Fenobucarb (BioDeep_00000403660)

Main id: BioDeep_00000009896

 

natural product


代谢物信息卡片


Pesticide3_Fenobucarb_C12H17NO2_Bassa

化学式: C12H17NO2 (207.1259)
中文名称: 丁苯威, 仲丁威
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C)C1=CC=CC=C1OC(=O)NC
InChI: InChI=1S/C12H17NO2/c1-4-9(2)10-7-5-6-8-11(10)15-12(14)13-3/h5-9H,4H2,1-3H3,(H,13,14)

描述信息

C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor

同义名列表

6 个代谢物同义名

2-Sec-butylphenyl N-methylcarbamate; Fenobucarb; BPMC; Pesticide3_Fenobucarb_C12H17NO2_Bassa; Fenobucarb; Fenobucarb



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 CASP3, CASP9, CAT, CHAT, DEF6, GAP43, GFAP, KCNQ1, NR5A2, TUBB4B
Peripheral membrane protein 3 ACHE, GAP43, MBP
Nucleus 9 ACHE, CASP3, CASP9, CHAT, DEF6, MANF, MBP, NR5A2, TUBB4B
cytosol 9 CASP3, CASP9, CAT, CHAT, DEF6, GFAP, MANF, MBP, TUBB4B
dendrite 1 GAP43
nucleoplasm 5 ATP2B1, CASP3, DEF6, NR5A2, SCNN1G
RNA polymerase II transcription regulator complex 1 NR5A2
Cell membrane 5 ACHE, ATP2B1, DEF6, GAP43, KCNQ1
Cytoplasmic side 2 GAP43, MBP
Cell projection, axon 1 GAP43
Multi-pass membrane protein 5 ATP2B1, CACNA1I, KCNA3, KCNQ1, SCNN1G
Synapse 5 ACHE, ATP2B1, CHAT, GAP43, MBP
cell surface 2 ACHE, MBP
glutamatergic synapse 3 ATP2B1, CASP3, KCNA3
Golgi apparatus 1 ACHE
neuromuscular junction 1 ACHE
neuronal cell body 3 CASP3, KCNQ1, MBP
presynaptic membrane 2 ATP2B1, KCNA3
Cytoplasmic vesicle, secretory vesicle 1 DEF6
Lysosome 1 KCNQ1
Presynapse 1 GAP43
plasma membrane 10 ACHE, ATP2B1, BCHE, CACNA1I, DEF6, GAP43, KCNA3, KCNQ1, MBP, SCNN1G
synaptic vesicle membrane 1 ATP2B1
Membrane 7 ACHE, ATP2B1, CACNA1I, CAT, DEF6, KCNA3, KCNQ1
apical plasma membrane 2 KCNQ1, SCNN1G
axon 1 KCNA3
basolateral plasma membrane 2 ATP2B1, KCNQ1
extracellular exosome 5 ATP2B1, CAT, MBP, SCNN1G, TUBB4B
endoplasmic reticulum 2 KCNQ1, MANF
extracellular space 4 ACHE, BCHE, DEF6, MANF
perinuclear region of cytoplasm 3 ACHE, DEF6, KCNA3
mitochondrion 2 CASP9, CAT
protein-containing complex 3 CASP9, CAT, MBP
intracellular membrane-bounded organelle 2 ATP2B1, CAT
filopodium 1 DEF6
postsynaptic density 2 CASP3, GAP43
Secreted 4 ACHE, BCHE, DEF6, MANF
extracellular region 7 ACHE, BCHE, CAT, DEF6, MANF, MBP, TUBB4B
astrocyte end-foot 1 GFAP
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 SCNN1G
Extracellular vesicle 1 TUBB4B
perikaryon 1 GAP43
microtubule cytoskeleton 1 TUBB4B
Early endosome 1 KCNQ1
postsynaptic membrane 1 KCNA3
Apical cell membrane 2 KCNQ1, SCNN1G
Cytoplasm, perinuclear region 1 DEF6
Membrane raft 2 KCNA3, KCNQ1
Cytoplasm, cytoskeleton 2 DEF6, TUBB4B
focal adhesion 1 CAT
microtubule 1 TUBB4B
GABA-ergic synapse 1 GAP43
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 MBP
intermediate filament 1 GFAP
lateral plasma membrane 2 ATP2B1, KCNQ1
Cell projection, filopodium 1 DEF6
Late endosome 1 KCNQ1
neuron projection 2 CHAT, KCNQ1
ciliary base 1 KCNQ1
chromatin 1 NR5A2
cell projection 2 ATP2B1, GFAP
cell periphery 1 MBP
mitotic spindle 1 TUBB4B
cytoskeleton 2 DEF6, TUBB4B
[Isoform 3]: Nucleus 1 MBP
blood microparticle 1 BCHE
Basolateral cell membrane 2 ATP2B1, KCNQ1
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 2]: Cell membrane 1 KCNA3
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
axonemal microtubule 1 TUBB4B
monoatomic ion channel complex 1 KCNQ1
Cytoplasmic vesicle membrane 1 KCNQ1
sodium channel complex 1 SCNN1G
Cell projection, dendrite 1 GAP43
Presynaptic cell membrane 1 ATP2B1
cell body 1 GFAP
side of membrane 1 ACHE
myelin sheath 1 MBP
intermediate filament cytoskeleton 1 GFAP
filopodium membrane 1 GAP43
voltage-gated potassium channel complex 2 KCNA3, KCNQ1
ficolin-1-rich granule lumen 2 CAT, MBP
secretory granule lumen 1 CAT
Golgi lumen 1 DEF6
endoplasmic reticulum lumen 2 BCHE, MANF
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 3 DEF6, KCNQ1, MBP
azurophil granule lumen 1 TUBB4B
immunological synapse 1 ATP2B1
nuclear envelope lumen 1 BCHE
apoptosome 1 CASP9
calyx of Held 1 KCNA3
Sarcoplasmic reticulum lumen 1 MANF
ribonucleoprotein complex 1 ELAVL3
synaptic cleft 1 ACHE
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 KCNA3
Cell projection, filopodium membrane 1 GAP43
cytoplasmic side of lysosomal membrane 1 GFAP
compact myelin 1 MBP
internode region of axon 1 MBP
catalase complex 1 CAT
photoreceptor ribbon synapse 1 ATP2B1
[Bone marrow proteoglycan]: Secreted 1 MBP
Cell projection, growth cone membrane 1 GAP43
growth cone membrane 1 GAP43
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
[Isoform H]: Cell membrane 1 ACHE
lumenal side of membrane 1 KCNQ1
basolateral part of cell 1 KCNQ1
caspase complex 1 CASP9
Myelin membrane 1 MBP


文献列表

  • Zongzhe He, Chenglong Li, Weitong Xia, Zhen Wang, Rui Li, Yanqing Zhang, Minghua Wang. Comprehensive Enantioselectivity Evaluation of Insecticidal Activity and Mammalian Toxicity of Fenobucarb. Journal of agricultural and food chemistry. 2022 May; 70(17):5330-5338. doi: 10.1021/acs.jafc.2c00093. [PMID: 35451821]
  • Guiling Yang, Chen Chen, Yijun Yu, Huiyu Zhao, Wen Wang, Yanhua Wang, Leiming Cai, Yueping He, Xinquan Wang. Combined effects of four pesticides and heavy metal chromium (Ⅵ) on the earthworm using avoidance behavior as an endpoint. Ecotoxicology and environmental safety. 2018 Aug; 157(?):191-200. doi: 10.1016/j.ecoenv.2018.03.067. [PMID: 29621711]
  • Nguyen Thanh Tam, Håkan Berg, Jenny Laureus, Nguyen Van Cong, Michael Tedengren. Effects of Sequential Applications of Bassa 50EC (Fenobucarb) and Vitashield 40EC (Chlorpyrifos ethyl) on Acetylcholinesterase Activity in Climbing Perch (Anabas testudineus) Cultured in Rice Fields in the Mekong Delta, Vietnam. Bulletin of environmental contamination and toxicology. 2016 Jul; 97(1):98-104. doi: 10.1007/s00128-016-1796-5. [PMID: 27075585]
  • Feng Jiang, Yixi Zhang, Huahua Sun, Xiangkun Meng, Haibo Bao, Jichao Fang, Zewen Liu. Identification of polymorphisms in Cyrtorhinus lividipennis RDL subunit contributing to fipronil sensitivity. Pesticide biochemistry and physiology. 2015 Jan; 117(?):62-7. doi: 10.1016/j.pestbp.2014.10.010. [PMID: 25619913]
  • Ahmed Mostafa, Gregory Medley, Darren M Roberts, Mosaad Sayed Mohamed, Abdalla A Elshanawani, Michael S Roberts, Xin Liu. Simultaneous quantification of carbamate insecticides in human plasma by liquid chromatography/tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Aug; 879(23):2234-8. doi: 10.1016/j.jchromb.2011.06.006. [PMID: 21723210]
  • Yuko Ito, Tomomi Goto, Sadaji Yamada, Tsutomu Ohno, Hiroshi Matsumoto, Hisao Oka, Yoichiro Ito. Rapid determination of carbamate pesticides in food using dual counter-current chromatography directly interfaced with mass spectrometry. Journal of chromatography. A. 2008 Apr; 1187(1-2):53-7. doi: 10.1016/j.chroma.2008.01.078. [PMID: 18295222]
  • C M P G Amorim, J R Albert-García, M C B S Montenegro, A N Araújo, J Martínez Calatayud. Photo-induced chemiluminometric determination of Karbutilate in a continuous-flow multicommutation assembly. Journal of pharmaceutical and biomedical analysis. 2007 Jan; 43(2):421-7. doi: 10.1016/j.jpba.2006.07.006. [PMID: 16930910]
  • Yuko Ito, Tomomi Goto, Sadaji Yamada, Hiroshi Matsumoto, Hisao Oka, Nobuyuki Takahashi, Hiroyuki Nakazawa, Hisamitsu Nagase, Yoichiro Ito. Application of dual counter-current chromatography for rapid sample preparation of N-methylcarbamate pesticides in vegetable oil and citrus fruit. Journal of chromatography. A. 2006 Mar; 1108(1):20-5. doi: 10.1016/j.chroma.2005.12.070. [PMID: 16445929]
  • Jialun Wu, Liqing Li, Yaohua Zou. Determination of carbamate insecticides in Chinese medicinal herbs by gas chromatography with a nitrogen-phosphorus detector. Journal of AOAC International. 2005 Jul; 88(4):1261-4. doi: . [PMID: 16152951]
  • T Ariyoshi, S Shiiba, H Hasegawa, K Arizono. Profile of metal-binding proteins and heme oxygenase in red carp treated with heavy metals, pesticides and surfactants. Bulletin of environmental contamination and toxicology. 1990 Apr; 44(4):643-9. doi: 10.1007/bf01700889. [PMID: 2322691]
  • T Miyaoka, S Tsuda, Y Shirasu. Mechanism of potentiation of BPMC toxicity by fenthion pretreatment in mice. Journal of pharmacobio-dynamics. 1986 Sep; 9(9):697-703. doi: 10.1248/bpb1978.9.697. [PMID: 3794990]
  • H Takahashi, T Miyaoka, S Tsuda, Y Shirasu. Potentiated toxicity of 2-sec-butylphenyl methylcarbamate (BPMC) by O,O-dimethyl O-(3-methyl-4-nitrophenyl)phosphorothioate (fenitrothion) in mice; relationship between acute toxicity and metabolism of BPMC. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1984 Oct; 4(5):718-23. doi: 10.1016/0272-0590(84)90092-7. [PMID: 6510602]
  • S Tsuda, T Miyaoka, M Iwasaki, Y Shirasu. Pharmacokinetic analysis of increased toxicity of 2-sec-butylphenyl methylcarbamate (BPMC) by fenitrothion pretreatment in mice. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1984 Oct; 4(5):724-30. doi: 10.1016/0272-0590(84)90093-9. [PMID: 6510603]
  • T Miyaoka, H Takahashi, S Tsuda, Y Shirasu. Potentiation of acute toxicity of 2-sec-butylphenyl N-methylcarbamate (BPMC) by fenthion in mice. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1984 Oct; 4(5):802-7. doi: 10.1016/0272-0590(84)90102-7. [PMID: 6510612]
  • M Ueji, J Kanazawa. Uptake and translocation of o-sec-butylphenyl N-methylcarbamate (BPMC) and O,O-diisopropyl S-benzyl phosphorothiolate (IBP) in rice plants applied as single and mixed preparations. Bulletin of environmental contamination and toxicology. 1980 Feb; 24(2):204-10. doi: 10.1007/bf01608098. [PMID: 7362899]