27-Hydroxycholesterol (BioDeep_00000010789)

Main id: BioDeep_00000014448

 

human metabolite Endogenous blood metabolite


代谢物信息卡片


17-(7-hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

化学式: C27H46O2 (402.3498)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)CO
InChI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3

描述信息

同义名列表

6 个代谢物同义名

17-(7-hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; Cholest-5-ene-3beta,27-diol; Cholest-5-ene-3beta,26-diol; 26-Hydroxycholesterol; 27-Hydroxycholesterol; Cholest-5-ene-3beta,26-diol



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Steve Meaney. Is C-26 hydroxylation an evolutionarily conserved steroid inactivation mechanism?. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2005 Aug; 19(10):1220-4. doi: 10.1096/fj.04-3304hyp. [PMID: 16051688]
  • S Li, J Pang, E M Jackson, W K Wilson, G E Mott, G J Schroepfer. Kinetics and plasma concentrations of 26-hydroxycholesterol in baboons. Biochimica et biophysica acta. 2000 May; 1485(2-3):173-84. doi: 10.1016/s1388-1981(00)00058-5. [PMID: 10832098]
  • S Garcia-Cruset, K L Carpenter, F Guardiola, M J Mitchinson. Oxysterols in cap and core of human advanced atherosclerotic lesions. Free radical research. 1999 May; 30(5):341-50. doi: 10.1080/10715769900300391. [PMID: 10342328]
  • K L Carpenter, S E Taylor, C van der Veen, B K Williamson, J A Ballantine, M J Mitchinson. Lipids and oxidised lipids in human atherosclerotic lesions at different stages of development. Biochimica et biophysica acta. 1995 May; 1256(2):141-50. doi: 10.1016/0005-2760(94)00247-v. [PMID: 7766691]
  • Y Ni, A Kisic, W K Wilson, G J Schroepfer. Inhibitors of sterol synthesis. Tritium-labeled 26-hydroxycholesterol of high specific activity from a byproduct of the Clemmensen reduction of diosgenin. Journal of lipid research. 1994 Mar; 35(3):546-59. doi: . [PMID: 8014589]
  • Q Zhou, F A Kummerow. Alterations of Ca++ uptake and lipid content in cultured human arterial smooth muscle cells treated with 26-hydroxycholesterol. Artery. 1994; 21(4):182-92. doi: NULL. [PMID: 8830645]
  • K L Carpenter, S E Taylor, J A Ballantine, B Fussell, B Halliwell, M J Mitchinson. Lipids and oxidised lipids in human atheroma and normal aorta. Biochimica et biophysica acta. 1993 Apr; 1167(2):121-30. doi: 10.1016/0005-2760(93)90151-x. [PMID: 8466938]
  • Q Zhou, T L Smith, F A Kummerow. Cytotoxicity of oxysterols on cultured smooth muscle cells from human umbilical arteries. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1993 Jan; 202(1):75-80. doi: 10.3181/00379727-202-43514. [PMID: 8424097]
  • N B Javitt. 26-Hydroxycholesterol: synthesis, metabolism, and biologic activities. Journal of lipid research. 1990 Sep; 31(9):1527-33. doi: NULL. [PMID: 2246606]
  • R Harik-Khan, R P Holmes. Estimation of 26-hydroxycholesterol in serum by high-performance liquid chromatography and its measurement in patients with atherosclerosis. Journal of steroid biochemistry. 1990 Jul; 36(4):351-5. doi: 10.1016/0022-4731(90)90228-k. [PMID: 2391964]
  • H Postlind, K Wikvall. Evidence for the formation of 26-hydroxycholesterol by cytochrome P-450 in pig kidney mitochondria. Biochemical and biophysical research communications. 1989 Mar; 159(3):1135-40. doi: 10.1016/0006-291x(89)92227-4. [PMID: 2930554]
  • B J Koopman, J C van der Molen, B G Wolthers, J B Vanderpas. Determination of some hydroxycholesterols in human serum samples. Journal of chromatography. 1987 Apr; 416(1):1-13. doi: 10.1016/0378-4347(87)80479-6. [PMID: 3597624]
  • S K Krisans, S L Thompson, L A Pena, E Kok, N B Javitt. Bile acid synthesis in rat liver peroxisomes: metabolism of 26-hydroxycholesterol to 3 beta-hydroxy-5-cholenoic acid. Journal of lipid research. 1985 Nov; 26(11):1324-32. doi: 10.1016/s0022-2275(20)34258-9. [PMID: 4067421]
  • A L Esterman, B I Cohen, N B Javitt. Cholesterol metabolism: use of D2O for determination of synthesis rate in cell culture. Journal of lipid research. 1985 Aug; 26(8):950-4. doi: 10.1016/s0022-2275(20)34297-8. [PMID: 2995527]
  • A L Esterman, H Baum, N B Javitt, G J Darlington. 26-hydroxycholesterol: regulation of hydroxymethylglutaryl-CoA reductase activity in Chinese hamster ovary cell culture. Journal of lipid research. 1983 Oct; 24(10):1304-9. doi: . [PMID: 6644180]
  • N B Javitt, E Kok, J Lloyd, A Benscath, F H Field. Cholest-5-ene-3 beta, 26-diol: synthesis and biomedical use of a deuterated compound. Biomedical mass spectrometry. 1982 Feb; 9(2):61-3. doi: 10.1002/bms.1200090203. [PMID: 7059660]
  • N B Javitt, E Kok, S Burstein, B Cohen, J Kutscher. 26-Hydroxycholesterol. Identification and quantitation in human serum. The Journal of biological chemistry. 1981 Dec; 256(24):12644-6. doi: 10.1016/s0021-9258(18)42940-7. [PMID: 7309726]