Alanine (BioDeep_00000404106)

Main id: BioDeep_00000014410

Secondary id: BioDeep_00000399983

natural product PANOMIX_OTCML-2023 Chemicals and Drugs Antibiotics BioNovoGene_Lab2019


代谢物信息卡片


L-α-Aminopropionic acid

化学式: C3H7NO2 (89.0477)
中文名称: L-丙氨酸, D-丙氨酸, 丙氨酸, L-α-丙氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 24.03%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Alanine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/alanine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000404106). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(C(=O)O)N
InChI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)

描述信息

An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Alanine (symbol Ala or A),[4] or α-alanine, is an α-amino acid that is used in the biosynthesis of proteins. It contains an amine group and a carboxylic acid group, both attached to the central carbon atom which also carries a methyl group side chain. Consequently it is classified as a nonpolar, aliphatic α-amino acid. Under biological conditions, it exists in its zwitterionic form with its amine group protonated (as −NH
+
3
) and its carboxyl group deprotonated (as −CO
−
2
). It is non-essential to humans as it can be synthesized metabolically and does not need to be present in the diet. It is encoded by all codons starting with GC (GCU, GCC, GCA, and GCG).

The L-isomer of alanine (left-handed) is the one that is incorporated into proteins. L-alanine is second only to L-leucine in rate of occurrence, accounting for 7.8\\\\\% of the primary structure in a sample of 1,150 proteins.[5] The right-handed form, D-alanine, occurs in peptides in some bacterial cell walls[6]: 131  (in peptidoglycan) and in some peptide antibiotics, and occurs in the tissues of many crustaceans and molluscs as an osmolyte.
D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.

同义名列表

9 个代谢物同义名

Alanine; POLY-L-ALANINE; L-alanine; D-Alanine; (R)-Alanine; Ba 2776; D-α-Alanine; L-Alanine; Alanine



数据库引用编号

61 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(11)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

237 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AKT1, ALB, GLUL, HPGDS, MYLK, PC, PKM
Endoplasmic reticulum membrane 1 CD4
Nucleus 4 AKT1, ALB, GLUL, PKM
cytosol 10 AGXT, AKT1, ALB, GLS, GLUL, HPGDS, MYLK, PC, PKM, PRKCQ
centrosome 1 ALB
nucleoplasm 2 AKT1, HPGDS
Cell membrane 5 AKT1, CD4, GLUL, SLC12A2, TNF
Lipid-anchor 1 GLUL
Cleavage furrow 1 MYLK
lamellipodium 2 AKT1, MYLK
Multi-pass membrane protein 1 SLC12A2
Synapse 2 GLS, MYLK
cell cortex 1 AKT1
cell surface 1 TNF
glutamatergic synapse 1 AKT1
Golgi apparatus 1 ALB
Golgi membrane 1 INS
lysosomal membrane 1 EGF
neuronal cell body 2 SLC12A2, TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 2 GLS, GLUL
plasma membrane 12 AKT1, CD4, EGF, F2, GCG, GLUL, IFNLR1, MYLK, PRKCQ, PRSS8, SLC12A2, TNF
Membrane 4 AKT1, EGF, IFNLR1, SLC12A2
apical plasma membrane 1 SLC12A2
basolateral plasma membrane 1 SLC12A2
extracellular exosome 8 ALB, EGF, F2, GLUL, LYZ, PKM, PRSS8, SLC12A2
endoplasmic reticulum 2 ALB, GLUL
extracellular space 8 ALB, EGF, F2, GCG, INS, LYZ, PRSS8, TNF
mitochondrion 4 GLS, GLUL, PC, PKM
protein-containing complex 2 AKT1, ALB
intracellular membrane-bounded organelle 2 AGXT, HPGDS
Single-pass type I membrane protein 2 CD4, IFNLR1
Secreted 4 ALB, F2, GCG, INS
extracellular region 9 ALB, EGF, F2, GCG, INS, LYZ, PKM, PRSS8, TNF
Mitochondrion matrix 1 PC
mitochondrial matrix 2 GLS, PC
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
external side of plasma membrane 2 CD4, TNF
Extracellular vesicle 2 PKM, SLC12A2
actin cytoskeleton 1 MYLK
microtubule cytoskeleton 1 AKT1
Early endosome 1 CD4
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 2 AKT1, PKM
Cell projection, lamellipodium 1 MYLK
Membrane raft 2 CD4, TNF
spindle 1 AKT1
Peroxisome 1 AGXT
peroxisomal matrix 1 AGXT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 2 F2, PKM
lateral plasma membrane 1 SLC12A2
neuron projection 1 SLC12A2
ciliary basal body 2 AKT1, ALB
cilium 1 PKM
cell projection 1 SLC12A2
phagocytic cup 1 TNF
cell periphery 1 SLC12A2
centriole 1 ALB
[Isoform 1]: Mitochondrion 1 GLS
spindle pole 1 ALB
blood microparticle 2 ALB, F2
Basolateral cell membrane 1 SLC12A2
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 SLC12A2
cell body 2 GLUL, SLC12A2
stress fiber 1 MYLK
basal plasma membrane 1 SLC12A2
Microsome 1 GLUL
ficolin-1-rich granule lumen 1 PKM
secretory granule lumen 3 GCG, INS, PKM
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 5 ALB, CD4, F2, GCG, INS
platelet alpha granule lumen 2 ALB, EGF
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
transport vesicle 1 INS
azurophil granule lumen 1 LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 2 CD4, EGF
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
Rough endoplasmic reticulum 1 PKM
[Isoform 3]: Mitochondrion 1 GLS
[Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix 1 GLS
[Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix 1 GLS
glial cell projection 1 GLUL
[Glucagon-like peptide 1]: Secreted 1 GCG
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
cell body membrane 1 SLC12A2
cell projection membrane 1 SLC12A2
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Kimberly N Karin, Mohammed A Mustafa, Justin L Poklis, Belle Buzzi, Joel E Schlosburg, Linda Parker, M Imad Damaj, Aron H Lichtman. N-oleoyl alanine attenuates nicotine reward and spontaneous nicotine withdrawal in mice. Drug and alcohol dependence. 2024 Jun; 259(?):111276. doi: 10.1016/j.drugalcdep.2024.111276. [PMID: 38676968]
  • Elisa de Lazzari, Eugenia B Negredo, Pere Domingo, Juan M Tiraboschi, Esteve Ribera, Nadia Abdulghani, Verònica Alba, Salvador Fernández-Arroyo, Consuelo Viladés, Joaquim Peraire, Jose M Gatell, Jose L Blanco, Francesc Vidal, Anna Rull, Esteban Martinez. Multiomics plasma effects of switching from triple antiretroviral regimens to dolutegravir plus lamivudine. The Journal of antimicrobial chemotherapy. 2024 May; 79(5):1133-1141. doi: 10.1093/jac/dkae083. [PMID: 38546974]
  • Dathan M Byonanebye, Mark N Polizzotto, Fernando Maltez, Andri Rauch, Katharina Grabmeier-Pfistershammer, Ferdinand Wit, Stéphane De Wit, Antonella Castagna, Antonella d'Arminio Monforte, Cristina Mussini, Jan-Christian Wasmuth, Eric Fontas, Irene Abela, Mario Sarcletti, Loveleen Bansi-Matharu, Nadine Jaschinski, Lars Peters, Sean R Hosein, Vani Vannappagari, Cal Cohen, Emiliano Bissio, Amanda Mocroft, Matthew Law, Lene Ryom, Kathy Petoumenos. Associations between change in BMI and the risk of hypertension and dyslipidaemia in people receiving integrase strand-transfer inhibitors, tenofovir alafenamide, or both compared with other contemporary antiretroviral regimens: a multicentre, prospective observational study from the RESPOND consortium cohorts. The lancet. HIV. 2024 May; 11(5):e321-e332. doi: 10.1016/s2352-3018(23)00328-4. [PMID: 38621392]
  • Setu Bazie Tagele, Emma W Gachomo. Evaluating the effects of mefenoxam on taxonomic and functional dynamics of nontarget fungal communities during carrot cultivation. Scientific reports. 2024 04; 14(1):9867. doi: 10.1038/s41598-024-59587-2. [PMID: 38684826]
  • Xiaogang Li, Zhuoling An, Aimin Yao, Rui Li, Suhan Zhang, Songlin Yu, Liangkun Ma, Yanping Liu. Targeted metabolomics profiling in pregnancy associated with vitamin D deficiency. BMC pregnancy and childbirth. 2024 Apr; 24(1):295. doi: 10.1186/s12884-024-06454-7. [PMID: 38643102]
  • Wenbo Sun, Dan Xu, YanXing Yang, Linfei Wen, Hanjiang Yu, Yaowen Xing, Xiaopeng Song, Huan Li, Haibo Xu. Improved Detection of Target Metabolites in Brain Tumors with Intermediate TE, High SNR, and High Bandwidth Spin-Echo Sequence at 5T. AJNR. American journal of neuroradiology. 2024 Apr; 45(4):461-467. doi: 10.3174/ajnr.a8150. [PMID: 38453417]
  • Jen-Yu Hsu, Hsin-Yun Sun, Ling-Ya Chen, Sui-Yuan Chang, Yu-Chung Chuang, Yu-Shan Huang, Yi-Ching Su, Wen-Chun Liu, Chien-Ching Hung. Weight and metabolic changes among virally suppressed people with HIV who switched to co-formulated bictegravir/emtricitabine/tenofovir alafenamide. Journal of global antimicrobial resistance. 2024 Mar; 36(?):426-435. doi: 10.1016/j.jgar.2023.10.012. [PMID: 37923129]
  • Jee Hoon Park, Rachel E Reviello, Patrick J Loll. Crystal structure of vancomycin bound to the resistance determinant D-alanine-D-serine. IUCrJ. 2024 Mar; ?(?):. doi: 10.1107/s2052252524000289. [PMID: 38277167]
  • Al Zahraa G Al Ashmawy, Gehan F Balata. Formulation and in vitro characterization of nanoemulsions containing remdesivir or licorice extract: A potential subcutaneous injection for coronavirus treatment. Colloids and surfaces. B, Biointerfaces. 2024 Feb; 234(?):113703. doi: 10.1016/j.colsurfb.2023.113703. [PMID: 38096607]
  • Nisreen A Al-Quraan, Nezar H Samarah, Ayah A Tanash. Effect of drought stress on wheat (Triticum durum) growth and metabolism: insight from GABA shunt, reactive oxygen species and dehydrin genes expression. Functional plant biology : FPB. 2024 01; 51(1):NULL. doi: 10.1071/fp22177. [PMID: 36346967]
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  • Jing Wu, Shaoqian Deng, Xinyue Yu, Yanlin Wu, Xiaoyi Hua, Zunjian Zhang, Yin Huang. Identify production area, growth mode, species, and grade of Astragali Radix using metabolomics "big data" and machine learning. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155201. doi: 10.1016/j.phymed.2023.155201. [PMID: 37976693]
  • Scott K Fung, Calvin Q Pan, Grace Lai-Hung Wong, Wai-Kay Seto, Sang Hoon Ahn, Chi-Yi Chen, Hie-Won L Hann, Maciej S Jablkowski, Yoon Jun Kim, Cihan Yurdaydin, Cheng-Yuan Peng, Tuan Nguyen, Hiroshi Yatsuhashi, John F Flaherty, Leland J Yee, Frida Abramov, Hongyuan Wang, Dzhamal Abdurakhmanov, Young-Suk Lim, Maria Buti. Atherosclerotic cardiovascular disease risk profile of patients with chronic hepatitis B treated with tenofovir alafenamide or tenofovir disoproxil fumarate for 96 weeks. Alimentary pharmacology & therapeutics. 2024 Jan; 59(2):217-229. doi: 10.1111/apt.17764. [PMID: 37905449]
  • Yi Shen, Yi-Qi Sun, He-Ming Li, Quan-Long Zhang, Qi-Ming Zhao, Jin-Long Xu, Lu-Ping Qin, Qiao-Yan Zhang. [UPLC-Q-TOF-MS-based metabolomics reveals mechanism of Morinda officinalis iridoid glycosides in treating rheumatoid arthritis and bone loss]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Jan; 49(2):453-460. doi: 10.19540/j.cnki.cjcmm.20230914.705. [PMID: 38403321]
  • Wan-Chen Wu, I-Hsuan Chen, Pei-Yu Hou, Lan-Hui Wang, Ching-Hsiu Tsai, Chi-Ping Cheng. The phosphorylation of the movement protein TGBp1 regulates the accumulation of the Bamboo mosaic virus. The Journal of general virology. 2024 01; 105(1):. doi: 10.1099/jgv.0.001945. [PMID: 38189334]
  • Pin-Nan Cheng, I-Cher Feng, Jyh-Jou Chen, Hsing-Tao Kuo, Pei-Lun Lee, Ming-Lung Yu, Yen-Cheng Chiu, Hung-Chih Chiu, Shih-Chieh Chien, Pei-Jer Chen, Chun-Jen Liu. Body weight increase and metabolic derangements after tenofovir disoproxil fumarate switch to tenofovir alafenamide in patients with chronic hepatitis B. Alimentary pharmacology & therapeutics. 2024 Jan; 59(2):230-238. doi: 10.1111/apt.17765. [PMID: 37845815]
  • Suvi E Laamanen, Aino-Maija Eloranta, Eero A Haapala, Taisa Sallinen, Ursula Schwab, Timo A Lakka. Associations of diet quality and food consumption with serum biomarkers for lipid and amino acid metabolism in Finnish children: the PANIC study. European journal of nutrition. 2023 Dec; ?(?):. doi: 10.1007/s00394-023-03293-8. [PMID: 38127151]
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  • Geeisy Angela Cid, Davide Francioli, Steffen Kolb, Yudelsy Antonia Tandron Moya, Nicolaus von Wirén, Mohammad-Reza Hajirezaei. Elucidating the systemic response of wheat plants under waterlogging based on transcriptomic and metabolic approaches. Journal of experimental botany. 2023 Nov; ?(?):. doi: 10.1093/jxb/erad453. [PMID: 38014629]
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  • Jie Chen, Shao Bai Huang, Xue Wang, Li Zhen Huang, Cheng Gao, Xin-Yuan Huang, Fang-Jie Zhao. IAR4 mutation enhances cadmium toxicity by disturbing auxin homeostasis in Arabidopsis thaliana. Journal of experimental botany. 2023 Sep; ?(?):. doi: 10.1093/jxb/erad366. [PMID: 37721748]
  • Nicole Canon, Catherine H Schein, Werner Braun, Surendra S Negi, Xueni Chen, Michael D Kulis, Edwin H Kim, Vidya Pathy, Marina Pozzoli, Weimin Liu, Stephen C Dreskin. Alanine Scanning of the Unstructured Region of Ara h 2 and of a Related Mimotope Reveals Critical Amino Acids for IgE Binding. Molecular nutrition & food research. 2023 Sep; ?(?):e2300134. doi: 10.1002/mnfr.202300134. [PMID: 37706599]
  • Juan Moreno-Vedia, Dídac Llop, Ricardo Rodríguez-Calvo, Núria Plana, Núria Amigó, Roser Rosales, Yaiza Esteban, Josefa Girona, Lluís Masana, Daiana Ibarretxe. Serum branch-chained amino acids are increased in type 2 diabetes and associated with atherosclerotic cardiovascular disease. Cardiovascular diabetology. 2023 Sep; 22(1):249. doi: 10.1186/s12933-023-01958-6. [PMID: 37710233]
  • Xi Meng, Guoqi Yu, Tingyu Luo, Ruiyuan Zhang, Jun Zhang, Yongjie Liu. Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat offspring. Chemosphere. 2023 Sep; 341(?):140120. doi: 10.1016/j.chemosphere.2023.140120. [PMID: 37696479]
  • Hong Wang, Jinyang Wang, Mouliang Xiao, Tida Ge, Anna Gunina, Davey L Jones. The fate of amino acid and peptide as affected by soil depth and fertilization regime in subtropical paddies. The Science of the total environment. 2023 Sep; 889(?):164245. doi: 10.1016/j.scitotenv.2023.164245. [PMID: 37211099]
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  • Marcus V Marin, Juliana S Baggio, Youngjae Oh, Hyeondae Han, Saket Chandra, Nan-Yi Wang, Seonghee Lee, Natalia A Peres. Identification of sequence mutations in Phytophthora cactorum genome associated with mefenoxam resistance and development of a molecular assay for the mutant detection in strawberry (F. × ananassa). Scientific reports. 2023 05; 13(1):7385. doi: 10.1038/s41598-023-34271-z. [PMID: 37149656]
  • Marta Mendes Costa, Alda Pereira Da Silva, Carolina Santos, Joana Ferreira, Mário Rui Mascarenhas, Manuel Bicho, Ana Paula Barbosa. Influence of the TAS2R38 Gene Single Nucleotide Polymorphisms in Metabolism and Anthropometry in Thyroid Dysfunction. Nutrients. 2023 May; 15(9):. doi: 10.3390/nu15092214. [PMID: 37432370]
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  • Courtney R Green, Roberto Bonelli, Brendan R E Ansell, Simone Tzaridis, Michal K Handzlik, Grace H McGregor, Barbara Hart, Jennifer Trombley, Mary M Reilly, Paul S Bernstein, Catherine Egan, Marcus Fruttiger, Martina Wallace, Melanie Bahlo, Martin Friedlander, Christian M Metallo, Marin L Gantner. Divergent amino acid and sphingolipid metabolism in patients with inherited neuro-retinal disease. Molecular metabolism. 2023 Mar; ?(?):101716. doi: 10.1016/j.molmet.2023.101716. [PMID: 36997154]
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  • Nathalie Lacrampe, Sophie Colombié, Doriane Dumont, Philippe Nicot, François Lecompte, Raphaël Lugan. Nitrogen-mediated metabolic patterns of susceptibility to Botrytis cinerea infection in tomato (Solanum lycopersicum) stems. Planta. 2023 Jan; 257(2):41. doi: 10.1007/s00425-022-04065-0. [PMID: 36680621]
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