Pravastatin (BioDeep_00000402573)

Main id: BioDeep_00000001762

 

natural product


代谢物信息卡片


(3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid

化学式: C23H36O7 (424.2461)
中文名称: 普伐他汀
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)O)O)O)O
InChI: InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)

描述信息

A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain > C10AA - Hmg coa reductase inhibitors
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
D004791 - Enzyme Inhibitors > D019161 - Hydroxymethylglutaryl-CoA Reductase Inhibitors
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
C471 - Enzyme Inhibitor > C1655 - HMG-CoA Reductase Inhibitor
D009676 - Noxae > D000963 - Antimetabolites
CONFIDENCE standard compound; INTERNAL_ID 659; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4302; ORIGINAL_PRECURSOR_SCAN_NO 4300
CONFIDENCE standard compound; INTERNAL_ID 659; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4318; ORIGINAL_PRECURSOR_SCAN_NO 4317
CONFIDENCE standard compound; INTERNAL_ID 659; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4275; ORIGINAL_PRECURSOR_SCAN_NO 4273
CONFIDENCE standard compound; INTERNAL_ID 659; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4300; ORIGINAL_PRECURSOR_SCAN_NO 4298
CONFIDENCE standard compound; INTERNAL_ID 659; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4285; ORIGINAL_PRECURSOR_SCAN_NO 4283
CONFIDENCE standard compound; INTERNAL_ID 659; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4291; ORIGINAL_PRECURSOR_SCAN_NO 4289
CONFIDENCE standard compound; INTERNAL_ID 2342
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 8558

同义名列表

5 个代谢物同义名

Pravastatin; (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid; FOH 23:6;O6; Pravastatin; Pravastatin



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

29 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ABCB1, ACE, APOB, APOE, CYP3A4, FNTA, MTOR
Peripheral membrane protein 2 CYP1B1, MTOR
Endosome membrane 1 APOB
Endoplasmic reticulum membrane 5 APOB, CD4, CYP1B1, CYP3A4, MTOR
Mitochondrion membrane 1 ABCG2
Nucleus 2 APOE, MTOR
cytosol 6 APOA1, APOB, FNTA, GPT, LEP, MTOR
dendrite 2 APOE, MTOR
mitochondrial membrane 1 ABCG2
phagocytic vesicle 1 MTOR
nucleoplasm 2 ABCG2, MTOR
Cell membrane 6 ABCB1, ABCG2, ACE, CD4, SLCO1B1, SLCO2B1
Cytoplasmic side 1 MTOR
Multi-pass membrane protein 6 ABCB1, ABCC2, ABCC3, ABCG2, SLCO1B1, SLCO2B1
Golgi apparatus membrane 1 MTOR
cell surface 2 ABCB1, ABCC2
glutamatergic synapse 1 APOE
Golgi apparatus 2 APOE, CCN2
Golgi membrane 2 INS, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 2 APOB, APOE
smooth endoplasmic reticulum 1 APOB
Lysosome 2 ACE, MTOR
endosome 1 ACE
plasma membrane 13 ABCB1, ABCC2, ABCC3, ABCG2, ACE, APOA1, APOB, APOE, CCN2, CD4, FNTA, SLCO1B1, SLCO2B1
Membrane 11 ABCB1, ABCC2, ABCC3, ABCG2, ACE, APOE, CYP1B1, CYP3A4, MTOR, SLCO1B1, SLCO2B1
apical plasma membrane 4 ABCB1, ABCC2, ABCG2, SLCO2B1
basolateral plasma membrane 3 ABCC3, SLCO1B1, SLCO2B1
extracellular exosome 6 ABCB1, ACE, APOA1, APOB, APOE, GPT
Lysosome membrane 1 MTOR
endoplasmic reticulum 1 APOE
extracellular space 8 ACE, APOA1, APOB, APOE, CCL2, CCN2, INS, LEP
lysosomal lumen 1 APOB
intercellular canaliculus 1 ABCC2
mitochondrion 1 CYP1B1
intracellular membrane-bounded organelle 4 APOB, CCN2, CYP1B1, CYP3A4
Microsome membrane 3 CYP1B1, CYP3A4, MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 ACE, CD4
Secreted 8 ACE, APOA1, APOB, APOE, CCL2, CCN2, INS, LEP
extracellular region 8 ACE, APOA1, APOB, APOE, CCL2, CCN2, INS, LEP
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
external side of plasma membrane 2 ACE, CD4
Endosome, multivesicular body 1 APOE
Extracellular vesicle 2 APOA1, APOE
Secreted, extracellular space, extracellular matrix 2 APOE, CCN2
chylomicron 3 APOA1, APOB, APOE
high-density lipoprotein particle 2 APOA1, APOE
low-density lipoprotein particle 3 APOA1, APOB, APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 3 APOA1, APOB, APOE
cytoplasmic vesicle 1 APOA1
Early endosome 4 APOA1, APOB, APOE, CD4
Apical cell membrane 4 ABCB1, ABCC2, ABCG2, SLCO2B1
Membrane raft 2 ABCG2, CD4
extracellular matrix 2 APOE, CCN2
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 2 APOA1, APOE
microtubule associated complex 1 FNTA
Secreted, extracellular space 1 APOE
brush border membrane 2 ABCG2, ACE
blood microparticle 2 APOA1, APOE
sperm midpiece 1 ACE
Basolateral cell membrane 3 ABCC3, SLCO1B1, SLCO2B1
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 2 APOB, INS
Lipid droplet 1 APOB
Melanosome 1 APOE
basal plasma membrane 4 ABCC3, ACE, SLCO1B1, SLCO2B1
secretory granule lumen 2 APOA1, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 5 APOA1, APOB, APOE, CD4, INS
endocytic vesicle 1 APOA1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
endoplasmic reticulum exit site 1 APOB
clathrin-coated endocytic vesicle membrane 3 APOB, APOE, CD4
synaptic cleft 1 APOE
Basal cell membrane 3 ABCC3, SLCO1B1, SLCO2B1
external side of apical plasma membrane 2 ABCB1, ABCG2
Cytoplasmic vesicle, phagosome 1 MTOR
discoidal high-density lipoprotein particle 1 APOE
spherical high-density lipoprotein particle 1 APOA1
endocytic vesicle lumen 3 APOA1, APOB, APOE
T cell receptor complex 1 CD4
chylomicron remnant 2 APOB, APOE
intermediate-density lipoprotein particle 2 APOB, APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
mature chylomicron 1 APOB
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
CAAX-protein geranylgeranyltransferase complex 1 FNTA
protein farnesyltransferase complex 1 FNTA


文献列表

  • Tingting Fu, Valentina Calabrese, Sarah Bancel, Hervé Quéau, Laura Garnero, Nicolas Delorme, Khedidja Abbaci, Arnaud Salvador, Arnaud Chaumot, Olivier Geffard, Davide Degli-Esposti, Sophie Ayciriex. ToF-SIMS imaging shows specific lipophilic vitamin alterations in chronic reprotoxicity caused by the emerging contaminant Pravastatin in Gammarus fossarum. Aquatic toxicology (Amsterdam, Netherlands). 2024 Jun; 271(?):106935. doi: 10.1016/j.aquatox.2024.106935. [PMID: 38723468]
  • Hacer Kayhan Kaya, Berjan Demirtas, Beran Yokus, Dilek Aygün Kesim, Ezel Tasdemir, Abdurrahman Sermet. Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model. Acta pharmaceutica (Zagreb, Croatia). 2024 Mar; 74(1):117-130. doi: 10.2478/acph-2024-0001. [PMID: 38554383]
  • Paolo Raggi, Farzin M Takyar, Varuna Gadiyaram, Chao Zhang, Arthur E Stillman, Amir H Davarpanah. Differential effect of atorvastatin and pravastatin on thoracic spine attenuation: A sub-analysis of a randomized clinical trial. Atherosclerosis. 2024 Jan; 388(?):117425. doi: 10.1016/j.atherosclerosis.2023.117425. [PMID: 38109819]
  • Cong Chen, Zheng-Feng Liang, Yu-Qi He, An-Qi Li, Yan Gao, Qun-Wen Pan, Jing-Song Cao. Pravastatin promotes type 2 diabetes vascular calcification through activating intestinal Bacteroides fragilis to induce macrophage M1 polarization. Journal of diabetes. 2023 Dec; ?(?):. doi: 10.1111/1753-0407.13514. [PMID: 38112268]
  • Abhinav Rana, Thakur Uttam Singh, Meemansha Sharma, Manju Gari, Tarun Kumar, Subhashree Parida, Madhu Cholenahalli Lingaraju, Asok Kumar Mariappan, Akhilesh Kumar, Dinesh Kumar. Pravastatin attenuates isoprenaline induced cardiac fibrosis in a mouse model. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2023 Oct; ?(?):1-11. doi: 10.1080/10520295.2023.2260303. [PMID: 37814775]
  • Stephen P Adams, Nima Alaeiilkhchi, Sara Tasnim, James M Wright. Pravastatin for lowering lipids. The Cochrane database of systematic reviews. 2023 09; 9(?):CD013673. doi: 10.1002/14651858.cd013673.pub2. [PMID: 37721222]
  • Caroline Nb Clezar, Carolina Dq Flumignan, Nicolle Cassola, Luis Cu Nakano, Virginia Fm Trevisani, Ronald Lg Flumignan. Pharmacological interventions for asymptomatic carotid stenosis. The Cochrane database of systematic reviews. 2023 Aug; 8(?):CD013573. doi: 10.1002/14651858.cd013573.pub2. [PMID: 37565307]
  • Jin Xu, Liyuan Zhu, Yingying Xie, Miao Zhang, Zixi Xiao, Rongkai Su, Tie Wen, Ling Liu. Effects of xuezhikang versus pravastatin on triglyceride level in patients with T2DM and dyslipidemia: study protocol for a multicenter randomized controlled trial. Current vascular pharmacology. 2023 Mar; ?(?):. doi: 10.2174/1570161121666230328110215. [PMID: 36998136]
  • Ruifeng Liang, Wenjing Ge, Bingjie Li, Weifeng Cui, Xiaofan Ma, Yuying Pan, Gengsheng Li. Evodiamine decreased the systemic exposure of pravastatin in non-alcoholic steatohepatitis rats due to the up-regulation of hepatic OATPs. Pharmaceutical biology. 2022 Dec; 60(1):359-373. doi: 10.1080/13880209.2022.2036767. [PMID: 35171063]
  • Hulusi Bulent Zeyneloglu, Yusuf Aytac Tohma, Emre Gunakan, Mehmet Ali Abasıyanık, Ceren Sozen, Gogsen Onalan. Diet and pravastatin administration prior to in vitro fertilization treatment may improve pregnancy outcome in women with dyslipidemia. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 2022 Aug; 42(6):2235-2240. doi: 10.1080/01443615.2022.2036968. [PMID: 35257641]
  • Ferran Trias, Xavier Pintó, Emili Corbella, Manuel Suárez-Tembra, Antonio Ruíz-García, José Luis Díaz-Díaz, Elena Sánchez-Ruíz-Granado, Itziar Sarasa, Raul Martínez-Porqueras, Maria Angeles Rodríguez-Sánchez, Xavier Corbella. Differences in the diabetogenic effect of statins in patients with prediabetes. The PRELIPID study. Medicina clinica. 2022 06; 158(11):531-539. doi: 10.1016/j.medcli.2021.06.018. [PMID: 34517987]
  • Jumpei Saito, Kayoko Kaneko, Sawako Abe, Naho Yakuwa, Hiroyo Kawasaki, Tomo Suzuki, Akimasa Yamatani, Haruhiko Sago, Atsuko Murashima. Pravastatin concentrations in maternal serum, umbilical cord serum, breast milk and neonatal serum during pregnancy and lactation: A case study. Journal of clinical pharmacy and therapeutics. 2022 May; 47(5):703-706. doi: 10.1111/jcpt.13590. [PMID: 34951046]
  • Zhen Zhou, Andrea J Curtis, Michael E Ernst, Joanne Ryan, Sophia Zoungas, Rory Wolfe, John J McNeil, Anne M Murray, Christopher M Reid, Enayet K Chowdhury, Robyn L Woods, Andrew M Tonkin, Mark R Nelson. Comparison of statins for primary prevention of cardiovascular disease and persistent physical disability in older adults. European journal of clinical pharmacology. 2022 Mar; 78(3):467-476. doi: 10.1007/s00228-021-03239-1. [PMID: 34698889]
  • Kacey Anderson, Cara H Nelson, Qi Gong, Muhsen Alani, Thomas Tarnowski, Ahmed A Othman. Assessment of the Effect of Filgotinib on the Pharmacokinetics of Atorvastatin, Pravastatin, and Rosuvastatin in Healthy Adult Participants. Clinical pharmacology in drug development. 2022 02; 11(2):235-245. doi: 10.1002/cpdd.1015. [PMID: 34468080]
  • Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Roxanne Hastie, Fiona Brownfoot, Catherine Cluver, Natalie Hannan. Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia. American journal of obstetrics and gynecology. 2022 02; 226(2S):S1157-S1170. doi: 10.1016/j.ajog.2020.09.014. [PMID: 32946849]
  • Seo Young Kang, Tae Hee Jeon, Keun-Sang Yum, Sung Sunwoo, Hyun-Young Shin, Dae Hyun Kim, Kiduk Kim, Jong Lull Yoon, Jae-Kyung Choi, Young Sik Kim. Relationship between Dietary Habits and Control of Lipid Profiles in Patients with Dyslipidemia Using Pravastatin. Nutrients. 2021 Oct; 13(11):. doi: 10.3390/nu13113784. [PMID: 34836040]
  • Yong Wang, Xiaoguang Lu, Xiaoping Wang, Qi Qiu, Ping Zhu, Lin Ma, Xiao Ma, Joerg Herrmann, Xueying Lin, Wei Wang, Xiaolei Xu. atg7-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity. Circulation research. 2021 10; 129(8):e166-e182. doi: 10.1161/circresaha.121.319104. [PMID: 34384247]
  • Fuyo Takeda, Masako Oda, Masaru Terasaki, Atsuhito Kubota, Keita Asada, Yuichi Ichimura, Hiroyuki Kojima, Hiroshi Saitoh. Downregulated expression of organic anion transporting polypeptide (Oatp) 2b1 in the small intestine of rats with acute kidney injury. Drug metabolism and pharmacokinetics. 2021 Oct; 40(?):100411. doi: 10.1016/j.dmpk.2021.100411. [PMID: 34284282]
  • Moritz Döbert, Anna Nektaria Varouxaki, An Chi Mu, Argyro Syngelaki, Anca Ciobanu, Ranjit Akolekar, Catalina De Paco Matallana, Simona Cicero, Elena Greco, Mandeep Singh, Deepa Janga, Maria Del Mar Gil, Jacques C Jani, José Luis Bartha, Kate Maclagan, David Wright, Kypros H Nicolaides. Pravastatin Versus Placebo in Pregnancies at High Risk of Term Preeclampsia. Circulation. 2021 08; 144(9):670-679. doi: 10.1161/circulationaha.121.053963. [PMID: 34162218]
  • Christine M Bowman, Buyun Chen, Jonathan Cheong, Liling Liu, Yuan Chen, Jialin Mao. Improving the Translation of Organic Anion Transporting Polypeptide Substrates using HEK293 Cell Data in the Presence and Absence of Human Plasma via Physiologically Based Pharmacokinetic Modeling. Drug metabolism and disposition: the biological fate of chemicals. 2021 07; 49(7):530-539. doi: 10.1124/dmd.120.000315. [PMID: 33958385]
  • V Sashi Gopaul, Elsbet J Pieterman, Hans M G Princen, Linnéa Bergenholm, Eva Lundborg, Anders Cavallin, Magnus J Johansson, Glen Hawthorne, Anders Björkbom, Maria Hammarberg, XueQing Li, Annica Jarke, Jonathan Bright, Lena Svensson, Rasmus Jansson-Löfmark, Bertil Abrahamsson, Rahul Agrawal, Eva Hurt-Camejo. Effects of mineral oil administration on the pharmacokinetics, metabolism and pharmacodynamics of atorvastatin and pravastatin in mice and dogs. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2021 Jun; 161(?):105776. doi: 10.1016/j.ejps.2021.105776. [PMID: 33667667]
  • Staci L Haney, Michelle L Varney, Yashpal Chhonker, Geoffrey Talmon, Lynette M Smith, Daryl J Murry, Sarah A Holstein. In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway. Pharmacological research. 2021 05; 167(?):105528. doi: 10.1016/j.phrs.2021.105528. [PMID: 33667685]
  • Hatice Nurdan Aksoy, Cagatay Ceylan. Comparison of the Effects of Statins on A549 Nonsmall-Cell Lung Cancer Cell Line Lipids Using Fourier Transform Infrared Spectroscopy: Rosuvastatin Stands Out. Lipids. 2021 05; 56(3):289-299. doi: 10.1002/lipd.12296. [PMID: 33611813]
  • Madhurima M Baliga, Jost Klawitter, Uwe Christians, Katharina Hopp, Michel Chonchol, Berenice Y Gitomer, Melissa A Cadnapaphornchai, Jelena Klawitter. Metabolic profiling in children and young adults with autosomal dominant polycystic kidney disease. Scientific reports. 2021 03; 11(1):6629. doi: 10.1038/s41598-021-84609-8. [PMID: 33758231]
  • Bo Feng, Rachel Pemberton, Wojciech Dworakowski, Zhengqi Ye, Craig Zetterberg, Guanyu Wang, Yoshio Morikawa, Sanjeev Kumar. Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Polypeptide Transporter Substrates. Drug metabolism and disposition: the biological fate of chemicals. 2021 03; 49(3):254-264. doi: 10.1124/dmd.120.000276. [PMID: 33376106]
  • Fan Deng, Jing-Juan Hu, Xiao Yang, Qi-Shun Sun, Ze-Bin Lin, Bing-Cheng Zhao, Zhi-Wen Yao, Si-Dan Luo, Ze-Ling Chen, Ying Liu, Zheng-Zheng Yan, Cai Li, Wei-Feng Liu, Ke-Xuan Liu. Gut Microbial Metabolite Pravastatin Attenuates Intestinal Ischemia/Reperfusion Injury Through Promoting IL-13 Release From Type II Innate Lymphoid Cells via IL-33/ST2 Signaling. Frontiers in immunology. 2021; 12(?):704836. doi: 10.3389/fimmu.2021.704836. [PMID: 34650552]
  • Anita Virtanen, Outi Huttala, Kati Tihtonen, Tarja Toimela, Tuula Heinonen, Hannele Laivuori, Jukka Uotila. Angiogenic Effect of Pravastatin Alone and with Sera from Healthy and Complicated Pregnancies Studied by in vitro Vasculogenesis/Angiogenesis Assay. Journal of vascular research. 2021; 58(3):139-147. doi: 10.1159/000512831. [PMID: 33571991]
  • Eleftheria Lefkou, Katerina Varoudi, Joaquim Pombo, Aleksandar Jurisic, Zaklina Jurisic, Greg Contento, Guillermina Girardi. Triple therapy with pravastatin, low molecular weight heparin and low dose aspirin improves placental haemodynamics and pregnancy outcomes in obstetric antiphospholipid syndrome in mice and women through a nitric oxide-dependent mechanism. Biochemical pharmacology. 2020 12; 182(?):114217. doi: 10.1016/j.bcp.2020.114217. [PMID: 32926874]
  • G-J Wang, Z Yang, J Huai, Q-Q Xiang. Pravastatin alleviates oxidative stress and decreases placental trophoblastic cell apoptosis through IL-6/STAT3 signaling pathway in preeclampsia rats. European review for medical and pharmacological sciences. 2020 12; 24(24):12955-12962. doi: 10.26355/eurrev_202012_24199. [PMID: 33378046]
  • Jonathan B Wagner, Melissa Ruggiero, J Steven Leeder, Bruno Hagenbuch. Functional Consequences of Pravastatin Isomerization on OATP1B1-Mediated Transport. Drug metabolism and disposition: the biological fate of chemicals. 2020 11; 48(11):1192-1198. doi: 10.1124/dmd.120.000122. [PMID: 32892153]
  • Begoña Lavin Plaza, Alkystis Phinikaridou, Marcelo E Andia, Myles Potter, Silvia Lorrio, Imran Rashid, Rene M Botnar. Sustained Focal Vascular Inflammation Accelerates Atherosclerosis in Remote Arteries. Arteriosclerosis, thrombosis, and vascular biology. 2020 09; 40(9):2159-2170. doi: 10.1161/atvbaha.120.314387. [PMID: 32673527]
  • Keigo Nakayama, Hidetaka Kamimura, Hiroshi Suemizu, Nao Yoneda, Megumi Nishiwaki, Kazuhiko Iwamoto, Mari Mizunaga, Tamotsu Negoro, Soichiro Ito, Hiroshi Yamazaki, Yukihiro Nomura. Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data. Drug metabolism and pharmacokinetics. 2020 Aug; 35(4):389-396. doi: 10.1016/j.dmpk.2020.05.004. [PMID: 32690433]
  • Sotirios Tsimikas, Philip L S M Gordts, Chelsea Nora, Calvin Yeang, Joseph L Witztum. Statin therapy increases lipoprotein(a) levels. European heart journal. 2020 06; 41(24):2275-2284. doi: 10.1093/eurheartj/ehz310. [PMID: 31111151]
  • David C Boettiger, Anthony T Newall, Pairoj Chattranukulchai, Romanee Chaiwarith, Suwimon Khusuwan, Anchalee Avihingsanon, Andrew Phillips, Eran Bendavid, Matthew G Law, James G Kahn, Jeremy Ross, Sergio Bautista-Arredondo, Sasisopin Kiertiburanakul. Statins for atherosclerotic cardiovascular disease prevention in people living with HIV in Thailand: a cost-effectiveness analysis. Journal of the International AIDS Society. 2020 06; 23 Suppl 1(?):e25494. doi: 10.1002/jia2.25494. [PMID: 32562359]
  • Lea Wagmann, Selina Hemmer, Achim T Caspar, Markus R Meyer. Method development for quantitative determination of seven statins including four active metabolites by means of high-resolution tandem mass spectrometry applicable for adherence testing and therapeutic drug monitoring. Clinical chemistry and laboratory medicine. 2020 04; 58(5):664-672. doi: 10.1515/cclm-2019-0763. [PMID: 31665111]
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