4-Guanidinobutyric acid (BioDeep_00000405707)

Main id: BioDeep_00000001253

 

PANOMIX_OTCML-2023 BioNovoGene_Lab2019 natural product


代谢物信息卡片


4-Guanidinobutanoic acid

化学式: C5H11N3O2 (145.0851)
中文名称: 4-呱基丁酸, 4-胍基丁酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CC(=O)O)CN=C(N)N
InChI: InChI=1S/C5H11N3O2/c6-5(7)8-3-1-2-4(9)10/h1-3H2,(H,9,10)(H4,6,7,8)

描述信息

4-Guanidinobutanoic acid is a normal metabolite present in low concentrations.
4-Guanidinobutanoic acid is a normal metabolite present in low concentrations.

同义名列表

3 个代谢物同义名

4-Guanidinobutanoic acid; 4-Guanidinobutyric acid; 4-Guanidinobutyric acid



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

78 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ALOX5, AOC3, ARG1, AXIN2, AZIN2, CRK, CRKL, GAMT, MPV17, MTOR, PDPK1
Peripheral membrane protein 2 ALOX5, MTOR
Endoplasmic reticulum membrane 1 MTOR
Nucleus 8 ARG1, AXIN2, AZIN2, CRK, GAMT, MTOR, PDPK1, RFC2
cytosol 12 ALOX5, ARG1, AXIN2, AZIN2, CRK, CRKL, GAMT, MPV17, MTOR, PDPK1, PRKCQ, SLC2A4
dendrite 2 AZIN2, MTOR
phagocytic vesicle 1 MTOR
trans-Golgi network 2 AZIN2, SLC2A4
centrosome 1 AXIN2
nucleoplasm 4 ALOX5, CRKL, MTOR, RFC2
Cell membrane 4 AOC3, CRK, SLC2A4, SLC6A8
Cytoplasmic side 1 MTOR
Cytoplasmic granule 1 ARG1
Multi-pass membrane protein 3 MPV17, SLC2A4, SLC6A8
Golgi apparatus membrane 1 MTOR
cell surface 2 AOC3, PLG
glutamatergic synapse 1 PLG
Golgi apparatus 1 AOC3
Golgi membrane 2 INS, MTOR
lysosomal membrane 1 MTOR
mitochondrial inner membrane 2 GATM, MPV17
neuromuscular junction 2 CRK, CRKL
sarcolemma 1 SLC2A4
Cytoplasm, cytosol 1 ALOX5
Lysosome 1 MTOR
Presynapse 1 SLC2A4
plasma membrane 8 AOC3, AXIN2, CRK, PDPK1, PLG, PRKCQ, SLC2A4, SLC6A8
Membrane 7 AOC3, AZIN2, CRK, MPV17, MTOR, SLC2A4, SLC6A8
apical plasma membrane 1 SLC6A8
axon 1 AZIN2
extracellular exosome 4 CRK, GATM, PLG, SLC2A4
Lysosome membrane 1 MTOR
endoplasmic reticulum 1 AOC3
extracellular space 4 ALOX5, ARG1, INS, PLG
perinuclear region of cytoplasm 3 ALOX5, AZIN2, SLC2A4
Schaffer collateral - CA1 synapse 1 PLG
mitochondrion 5 ABAT, AGMAT, AZIN2, GATM, MPV17
protein-containing complex 2 CRK, CRKL
Microsome membrane 1 MTOR
postsynaptic density 1 PDPK1
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 2 INS, PLG
extracellular region 4 ALOX5, ARG1, INS, PLG
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
mitochondrial matrix 1 ABAT
centriolar satellite 1 PRKCQ
Nucleus membrane 1 ALOX5
nuclear membrane 1 ALOX5
external side of plasma membrane 2 PLG, SLC2A4
multivesicular body 1 SLC2A4
actin cytoskeleton 1 CRK
T-tubule 1 SLC2A4
perikaryon 1 AZIN2
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 2 AZIN2, PDPK1
Early endosome 1 AOC3
clathrin-coated pit 1 SLC2A4
Single-pass type II membrane protein 1 AOC3
Apical cell membrane 1 SLC6A8
Cytoplasm, perinuclear region 2 ALOX5, SLC2A4
Mitochondrion inner membrane 2 GATM, MPV17
Membrane raft 1 SLC2A4
focal adhesion 1 PDPK1
cis-Golgi network 1 AZIN2
Peroxisome 1 MPV17
sarcoplasmic reticulum 1 SLC2A4
peroxisomal membrane 1 MPV17
Nucleus, PML body 1 MTOR
PML body 1 MTOR
mitochondrial intermembrane space 1 GATM
collagen-containing extracellular matrix 1 PLG
cell projection 1 PDPK1
blood microparticle 1 PLG
nuclear envelope 2 ALOX5, MTOR
Nucleus envelope 1 ALOX5
Endomembrane system 2 MTOR, SLC2A4
endosome lumen 1 INS
microvillus 1 AOC3
Cytoplasmic vesicle membrane 1 SLC2A4
clathrin-coated vesicle 1 SLC2A4
trans-Golgi network transport vesicle 1 SLC2A4
ficolin-1-rich granule lumen 1 ALOX5
secretory granule lumen 2 ALOX5, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
nuclear matrix 1 ALOX5
platelet alpha granule lumen 1 PLG
specific granule lumen 1 ARG1
transport vesicle 2 AZIN2, INS
azurophil granule lumen 1 ARG1
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 AZIN2, INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
vesicle membrane 1 SLC2A4
endoplasmic reticulum-Golgi intermediate compartment 1 AZIN2
Golgi apparatus, cis-Golgi network 1 AZIN2
Cytoplasmic vesicle, phagosome 1 MTOR
extrinsic component of postsynaptic membrane 1 CRKL
Nucleus intermembrane space 1 ALOX5
insulin-responsive compartment 1 SLC2A4
Ctf18 RFC-like complex 1 RFC2
DNA replication factor C complex 1 RFC2
4-aminobutyrate transaminase complex 1 ABAT
granular vesicle 1 AZIN2


文献列表

  • S A Majidano, M Y Khuhawar. Gas chromatographic determination of guanidino compounds in uremic patients using glyoxal as derivatizing reagent. Journal of chromatographic science. 2012 May; 50(5):380-6. doi: 10.1093/chromsci/bms013. [PMID: 22392369]
  • Eva Schepers, Griet Glorieux, Laetitia Dou, Claire Cerini, Nathalie Gayrard, Loïc Louvet, Charlotte Maugard, Pierre Preus, Maria Rodriguez-Ortiz, Angel Argiles, Philippe Brunet, Gerald Cohen, Joachim Jankowski, Vera Jankowski, Ziad Massy, Mariano Rodriguez, Raymond Vanholder. Guanidino compounds as cause of cardiovascular damage in chronic kidney disease: an in vitro evaluation. Blood purification. 2010; 30(4):277-87. doi: 10.1159/000320765. [PMID: 21079396]
  • Linda Metzner, Madlen Dorn, Fritz Markwardt, Matthias Brandsch. The orally active antihyperglycemic drug beta-guanidinopropionic acid is transported by the human proton-coupled amino acid transporter hPAT1. Molecular pharmaceutics. 2009 May; 6(3):1006-11. doi: 10.1021/mp9000684. [PMID: 19358571]
  • R Gatti, M G Gioia. Anisoin: a useful pre-chromatographic derivatization fluorogenic reagent for LC analysis of guanidino compounds. Journal of pharmaceutical and biomedical analysis. 2006 Sep; 42(1):11-6. doi: 10.1016/j.jpba.2005.12.035. [PMID: 16460903]
  • Erwin E W Jansen, Nanda M Verhoeven, Cornelis Jakobs, Andreas Schulze, Henry Senephansiri, Maneesh Gupta, O Carter Snead, K Michael Gibson. Increased guanidino species in murine and human succinate semialdehyde dehydrogenase (SSADH) deficiency. Biochimica et biophysica acta. 2006 Apr; 1762(4):494-8. doi: 10.1016/j.bbadis.2006.01.006. [PMID: 16504488]
  • Olivier Levillain, Bart Marescau, Ilse Possemiers, Paul De Deyn. Dehydration modifies guanidino compound concentrations in the different zones of the rat kidney. Pflugers Archiv : European journal of physiology. 2002 May; 444(1-2):143-52. doi: 10.1007/s00424-002-0787-z. [PMID: 11976926]
  • M Al Banchaabouchi, B Marescau, R D'Hooge, P P De Deyn. The effect of high protein diet on urea and guanidino compound levels in renal insufficient mice. Amino acids. 2001 Dec; 21(4):401-15. doi: 10.1007/s007260170005. [PMID: 11858699]
  • M Al Banchaabouchi, B Marescau, E Van Marck, R D'hooge, P P De Deyn. Long-term effect of partial nephrectomy on biological parameters, kidney histology, and guanidino compound levels in mice. Metabolism: clinical and experimental. 2001 Dec; 50(12):1418-25. doi: 10.1053/meta.2001.26763. [PMID: 11735086]
  • O Levillain, B Marescau, I Possemiers, M Al Banchaabouchi, P P De Deyn. Influence of 72\% injury in one kidney on several organs involved in guanidino compound metabolism: a time course study. Pflugers Archiv : European journal of physiology. 2001 Jul; 442(4):558-69. doi: 10.1007/s004240100581. [PMID: 11510889]
  • A Schulze, E Mayatepek, S Frank, B Marescau, P P De Deyn, P Bachert. Disturbed metabolism of guanidino compounds characterized by elevated excretion of beta-guanidinopropionic acid and gamma-guanidinobutyric acid--an effect of vigabatrin treatment?. Journal of inherited metabolic disease. 1998 Jun; 21(3):268-71. doi: 10.1023/a:1005376307471. [PMID: 9686372]
  • M Al Banchaabouchi, B Marescau, R D'Hooge, E Van Marck, A Van Daele, O Levillain, P P De Deyn. Biochemical and histopathological changes in nephrectomized mice. Metabolism: clinical and experimental. 1998 Mar; 47(3):355-61. doi: 10.1016/s0026-0495(98)90271-2. [PMID: 9500577]
  • B Marescau, P P De Deyn, J Holvoet, I Possemiers, G Nagels, V Saxena, C Mahler. Guanidino compounds in serum and urine of cirrhotic patients. Metabolism: clinical and experimental. 1995 May; 44(5):584-8. doi: 10.1016/0026-0495(95)90114-0. [PMID: 7752905]
  • S Shindo, Y Watanabe, A Mori. Effects of starvation on guanidino compound metabolism in mice. Research communications in chemical pathology and pharmacology. 1986 Oct; 54(1):73-85. doi: . [PMID: 3797807]
  • B Marescau, A Lowenthal, H G Terheggen, E Esmans, F Alderweireldt. Guanidino compounds in hyperargininemia. Advances in experimental medicine and biology. 1982; 153(?):427-34. doi: 10.1007/978-1-4757-6903-6_52. [PMID: 7164915]
  • N M Pattnaik, F J Kézdy, A M Scanu. Kinetic study of the action of snake venom phospholipase A2 on human serum high density lipoprotein 3. The Journal of biological chemistry. 1976 Apr; 251(7):1984-90. doi: NULL. [PMID: 5436]
  • P BOULANGER, E SACQUET, R OSTEUX, H CHARLIER. [FORMATION OF GAMMA-GUANIDINOBUTYRIC ACID FROM ARGININE IN THE WHITE RAT]. Comptes rendus hebdomadaires des seances de l'Academie des sciences. 1964 Apr; 258(?):4159-61. doi: . [PMID: 14146810]
  • R L BARNES. Formation of gamma-guanidinobutyric acid in pine tissue. Nature. 1962 Feb; 193(?):781. doi: 10.1038/193781a0. [PMID: 13865107]