N-Acetyl-L-leucine (BioDeep_00000400101)

Main id: BioDeep_00000001391

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


N-Acetyl-L-leucine

化学式: C8H15NO3 (173.105188)
中文名称: N-乙酰-L-亮氨酸, N-乙酰基-L-亮氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(C(=O)O)NC(=O)C
InChI: InChI=1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)/t7-/m0/s1

描述信息

The N-acetyl derivative of L-leucine.
N-Acetyl-L-leucine is an endogenous metabolite.

同义名列表

2 个代谢物同义名

N-Acetyl-L-leucine; N-Acetyl-L-leucine



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Grant C Churchill, Michael Strupp, Antony Galione, Frances M Platt. Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance. PloS one. 2020; 15(2):e0229585. doi: 10.1371/journal.pone.0229585. [PMID: 32108176]
  • Hasene Keskin Çavdar, Derya Koçak Yanık, Fahrettin Göğüş, Sibel Fadıloğlu. A Novel Modified Lipid: Enzymatic Esterification of 2-Monoacylglycerol with N-acetyl-l-leucine. Journal of food science. 2018 Mar; 83(3):597-604. doi: 10.1111/1750-3841.14070. [PMID: 29437236]
  • Anthony J Lee, David W A Beno, Xiaolin Zhang, Robin Shapiro, Mark Mason, Tanita Mason-Bright, Bruce Surber, Neilé K Edens. A (14)C-leucine absorption, distribution, metabolism and excretion (ADME) study in adult Sprague-Dawley rat reveals β-hydroxy-β-methylbutyrate as a metabolite. Amino acids. 2015 May; 47(5):917-24. doi: 10.1007/s00726-015-1920-6. [PMID: 25618754]
  • Ying-Yong Zhao, Jing Liu, Xian-Long Cheng, Xu Bai, Rui-Chao Lin. Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS. Clinica chimica acta; international journal of clinical chemistry. 2012 Mar; 413(5-6):642-9. doi: 10.1016/j.cca.2011.12.014. [PMID: 22227165]
  • Haruhito Tsutsui, Toshio Maeda, Jun Zhe Min, Shinsuke Inagaki, Tatsuya Higashi, Yoshiyuki Kagawa, Toshimasa Toyo'oka. Biomarker discovery in biological specimens (plasma, hair, liver and kidney) of diabetic mice based upon metabolite profiling using ultra-performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry. Clinica chimica acta; international journal of clinical chemistry. 2011 May; 412(11-12):861-72. doi: 10.1016/j.cca.2010.12.023. [PMID: 21185819]
  • T Gopinath, Raffaello Verardi, Nathaniel J Traaseth, Gianluigi Veglia. Sensitivity enhancement of separated local field experiments: application to membrane proteins. The journal of physical chemistry. B. 2010 Apr; 114(15):5089-95. doi: 10.1021/jp909778a. [PMID: 20349983]
  • T Gopinath, Nathaniel J Traaseth, Kaustubh Mote, Gianluigi Veglia. Sensitivity enhanced heteronuclear correlation spectroscopy in multidimensional solid-state NMR of oriented systems via chemical shift coherences. Journal of the American Chemical Society. 2010 Apr; 132(15):5357-63. doi: 10.1021/ja905991s. [PMID: 20345172]
  • T Gopinath, Gianluigi Veglia. Sensitivity enhancement in static solid-state NMR experiments via single- and multiple-quantum dipolar coherences. Journal of the American Chemical Society. 2009 Apr; 131(16):5754-6. doi: 10.1021/ja900096d. [PMID: 19351170]
  • D H Jones, S J Opella. Application of Maximum Entropy reconstruction to PISEMA spectra. Journal of magnetic resonance (San Diego, Calif. : 1997). 2006 Mar; 179(1):105-13. doi: 10.1016/j.jmr.2005.11.014. [PMID: 16343957]