ST 27:1;O2 (BioDeep_00000636693)

 

Secondary id: BioDeep_00000003251, BioDeep_00000005828, BioDeep_00000005853, BioDeep_00000010789, BioDeep_00000014448, BioDeep_00000016647, BioDeep_00000171725, BioDeep_00000269112, BioDeep_00000843560, BioDeep_00000895695, BioDeep_00001868638, BioDeep_00001869376, BioDeep_00001891735


代谢物信息卡片


5alpha,6alpha-epoxy-5alpha-cholestan-3beta-ol

化学式: C27H46O2 (402.34976159999997)
中文名称: 19-羟基胆固醇, 22(R)-羟基胆固醇, 7-羟基胆固醇, 5α,6α-epoxy Cholestanol
谱图信息: 最多检出来源 Viridiplantae(plant) 0.08%

分子结构信息

SMILES: C1C[C@H](O)CC2=CC[C@]3([H])[C@@]([H])([C@]21C)CC[C@]1(C)[C@@]([H])([C@@](O)(CCCC(C)C)C)CC[C@]13[H]
InChI: InChI=1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h17-24,28H,6-16H2,1-5H3/t18-,19+,20+,21+,22-,23+,24+,26+,27-/m1/s1

描述信息

D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
D009676 - Noxae > D000963 - Antimetabolites

同义名列表

58 个代谢物同义名

12alpha-Hydroxy-5beta-cholestan-3-one; ST 27:1;O2; 5beta-cholest-25-ene-3alpha,7alpha-diol; 5beta-cholest-24-ene-3alpha,7alpha-diol; 7alpha-Hydroxy-5beta-cholestan-3-one; cholest-5-en-3beta,4alpha-diol; 4alpha-hydroxy-cholesterol; 5alpha-cholesta-9(11)-en-3beta, 20beta-diol; cholest-5-en-3beta,22S-diol; 22S-hydroxycholesterol; 24-oxo-5alpha-cholestan-3beta-ol; 24-ketocholestanol; Cholest-5-en-3beta,19-diol; 19-HYDROXYCHOLESTEROL; 3beta-hydroxy-5alpha-cholestan-15-one; 15-ketocholestane; 5alpha-cholest-8(14)-en-3beta,15beta-diol; 15beta-hydroxycholestene; 5alpha-cholest-8(14)-en-3beta,15alpha-diol; 15alpha-hydroxycholestene; 20a-hydroxy cholesterol; cholest-5-en-3beta,20S-diol; (20S)-20-Hydroxycholesterol; 20beta-Hydroxycholesterol; 20S-hydroxycholesterol; 20(S)-OHC; (24R)-cholest-5-ene-3beta,24-diol; (24R)-cholest-5-en-3beta,24-diol; (24R)-24-hydroxycholesterol; 24R-hydroxycholesterol; 22-alpha-Hydroxy Cholesterol; cholest-5-en-3beta,22R-diol; 22R-hydroxycholesterol; Cholest-5-ene-3beta,27-diol; Cholest-5-ene-3beta,26-diol; cholest-5-en-3beta,26-diol; 27-hydroxy-cholesterol; 26-hydroxy-cholesterol; 26-Hydroxycholesterol; 27-Hydroxycholesterol; cholest-5-en-3beta,22-diol; 22-Hydroxycholesterol; 5-cholestene-3beta,7beta-diol; 7beta-hydroxycholesterol; 7β-hydroxycholesterol; cholest-5-en-3beta,4beta-diol; 4beta-hydroxy-cholesterol; cholest-5-en-3beta,7alpha-diol; 7alpha-hydroxy-cholesterol; 5alpha,6alpha-epoxy-5alpha-cholestan-3beta-ol; 5,6alpha-Epoxy-5alpha-cholestan-3beta-ol; Cholesterol-5alpha,6alpha-epoxide; 5,6α-epoxy-5α-cholestan-3β-ol; 5,6alpha-epoxy-cholestanol; 5,6alpha-epoxy-cholesterol; 5beta,6beta-epoxy-cholestan-3beta-ol; 5beta,6beta-epoxy-cholestanol; 5beta,6beta-epoxy-cholesterol



数据库引用编号

92 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(6)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Imen Ghzaiel, Amira Zarrouk, Vivien Pires, Jean-Paul Pais de Barros, Sonia Hammami, Mohamed Ksila, Mohamed Hammami, Taoufik Ghrairi, Pierre Jouanny, Anne Vejux, Gérard Lizard. 7β-Hydroxycholesterol and 7-ketocholesterol: New oxidative stress biomarkers of sarcopenia inducing cytotoxic effects on myoblasts and myotubes. The Journal of steroid biochemistry and molecular biology. 2023 Jun; 232(?):106345. doi: 10.1016/j.jsbmb.2023.106345. [PMID: 37286110]
  • Leila Rezig, Imen Ghzaiel, Mohamed Ksila, Aline Yammine, Thomas Nury, Amira Zarrouk, Mohammad Samadi, Moncef Chouaibi, Anne Vejux, Gérard Lizard. Cytoprotective activities of representative nutrients from the Mediterranean diet and of Mediterranean oils against 7-ketocholesterol- and 7β-hydroxycholesterol-induced cytotoxicity: Application to age-related diseases and civilization diseases. Steroids. 2022 11; 187(?):109093. doi: 10.1016/j.steroids.2022.109093. [PMID: 36029811]
  • Imen Ghzaiel, Amira Zarrouk, Soukaina Essadek, Lucy Martine, Souha Hammouda, Aline Yammine, Mohamed Ksila, Thomas Nury, Wiem Meddeb, Mounia Tahri Joutey, Wafa Mihoubi, Claudio Caccia, Valerio Leoni, Mohammad Samadi, Niyazi Acar, Pierre Andreoletti, Sonia Hammami, Taoufik Ghrairi, Anne Vejux, Mohamed Hammami, Gérard Lizard. Protective effects of milk thistle (Sylibum marianum) seed oil and α-tocopherol against 7β-hydroxycholesterol-induced peroxisomal alterations in murine C2C12 myoblasts: Nutritional insights associated with the concept of pexotherapy. Steroids. 2022 07; 183(?):109032. doi: 10.1016/j.steroids.2022.109032. [PMID: 35381271]
  • Chen Zhou, Yuhui Yang, Jingyi Tian, Yihan Wu, Faliang An, Changfu Li, Yansheng Zhang. 22R- but not 22S-hydroxycholesterol is recruited for diosgenin biosynthesis. The Plant journal : for cell and molecular biology. 2022 02; 109(4):940-951. doi: 10.1111/tpj.15604. [PMID: 34816537]
  • Yaoyao Xiao, Lijia Zhao, Weidong Li, Xiaoyu Wang, Tiantian Ma, Luda Yang, Lei Gao, Cuimei Li, Manhui Zhang, Dan Yang, Jing Zhang, Haizhen Jiang, Hongcong Zhao, Yiqun Wang, Hsu-Wen Chao, Aihua Wang, Yaping Jin, Huatao Chen. Circadian clock gene BMAL1 controls testosterone production by regulating steroidogenesis-related gene transcription in goat Leydig cells. Journal of cellular physiology. 2021 09; 236(9):6706-6725. doi: 10.1002/jcp.30334. [PMID: 33598947]
  • T Nury, A Yammine, I Ghzaiel, K Sassi, A Zarrouk, F Brahmi, M Samadi, S Rup-Jacques, D Vervandier-Fasseur, J P Pais de Barros, V Bergas, S Ghosh, M Majeed, A Pande, A Atanasov, S Hammami, M Hammami, J Mackrill, B Nasser, P Andreoletti, M Cherkaoui-Malki, A Vejux, G Lizard. Attenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases. Ageing research reviews. 2021 07; 68(?):101324. doi: 10.1016/j.arr.2021.101324. [PMID: 33774195]
  • Souha Hammouda, Imen Ghzaiel, Pol Picón-Pagès, Wiem Meddeb, Wided Khamlaoui, Sonia Hammami, Francisco J Muñoz, Mohamed Hammami, Amira Zarrouk. Nigella and Milk Thistle Seed Oils: Potential Cytoprotective Effects against 7β-Hydroxycholesterol-Induced Toxicity on SH-SY5Y Cells. Biomolecules. 2021 05; 11(6):. doi: 10.3390/biom11060797. [PMID: 34071950]
  • Mason McComb, Richard W Browne, Sonia Bhattacharya, Mary Lou Bodziak, Dejan Jakimovski, Bianca Weinstock-Guttman, Jens Kuhle, Robert Zivadinov, Murali Ramanathan. The cholesterol autoxidation products, 7-ketocholesterol and 7β-hydroxycholesterol are associated with serum neurofilaments in multiple sclerosis. Multiple sclerosis and related disorders. 2021 May; 50(?):102864. doi: 10.1016/j.msard.2021.102864. [PMID: 33677412]
  • Syed Kashif Zaidi, Wen-Jun Shen, Yuan Cortez, Stefanie Bittner, Alex Bittner, Sara Arshad, Ting-Ting Huang, Fredric B Kraemer, Salman Azhar. SOD2 deficiency-induced oxidative stress attenuates steroidogenesis in mouse ovarian granulosa cells. Molecular and cellular endocrinology. 2021 01; 519(?):110888. doi: 10.1016/j.mce.2020.110888. [PMID: 32717420]
  • Anne Vejux, Dehbia Abed-Vieillard, Khadija Hajji, Amira Zarrouk, John J Mackrill, Shubhrima Ghosh, Thomas Nury, Aline Yammine, Mohamed Zaibi, Wafa Mihoubi, Habiba Bouchab, Boubker Nasser, Yaël Grosjean, Gérard Lizard. 7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity. Biochemical pharmacology. 2020 03; 173(?):113648. doi: 10.1016/j.bcp.2019.113648. [PMID: 31586589]
  • Hiroshi Takahashi, Tatsuya Hoshino. A comparative study of the effects of 7β-hydroxycholesterol, 25-hydroxycholesterol, and cholesterol on the structural and thermal phase behavior of multilamellar dipalmitoylphosphatidylcholine bilayer vesicles. Chemistry and physics of lipids. 2020 03; 227(?):104872. doi: 10.1016/j.chemphyslip.2020.104872. [PMID: 31926857]
  • Thomas Nury, Aline Yammine, Franck Menetrier, Amira Zarrouk, Anne Vejux, Gérard Lizard. 7-Ketocholesterol- and 7β-Hydroxycholesterol-Induced Peroxisomal Disorders in Glial, Microglial and Neuronal Cells: Potential Role in Neurodegeneration : 7-ketocholesterol and 7β-hydroxycholesterol-Induced Peroxisomal Disorders and Neurodegeneration. Advances in experimental medicine and biology. 2020; 1299(?):31-41. doi: 10.1007/978-3-030-60204-8_3. [PMID: 33417205]
  • William J Griffiths, Eylan Yutuc, Jonas Abdel-Khalik, Peter J Crick, Thomas Hearn, Alison Dickson, Brian W Bigger, Teresa Hoi-Yee Wu, Anu Goenka, Arunabha Ghosh, Simon A Jones, Douglas F Covey, Daniel S Ory, Yuqin Wang. Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders. Free radical biology & medicine. 2019 11; 144(?):124-133. doi: 10.1016/j.freeradbiomed.2019.04.020. [PMID: 31009661]
  • Randa Sghaier, Thomas Nury, Valerio Leoni, Claudio Caccia, Jean-Paul Pais De Barros, Ameur Cherif, Anne Vejux, Thibault Moreau, Khalifa Limem, Mohammad Samadi, John J Mackrill, Ahmed Slaheddine Masmoudi, Gérard Lizard, Amira Zarrouk. Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrial alterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol. The Journal of steroid biochemistry and molecular biology. 2019 11; 194(?):105432. doi: 10.1016/j.jsbmb.2019.105432. [PMID: 31344443]
  • K Sassi, T Nury, A Zarrouk, R Sghaier, A Khalafi-Nezhad, A Vejux, M Samadi, F Ben Aissa-Fennira, G Lizard. Induction of a non-apoptotic mode of cell death associated with autophagic characteristics with steroidal maleic anhydrides and 7β-hydroxycholesterol on glioma cells. The Journal of steroid biochemistry and molecular biology. 2019 07; 191(?):105371. doi: 10.1016/j.jsbmb.2019.04.020. [PMID: 31034873]
  • B Šošić-Jurjević, D Lütjohann, K Renko, B Filipović, N Radulović, V Ajdžanović, S Trifunović, N Nestorović, J Živanović, M Manojlović Stojanoski, J Kӧhrle, V Milošević. The isoflavones genistein and daidzein increase hepatic concentration of thyroid hormones and affect cholesterol metabolism in middle-aged male rats. The Journal of steroid biochemistry and molecular biology. 2019 06; 190(?):1-10. doi: 10.1016/j.jsbmb.2019.03.009. [PMID: 30885834]
  • Randa Sghaier, Amira Zarrouk, Thomas Nury, Ilham Badreddine, Nora O'Brien, John J Mackrill, Anne Vejux, Mohammad Samadi, Boubker Nasser, Claudio Caccia, Valerio Leoni, Thibault Moreau, Mustapha Cherkaoui-Malki, Ahmed Salhedine Masmoudi, Gérard Lizard. Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes. Free radical research. 2019 05; 53(5):535-561. doi: 10.1080/10715762.2019.1612891. [PMID: 31039616]
  • Amira Zarrouk, Mohammed Ali Smach, Jawhar Hafsa, Randa Sghaier, Hatem Majdoub, Mohammed Hammami, Bassem Charfeddine. Effects of Carpobrotus edulis Extract on Oxidative Stress and 158N Oligodendrocyte Death. Biomedical and environmental sciences : BES. 2019 Apr; 32(4):291-299. doi: 10.3967/bes2019.039. [PMID: 31217065]
  • Amira Zarrouk, Yosra Ben Salem, Jawhar Hafsa, Randa Sghaier, Bassem Charfeddine, Khalifa Limem, Mohamed Hammami, Hatem Majdoub. 7β-hydroxycholesterol-induced cell death, oxidative stress, and fatty acid metabolism dysfunctions attenuated with sea urchin egg oil. Biochimie. 2018 Oct; 153(?):210-219. doi: 10.1016/j.biochi.2018.06.027. [PMID: 30003930]
  • Yidan Sun, Susanne Kopp, Jasmin Strutz, Chaitanya Chakravarthi Gali, Martina Zandl-Lang, Elham Fanaee-Danesh, Andrijana Kirsch, Silvija Cvitic, Saša Frank, Richard Saffery, Ingemar Björkhem, Gernot Desoye, Christian Wadsack, Ute Panzenboeck. Gestational diabetes mellitus modulates cholesterol homeostasis in human fetoplacental endothelium. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2018 09; 1863(9):968-979. doi: 10.1016/j.bbalip.2018.05.005. [PMID: 29778664]
  • K Yoshida, Y Ohta, N Kawate, M Takahashi, T Inaba, S Hatoya, H Morii, K Takahashi, M Ito, H Tamada. Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats. Andrologia. 2018 Feb; 50(1):. doi: 10.1111/and.12803. [PMID: 28295471]
  • Monica Deiana, Simone Calfapietra, Alessandra Incani, Angela Atzeri, Daniela Rossin, Roberto Loi, Barbara Sottero, Noemi Iaia, Giuseppe Poli, Fiorella Biasi. Derangement of intestinal epithelial cell monolayer by dietary cholesterol oxidation products. Free radical biology & medicine. 2017 12; 113(?):539-550. doi: 10.1016/j.freeradbiomed.2017.10.390. [PMID: 29102636]
  • Teerasak Wongwan, Suticha Kittayaruksakul, Nithi Asavapanumas, Varanuj Chatsudthipong, Sunhapas Soodvilai. Activation of liver X receptor inhibits OCT2-mediated organic cation transport in renal proximal tubular cells. Pflugers Archiv : European journal of physiology. 2017 11; 469(11):1471-1481. doi: 10.1007/s00424-017-2033-8. [PMID: 28741179]
  • Myeongjin Yi, Jae-Gook Shin, Su-Jun Lee. Expression of CYP4V2 in human THP1 macrophages and its transcriptional regulation by peroxisome proliferator-activated receptor gamma. Toxicology and applied pharmacology. 2017 09; 330(?):100-106. doi: 10.1016/j.taap.2017.07.009. [PMID: 28729181]
  • Frans Stellaard, Klaus von Bergmann, Thomas Sudhop, Dieter Lütjohann. The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies. The Journal of steroid biochemistry and molecular biology. 2017 05; 169(?):111-122. doi: 10.1016/j.jsbmb.2016.03.030. [PMID: 27060336]
  • Pascal Heitel, Janosch Achenbach, Daniel Moser, Ewgenij Proschak, Daniel Merk. DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators. Bioorganic & medicinal chemistry letters. 2017 03; 27(5):1193-1198. doi: 10.1016/j.bmcl.2017.01.066. [PMID: 28169169]
  • Sathvika Venugopal, Daniel Benjamin Martinez-Arguelles, Seimia Chebbi, Françoise Hullin-Matsuda, Toshihide Kobayashi, Vassilios Papadopoulos. Plasma Membrane Origin of the Steroidogenic Pool of Cholesterol Used in Hormone-induced Acute Steroid Formation in Leydig Cells. The Journal of biological chemistry. 2016 Dec; 291(50):26109-26125. doi: 10.1074/jbc.m116.740928. [PMID: 27815506]
  • Willem-Jan Keune, Jens Hausmann, Ruth Bolier, Dagmar Tolenaars, Andreas Kremer, Tatjana Heidebrecht, Robbie P Joosten, Manjula Sunkara, Andrew J Morris, Elisa Matas-Rico, Wouter H Moolenaar, Ronald P Oude Elferink, Anastassis Perrakis. Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. Nature communications. 2016 Apr; 7(?):11248. doi: 10.1038/ncomms11248. [PMID: 27075612]
  • Zoltán Pataj, Gerhard Liebisch, Gerd Schmitz, Silke Matysik. Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. Journal of chromatography. A. 2016 Mar; 1439(?):82-88. doi: 10.1016/j.chroma.2015.11.015. [PMID: 26607314]
  • Aliki A Rasmiena, Christopher K Barlow, Theodore W Ng, Dedreia Tull, Peter J Meikle. High density lipoprotein efficiently accepts surface but not internal oxidised lipids from oxidised low density lipoprotein. Biochimica et biophysica acta. 2016 Feb; 1861(2):69-77. doi: 10.1016/j.bbalip.2015.11.002. [PMID: 26569052]
  • Thomas Nury, Amira Zarrouk, John J Mackrill, Mohammad Samadi, Philippe Durand, Jean-Marc Riedinger, Margaux Doria, Anne Vejux, Emeric Limagne, Dominique Delmas, Michel Prost, Thibault Moreau, Mohamed Hammami, Régis Delage-Mourroux, Nora M O'Brien, Gérard Lizard. Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). Steroids. 2015 Jul; 99(Pt B):194-203. doi: 10.1016/j.steroids.2015.02.003. [PMID: 25683890]
  • Oliver Weingärtner, Constanze Husche, Hans F Schött, Timo Speer, Michael Böhm, Charlotte M Miller, Florence McCarthy, Jogchum Plat, Dieter Lütjohann, Ulrich Laufs. Vascular effects of oxysterols and oxyphytosterols in apoE -/- mice. Atherosclerosis. 2015 May; 240(1):73-9. doi: 10.1016/j.atherosclerosis.2015.02.032. [PMID: 25765595]
  • Tae-Young Na, Young-Hyun Han, Na-Lee Ka, Han-Su Park, Yun Pyo Kang, Sung Won Kwon, Byung-Hoon Lee, Mi-Ock Lee. 22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. The Journal of pathology. 2015 Apr; 235(5):710-20. doi: 10.1002/path.4494. [PMID: 25557254]
  • Yalong Wang, Han Jiang, Huizhi Huang, Yanqi Xie, Yunshi Zhao, Xiuhua You, Lipeng Tang, Youqiong Wang, Wei Yin, Pengxin Qiu, Guangmei Yan, Haiyan Hu. Determination of neuroprotective oxysterols in Calculus bovis, human gallstones, and traditional Chinese medicine preparations by liquid chromatography with mass spectrometry. Journal of separation science. 2015 Mar; 38(5):796-803. doi: 10.1002/jssc.201400850. [PMID: 25545614]
  • Jing-Min Wang, Dong Wang, Yu-Yan Tan, Gang Zhao, Zhen-Ling Ji. 22(R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARγ-LXRα-ABCA1 pathway in cholesterosis of the gallbladder. Biochemical and biophysical research communications. 2014 Apr; 447(1):152-7. doi: 10.1016/j.bbrc.2014.03.130. [PMID: 24704452]
  • C Helmschrodt, S Becker, J Thiery, U Ceglarek. Preanalytical standardization for reactive oxygen species derived oxysterol analysis in human plasma by liquid chromatography-tandem mass spectrometry. Biochemical and biophysical research communications. 2014 Apr; 446(3):726-30. doi: 10.1016/j.bbrc.2013.12.087. [PMID: 24370823]
  • Tadashi Ikegami, Akira Honda, Teruo Miyazaki, Motoyuki Kohjima, Makoto Nakamuta, Yasushi Matsuzaki. Increased serum oxysterol concentrations in patients with chronic hepatitis C virus infection. Biochemical and biophysical research communications. 2014 Apr; 446(3):736-40. doi: 10.1016/j.bbrc.2014.01.176. [PMID: 24525121]
  • Yoshiro Saito, Noriko Noguchi. 7-Hydroxycholestrol as a possible biomarker of cellular lipid peroxidation: difference between cellular and plasma lipid peroxidation. Biochemical and biophysical research communications. 2014 Apr; 446(3):741-4. doi: 10.1016/j.bbrc.2013.12.083. [PMID: 24380859]
  • Soliman Khatib, Jacob Vaya. Oxysterols and symptomatic versus asymptomatic human atherosclerotic plaque. Biochemical and biophysical research communications. 2014 Apr; 446(3):709-13. doi: 10.1016/j.bbrc.2013.12.116. [PMID: 24393847]
  • Christin Helmschrodt, Susen Becker, Jenny Schröter, Max Hecht, Gabriela Aust, Joachim Thiery, Uta Ceglarek. Fast LC-MS/MS analysis of free oxysterols derived from reactive oxygen species in human plasma and carotid plaque. Clinica chimica acta; international journal of clinical chemistry. 2013 Oct; 425(?):3-8. doi: 10.1016/j.cca.2013.06.022. [PMID: 23827692]
  • Satoshi Hirayama, Saori Nakagawa, Satoshi Soda, Yumiko Kamimura, Emiko Nishioka, Tsuyoshi Ueno, Yoshifumi Fukushima, Ken-ichi Higuchi, Masanori Inoue, Utako Seino, Hirotoshi Ohmura, Susumu Yamato, Takashi Miida. Ezetimibe decreases serum oxidized cholesterol without impairing bile acid synthesis in Japanese hypercholesterolemic patients. Atherosclerosis. 2013 Sep; 230(1):48-51. doi: 10.1016/j.atherosclerosis.2013.06.016. [PMID: 23958251]
  • Yaoyao Jia, Minh Hien Hoang, Hee-Jin Jun, Ji Hae Lee, Sung-Joon Lee. Cyanidin, a natural flavonoid, is an agonistic ligand for liver X receptor alpha and beta and reduces cellular lipid accumulation in macrophages and hepatocytes. Bioorganic & medicinal chemistry letters. 2013 Jul; 23(14):4185-90. doi: 10.1016/j.bmcl.2013.05.030. [PMID: 23769638]
  • Tijana Mitić, Steven Shave, Nina Semjonous, Iain McNae, Diego F Cobice, Gareth G Lavery, Scott P Webster, Patrick W F Hadoke, Brian R Walker, Ruth Andrew. 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo. Biochemical pharmacology. 2013 Jul; 86(1):146-53. doi: 10.1016/j.bcp.2013.02.002. [PMID: 23415904]
  • Kévin Ragot, John J Mackrill, Amira Zarrouk, Thomas Nury, Virginie Aires, Agnès Jacquin, Anne Athias, Jean-Paul Pais de Barros, Anne Véjux, Jean-Marc Riedinger, Dominique Delmas, Gérard Lizard. Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes. Biochemical pharmacology. 2013 Jul; 86(1):67-79. doi: 10.1016/j.bcp.2013.02.028. [PMID: 23473804]
  • Jan de Weille, Christine Fabre, Camille Gaven, Norbert Bakalara. Similar pyruvate kinase modifications in glioblastoma cells by 7β-hydroxycholesterol and glutamine withdrawal. Biochemical pharmacology. 2013 Jul; 86(1):161-7. doi: 10.1016/j.bcp.2013.03.012. [PMID: 23537700]
  • Raymond C S Seet, Amy M L Quek, Erle C H Lim, Barry Halliwell. Biomarkers of oxidative damage are elevated among individuals with high cardiovascular risk: refining subject selection strategies for antioxidant trials. Free radical research. 2013 Apr; 47(4):283-90. doi: 10.3109/10715762.2013.769215. [PMID: 23343456]
  • Ming Long Sirius Chung, Kai Yan Eric Lee, Chung-Yung Jetty Lee. Profiling of oxidized lipid products of marine fish under acute oxidative stress. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Mar; 53(?):205-13. doi: 10.1016/j.fct.2012.11.047. [PMID: 23220612]
  • Morten Blaabjerg, Dragan Marjanovic. [Cerebrotendinous xanthomatosis is a rare disorder, which requires a specific treatment]. Ugeskrift for laeger. 2013 Jan; 175(5):285-6. doi: ". [PMID: 23369332]
  • Sunhapas Soodvilai, Zhanjun Jia, Somsak Fongsupa, Varanuj Chatsudthipong, Tianxin Yang. Liver X receptor agonists decrease ENaC-mediated sodium transport in collecting duct cells. American journal of physiology. Renal physiology. 2012 Dec; 303(12):F1610-6. doi: 10.1152/ajprenal.00283.2012. [PMID: 23077096]
  • Ana C Valbuena-Diez, Francisco J Blanco, Barbara Oujo, Carmen Langa, María Gonzalez-Nuñez, Elena Llano, Alberto M Pendas, Mercedes Díaz, Antonio Castrillo, José M Lopez-Novoa, Carmelo Bernabeu. Oxysterol-induced soluble endoglin release and its involvement in hypertension. Circulation. 2012 Nov; 126(22):2612-24. doi: 10.1161/circulationaha.112.101261. [PMID: 23110859]
  • Eili Tranheim Kase, Nataša Nikolić, Nina Pettersen Hessvik, Ase-Karine Fjeldheim, Jørgen Jensen, G Hege Thoresen, Arild C Rustan. Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. Lipids. 2012 May; 47(5):483-93. doi: 10.1007/s11745-012-3663-4. [PMID: 22426832]
  • Mario Arciello, Salvatore Petta, Valerio Leoni, Gino Iannucci, Giancarlo Labbadia, Carlo Cammà, Antonio Craxì, Clara Balsano. Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2012 Mar; 44(3):245-50. doi: 10.1016/j.dld.2011.10.022. [PMID: 22154950]
  • Suticha Kittayaruksakul, Sunhapas Soodvilai, Nithi Asavapanumas, Chatchai Muanprasat, Varanuj Chatsudthipong. Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule. American journal of physiology. Renal physiology. 2012 Mar; 302(5):F552-60. doi: 10.1152/ajprenal.00341.2011. [PMID: 22169006]
  • Se-Hwan Joo, Tae-Wuk Kim, Seung-Hyun Son, Woo Sung Lee, Takao Yokota, Seong-Ki Kim. Biosynthesis of a cholesterol-derived brassinosteroid, 28-norcastasterone, in Arabidopsis thaliana. Journal of experimental botany. 2012 Mar; 63(5):1823-33. doi: 10.1093/jxb/err354. [PMID: 22170941]
  • Nina Pettersen Hessvik, Siril Skaret Bakke, Robert Smith, Aina Westrheim Ravna, Ingebrigt Sylte, Arild Christian Rustan, G Hege Thoresen, Eili Tranheim Kase. The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. The Journal of steroid biochemistry and molecular biology. 2012 Feb; 128(3-5):154-64. doi: 10.1016/j.jsbmb.2011.10.006. [PMID: 22051079]
  • Md Omedul Islam, Yan Ting Lim, Conrad En Zuo Chan, Amaury Cazenave-Gassiot, J Ludovic Croxford, Markus R Wenk, Paul A Macary, Brendon J Hanson. Generation and characterization of a novel recombinant antibody against 15-ketocholestane isolated by phage-display. International journal of molecular sciences. 2012; 13(4):4937-48. doi: 10.3390/ijms13044937. [PMID: 22606021]
  • Kuan-Hao Tsui, Jyun-Yuan Wang, Leang-Shin Wu, Chih-Hsien Chiu. Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):190107. doi: 10.1155/2012/190107. [PMID: 22666287]
  • Ludovic Clarion, Mathilde Schindler, Jan de Weille, Karine Lolmède, Audrey Laroche-Clary, Emmanuelle Uro-Coste, Jacques Robert, Marcel Mersel, Norbert Bakalara. 7β-Hydroxycholesterol-induced energy stress leads to sequential opposing signaling responses and to death of C6 glioblastoma cells. Biochemical pharmacology. 2012 Jan; 83(1):37-46. doi: 10.1016/j.bcp.2011.09.022. [PMID: 21983033]
  • Jorge A López-Velázquez, Luis D Carrillo-Córdova, Norberto C Chávez-Tapia, Misael Uribe, Nahum Méndez-Sánchez. Nuclear receptors in nonalcoholic Fatty liver disease. Journal of lipids. 2012; 2012(?):139875. doi: 10.1155/2012/139875. [PMID: 22187655]
  • Nancy Nader, Sinnie Sin Man Ng, Yonghong Wang, Brent S Abel, George P Chrousos, Tomoshige Kino. Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism. PloS one. 2012; 7(3):e26751. doi: 10.1371/journal.pone.0026751. [PMID: 22457708]
  • Vishal Gupta. Mineralocorticoid hypertension. Indian journal of endocrinology and metabolism. 2011 Oct; 15 Suppl 4(?):S298-312. doi: 10.4103/2230-8210.86972. [PMID: 22145132]
  • Lourdes Cruz-Garcia, Joan Sánchez-Gurmaches, Joaquim Gutiérrez, Isabel Navarro. Regulation of LXR by fatty acids, insulin, growth hormone and tumor necrosis factor-α in rainbow trout myocytes. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2011 Oct; 160(2):125-36. doi: 10.1016/j.cbpa.2011.05.013. [PMID: 21635958]
  • Rodrigo T Iborra, Adriana Machado-Lima, Gabriela Castilho, Valeria S Nunes, Dulcinéia S P Abdalla, Edna R Nakandakare, Marisa Passarelli. Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. Lipids in health and disease. 2011 Sep; 10(?):172. doi: 10.1186/1476-511x-10-172. [PMID: 21957962]
  • Soichi Yamashita, Ping Tai, Jean Charron, CheMyong Ko, Mario Ascoli. The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility. Molecular endocrinology (Baltimore, Md.). 2011 Jul; 25(7):1211-22. doi: 10.1210/me.2011-0059. [PMID: 21527500]
  • Wei Li, Moumita Ghosh, Sina Eftekhari, Xi-Ming Yuan. Lipid accumulation and lysosomal pathways contribute to dysfunction and apoptosis of human endothelial cells caused by 7-oxysterols. Biochemical and biophysical research communications. 2011 Jun; 409(4):711-6. doi: 10.1016/j.bbrc.2011.05.071. [PMID: 21621514]
  • Raymond C S Seet, Chung-Yung J Lee, Wai Mun Loke, Shan Hong Huang, Huiwen Huang, Woan Foon Looi, Eng Soh Chew, Amy M L Quek, Erle C H Lim, Barry Halliwell. Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress?. Free radical biology & medicine. 2011 Jun; 50(12):1787-93. doi: 10.1016/j.freeradbiomed.2011.03.019. [PMID: 21420490]
  • Paola Gamba, Gabriella Leonarduzzi, Elena Tamagno, Michela Guglielmotto, Gabriella Testa, Barbara Sottero, Simona Gargiulo, Fiorella Biasi, Alessandro Mauro, José Viña, Giuseppe Poli. Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. Aging cell. 2011 Jun; 10(3):403-17. doi: 10.1111/j.1474-9726.2011.00681.x. [PMID: 21272192]
  • Cynthia Hong, Robert Walczak, Helena Dhamko, Michelle N Bradley, Chaitra Marathe, Rima Boyadjian, Jon V Salazar, Peter Tontonoz. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. Journal of lipid research. 2011 Mar; 52(3):531-9. doi: 10.1194/jlr.m010686. [PMID: 21187453]
  • I L M H Aye, B J Waddell, P J Mark, J A Keelan. Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors. Placenta. 2011 Feb; 32(2):183-91. doi: 10.1016/j.placenta.2010.12.007. [PMID: 21208656]
  • I Björkhem, A Lövgren-Sandblom, F Piehl, M Khademi, H Pettersson, V Leoni, T Olsson, U Diczfalusy. High levels of 15-oxygenated steroids in circulation of patients with multiple sclerosis: fact or fiction?. Journal of lipid research. 2011 Jan; 52(1):170-4. doi: 10.1194/jlr.d011072. [PMID: 20934989]
  • Thomas J Berrodin, Qi Shen, Elaine M Quinet, Matthew R Yudt, Leonard P Freedman, Sunil Nagpal. Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity. Molecular pharmacology. 2010 Dec; 78(6):1046-58. doi: 10.1124/mol.110.065193. [PMID: 20837678]
  • Ş Arikan, H Kalender, O Simsek. Effects of cholesterol on progesterone production by goat luteal cell subpopulations at two different stages of the luteal phase. Reproduction in domestic animals = Zuchthygiene. 2010 Dec; 45(6):e434-9. doi: 10.1111/j.1439-0531.2010.01596.x. [PMID: 20345591]
  • Antonina Kolmakova, Jiangxia Wang, Rebecca Brogan, Charles Chaffin, Annabelle Rodriguez. Deficiency of scavenger receptor class B type I negatively affects progesterone secretion in human granulosa cells. Endocrinology. 2010 Nov; 151(11):5519-27. doi: 10.1210/en.2010-0347. [PMID: 20844007]
  • Yongsheng Wang, Lili Wang, Yan Hu, Lantong Zhang, Zhihan Wang. Isolation and identification of two steroid compounds from Oviductus Ranae. Natural product research. 2010 Oct; 24(16):1518-22. doi: 10.1080/14786419.2010.484391. [PMID: 20835952]
  • Zhongmei Tang, F Peter Guengerich. Dansylation of unactivated alcohols for improved mass spectral sensitivity and application to analysis of cytochrome P450 oxidation products in tissue extracts. Analytical chemistry. 2010 Sep; 82(18):7706-12. doi: 10.1021/ac1015497. [PMID: 20795636]
  • Hitoshi Kotani, Hiroki Tanabe, Hajime Mizukami, Makoto Makishima, Makoto Inoue. Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor. Journal of natural products. 2010 Aug; 73(8):1332-6. doi: 10.1021/np100120c. [PMID: 20695472]
  • WenChieh Chen, Shaw-Jenq Tsai, Hamm-Ming Sheu, Jih-Chien Tsai, Christos C Zouboulis. Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone. Experimental dermatology. 2010 May; 19(5):470-2. doi: 10.1111/j.1600-0625.2009.00996.x. [PMID: 20337700]
  • Kenichi Matsushita, Fulvio Morello, Yaojiong Wu, Lunan Zhang, Shiro Iwanaga, Richard E Pratt, Victor J Dzau. Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha. The Journal of biological chemistry. 2010 Apr; 285(16):11974-82. doi: 10.1074/jbc.m109.099671. [PMID: 20118482]
  • T Vallim, A M Salter. Regulation of hepatic gene expression by saturated fatty acids. Prostaglandins, leukotrienes, and essential fatty acids. 2010 Apr; 82(4-6):211-8. doi: 10.1016/j.plefa.2010.02.016. [PMID: 20227267]
  • Concetta Crisafulli, Emanuela Mazzon, Irene Paterniti, Maria Galuppo, Placido Bramanti, Salvatore Cuzzocrea. Effects of Liver x receptor agonist treatment on signal transduction pathways in acute lung inflammation. Respiratory research. 2010 Feb; 11(?):19. doi: 10.1186/1465-9921-11-19. [PMID: 20175894]
  • Janaína A Couto, Karina L A Saraiva, Cleiton D Barros, Daniel P Udrisar, Christina A Peixoto, Juliany S B César Vieira, Maria C Lima, Suely L Galdino, Ivan R Pitta, Maria I Wanderley. Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies. Reproductive biology and endocrinology : RB&E. 2010 Feb; 8(?):13. doi: 10.1186/1477-7827-8-13. [PMID: 20144211]
  • Guihua Xu, Lei Guan, Junliang Sun, Zhen-Yu Chen. Oxidation of cholesterol and beta-sitosterol and prevention by natural antioxidants. Journal of agricultural and food chemistry. 2009 Oct; 57(19):9284-92. doi: 10.1021/jf902552s. [PMID: 19754120]
  • Marina Cardellini, Rossella Menghini, Eugenio Martelli, Viviana Casagrande, Arianna Marino, Stefano Rizza, Ottavia Porzio, Alessandro Mauriello, Anna Solini, Arnaldo Ippoliti, Renato Lauro, Franco Folli, Massimo Federici. TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1. Diabetes. 2009 Oct; 58(10):2396-401. doi: 10.2337/db09-0280. [PMID: 19581416]
  • Raymond C S Seet, Chung-Yung J Lee, Erle C H Lim, Amy M L Quek, Leonard L L Yeo, Shan-Hong Huang, Barry Halliwell. Oxidative damage in dengue fever. Free radical biology & medicine. 2009 Aug; 47(4):375-80. doi: 10.1016/j.freeradbiomed.2009.04.035. [PMID: 19427377]
  • Hirohisa Minagawa, Jiang-Sheng Gong, Cha-Gyun Jung, Atsushi Watanabe, Sissel Lund-Katz, Michael C Phillips, Hiroyuki Saito, Makoto Michikawa. Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture. Journal of neuroscience research. 2009 Aug; 87(11):2498-508. doi: 10.1002/jnr.22073. [PMID: 19326444]
  • Riikka Hynynen, Monika Suchanek, Johanna Spandl, Nils Bäck, Christoph Thiele, Vesa M Olkkonen. OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. Journal of lipid research. 2009 Jul; 50(7):1305-15. doi: 10.1194/jlr.m800661-jlr200. [PMID: 19224871]
  • Marianne Demerjian, Eung-Ho Choi, Mao-Qiang Man, Sandra Chang, Peter M Elias, Kenneth R Feingold. Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis. Experimental dermatology. 2009 Jul; 18(7):643-9. doi: 10.1111/j.1600-0625.2009.00841.x. [PMID: 19236478]
  • Marina S Figueiroa, Juliany S B César Vieira, Disleide S Leite, Ruben C O Andrade Filho, Fabiano Ferreira, Patrícia S Gouveia, Daniel P Udrisar, Maria I Wanderley. Green tea polyphenols inhibit testosterone production in rat Leydig cells. Asian journal of andrology. 2009 May; 11(3):362-70. doi: 10.1038/aja.2009.2. [PMID: 19330017]
  • Akira Honda, Kouwa Yamashita, Takashi Hara, Tadashi Ikegami, Teruo Miyazaki, Mutsumi Shirai, Guorong Xu, Mitsuteru Numazawa, Yasushi Matsuzaki. Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. Journal of lipid research. 2009 Feb; 50(2):350-7. doi: 10.1194/jlr.d800040-jlr200. [PMID: 18815436]
  • Tiangang Li, John Y L Chiang. Regulation of bile acid and cholesterol metabolism by PPARs. PPAR research. 2009; 2009(?):501739. doi: 10.1155/2009/501739. [PMID: 19636418]
  • Dalal Alkazemi, Grace Egeland, Jacob Vaya, Sara Meltzer, Stan Kubow. Oxysterol as a marker of atherogenic dyslipidemia in adolescence. The Journal of clinical endocrinology and metabolism. 2008 Nov; 93(11):4282-9. doi: 10.1210/jc.2008-0586. [PMID: 18713821]
  • Noriko Noguchi. Role of oxidative stress in adaptive responses in special reference to atherogenesis. Journal of clinical biochemistry and nutrition. 2008 Nov; 43(3):131-8. doi: 10.3164/jcbn.2008068. [PMID: 19015746]
  • Antonella Rosa, M Paola Melis, Monica Deiana, Angela Atzeri, Giovanni Appendino, Giulia Corona, Alessandra Incani, Debora Loru, M Assunta Dessì. Protective effect of the oligomeric acylphloroglucinols from Myrtus communis on cholesterol and human low density lipoprotein oxidation. Chemistry and physics of lipids. 2008 Sep; 155(1):16-23. doi: 10.1016/j.chemphyslip.2008.04.005. [PMID: 18498764]
  • Andrea Crosignani, Marina Del Puppo, Emma De Fabiani, Donatella Caruso, Domenico Gallisai, Maria G Mela, Maria L Melzi, Marzia Galli Kienle, Carla Colombo. Plasma oxysterols in normal and cholestatic children as indicators of the two pathways of bile acid synthesis. Clinica chimica acta; international journal of clinical chemistry. 2008 Sep; 395(1-2):84-8. doi: 10.1016/j.cca.2008.05.011. [PMID: 18538136]
  • Shui-Ping Zhao, Bi-Lian Yu, Xiang-Zhu Xie, Shao-Zhuang Dong, Jing Dong. Dual effects of oxidized low-density lipoprotein on LXR-ABCA1-apoA-I pathway in 3T3-L1 cells. International journal of cardiology. 2008 Aug; 128(1):42-7. doi: 10.1016/j.ijcard.2007.05.017. [PMID: 17643522]
  • Wei Li, Caroline Lidebjer, Xi-Ming Yuan, Aleksander Szymanowski, Karin Backteman, Jan Ernerudh, Per Leanderson, Lennart Nilsson, Eva Swahn, Lena Jonasson. NK cell apoptosis in coronary artery disease: relation to oxidative stress. Atherosclerosis. 2008 Jul; 199(1):65-72. doi: 10.1016/j.atherosclerosis.2007.10.031. [PMID: 18068708]
  • A Vejux, L Malvitte, G Lizard. Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2008 Jul; 41(7):545-56. doi: 10.1590/s0100-879x2008000700001. [PMID: 18719735]
  • Dennis H Kim, John A Frangos. Effects of amyloid beta-peptides on the lysis tension of lipid bilayer vesicles containing oxysterols. Biophysical journal. 2008 Jul; 95(2):620-8. doi: 10.1529/biophysj.107.114983. [PMID: 18390616]
  • Mireille Ouimet, Ming-Dong Wang, Natalie Cadotte, Kenneth Ho, Yves L Marcel. Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux. Arteriosclerosis, thrombosis, and vascular biology. 2008 Jun; 28(6):1144-50. doi: 10.1161/atvbaha.107.157115. [PMID: 18369155]