-7. doi: 10.1055/s-2006-957355. [PMID: 9491761]
  • G R Waller, C F Yang, L F Chen, C H Su, R M Liou, S C Wu, C C Young, M R Lee, J S Lee, C H Chou, D Kim. Can soyasaponin I and mono- and bi-desmosides isolated from mungbeans serve as growth enhancers in mungbeans and lettuce?. Advances in experimental medicine and biology. 1996; 405(?):123-39. doi: 10.1007/978-1-4613-0413-5_11. [PMID: 8910700]
  • M K Lee, Y C Ling, M Jurzysta, G R Waller. Saponins from alfalfa, clover, and mungbeans analyzed by electrospray ionization-mass spectrometry as compared with positive and negative FAB-mass spectrometry. Advances in experimental medicine and biology. 1996; 405(?):353-64. doi: 10.1007/978-1-4613-0413-5_30. [PMID: 8910718]
  • H Frøkiaer, P Møller, H Sørensen, S Sørensen. High-performance capillary electrophoresis for characterization of hapten-protein conjugates used for production of antibodies against soyasaponin I. Journal of chromatography. A. 1994 Oct; 680(2):437-45. doi: 10.1016/0021-9673(94)85141-7. [PMID: 7981825]
  • O B McManus, G H Harris, K M Giangiacomo, P Feigenbaum, J P Reuben, M E Addy, J F Burka, G J Kaczorowski, M L Garcia. An activator of calcium-dependent potassium channels isolated from a medicinal herb. Biochemistry. 1993 Jun; 32(24):6128-33. doi: 10.1021/bi00075a002. [PMID: 7685635]
  • S Tsurumi, T Takagi, T Hashimoto. A gamma-pyronyl-triterpenoid saponin from Pisum sativum. Phytochemistry. 1992 Jul; 31(7):2435-8. doi: 10.1016/0031-9422(92)83294-9. [PMID: 1368388]
  • S Southon, A J Wright, K R Price, S J Fairweather-Tait, G R Fenwick. The effect of three types of saponin on iron and zinc absorption from a single meal in the rat. The British journal of nutrition. 1988 May; 59(3):389-96. doi: 10.1079/bjn19880048. [PMID: 3395602]